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Cat. No.	Product Name	Target	Signaling Pathways
T40319	PIM-IN-1
	PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).
T5093	Pim1/AKK1-IN-1 LKB1/AAK1 dual inhibitor,MDK-2275	Pim; Hippo pathway	Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) 是多种酶抑制剂，能够作用于Pim1、AKK1、MST2 和 LKB1，Kd 值分别为 35、53、75 和 380 nM，还抑制 MPSK1 和 TNIK。
T40092	MNK/PIM-IN-1
	MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.
T12474	PIM1-IN-1	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti-cancer activity.
T61510	PIM-1/HDAC-IN-1
	PIM-1/HDAC-IN-1 (compound 4d) is a potent inhibitor of PIM-1, with an IC 50 of 343.87 nM. It also exhibits strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC 50 values of 63.65 and 62.39 nM, respectively. Furthermore, PIM-1/HDAC-IN-1 demonstrates apoptosis-inducing potential in MCF-7 cell lines, specifically inducing pre-G1 apoptosis and causing cell cycle arrest at the G2/M phase [1].
T9229	Pim-1/2 kinase inhibitor 1	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	Pim-1/2 kinase inhibitor 1 是一种具有口服活性的 Pim-1/2 激酶抑制剂。Pim-1/2 kinase inhibitor 1 能阻断 Pim 激酶磷酸化肽的能力，并且抑制4E-BP1和p27Kip1的Pim 蛋白激酶定向磷酸化。Pim-1/2 kinase inhibitor 1 可用于癌症，尤其是前列腺癌的研究。
T77526	Pim-1 kinase inhibitor 4	Apoptosis; Pim	Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling
	Pim-1 kinase inhibitor 4 是一种高效的 Pim-1 激酶抑制剂，IC50 值为 17.01 nM。Pim-1 kinase inhibitor 4 还具有抗氧化活性和潜在的抗癌活性，对 DPPH 有抑制作用。Pim-1 kinase inhibitor 4 促进 PC-3 细胞凋亡 (apoptosis)，对 PC-3 细胞生长有抑制作用，IC50 为 16 nM。Pim-1 kinase inhibitor 4 可用于研究前列腺癌。
T3078	SGI-1776 SGI-1776 free base,Pim-Kinase Inhibitor IX	Apoptosis; FLT; Pim; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	SGI-1776 (Pim-Kinase Inhibitor IX) 是一种Pim 抑制剂，抑制 Pim-1、Pim-2 和 Pim-3 的活性，IC50值分别为 7 nM、363 nM 和 69 nM。
T27704	K00135 K-00135,Imidazol[1,2-b]pyridazine 1,K 00135,IMIDAZOPYRIDAZIN 1	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	K00135 (IMIDAZOPYRIDAZIN 1) 是 Pim 激酶的选择性抑制剂，可用于胃癌和抗白血病治疗的研究。
TP2128	R8-T198wt
	Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells
T60972	Pim-1 kinase inhibitor 1
	Pim-1 kinase inhibitor 1 可用于癌症领域研究，通过促进细胞凋亡对多种癌细胞系表现出抗癌活性。Pim-1 kinase inhibitor 1 是一种Pim-1 激酶抑制剂 (IC50 = 0.11 μM)。
T71558	Pim-IN-14j
	Pim-IN-14j is a potent, highly selective, and orally bioavailable inhibitor of PIM-1 kinases.
T81460	PIM-IN-2	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	PIM-IN-2是Pim激酶抑制剂，具有25 nM 的半抑制浓度(IC50)。它能增强细胞存活、防止凋亡，并在多种人类肿瘤中高表达。
T68341	HS56
	HS56 是一种 ATP 竞争性 Pim/DAPK3双重抑制剂，对 DAPK3、Pim-3、Pim-1和 Pim-2 的 Ki 值分别为 0.26、0.208、2.94 和＞100 μM。 HS56 抑制 LC20 磷酸化和平滑肌收缩。HS56 降低自发性高血压小鼠的血压。HS56可用于高血压研究。
T63720	PIM1-IN-3
	PIM1-IN-3 (Compound HL8) 是一种 PIM1 的有效抑制剂，能够选择性抑制 PIM-1 酶，可有效的诱导 Colo320 细胞凋亡。PIM1-IN-3 对癌症疾病表现出研究潜力。
T62188	PIM1-IN-6
	PIM1-IN-6 (compound 5h) 是一种 PIM-1 的有效抑制剂 (IC50: 0.60 μM)。PIM1-IN-6 对 HCT-116 和 MCF-7 细胞具有较高的细胞毒作用，他们的 IC50 值分别为 1.51 和 15.2 μM。
T61700	PIM1-IN-7
	PIM1-IN-7 (compound 6c) is a powerful inhibitor of PIM-1, effectively suppressing its activity with an IC50 of 0.67 μM. This compound also exhibits significant cytotoxicity against HCT-116 and MCF-7 cells, as demonstrated by their respective IC50 values of 42.9 and 7.68 μM [1].
T79456	FD1024	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	FD1024是一种PIM抑制剂，对PIM1、PIM2和PIM3的IC50s分别为1.96、38.9及4.17 nM。用于急性髓系白血病研究的FD1024，对AML细胞系显示出显著的抗增殖效果，其对EOL-1、MV-4-11、KG-1和MOLM-16细胞的抑制浓度(IC50s)分别为0.16 μM、0.12 μM、1.05 μM和1.39 μM。此外，FD1024在小鼠模型中也表现出抗肿瘤活性。

化合物

Cat.No: T40319

Pim1/AKK1-IN-1

Cat.No: T5093

Synonym: LKB1/AAK1 dual inhibitor,MDK-2275

Target: Pim, Hippo pathway

Cat.No: T40092

Cat.No: T12474

Target: Pim

PIM-1/HDAC-IN-1

Cat.No: T61510

Pim-1/2 kinase inhibitor 1

Cat.No: T9229

Target: Pim

Pim-1 kinase inhibitor 4

Cat.No: T77526

Target: Apoptosis, Pim

Cat.No: T3078

Synonym: SGI-1776 free base,Pim-Kinase Inhibitor IX

Target: Apoptosis, FLT, Pim, Autophagy

Cat.No: T27704

Synonym: K-00135,Imidazol[1,2-b]pyridazine 1,K 00135,IMIDAZOPYRIDAZIN 1

Target: Pim

Cat.No: TP2128

Pim-1 kinase inhibitor 1

Cat.No: T60972

Cat.No: T71558

Cat.No: T81460

Target: Pim

Cat.No: T68341

Cat.No: T63720

Cat.No: T62188

Cat.No: T61700

Cat.No: T79456

Target: Pim

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