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87

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T18991	Fluorescein-5-maleimide N-(5-Fluoresceinyl)maleimide,荧光素-5-马来酰亚胺	Others	Others
	Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) 是硫醇反应荧光染料 (λex=494 nm，λem=519 nm)，可用于将荧光素与蛋白质缀合。
T38402	Maleimide-DOTA Maleimide-DOTA,Maleimido-mono-amide-DOTA
	Maleimide-DOTA is a non-cleavable linker utilized for the synthesis of antibody-drug conjugates (ADCs).
T78397	Janelia Fluor® 646, Maleimide JF646, Maleimide
	Janelia Fluor® 646, Maleimide (JF646, Maleimide) 是一种红色荧光染料，配备了马来酰亚胺修饰基团，适用于细胞成像研究。
T41010	Maleimide-C10-NHS ester Maleimide-C10-NHS ester
	Maleimide-C10-NHS ester is an alkyl/ether-based linker for PROTAC synthesis.
T84299	BHQ3 Maleimide
	BHQ3 Maleimide 属于荧光探针，可以消除背景荧光，可用于蛋白质标记、核酸标记和细胞成像。
T82014	Janelia Fluor® 549, Maleimide TFA JF549, Maleimide TFA
	Janelia Fluor® 549, Maleimide TFA (JF549, Maleimide TFA) 是荧光染料，λab (max) 为549 nm，λem (max) 为571 nm。
T15960	Mal-amido-PEG7-acid Maleimide-NH-PEG7-CH2CH2COOH,Mal-NH-PEG7-COOH	Others; PROTAC Linker	Others; PROTAC
	Mal-amido-PEG7-acid (Mal-NH-PEG7-COOH) 是一种基于 PEG 的 PROTAC linker，可用于合成 PROTAC。
T27974	Maleimide-PEG4-NHS MAL-PEG-NHS,Maleimide PEG NHS,Maleimido-Tetra(Ethylene Glycol)-Acetic Acid NHS ester,MAL-PEG4-NHS
	Maleimide-PEG4-NHS is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds formed through Maleimide-PEG4-NHS linker are stable and are not cleavable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond wh
T70831	Glutathione maleimide
	Glutathione maleimide is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.
T21905	N-Arachidonyl Maleimide
	N-Arachidonyl maleimide 是一种有效且不可逆的单酰基甘油脂肪酶 (MAGL) 抑制剂，IC50值为 140 nM。
T18355	Methyltetrazine-PEG6-maleimide	Others	Others
	Methyltetrazine-PEG6-maleimide is a PEG-derived linker compound utilized for synthesizing PROTACs[1].
T18775	TCO-PEG5-maleimide	Others	Others
	TCO-PEG5-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15060	DBCO-Maleimide	Others	Others
	DBCO-Maleimide is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs). [1]
T15072	DBCO-PEG4-Maleimide	Others	Others
	DBCO-PEG4-Maleimide is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T18784	TCO-PEG9-maleimide	Others	Others
	TCO-PEG9-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14429	Azido-PEG3-maleimide	Others	Others
	Azido-PEG3-maleimide is a PEG-based PROTAC linker primarily used for the synthesis of PROTACs[1]. Additionally, it serves as a cleavable 3-unit PEG ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[2].
T16058	Methyltetrazine-PEG4-maleimide	Others	Others
	Methyltetrazine-PEG4-maleimide is a PEG-based linker that is utilized in PROTAC synthesis[1].
T17516	Azido-PEG5-maleimide	Others	Others
	Azido-PEG5-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17772	DBCO-NHCO-PEG6-maleimide	Others	Others
	DBCO-NHCO-PEG6-maleimide is a polyethylene glycol (PEG)-based linker compound employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T18767	TCO-PEG3-maleimide	Others	Others
	TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
T14183	Alkyne-PEG4-maleimide	Others	Others
	Alkyne-PEG4-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17766	DBCO-NHCO-PEG2-maleimide	Others	Others
	DBCO-NHCO-PEG2-maleimide is a polyethylene glycol (PEG) derived PROTAC linker utilized during PROTAC synthesis[1].
T17760	DBCO-NHCO-PEG12-maleimide	Others	Others
	DBCO-NHCO-PEG12-maleimide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs[1].
T16167	N-(4-Carboxycyclohexylmethyl)maleimide	Others	Others
	N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker suitable for synthesizing PROTACs[1].
T16958	Sulfo DBCO-PEG4-Maleimide	Others	Others
	Sulfo DBCO-PEG4-Maleimide is a PEGylated derivative containing a maleimide group commonly employed as a linker for the synthesis of PROteolysis TAgeting Chimeras (PROTACs)[1].
T18369	N-(5-Hydroxypentyl)maleimide	Others	Others
