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Search Results for " positron emission tomography "

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Cat. No.	Product Name	Target	Signaling Pathways
T17842	DOTA-NHS-ester	Others	Others
	DOTA-NHS-ester 是 affibody 分子的接头，应用于小动物 PET、SPECT 和 CT。它可用于标记放射治疗剂或成像探针以检测肿瘤。
T7196	HG-10-102-01 [4-[[5-氯-4-(甲基氨基)-2-嘧啶基]氨基]-3-甲氧基苯基]-4-吗啉基甲酮	LRRK2	Autophagy
	HG-10-102-01 是富含亮氨酸重复激酶 2 和突变型G2019S 抑制剂，IC50分别为20.3 nM 和3.2 nM。
T19573	T807 AV-1451	Microtubule Associated	Cytoskeletal Signaling
	T807 (AV-1451) 是新型的tau 正电子发射断层扫描示踪剂。
T26360	Benperidol R4584,R-4584,Anquil,McN-JR-4584,R 4584
	Benperidol (Anquil)是一种具有抗精神病和安定作用的丁酮类化合物，在阻断 D2 受体方面具有很好的疗效。Benperidol可用于正电子发射断层扫描(PET)测量体内 D(2)类多巴胺受体的结合情况。
T15162	DPA-714	Others	Others
	DPA-714 是高亲和力的移位蛋白配体 (Ki=7 nM)，它结构中有一个氟原子，能够被氟 -18 进行标记，并可通过正电子发射断层成像进行活体成像。它可在各种神经炎症模型及脑肿瘤模型中成功评估炎症的特异性成像。
T28466	PSMA-11 HBED-CC-PSMA,Psma-hbed-CC,PSMA11
	PSMA-11 (HBED-CC-PSMA)通过与前列腺特异性膜抗原(PSMA)的细胞外结构域结合来检测前列腺癌的复发和转移。PSMA-11常被用作正电子发射断层扫描(PET)中用作表达PSMA 的肿瘤的示踪剂，通过静脉注射镓Ga 68标记的PSMA-11，Glu-urea-Lys(Ahx)分子靶向并结合表达PSMA 的肿瘤细胞。内化后，PSMA 表达的肿瘤细胞可在PET 成像中被检测到。
T20771	Lissamine rhodamine B
	Lissamine rhodamine B, a new Radiotracer, is used for Imaging Tumors by Positron Emission Tomography.
T27494	GSK931145 GSK 931145,GSK-931145
	GSK931145 is a positron emission tomography (PET) radioligand, it is suitable for quantifying glycine transporter (GlyT1) availability in the living brain.
T24406	L-FMAC F-18 L-(18F)-FMAC
	L-FMAC F-18 has potential diagnostic activity during positron emission tomography (PET) imaging. After phosphorylation by DCK, the 18F moiety can be visualized by PET imaging.
T39069	UCB-J
	UCB-J is a radioligand for the synaptic vesicle protein 2A (SV2A), utilized in positron emission tomography (PET)[4].
T33493	Mppf F-18 J1.050.795B,P-18FMPPF,(18F) Mppf,(18F)Mppf,(18F)-Mppf
	Mppf F-18, which has been used as a radioactive ligand for positron emission tomography, is a compound that binds to the serotonin-1A receptor.
T31787	Fet F-18 Fet F18,18F-Fluoroethyltyrosine,18F-FET
	Fet F-18 is an amino acid analog radiolabeled with fluorine F-18, a positron-emitting isotope, can be used as a tracer in positron emission tomography (PET).
T24956	(18F)LBT 999 (18F)LBT999,LBT999 18F,LBT 999 18F,LBT-999 18F,(18F)LBT-999
	(18F)LBT 999 is a positron emission tomography (PET) tracer, used for the quantification of the dopamine transporter (DAT) in the healthy rat brain.
T19429	MK-6240	Others	Others
	MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs). MK-6240 exhibits high specificity and selectivity for binding to NFTs.
T39192	DOTATATE
	DOTATATE, a DOTA-conjugated peptide, is utilized for its ability to be labeled with radionuclides, facilitating positron emission tomography (PET) imaging and peptide receptor radionuclide therapy (PRRT)[4].
T29913	Altanserin R-53200,R53200,R 53200
	Altanserin can binds to the 5-HT2A receptor. Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain.
T27840	LMI-1195 LMI 1195
	LMI-1195 is a 18F-labeled ligand for the norepinephrine transporter. LMI-1195 is used for mapping cardiac nerve terminals in vivo using positron emission tomography (PET).
T33448	ML 10 ML-10,ML10
	ML 10 is is a [18F] positron emission tomography (PET) radiotracer that accumulates in cells presenting apoptosis-specific membrane alterations. [18F]ML-10 allows for the detection of apoptotic cells located in atherosclerotic plaques.
T29913L	Altanserin tartrate R-53,200
	Altanserin tartrate is a compound that binds to the 5-HT2A receptor. Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain.
T33446	MK-9470 MK 9470,MK9470
	MK-9470 is a selective, high-affinity reverse agonist and is also a fluorine 18 labeled positron emission tomography (PET) radiotracer [(18) F]. The MK-9470 has been used to image cannabinoid receptor type 1 in healthy and ill human brains.
T25294	DCFBC F-18 18F-DCFBC
	DCFBC F-18 is a radioconjugate containing a low molecular weight tracer, DCFBC, specific for prostate-specific membrane antigen (PSMA) and labeled with the positron-emitting isotope F 18 with potential prostate tumor imaging upon positron emission tomogra
T39120	Fluoroethylnormemantine
