Cat. No. | Product Name | Target | Signaling Pathways |
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T38836L |
Protease-Activated Receptor-1, PAR-1 Agonist acetate
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Protease-activated Receptor | GPCR/G Protein |
Protease-Activated Receptor-1, PAR-1 Agonist acetate 是一种选择性蛋白酶激活受体 1 (PAR-1) 激动剂肽。 它对应于 PAR1 栓系配体,可以选择性地模拟凝血酶通过该受体的作用。 | |||
T38836 |
Protease-Activated Receptor-1, PAR-1 Agonist
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Protease-Activated Receptor-1 (PAR-1) Agonist, a selective peptide, activates the PAR-1 receptor by mimicking the specific actions of thrombin. It corresponds to the PAR1 tethered ligand, facilitating selective activation of this receptor. | |||
T36288 |
Protease-Activated Receptor-1, PAR-1 Agonist TFA
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Protease-Activated Receptor-1 (PAR-1) Agonist TFA is a selective peptide that acts as an agonist for the proteinase-activated receptor-1 (PAR-1). Corresponding to the tethered ligand of PAR-1, this compound mimics the actions of thrombin through the PAR-1 receptor[1][2]. | |||
TP1046 |
SLIGRL-NH2
Protease-Activated Receptor-2 Activating Peptide |
Protease-activated Receptor | GPCR/G Protein |
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) 为一种蛋白酶激活受体-2 (PAR-2) 激动剂,具有诱导非组胺能性瘙痒的功能。 | |||
T36289 |
Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA
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Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a peptide that acts as an agonist for the proteinase-activated receptor (PAR-3)[1]. | |||
T36286 |
Protease-Activated Receptor-3 (PAR-3) (1-6), human
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TFRGAP-amide, human PAR-3-derived tethered ligand sequence which does not activate PAR-3 but rather activates PAR-1 and PAR-2, either in Jurkat or in other PAR-expressing cells. | |||
T1986 |
Atopaxar
E5555,ER-172594-00 |
Protease-activated Receptor | GPCR/G Protein |
Atopaxar (E5555) 是一种高效、可口服的,选择性的,可逆的凝血酶受体蛋白酶激活受体-1 (PAR-1) 拮抗剂。它是一种抗血小板剂,能干扰血小板信号,可用于动脉粥样硬化血栓性疾病的研究。 | |||
TP1046L |
PAR-2 Activating Peptide acetate
SLIGRL-NH2 acetate,PAR-2 Activating Peptide acetate(171436-38-7 free base),Protease-Activated Receptor-2 Activating Peptide acetate |
Protease-activated Receptor | GPCR/G Protein |
PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate)(171436-38-7 free base) 是 Protease-Activated Receptor-2 (PAR-2) 的激动剂。 | |||
T7137 |
I-191
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Protease-activated Receptor | GPCR/G Protein |
I-191 是选择性有效的蛋白酶激活受体 2 拮抗剂。 | |||
TQ0012 |
AZ3451
|
Protease-activated Receptor | GPCR/G Protein |
AZ3451 是蛋白酶激活受体 2 的变构拮抗剂,IC50值为 23 nM。 | |||
TP1065 |
PAR-4 Agonist Peptide, amide TFA
PAR-4-AP (TFA),AY-NH2 (TFA) |
