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Search Results for " p19 "

Targets Recommended: CYP19A1 Wnt/beta-catenin

18

抑制剂 & 化合物

19

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3635	IQ 1 IQ1,IQ-1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	IQ 1 有多种作用，如保持小鼠ESCs 的多功能性、降低Wnt 刺激的磷酸化、阻止PP2A/Nkd 的相互作用等等。
TP2110L	TAT-Gap19 acetate	Gap Junction Protein	Cytoskeletal Signaling
	TAT-Gap19 acetate 是 connexin43 hemichannel (Cx43 HC) 的特异性抑制剂。它穿过血脑屏障并减轻小鼠的肝纤维化。它不抑制相应的 Cx43 GJC。
TP1563	Gap19	Gap Junction Protein	Cytoskeletal Signaling
	Gap19 是一种衍生自 Cx43 细胞质环九个氨基酸的肽，是选择性连接蛋白 43 半通道阻滞剂。它可以防止 C 末端与 CL 的分子内相互作用，具有保护心肌作用。
T3983	TMP195 TFMO 2,TMP 195	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TMP195 (TFMO 2) 是一种选择性 IIa 类组蛋白脱乙酰酶 (HDAC) 抑制剂。对 HDAC4、HDAC5、HDAC7，HDAC9的 Ki 值分别为59、60、26，5 nM。
T75821	TAT-Gap19 TFA
	TAT-Gap19 TFA为Cx模拟肽，特异性抑制connexin43半通道(Cx43 HC)，但不影响相应的Cx43 GJC。该化合物具备透过血脑屏障功能，能够减轻小鼠肝纤维化。
TP1511	Gap19 TFA (1507930-57-5 free base) Gap19 TFA
	Gap19 TFA is a peptide derived from nine amino acids of Cx43 cytoplasmic ring (CL), an effective, selective connexin 43 (Cx43) half-channel blocker.
TP2110	TAT-Gap19
	Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19. Active in vivo. Brain penet
T75820	Gap19 TFA
	Gap19 TFA，源自Cx43胞浆环(CL)的九个氨基酸肽，是高效且选择性的连接蛋白43 (Cx43) 半通道阻滞剂。该肽阻止C末端（CT）与CL之间的分子内相互作用，但不影响GJ通道或Cx40/pannexin-1半通道。此外，Gap19 TFA对心肌有保护作用。
T41204	TAT-Gap19(I130A) TAT-Gap19(I130A)
	TAT-Gap19(I130A) is a control peptide for TAT-Gap19, a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca2+]i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable.
T73571	CP19
	CP19, 作为一种组胺受体(histamine receptor)拮抗剂，展现出针对埃博拉病毒(EBOV)及马尔堡病毒(MARV)的进入抑制活性，其IC50值对EBOV为3.4 μM，对MARV为29.5 μM。该化合物针对EBOV和MARV的SI值分别达到29.4及3.4，表明CP19具备显著的抗病毒效能。
T76273	Pep19-2.5
	Pep19-2.5为合成抗毒素肽，能阻断内毒素信号级联。通过抑制跨膜及胞质模式识别受体（PRRs）介导的脂肽（LP）与脂多糖（LPS）的信号通路，Pep19-2.5关键调控与炎症及细胞焦亡（pyroptosis）相关的信号级联。
T36900	PD-1/PD-L1-IN-NP19 PD-1/PD-L1-IN-NP19	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-NP19 是 PD-1/PD-L1 的抑制剂，抑制人类 PD-1/PD-L1 相互作用的 IC50 值为 12.5 nM。PD-1/PD-L1-IN-NP19 可以激活肿瘤的免疫微环境，这可能有助于其抗肿瘤作用。
T76784	Tildrakizumab MK 3222,SCH 900222	IL Receptor	Immunology/Inflammation
	Tildrakizumab (SCH 900222) 是一种有效的人源化抗-IL-23 (p19 亚基) 单克隆抗体。Tildrakizumab 靶向单链 IL-23 ，Kd 值为 136 pM。Tildrakizumab 可用于研究银屑病和牛皮癣。
T76778	Risankizumab Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066	IL Receptor	Immunology/Inflammation
	Risankizumab (BI 655066) 是一种人源化靶向 IL-23 p19 亚基的 IgG 单克隆抗体(Kd <10 pM)。 Risankizumab 能抑制人 IL-23 在小鼠脾细胞中诱导的 IL-17 产生，IC50 值为 2 pM。Risankizumab 可用于预防和治疗如寻常型银屑病、银屑病关节炎、广泛性脓疱型银屑病和红皮病型银屑病类的免疫性和炎症性疾病。
T33652	Neurodazole
	Neurodazole is a neurogenic inducer for converting pluripotent P19 cells into electrophysiologically active neurons.
T76934	Brazikumab
	Brazikumab (AMG 139) 是一种人IgG2单克隆抗体，可选择性结合IL-23的 p19 亚基，对人IL-23的KD 值为 0.138 nM 的。Brazikumab 可用于克罗恩病的研究。
T61858	HDAC8-IN-3
	HDAC8-IN-3 (compound P19) is a highly potent inhibitor of HDAC8, displaying an IC50 value of 9.3 μM and producing thermal stabilization. Moreover, HDAC8-IN-3 exhibits cytotoxicity and induces apoptosis specifically in leukemic cell lines [1].
T77088	Mirikizumab
	Mirikizumab (LY3074828)，一种靶向白介素23的p19亚基的人源化IgG4单克隆抗体，适用于溃疡性结肠炎的研究。