	Fluoroethylnormemantine, a derivative of Memantine, acts as an N-methyl-D-aspartate (NMDA) receptor antagonist. It can function as a positron emission tomography (PET) tracer, known as [18F]-fluoroethylnormemantine. This compound displays anti-amnesic, neuroprotective, antidepressant-like, and fear-attenuating properties.
T78667	FAPI-74
	FAPI-74是一种专门针对成纤维细胞激活蛋白（FAP）的PET示踪剂，适用于FAP阳性肿瘤的研究。
T38713	Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH Fmoc-Asn(Ac3AcNH-beta-Glc)-OH,Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH
	Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH, also known as Fmoc-Asn(Ac3AcNH-beta-Glc)-OH, is a chemical compound used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, which serve as tumor imaging agents, are valuable tools for positron emission tomography (PET) research.
T39119	Fluoroethylnormemantine hydrochloride
	Fluoroethylnormemantine hydrochloride, a Memantine derivative, functions as an antagonist for the N-methyl-D-aspartate (NMDA) receptor. It can also serve as a positron emission tomography (PET) tracer, specifically as [18F]-Fluoroethylnormemantine hydrochloride. Notably, this compound displays a range of effects, including anti-amnesic, neuroprotective, antidepressant-like, and fear-attenuating properties.
T36571	N-Descyclopropanecarbaldehyde Olaparib
	N-Descyclopropanecarbaldehyde Olaparib, an Olaparib analogue, incorporates a DOTA moiety. It acts as a CRBN-based ligand for the formation of novel dual EGFR and PARP PROTAC, DP-C-4[1]. N-Descyclopropanecarbaldehyde Olaparib is suitable for radiolabeling with F-18 or a fluorophore to visualize tumors using positron emission tomography (PET) or optical imaging[2].
T79070	Pentixafor	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Pentixafor是靶向CXCR4受体的肽类化合物，可结合68Gallium (68Ga) 进行正电子发射断层扫描 (PET) 成像。
T78927	PSMA-IN-3
	PSMA-IN-3（compound 17）是一种高亲和力的新型PSMA抑制剂，IC50为13 nM。该化合物可作为开发18F标记的放射性配体的基础，用于前列腺癌PSMA的PET成像。
T60728	M1 ligand 1
	M1 ligand 1 (compound 3b-b) 是槟榔碱衍生物的 N- 去甲基同源物，是毒蕈碱乙酰胆碱受体 M1 的配体。M1 ligand 1 用作正电子发射断层扫描(PET)的放射性示踪剂。
T79577	CB2 PET Radioligand 1	Cannabinoid Receptor	GPCR/G Protein
	CB2PET Radioligand 1 (compound [18F]9) 作为hCB2靶向的PET Radioligand (Ki=7.7 nM)，采用Cu介导的18F-氟化方法制备，并在小鼠神经炎症模型中展现了高脑摄取率。
T61087	THK-5105
	THK-5105为芳基喹啉衍生物，具备与tau原纤维高度结合的亲和力。它对tau蛋白聚集体及含tau的阿尔茨海默病(AD)脑匀浆显示出显著的结合能力。18F-THK-5105展现出作为tau成像PET探针的潜能。
T16547	PK14105	Others	Others
	PK14105 has been evaluated biologically as a potential radioligand for positron emission tomography (PET) studies targeting peripheral benzodiazepine binding sites (PBBS) receptors. When administered to rats with unilaterally lesioned striata, PK14105 was observed to quickly cross the blood-brain barrier, displaying significant radioactivity retention in the lesioned striatum, in contrast to the unlesioned striatum or cerebellar vermis. Additionally, PK14105 has the capability to inhibit recepto...
T78076	PBR28	Others	Others
	PBR28是一种TSPO调节剂，适用于肺动脉高压(PAH)预防研究。通过增加放射性标记的PBR28能够示踪18KDa转运蛋白(TSPO)，在脑正电子发射断层扫描(PET)成像中具有关键作用。
T74546	FAP-2286
	FAP-2286，一种与放射性核素螯合剂 DOTA 偶联的 FAP 结合肽大环化合物。FAP-2286 对人 FAP 蛋白具有强亲和力，Kd 为 1.1 nM。FAP-2286 具有抗肿瘤活性。FAP-2286 可用放射性核素标记，用于治疗及诊断。
T83490	[Lys3]-Bombesin
	[Lys3]-Bombesin 是具有生物活性的肽类化合物，用于 PET（正电子发射断层扫描）成像检测 GRPR（胃泌素释放肽受体）阳性的前列腺癌。此外，[Lys3]-Bombesin 及其单克隆抗体的免疫缀合物能特异性诱导 CD64 依赖的单核细胞和中性粒细胞介导的小细胞肺癌细胞裂解。
T64640	Melanin probe-2
	Melanoma is a lethal skin cancer. The early detection of melanoma using positron emission tomography (PET) probes is critical for improving the survival of melanoma patients. Melanin probe-2 is a non-radioactive bromo-picolinamide precursor that has been used for the synthesis of18F-picolinamides based PET probe (melanin probe-1). The tumor-targeting efficacy and imaging property of three melanin probes were evaluated in B16F10 tumor-bearing mice.18F-1 and18F-3 had much lower tumor uptake compar...
T73317	JZP-MA-13
	JZP-MA-13是一种选择性α/β-水解酶结构域6 (ABHD6) 抑制剂，其IC50值为392 nM。该化合物对MAGL、ABHD12、FAAH或其它丝氨酸水解酶不表现出抑制作用。JZP-MA-13还被用作ABHD6在体内成像的正电子发射断层扫描(PET)配体。
T79716	c-ABL-IN-5	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	c-ABL-IN-5是一种选择性c-Abl抑制剂，具有神经保护功能。该化合物显示出血脑屏障渗透性、代谢稳定性和优良的药物动力学特性。经[18F]标记的c-ABL-IN-5（化合物[18F]3）可用作PET示踪剂，以评估疾病改善的功效。此外，c-ABL-IN-5适用于帕金森病（PD）等神经退行性疾病的研究。
T75022	JZP-MA-11
	JZP-MA-11是一种用于正电子发射断层扫描(PET)的配体，专一性靶向内源性大麻素α/β-水解酶结构域6(ABHD6)酶，并具有126 nM的IC50值，表明其对ABHD6有选择性抑制作用。JZP-MA-11能有效穿过血脑屏障(BBB)。[18F]JZP-MA-11展现出在靶向小鼠及非人灵长类(NHP)大脑ABHD6方面的临床前评估潜力。