Protease-activated Receptor | GPCR/G Protein |
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) 是一种蛋白酶激活受体 4 (PAR-4) 激动剂,对 PAR-1 或 PAR-2 均无影响,其作用可被 PAR-4 拮抗剂阻断。 | |||
T7625 |
TRAP-6
PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA) |
Protease-activated Receptor | GPCR/G Protein |
TRAP-6 (Thrombin Receptor Activator Peptide 6) 是一种多肽片段,是选择性的蛋白酶激活受体 1 (PAR1) 激动剂,通过凝血酶受体激活人血小板。 | |||
T1893 |
Parmodulin 2
ML 161 |
Protease-activated Receptor | GPCR/G Protein |
Parmodulin 2 (ML 161) 是一种蛋白酶激活受体 1(PAR1) 变构抑制剂,IC50为 0.26 μM。它是蛋白酶激活受体 1 (PAR1) 介导的血小板活化的抑制剂,可以抑制体外血小板聚集和体内血小板血栓形成。 | |||
T7513 |
Protease-Activated Receptor-2, amide
蛋白酶活化的受体-2,酰胺,SLIGKV-NH2,H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2 |
Protease-activated Receptor | GPCR/G Protein |
Protease-Activated Receptor-2, amide (SLIGKV-NH2) 是 PAR2 的激动剂,IC50为 10.4 M。 | |||
T2370 |
AC-55541
AOB2796 |
Proteasome; Protease-activated Receptor | GPCR/G Protein; Proteases/Proteasome; Ubiquitination |
AC-55541 (AOB2796) 是高选择性的蛋白酶激活受体 2(PAR2)激动剂,pEC50为6.7。它在 PI 水解测定和 Ca2+动态测定中的pEC50值为 5.9 和 6.6,在体内表现出伤害感受器活性。 | |||
T8917 |
PAR-2-IN-1
IUN76750,8-(叔丁基)-6-氯咪唑并[1,2-B]吡啶-2-羧酸甲酯 |
Protease-activated Receptor | GPCR/G Protein |
PAR-2-IN-1 (IUN76750) 是一种 PAR-2 信号通路抑制剂,具有抗炎和抗癌作用。 | |||
T7013 |
Vorapaxar
SCH 530348,MK-5348,沃拉帕沙 |
Protease-activated Receptor | GPCR/G Protein |
Vorapaxar (MK-5348) 是抗血小板药物,是一种选择性、口服活性和竞争性的凝血酶受体蛋白酶激活受体(PAR-1)拮抗剂,Ki 值为 8.1 nM。它靠剂量依赖性抑制凝血酶受体激活肽 (TRAP) 诱导的血小板聚集。 | |||
T12870 |
SCH79797 dihydrochloride
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Apoptosis; Others; Protease-activated Receptor | Apoptosis; GPCR/G Protein; Others |
SCH79797 dihydrochloride 是一种有效的特异性蛋白酶激活受体 1 (PAR1) 拮抗剂,IC50 为 70 nM,Ki 为 35 nM。SCH79797 dihydrochloride 具有抗增殖和促凋亡作用。 | |||
T3098 |
Vorapaxar sulfate
SCH 530348 sulfate,Zontivity,vorapaxar monosulfate,沃拉帕沙 |
Protease-activated Receptor | GPCR/G Protein |
Vorapaxar sulfate (Zontivity) 是一种选择性、口服活性和竞争性的凝血酶受体蛋白酶激活受体(PAR-1)拮抗剂,Ki 值为 8.1 nM。它剂量依赖性抑制凝血酶受体激活肽 (TRAP) 诱导的血小板聚集,是抗血小板药物。 | |||
T7380 |
Protease-Activated Receptor-4
蛋白酶活化的受体-4 |
Protease-activated Receptor | GPCR/G Protein |
Protease-Activated Receptor-4 是蛋白酶激活受体 4 激动剂,具有抗血小板治疗。 | |||
T1986L |
Atopaxar Hydrobromide
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Protease-activated Receptor | GPCR/G Protein |
Atopaxar hydrobromide 是可口服的,高效选择性的可逆凝血酶受体蛋白酶激活受体-1 拮抗剂。它是一种抗血小板剂,能干扰血小板信号,用于动脉粥样硬化血栓性疾病的研究。 | |||
T4186 |
AC-264613
AC264613 |
Protease-activated Receptor | GPCR/G Protein |
AC-264613 是一种选择性蛋白酶激活受体 (PAR-2) 激动剂,pEC50为 7.5。 | |||
T7623 |
PAR-4 Agonist Peptide, amide
AY-NH2,PAR-4 Agonist Peptide, amide(2TFA),PAR-4-AP |
Protease-activated Receptor | GPCR/G Protein |
PAR-4 Agonist Peptide, amide (AY-NH2) 是蛋白酶激活受体 4 (PAR-4) 的激动剂,对 PAR-1 或 PAR-2 均无影响,其作用可被 PAR-4 拮抗剂阻断。 | |||
T7573 |
TFLLR-NH2
