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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1327	Nortriptyline hydrochloride Desitriptyline HCl,EN-7048 hydrochloride,盐酸去甲替林,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride,去甲替林	Apoptosis; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Norepinephrine; Autophagy; Histamine Receptor; Drug Metabolite	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Nortriptyline hydrochloride (ELF-101 hydrochloride) 是一种三环类抗抑郁药，用于缓解抑郁症的症状。它是 Amitriptyline 的主要活性代谢产物，是有效自噬抑制剂。
T13377	(Z)-10-Hydroxynortriptyline (Z)-10-Hydroxy Nortriptyline	IL Receptor	Immunology/Inflammation
	(Z)-10-Hydroxy Nortriptyline is a Nortriptyline metabolite, and is a tricyclic antidepressant,and is used to relieve the symptoms of depression.
T11135	(E)-10-Hydroxynortriptyline maleate (E)-10-Hydroxy Nortriptyline maleate	Others	Others
	(E)-10-Hydroxy Nortriptyline maleate, a metabolite of Nortriptyline, serves as a key active metabolite of the tricyclic antidepressant Amitriptyline, primarily utilized in alleviating depression symptoms.
T38131	(E)-10-Hydroxynortriptyline
	(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1]. [1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology ...
T11008	Desmethylnortriptyline	Others	Others
	Desmethylnortriptyline is a metabolite of nortriptyline. Nortriptyline is a tricyclic antidepressant. It is the main active metabolite of amitriptyline and is used to relieve depressive symptoms.

化合物

Nortriptyline hydrochloride

Cat.No: T1327

Synonym: Desitriptyline HCl,EN-7048 hydrochloride,盐酸去甲替林,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride,去甲替林

Target: Apoptosis, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Autophagy, Histamine Receptor, Drug Metabolite

(Z)-10-Hydroxynortriptyline

Cat.No: T13377

Synonym: (Z)-10-Hydroxy Nortriptyline

Target: IL Receptor

(E)-10-Hydroxynortriptyline maleate

Cat.No: T11135

Synonym: (E)-10-Hydroxy Nortriptyline maleate

Target: Others

(E)-10-Hydroxynortriptyline

Cat.No: T38131

Synonym:

Target:

Desmethylnortriptyline

Cat.No: T11008

Synonym:

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T73844	Nortriptyline
	Nortriptyline (Desmethylamitriptyline) 是三环类抗抑郁药，是 Amitriptyline 的主要活性代谢产物，用于缓解抑郁症症状。Nortriptyline 是有效自噬 (autophagy) 抑制剂。