化合物

Cat.No: T17842

Target: Others

Cat.No: T7196

Synonym: [4-[[5-氯-4-(甲基氨基)-2-嘧啶基]氨基]-3-甲氧基苯基]-4-吗啉基甲酮

Target: LRRK2

Cat.No: T19573

Synonym: AV-1451

Target: Microtubule Associated

Cat.No: T26360

Synonym: R4584,R-4584,Anquil,McN-JR-4584,R 4584

Cat.No: T15162

Target: Others

Cat.No: T28466

Synonym: HBED-CC-PSMA,Psma-hbed-CC,PSMA11

Lissamine rhodamine B

Cat.No: T20771

Cat.No: T27494

Synonym: GSK 931145,GSK-931145

Cat.No: T24406

Synonym: L-(18F)-FMAC

Cat.No: T39069

Cat.No: T33493

Synonym: J1.050.795B,P-18FMPPF,(18F) Mppf,(18F)Mppf,(18F)-Mppf

Cat.No: T31787

Synonym: Fet F18,18F-Fluoroethyltyrosine,18F-FET

Cat.No: T24956

Synonym: (18F)LBT999,LBT999 18F,LBT 999 18F,LBT-999 18F,(18F)LBT-999

Cat.No: T19429

Target: Others

Cat.No: T39192

Cat.No: T29913

Synonym: R-53200,R53200,R 53200

Cat.No: T27840

Synonym: LMI 1195

Cat.No: T33448

Synonym: ML-10,ML10

Altanserin tartrate

Cat.No: T29913L

Synonym: R-53,200

Cat.No: T33446

Synonym: MK 9470,MK9470

Cat.No: T25294

Synonym: 18F-DCFBC

Fluoroethylnormemantine

Cat.No: T39120

Cat.No: T78667

Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH

Cat.No: T38713

Synonym: Fmoc-Asn(Ac3AcNH-beta-Glc)-OH,Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH

Fluoroethylnormemantine hydrochloride

Cat.No: T39119

N-Descyclopropanecarbaldehyde Olaparib

Cat.No: T36571

Cat.No: T79070

Target: CXCR

Cat.No: T78927

Cat.No: T60728

CB2 PET Radioligand 1

Cat.No: T79577

Target: Cannabinoid Receptor

Cat.No: T61087

Cat.No: T16547

Target: Others

Cat.No: T78076

Target: Others

Cat.No: T74546

[Lys3]-Bombesin

Cat.No: T83490

Melanin probe-2

Cat.No: T64640

Cat.No: T73317

Cat.No: T79716

Target: Bcr-Abl

Cat.No: T75022

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