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Search Results for " nile "

25

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19033	Nile Red Phenoxazone 9,尼罗红,Nile Blue A oxazone	Others	Others
	Nile Red (Nile Blue A oxazone) 是一种选择性疏水性荧光染料，针对细胞内脂质小滴和中性脂质。它在所有有机溶剂中均具有强烈的荧光性，其荧光颜色范围从金黄色到深红色。
T19034	Nile Blue A sulfate Nile blue sulfate	Others	Others
	Nile Blue A (Nile blue sulfate) is used as the differentiation of melanins and lipofuscins. It is also useful for staining fats and the preparation of an amperometric glucose sensor.
T65364	Nile blue chloride
	Nile blue chloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65364，CAS号为 2381-85-3。
T80286	TP4 (Nile tilapia piscidin)	Necroptosis	Apoptosis
	TP4（Nile tilapia piscidin）是一种piscidin样的抗菌肽，其口服活性被证实。此化合物对多种革兰氏阳性及阴性菌株均有效（MIC: 0.03-10 μg/mL），并展现了溶血性。TP4还能增强免疫响应、提升抗氧化能力和改善肠道健康，助于防御细菌感染。除此之外，TP4显示抗肿瘤效果，并可通过激发癌细胞线粒体功能障碍导致坏死（necrosis）。
T9618	HeE1-2Tyr	SARS-CoV	Microbiology/Virology
	HeE1-2Tyr 是一种pyridobenzothiazole，抑制黄病毒 RNA 依赖性 RNA 聚合酶。HeE1-2Tyr 在体外对Dengue, West Nile 和 SARS-CoV-2 RdRps 有显著的抑制活性(IC50为 27.6 µM) 。
T33315L	Methaphenilene hydrochloride NSC 516334,NSC-516334,NSC516334
	Methaphenilene hydrochloride is a biochemical.
T73697	Denileukin diftitox
	Denileukin diftitox (DAB 389IL-2) 是一种融合蛋白毒素，将白喉毒素 (DT) 与白细胞介素 2 (IL-2) 结合，专门针对表达高亲和力IL-2受体 (IL-2R)、CD25 的细胞。它通过与IL-2R阳性细胞结合并利用白喉毒素片段的内化作用来抑制蛋白质合成，从而达到耗尽目标细胞的效果。
T25543	Isoaminile citrate
	Isoaminile citrate 是一种安全有效的中枢镇咳药。在动物实验中，它与 codeine 一样有效，但没有任何呼吸抑制作用。
T10309	Amphethinile Amphetinile,CRC 82-07	Others	Others
	Amphethinile is an anti-tubulin agent. The Ka of Amphethinile with tubulin is 1.3 μM.
T33315	Methaphenilene W50 Base,W-50 Base,W 50 Base
	MethaphenileneMethaphenilene is a biochemical.
T72041	Flaviviruses-IN-2	Virus Protease	Microbiology/Virology
	Flaviviruses-IN-2 是一种有效的 flaviviruses 抑制剂。 Flaviviruses-IN-2 可降低西尼罗河病毒（WNV）蛋白酶活性，对西尼罗河病毒的抑制率为 56%。
T67777	Flaviviruses-IN-3 WAY-324593	Virus Protease	Microbiology/Virology
	Flaviviruses-IN-3（化合物87）是flaviviruse 的有效抑制剂。Flaviviruses-IN-3可降低西尼罗河病毒（WNV）蛋白酶活性，抑制率为54%。
TNU0060	3’-O-Methyladenosine	Antiviral; Adenosine deaminase	Immunology/Inflammation; Metabolism
	3’-O-Methyladenosine 是一种抗病毒化合物，对西尼罗河病毒具有抑制作用，可用于治疗病毒感染。3’-O-Methyladenosine 对腺苷脱氨酶VII型具有抑制作用，Ki 值为 493 µM。
T4027	KIN1148	Influenza Virus	Microbiology/Virology
	KIN1148 是一种新型小分子佐剂，是IRF3激动剂，用于增强流感疫苗效率。
TNU0007	3'-Deoxy-3'-fluoroadenosine	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	3'-Deoxy-3'-fluoroadenosine 是一种嘌呤核苷类似物，具有广泛的抗肿瘤活性和抗病毒活性，对蜱传脑炎病毒（TBEV），寨卡病毒和西尼罗河病毒（WNV）具有抑制作用，EC50分别为1.1μM、 0.1 μM和4.7 1.5 μM。3'-Deoxy-3'-fluoroadenosine可用于研究肿瘤疾病。