化合物

Cat.No: T3635

Synonym: IQ1,IQ-1

Target: Wnt/beta-catenin

TAT-Gap19 acetate

Cat.No: TP2110L

Target: Gap Junction Protein

Cat.No: TP1563

Target: Gap Junction Protein

Cat.No: T3983

Synonym: TFMO 2,TMP 195

Target: HDAC

Cat.No: T75821

Gap19 TFA (1507930-57-5 free base)

Cat.No: TP1511

Synonym: Gap19 TFA

Cat.No: TP2110

Cat.No: T75820

TAT-Gap19(I130A)

Cat.No: T41204

Synonym: TAT-Gap19(I130A)

Cat.No: T73571

Cat.No: T76273

PD-1/PD-L1-IN-NP19

Cat.No: T36900

Synonym: PD-1/PD-L1-IN-NP19

Target: PD-1/PD-L1

Cat.No: T76784

Synonym: MK 3222,SCH 900222

Target: IL Receptor

Cat.No: T76778

Synonym: Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066

Target: IL Receptor

Cat.No: T33652

Cat.No: T76934

Cat.No: T61858

Cat.No: T77088

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04874	IL-23 P19/IL23A Protein, Human, Recombinant (hFc) IL-23A,IL-23,interleukin 23, alpha subunit p19,SGRF...	Human	HEK293 Cells
	IL-23 P19/IL23A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9NPF7.
TMPY-02495	p19 INK4d Protein, Human, Recombinant (GST) p19-INK4D,INK4D,cyclin-dependent kinase inhibitor 2...	Human	E. coli
	Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. It is clearly shown that DNA repair is the main target of p19ink4d effect and that diminished apoptosis is a downstream event. Experiments has uncovered a role of p19INK4d as a regulator of DNA-damage-ind...
TMPY-03526	IL-23 Protein, Mouse, Recombinant (His) IL-23,白细胞介素,p19,白介素	Mouse	HEK293 Cells
	IL-23 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.3 kDa and the accession number is Q9EQ14&P43432.
TMPY-00406	IL-23 Protein, Human, Recombinant (His) IL23P19,P19,SGRF,IL-23,IL-23A,IL23	Human	HEK293 Cells
	IL-23 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPY-04987	IL-23 P19/IL23A Protein, Human, Recombinant (mFc) IL-23,interleukin 23, alpha subunit p19,SGRF,IL23	Human	HEK293 Cells
	IL-23 P19/IL23A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9NPF7.
TMPY-05247	IL-23 Protein, Human, Recombinant (His), Biotinylated IL23P19,IL23,P19,IL-23A,IL-23,SGRF	Human	HEK293 Cells
	IL-23 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPY-02215	Coagulation factor IX/F9 Protein, Human, Recombinant (His) FIX,PTC,Coagulation factor 9,coagulation factor IX,HEMB,THPH...	Human	HEK293 Cells
	Coagulation factor IX/F9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is AAB59620.1.
TMPY-05648	IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated IL23,IL-23,白细胞介素,白介素,P19,IL23P19,SGRF,IL-2...	Human	HEK293 Cells
	IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 57.6 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPK-01169	IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated Interleukin-23 subunit α,Interleukin-23 subunit alpha,IL-23 ...	Mouse	HEK293 Cells
	The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells. A recent study has reported that IL-23 is also secreted by lung adenoma cells and generates an inflammatory and immune-suppressed stroma.
TMPY-05355	Coagulation factor IX/F9 Protein, Human, Recombinant (hFc) P19,Coagulation factor 9,HEMB,FIX,THPH8,Coagulation...	Human	HEK293 Cells
	Coagulation factor IX/F9 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.5 kDa and the accession number is P00740-1.
TMPH-00779	IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)	Guinea pig	E. coli
	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible fo...
TMPY-01335	REG1A Protein, Human, Recombinant (His) regenerating family member 1 alpha,P19,MGC12447,REG...	Human	HEK293 Cells
	REG1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P05451.
TMPY-05474	REG1A Protein, Human, Recombinant (His), Biotinylated PSPS,R EG,PSPS1,MGC12447,ICRF,REG1A,regenerating family memb...	Human	HEK293 Cells
	REG1A Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P05451.
