Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T29956 |
Amchem R 14
R14,Polyurethane Y-195,R-14 |
Others | Others |
Amchem R 14 is a biochemical. | |||
T7667 |
R1487
|
p38 MAPK | MAPK |
R1487 是一种口服生物可利用的高选择性 p38α 丝裂原活化蛋白激酶抑制剂。 | |||
T79745 |
IDH2R140Q-IN-2
|
Dehydrogenase | Metabolism |
IDH2R140Q-IN-2 是一种具有口服活性和高效性的 IDH2R140Q 抑制剂,IC50为29 nM。IDH2R140Q-IN-2 具有潜在的抗肿瘤活性,能减少携带IDH2R140Q突变的TF-1细胞系中D2HG的生成(IC50为10 nM),抑制肿瘤组织中D2HG的水平。IDH2R140Q-IN-2适用于研究急性髓系白血病(AML)。 | |||
T15416 |
GR148672X
4,4,4-三氟-1-(2-噻吩基)-1,2,3-丁三酮 2-[(3-甲基苯基)腙] |
Others | Others |
GR148672X 是三酰甘油水解酶抑制剂(IC50:4 nM)。 | |||
T9316 |
JR14a
5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride |
Complement System | Immunology/Inflammation |
JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) 是补体C3a 受体噻吩拮抗剂,可抑制 C3aR 介导的炎症,对人 C3a 受体的选择性高于 C5a 受体。 | |||
T16928 |
SR144528
|
Cannabinoid Receptor | GPCR/G Protein |
SR144528 是 CB2 受体的拮抗剂 (Ki = 0.6 nM) 并抑制微粒体 ACAT 活性 (IC50 = 3.6 μM)。 | |||
TP1312L |
[SER140]-PLP(139-151) acetate
[SER140]-PLP(139-151) acetate (122018-58-0 Free base) |
Others | Others |
[SER140]-PLP(139-151) acetate 是来自髓鞘蛋白脂蛋白 (PLP) 的肽片段。 | |||
T80897 |
UniPR1447
|
Ephrin Receptor | Tyrosine Kinase/Adaptors |
UniPR1447 是一种双重EphA2和EphB2拮抗剂,其对EphA2−ephrin-A1结合的IC50为6.6 μM。 | |||
T7162 |
R1487 Hydrochloride
R1487 (Hydrochloride) |
p38 MAPK; Autophagy | Autophagy; MAPK |
R1487 Hydrochloride (R1487(Hydrochloride)) 是一种可口服的高选择性 p38α 抑制剂,对 p38α 和 p38β 的Kd 值分别为 0.2 nM 和 29 nM。 | |||
T28845 |
SR142948A HCl
SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride |
Others | Others |
SR 142948A is a non-peptide antagonist of neurotensin receptor. SR 142948A affects the expression of c-Fos and has properties of antipsychotic agent. SR 142948A blocks hypothermia and analgesia induced by neurotensin. It blocks the increase in the concent | |||
T81039 |
TAS2R14 agonist-2
|
Others | Others |
TAS2R14 agonist-2 (compound 28.1) 作为选择性TAS2R14抑制剂,其EC50为72 nM。 | |||
T24699 |
R1498
R-1498,R 1498 |
Others | Others |
R1498 is an inhibitor of cyclin-dependent kinase 2. It also acts by targeting angiogenesis and mitosis pathways. It is well-tolerated and orally active for hepatocellular carcinoma and gastric cancer treatment. | |||
TP1312 |
[SER140]-PLP(139-151)
|
||
[SER140]-PLP(139-151) is a polypeptide fragment of the lipid protein of myelin. | |||
T80896 |
UniPR1449
|
Ephrin Receptor | Tyrosine Kinase/Adaptors |
UniPR1449为EphA2受体拮抗剂,具有KD值约为3.8±2.4 μM,对癌症具有关键影响。 | |||
T69340 |
R140309
|
Others | Others |
R140309 is an UCHL3 inhibitor. | |||
T81040 |
TAS2R14 agonist-1
|
Others | Others |
TAS2R14 agonist为一种TAS2R14受体的部分激活分子,其EC50值确定为116.6±23.6 nM。 | |||
T24828 |
SR14150
SR-14150,SR 14150 |
Others | Others |
SR14150 is a partial agonist of high-affinity NOP receptor. | |||
TP1402 |
[SER140]-PLP(139-151) TFA (122018-58-0 free base)
[SER140]-PLP(139-151) TFA |
||
[SER140]-PLP(139-151) (TFA) is a polypeptide fragment of the myelin lipid protein. | |||
T63193 |
IDH2R140Q-IN-1
|
Others | Others |
IDH2R140Q-IN-1 是IDH2R140Q 有效的抑制剂(IC50: 6.1 nM),能够用于急性髓细胞白血病的研究。 |