T30554	bNR10S bNR 10S,bNR-10S
	bNR10S is a solvatochromic nile red probe with FRET quencher reveal lipid order heterogeneity in living and apoptotic cells.
T70855	Favipiravir sodium
	Favipiravir sodium is a selective inhibitor of viral RNA-dependent RNA polymerase with activity against many RNA viruses, influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as other flaviviruses, arenaviruses, bunyaviruses and alphaviruses.
T39915	Trx-red Trx-red,NBL-SS perchlorate
	Trx-red (NBL-SS perchlorate) is a red-emitting fluorescent probe derived from the nile blue fluorophore. It is specifically designed for imaging thioredoxin (Trx) in live cells and in vivo, with excitation and emission wavelengths of 615 nm and 661 nm, respectively.
T81309	RCB16007
	RCB16007为一种抗黄热病毒(YFV)化合物，对西尼罗河病毒显示出抑制活性，具体抑制浓度为EC50: 7.9 μM，细胞毒性浓度为CC50: 17 μM。
T39855	LysoTracker Red LysoTracker Red DND-99
	LysoTracker Red (LysoTracker Red DND-99) is a paraformaldehyde fixable probe that concentrates into acidic compartments of cells and tissues. LysoTracker Red is an indicator of cell death in a manner similar to other standard assays (Annexin, terminal dUTP nick end labeling, Nile blue sulfate, neutral red, and acridine orange). LysoTracker Red is a marker for late endosomes and lysosomes.
T38861	Tat-beclin 1
	Tat-beclin 1, a peptide derived from the autophagy protein beclin 1, is a powerful inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a negative regulator of autophagy. Tat-beclin 1 effectively reduces the buildup of polyglutamine expansion protein aggregates and inhibits the replication of various pathogens, such as HIV-1, in laboratory experiments. In addition, it has demonstrated the ability to decrease mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).
T74828	AcrB-IN-3
	Efflux pump-IN-3为一种AcrB外排泵抑制剂，具有增强抗生素效力的特性。该化合物能阻断尼罗红（AcrB已知的一种底物）的外排，而不会破坏细菌的外膜，并且在线虫模型中未展现出毒性。
T74827	AcrB-IN-2
	Efflux pump-IN-2 是一种 AcrB 外排泵抑制剂，能够增强抗生素的作用。Efflux pump-IN-2 抑制尼罗红 (AcrB 的一种已知底物) 外排。Efflux pump-IN-2 不破坏细菌外膜，也不会在线虫模型中显示毒性。
T74829	AcrB-IN-4
	Efflux pump-IN-4是一种针对AcrB外排泵的抑制剂，能够增强抗生素效果。该化合物通过抑制尼罗红（AcrB的已知底物）的外排来发挥作用，同时不破坏细菌外膜，且在线虫模型中未显示出毒性。
T76058	Tat-beclin 1 TFA
	Tat-beclin 1 TFA是一种来源于自噬蛋白区域(beclin 1)的肽，有效诱导自噬(autophagy)并与GAPR-1 (GLIPR2)发生相互作用，具有显著的自噬负调控作用。该化合物能有效减少体外聚谷氨酰胺扩增蛋白聚集体的积累，并抑制HIV-1等多种病原体的复制。同时，Tat-beclin 1 TFA能显著降低感染基孔肯雅病(CHIKV)或西尼罗河病毒(WNV)小鼠的死亡率。

