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Search Results for " pbef "

Targets Recommended: NAMPT

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4335	GNE-617 GNE617	NAMPT	Metabolism
	GNE-617 是一种新型的、特异性的Nampt 抑制剂，在A549细胞中IC50为18.9nM。
T12171	Nampt-IN-5	P450; NAMPT	Metabolism
	Nampt-IN-5 是烟酰胺磷酸核糖基转移酶抑制剂。它可抑制 A2780 和 COR-L23 细胞，IC50值分别为 0.7 nM 和 3.9 nM。它还抑制 CYP3A4 活性。
T6682	STF-118804 STF 118804,STF118804	Apoptosis; NAMPT	Apoptosis; Metabolism
	STF-118804是一种烟酰胺磷酸核糖基转移酶 Nampt 高选择性抑制剂，降低大多数 B-ALL 细胞系的活力，IC50 <10 nM。
T4376	Nampt-IN-1 LSN3154567	c-Fms; NAMPT; CSF-1R	Metabolism; Tyrosine Kinase/Adaptors
	Nampt-IN-1 (LSN3154567) 是选择性的 NAMPT 抑制剂，能够抑制纯化的 NAMPT，IC50=3.1 nM。
T1998	CHS-828 CHS 828,GMX1778	Apoptosis; NAMPT	Apoptosis; Metabolism
	CHS-828 (GMX1778) 是一种竞争性的烟酰胺磷酸化转移酶抑制剂，IC50值 <25 nM。它通过降低细胞中的 NAD+水平发挥细胞毒性作用，具有抗癌活性。
T12854	SBI-797812	NAMPT	Metabolism
	SBI-797812 是在结构上类似于活性位点定向的 NAMPT 抑制剂的化合物，能够阻断这些抑制剂与 NAMPT 的结合。它将 NAMPT 反应平衡转向 NMN 形成，提高 NAMPT 对 ATP 的亲和力，稳定 His247 处的磷酸化 NAMPT，增加焦磷酸盐副产物的消耗，并通过 NAD+钝化反馈抑制。
T2644	(E)-Daporinad Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866,达珀利奈	NAMPT; Transferase; Autophagy	Autophagy; Metabolism
	(E)-Daporinad (FK866) 是一种烟酰胺磷酸核糖基转移酶的小分子抑制剂，具有潜在的抗肿瘤和抗血管生成活性，IC50为 0.09 nM。

化合物

Target: P450, NAMPT

STF-118804

Cat.No: T6682

Synonym: STF 118804,STF118804

Target: Apoptosis, NAMPT

Nampt-IN-1

Cat.No: T4376

Synonym: LSN3154567

Target: c-Fms, NAMPT, CSF-1R

CHS-828

Cat.No: T1998

Synonym: CHS 828,GMX1778

Target: Apoptosis, NAMPT

Synonym: Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866,达珀利奈

Target: NAMPT, Transferase, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02577	NAMPT Protein, Human, Recombinant (His & GST) VISFATIN,PBEF,PBEF1,1110035O14Rik,VF,nicot...	Human	Baculovirus Insect Cells
	Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B-cell colony-enhancing factor 1 (PBEF1) or visfatin, is an enzyme belonging to the family of glycosyltransferases, to be specific, the pentosyltransferases. This enzyme participates in nicotinate and nicotinamide metabolism. This enzyme catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1- pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. NAMPT is...
TMPJ-00968	NAMPT Protein, Human, Recombinant (His) PBEF,PBEF1,Nicotinamide phosphoribosyltran...	Human	E. coli
	Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are ...

重组蛋白

NAMPT Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02577

Species: Human

Expression System: Baculovirus Insect Cells

NAMPT Protein, Human, Recombinant (His)

Cat.No: TMPJ-00968

Species: Human

Expression System: E. coli

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