TFLLR-NH2(2TFA) |
Protease-activated Receptor | GPCR/G Protein |
TFLLR-NH2 是选择性的一种PAR1激动剂,EC50值为1.9 μM。 | |||
T7496 |
Thrombin Receptor Activator for Peptide 5 (TRAP-5)
Thrombin Receptor Activator for Peptide |
Protease-activated Receptor | GPCR/G Protein |
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。 | |||
T63966 |
BMS-986141
UDM-003183 |
Protease-activated Receptor | GPCR/G Protein |
BMS-986141(UDM-003183) 是一种具有口服活性的选择性和高效性的凝血酶受体蛋白酶激活受体-4 (protease-activated receptor-4 (PAR-4)) 拮抗剂,其 IC50 值为 0.4 nM。BMS-98614 表现出显著的抗血栓作用。 | |||
T75902 |
SLIGRL-NH2 TFA
Protease-Activated Receptor-2 Activating Peptide TFA |
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SLIGRL-NH2 TFA(Protease-Activated Receptor-2 Activating Peptide TFA)作为PAR-2(蛋白酶激活受体-2)的激动剂,具有高度特异性。 | |||
T62507 | Protease-Activated Receptor-1 antagonist 1 | ||
Protease-Activated Receptor-1 antagonist 1 (Compound 13) 是一种蛋白酶激活受体 1 (PAR-1) 拮抗剂,通过 FLIPR 技术得到的 IC50 为 3 nM。Protease-Activated Receptor-1 antagonist 1 能够用于研究血栓性心血管、心肌梗塞和外周动脉疾病。 | |||
T80111 |
TRAP-5 amide
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TRAP-5 amide为蛋白酶激活受体1(PAR1)特异性的激动剂肽。 | |||
T64285 | Protease-Activated Receptor-1 antagonist 2 | ||
Protease-Activated Receptor-1 antagonist 2 是一种选择性的、口服具有活力的蛋白酶激活受体-1 (PAR-1) 拮抗剂 (IC50: 7 nM)。Protease-Activated Receptor-1 antagonist 2 显示出良好的药代动力学特性,能够用于进行心血管疾病 (CVD) 的相关研究(如动脉粥样硬化和再狭窄)。 | |||
T75904 |
PAR 4 (1-6) (TFA)
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GYPGQV TFA (PAR 4 (1-6) TFA) 是一种六肽,作为蛋白酶激活受体 4 (PAR4) 片段,能特异性抑制PAR4。 | |||
T74266 |
Protease-Activated Receptor-1 antagonist 2
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Protease-Activated Receptor-1 antagonist 2 是一种选择性蛋白酶激活受体-1 (PAR-1) 拮抗剂,口服活性,IC50值为7 nM。该化合物具有优良的药代动力学特性,适用于心血管疾病 (CVD) 如动脉粥样硬化和再狭窄的研究。 | |||
T80240 |
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
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Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2是一类具有生物活性的肽,作为蛋白酶激活受体1 (PAR-1) 的选择性激动剂,其特异性优于PAR-2。该肽通过HEK293细胞进行的基于细胞的钙信号传导测定确认了其对PAR-1的高特异性,并可用于研究PAR-1在体内的激活。PAR-1除了介导凝血酶的多种细胞作用外,还与PAR-4协作,参与调控凝血酶诱导的被分类为“凝血型”的肝细胞癌。 | |||
T80234 |
SFNGGP-NH2
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SFNGGP-NH2是一种具有生物活性的肽。PAR-3是一种与凝血酶高亲和力结合的受体,其mRNA在人类皮肤肥大细胞中得到表达。研究指出,蛋白酶激活受体(PAR)在瘙痒反应中的作用涉及组胺依赖性及独立途径。虽然PAR-3本身不直接诱发瘙痒,却可能与PAR-4共同促发此症状。它们的共同表达可增强凝血酶的效应,这表明PAR-3单独时不进行跨膜信号传导,而是作为激活PAR-4的协同因子。 | |||
T35955 |
PAR2 (1-6) amide (human) (trifluoroacetate salt)
PAR2 (1-6) amide (human) (trifluoroacetate salt) |
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PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide prod... | |||
T36717 |
RWJ-56110 dihydrochloride
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RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap... |