	N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs). It serves as a crucial component in the production of Gemcitabine-O-Si(di-iso)-O-Mc, an ADC compound [1].
T33167	Maleimide, N-(5-(p-aminophenoxy)pentyl)-
	Maleimide, N-(5-(p-aminophenoxy)pentyl)- is a Drug / Therapeutic Agent.
T17853	DSPE-PEG-Maleimide (MW 5000)	Others	Others
	DSPE-PEG-Maleimide (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T74120	Cy5 maleimide
	Cy5 maleimide 是一种 CY 染料。CY 为花菁 (Cyanine) 的缩写，是由奇数个甲基单位连接的两个氮原子组成的化合物。菁类化合物具有波长长、吸收和发射可调、消光系数高、水溶性好、合成相对简单等特点。CY 系类染料常被用于蛋白，抗体以及小分子化合物的标记，对于蛋白抗体的标记，可以通过简单的混合反应来完成结合，以下我们介绍了蛋白抗体标记的标记方法，具有一定的参考意义。储存方式：避光。
T83929	(+)-JQ1 maleimide
	(+)-JQ1 maleimide是一种探针，由一个与BRD4配体JQ1通过PEG2连接器相连的含有活性的maleimide组成。它可用于COFFEE方法（COvalent Functionalization Followed by E3 Electroporation），在该方法中，(+)-JQ1 maleimide与VHL共价连接后通过电穿孔导入活细胞。E3连接酶在细胞内与BRD4形成复合物，引导其降解。
T82875	Biotin-PEG7-Maleimide
	Biotin-PEG7-Maleimide是一种能与硫醇基(SH)反应的生物素化试剂，适用于作为ADC药物连接偶联剂(Drug-Linker Conjugates for ADC)。
T82906	BDP FL maleimide
	BDP FL maleimide为一硫醇反应性染料（Ex: 503 nm；Em: 509 nm）。适用于蛋白质标记及肽修饰，亦可作为荧光素（FAM）替代品于显微镜下观察使用。
T18239	Mal-amido-PEG16-acid Maleimide-NH-PEG16-CH2CH2COOH	Others	Others
	Mal-amido-PEG16-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15964	Mal-amido-PEG9-acid Maleimide-NH-PEG9-CH2CH2COOH	Others	Others
	Mal-amido-PEG9-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T64567	DSPE-PEG-Maleimide
	DSPE-PEG-Maleimide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64567。
T83290	5-FAM maleimide
	5-FAMmaleimide为5-FAM的衍生化合物，适用于蛋白质标记。
T81047	TAMRA-PEG2-Maleimide
	TAMRA-PEG2-Maleimide，一种TAMRA衍生物，含有4个PEG单元。其结构中的maleimide基团能够与硫醇基发生反应，形成共价键。
T78438	N-(9-Acridinyl)maleimide
	N-(9-Acridinyl)maleimide为一类马来酰亚胺荧光硫醇探针，本身不具较强荧光。当N-(9-Acridinyl)maleimide与含硫醇的化合物发生偶联反应时，会产生具有显著蓝色荧光的产物，适用于半胱氨酸和谷胱甘肽的荧光分析。
T82618	DACM N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide
	DACM (N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide)为针对巯基的荧光染料，具有激发波长为396 nm及发射波长为468 nm。
T74168	DSPE-PEG-Maleimide (MW 2000)
	DSPE-PEG-Maleimide (MW 2000) 是一种由 DSPE 和马来酰亚胺基团组成的 PEG 化合物。DSPE-PEG-Maleimide (MW 2000) 可用于构建脂质体。
T81718	N-[4-(2-Benzimidazolyl)phenyl]maleimide
	N-[4-(2-Benzimidazolyl)phenyl]maleimide，作为荧光探针，具有315 nm的最大激发波长和360 nm的最大发射波长。该化合物适用于对硫醇类化合物进行荧光检测。
T7659	Bisindolylmaleimide IV	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Bisindolylmaleimide IV 是一种蛋白激酶 C 细胞渗透抑制剂，其 IC50范围为 0.1-0.55 μM。它也抑制 PKA，IC50范围为3.1-11.8 μM。在细胞培养中，它有效抑制人巨细胞病毒(HCMV)复制，IC50为 0.2 μM。
T21044	p-Tolylmaleimide p Tolylmaleimide	Aquaporin	Membrane transporter/Ion channel
	p-Tolylmaleimide (p Tolylmaleimide) 是一种水通道抑制剂，可与 Aquaporin Z 结合。
T10549	Bisindolylmaleimide VIII acetate Ro 31-7549 acetate,Bis VIII acetate	Apoptosis; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling
	Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) 是一种选择性蛋白激酶 C 抑制剂。它促进 Fas 介导的细胞凋亡，并抑制 T 细胞介导的自身免疫性疾病。
T6513	Bisindolylmaleimide I GF109203X,Go 6850,3-[1-[3-(二甲氨基)丙基]1H-吲哚-3-基]-4-(吲哚-3-基)1H-吡咯-2,5二酮	PDGFR; PKC	Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Bisindolylmaleimide I (GF109203X) 是一种有效且高度选择性的蛋白激酶 C(PKC) 抑制剂，Ki 值为 14 nM。
T7790	Bisindolylmaleimide V 双吲哚马来酰亚胺 V,双吲哚马来酰亚胺	PKC; S6 Kinase	Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Bisindolylmaleimide V 是一种弱蛋白激酶 C (PKC) 抑制剂( IC50 >100 µM)。
T3088	N-Ethylmaleimide 1-Ethyl-1H-pyrrole-2,5-dione,n-乙基马来酰亚胺,Ethylmaleimide,NEM	Cysteine Protease; DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Proteases/Proteasome; Ubiquitination
	N-Ethylmaleimide (NEM) 是烷基化自由巯基的试剂，是一种半胱氨酸蛋白酶抑制剂，用于实验生化研究。它也是一种去泛素化酶抑制剂，特异性抑制线粒体中的磷酸盐转运。
T77628	Bisindolylmaleimide III	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6 protein kinase 1 upon activation of these kinases.
T10550	Bisindolylmaleimide X hydrochloride BIM-X hydrochloride,Ro31-8425 hydrochloride	CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling
	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).
T19957	Bismaleimide XU 292A,XU-292A,XU292A	Others	Others
	Bismaleimide (XU 292A) 具有抗热性、抗氧化性、抗辐射性，可用于制备电器绝缘材料、耐磨材料、增强塑料添加剂、砂轮粘结剂等。