化合物

Cat.No: T19033

Synonym: Phenoxazone 9,尼罗红,Nile Blue A oxazone

Target: Others

Nile Blue A sulfate

Cat.No: T19034

Synonym: Nile blue sulfate

Target: Others

Nile blue chloride

Cat.No: T65364

TP4 (Nile tilapia piscidin)

Cat.No: T80286

Target: Necroptosis

Cat.No: T9618

Target: SARS-CoV

Methaphenilene hydrochloride

Cat.No: T33315L

Synonym: NSC 516334,NSC-516334,NSC516334

Denileukin diftitox

Cat.No: T73697

Isoaminile citrate

Cat.No: T25543

Cat.No: T10309

Synonym: Amphetinile,CRC 82-07

Target: Others

Cat.No: T33315

Synonym: W50 Base,W-50 Base,W 50 Base

Flaviviruses-IN-2

Cat.No: T72041

Target: Virus Protease

Flaviviruses-IN-3

Cat.No: T67777

Synonym: WAY-324593

Target: Virus Protease

3’-O-Methyladenosine

Cat.No: TNU0060

Target: Antiviral, Adenosine deaminase

Cat.No: T4027

Target: Influenza Virus

3'-Deoxy-3'-fluoroadenosine

Cat.No: TNU0007

Target: Nucleoside Antimetabolite/Analog

Cat.No: T30554

Synonym: bNR 10S,bNR-10S

Favipiravir sodium

Cat.No: T70855

Cat.No: T39915

Synonym: Trx-red,NBL-SS perchlorate

Cat.No: T81309

LysoTracker Red

Cat.No: T39855

Synonym: LysoTracker Red DND-99

Cat.No: T38861

Cat.No: T74828

Cat.No: T74827

Cat.No: T74829

Tat-beclin 1 TFA

Cat.No: T76058

Cat. No.	Product Name	Target	Signaling Pathways
T2718	Palmatine chloride	Others; Indoleamine 2,3-Dioxygenase (IDO); Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Others
	Palmatine chloride 是口服具有活力的不可逆 IDO-1抑制剂。它能够减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，并改善 DSS 诱发的结肠炎。
T5S0802	Palmatine 巴马汀,Berbericinine,Burasaine	Indoleamine 2,3-Dioxygenase (IDO); AChR; AChE; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Neuroscience
	Palmatine (Burasaine) 是口服具有活力的、不可逆IDO-1抑制剂。它可以减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。它有用于结肠炎的研究潜力。
T83531	(Rac)-Juvenile hormone III
	(Rac)-Juvenile hormone III，一种自法脂酸分离的天然产物，作为幼体激素的同源物具有最广泛分布。
TN5330	Lacinilene C 3,10-Dihydroxy-1,3,5,7-cadinatetraen-9-one
	Lacinilene C, lacinilene C 7-methyl ether, scopoletin, 2-hydroxy-7-methoxycadalene and 2,7-dihydroxycadalene are 5 induced phytoalexins in cotton leaves. Lacinilene C methyl ether elicits contraction of TSM by enhancing the movement of calcium through pot
T25789	Melianone NSC 302037,NSC-302037,NSC302037
	Melianone exhibits antiviral activity (EC50s: 3-11μM) against three important human pathogens, belonging to the Flaviviridae family, West Nile virus, Dengue virus, and Yellow Fever virus.
T72508	Palmatine hydroxide
	Palmatine hydroxide 是不可逆的口服活性IDO-1抑制剂，其对HEK 293-hIDO-1 和 rhIDO-1的IC50值分别为3 μM和157 μM。该化合物还能非竞争性抑制(WNV)NS2B-NS3蛋白酶，IC50值为96 μM。Palmatine hydroxide展现了抗癌、抗炎、神经保护、抗细菌和抗病毒的活性。

天然产物

Palmatine chloride

Cat.No: T2718

Target: Others, Indoleamine 2,3-Dioxygenase (IDO), Aurora Kinase

Cat.No: T5S0802

Synonym: 巴马汀,Berbericinine,Burasaine

Target: Indoleamine 2,3-Dioxygenase (IDO), AChR, AChE, Aurora Kinase

(Rac)-Juvenile hormone III

Cat.No: T83531

Cat.No: TN5330

Synonym: 3,10-Dihydroxy-1,3,5,7-cadinatetraen-9-one

Cat.No: T25789

Synonym: NSC 302037,NSC-302037,NSC302037

Palmatine hydroxide

Cat.No: T72508

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