Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14489 |
Azvudine
4-氨基-1-(4-C-叠氮基-2-脱氧-2-氟-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮,FNC,RO-0622 |
HCV Protease; HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Azvudine (FNC) 是一种有效的核苷逆转录酶抑制剂 (NRTI),对 HIV、HBV 和 HCV 具有抗病毒活性。它抑制耐 NRTI 的病毒株,高效抑制 HIV-1和 HIV-2。 | |||
T78737 |
NNRTIs-IN-3
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
NNRTIs-IN-3(化合物8)作为一种HIV-1非核苷逆转录酶抑制剂,表现出较高的效力(EC50=0.01 µM)。 | |||
T78948 | NNRTIs-IN-1 | ||
NNRTIs-IN-1是一种非核苷逆转录酶抑制剂, 对野生型HIV-1及五种突变株表现出有效抑制作用, 其EC50值处于纳摩尔量级。该化合物同时展现出优良的药代动力学性质, 并具备显著的抗抗药性特点。 | |||
T0110 |
Zalcitabine
Dideoxycytidine,ddC,扎西他滨,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Zalcitabine (Dideoxycytidine) 是一种核苷类似物逆转录酶抑制剂,用于HIV 感染相关研究。 | |||
T2409 |
Tenofovir alafenamide
替诺福韦艾拉酚胺,替诺福韦,GS-7340 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir alafenamide (GS-7340) 是一种核苷酸逆转录酶抑制剂和抗逆转录病毒替诺福韦的新型酯类前药。 | |||
T2279 |
Tizoxanide
替唑尼特,Desacetyl-nitazoxanide,TIZ |
Antiviral; HIV Protease; Antibacterial; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Tizoxanide (Desacetyl-nitazoxanide) 是 Nitazoxanide 活性代谢物,有抗HIV-1的活性。Nitazoxanide 可抗细菌和多种病毒复制。 | |||
T6214 |
Emtricitabine
恩曲他滨,FTC,Emtriva,BW1592 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Emtricitabine (FTC) 是一种核苷逆转录酶抑制剂, 在 PBMC 细胞中的 EC50值为0.01 µM,可研究 HIV 感染。 | |||
T38727 |
Azvudine hydrochloride
RO-0622 hydrochloride,Azvudine hydrochloride,FNChydrochloride |
||
Azvudine hydrochloride (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI) that exhibits strong antiviral effects against HIV, HBV, and HCV. It demonstrates highly potent inhibition of HIV-1 (EC 50 ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 ranging from 0.018 to 0.025 nM). Additionally, Azvudine hydrochloride effectively inhibits NRTI-resistant viral strains. | |||
T61427 | Lamivudine salicylate | ||
Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that effectively inhibits the reverse transcriptase activity of both HIV 1/2 and hepatitis B virus. Moreover, it demonstrates the ability to penetrate the central nervous system [1] [2]. | |||
T60356 |
Stavudine sodium
|
||
Stavudine (d4T) sodium 是一种口服活性核苷逆转录酶抑制剂 (NRTI), 具有抗HIV-1和HIV-2的活性。Stavudine sodium 还抑制线粒体 DNA (mtDNA) 的复制。Stavudine sodium 降低 NLRP3 炎症小体激活并调节淀粉样 β 自噬。Stavudine sodium 诱导细胞凋亡。 | |||
T71983 |
Zidovudine glucuronide
|
||
Zidovudine glucuronide is an antiretroviral medication used to prevent and treat HIV/AIDS. It is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. Zidovudine inhibits the enzyme (reverse transcriptase) that HIV uses to synthesize DNA, thus preventing viral DNA from forming. | |||
T71518 |
Zidovudine diphosphate
|
||
Zidovudine diphosphate is an antiretroviral medication used to prevent and treat HIV/AIDS. It is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. Zidovudine inhibits the enzyme (reverse transcriptase) that HIV uses to synthesize DNA, thus preventing viral DNA from forming. | |||
T71241 |
Carbovir
|
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Carbovir, also known as (-)-Carbovir, is a nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) caused mitochondrial toxicity in human hepatoma carcinoma cell. | |||
T40120 |
FNC-TP
|
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FNC-TP, the intracellular active form of FNC, is a potent nucleoside reverse transcriptase inhibitor (NRTI) with broad-spectrum antiviral activity against HIV, HBV, and HCV. | |||
T14488 |
Azt-pmap
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1]. As a nucleoside reverse transcriptase inhibitor (NRTI), AZT-PMPA targets HIV infection effectively[2]. | |||
T64188 | FNC-TP trisodium | ||
FNC-TP trisodium 是 FNC 的细胞内活性形式。FNC 是一种核苷逆转录酶的有效抑制剂 (NRTI),对 HIV、HBV 和 HCV 表现出抗病毒作用。 | |||
T24839 |
Stampidine
HI-113,HI 113,HI113 |
||
Stampidine can prevent the sexual transmission of HIV-1. It exhibited remarkable subnanomolar to low nanomolar in vitro antiretroviral potency against nucleoside reverse transcriptase inhibitor-resistant primary clinical HIV isolates, non-nucleoside RT-re |