TMPJ-00720	TXNDC12 Protein, Human, Recombinant (His) TLP19,ERp19,Thioredoxin Domain-Containing ...	Human	HEK293 Cells
	Thioredoxin Domain-Containing Protein 12 belongs to the thioredoxin superfamily. In this family, proteins possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors. TXNDC12 is widely expressed in many tissues and contains one thioredoxin domain.
TMPY-06219	SARS-CoV-2 Nucleocapsid Protein (P67S & P199L, His)	SARS-CoV-2	E. coli
	SARS-CoV-2 Nucleocapsid Protein (P67S & P199L, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46.6 kDa and the accession number is P0DTC9.
TMPY-06220	SARS-CoV-2 Nucleocapsid Protein (P199L & M234I, His)	SARS-CoV-2	E. coli
	SARS-CoV-2 Nucleocapsid Protein (P199L & M234I, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46.6 kDa and the accession number is P0DTC9.
TMPY-06190	SARS-CoV-2 Nucleocapsid Protein (P199L, His)	SARS-CoV-2	E. coli
	SARS-CoV-2 Nucleocapsid Protein (P199L, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46.6 kDa and the accession number is P0DTC9.
TMPH-00956	Aromatase/CYP19A1 Protein, Human, Recombinant (His) ARO1,CYP19A1,Estrogen synthase,Cytochrome P450 19A1...	Human	E. coli
	Aromatase/CYP19A1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPJ-00238	Lefty-A Protein, Human, Recombinant (His) Endometrial bleeding-associated factor,TGFB4,TGF-β-4,EBAF,LE...	Human	HEK293 Cells
	Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name “Lefty”. The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins a...

重组蛋白

IL-23 P19/IL23A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04874

Species: Human

Expression System: HEK293 Cells

p19 INK4d Protein, Human, Recombinant (GST)

Cat.No: TMPY-02495

Species: Human

Expression System: E. coli

IL-23 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03526

Species: Mouse

Expression System: HEK293 Cells

IL-23 Protein, Human, Recombinant (His)

Cat.No: TMPY-00406

Species: Human

Expression System: HEK293 Cells

IL-23 P19/IL23A Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04987

Species: Human

Expression System: HEK293 Cells

IL-23 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05247

Species: Human

Expression System: HEK293 Cells

Coagulation factor IX/F9 Protein, Human, Recombinant (His)

Cat.No: TMPY-02215

Species: Human

Expression System: HEK293 Cells

IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05648

Species: Human

Expression System: HEK293 Cells

IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01169

Species: Mouse

Expression System: HEK293 Cells

Coagulation factor IX/F9 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05355

Species: Human

Expression System: HEK293 Cells

IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)

Cat.No: TMPH-00779

Species: Guinea pig

Expression System: E. coli

REG1A Protein, Human, Recombinant (His)

Cat.No: TMPY-01335

Species: Human

Expression System: HEK293 Cells

REG1A Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05474

Species: Human

Expression System: HEK293 Cells

TXNDC12 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00720

Species: Human

Expression System: HEK293 Cells

SARS-CoV-2 Nucleocapsid Protein (P67S & P199L, His)

Cat.No: TMPY-06219

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 Nucleocapsid Protein (P199L & M234I, His)

Cat.No: TMPY-06220

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 Nucleocapsid Protein (P199L, His)

Cat.No: TMPY-06190

Species: SARS-CoV-2

Expression System: E. coli

Aromatase/CYP19A1 Protein, Human, Recombinant (His)

Cat.No: TMPH-00956

Species: Human

Expression System: E. coli

Lefty-A Protein, Human, Recombinant (His)

Cat.No: TMPJ-00238

Species: Human

Expression System: HEK293 Cells

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