化合物

Fluorescein-5-maleimide

Cat.No: T18991

Synonym: N-(5-Fluoresceinyl)maleimide,荧光素-5-马来酰亚胺

Target: Others

Maleimide-DOTA

Cat.No: T38402

Synonym: Maleimide-DOTA,Maleimido-mono-amide-DOTA

Janelia Fluor® 646, Maleimide

Cat.No: T78397

Synonym: JF646, Maleimide

Maleimide-C10-NHS ester

Cat.No: T41010

Synonym: Maleimide-C10-NHS ester

BHQ3 Maleimide

Cat.No: T84299

Janelia Fluor® 549, Maleimide TFA

Cat.No: T82014

Synonym: JF549, Maleimide TFA

Mal-amido-PEG7-acid

Cat.No: T15960

Synonym: Maleimide-NH-PEG7-CH2CH2COOH,Mal-NH-PEG7-COOH

Target: Others, PROTAC Linker

Maleimide-PEG4-NHS

Cat.No: T27974

Synonym: MAL-PEG-NHS,Maleimide PEG NHS,Maleimido-Tetra(Ethylene Glycol)-Acetic Acid NHS ester,MAL-PEG4-NHS

Glutathione maleimide

Cat.No: T70831

N-Arachidonyl Maleimide

Cat.No: T21905

Methyltetrazine-PEG6-maleimide

Cat.No: T18355

Target: Others

TCO-PEG5-maleimide

Cat.No: T18775

Target: Others

DBCO-Maleimide

Cat.No: T15060

Target: Others

DBCO-PEG4-Maleimide

Cat.No: T15072

Target: Others

TCO-PEG9-maleimide

Cat.No: T18784

Target: Others

Azido-PEG3-maleimide

Cat.No: T14429

Target: Others

Methyltetrazine-PEG4-maleimide

Cat.No: T16058

Target: Others

Azido-PEG5-maleimide

Cat.No: T17516

Target: Others

DBCO-NHCO-PEG6-maleimide

Cat.No: T17772

Target: Others

TCO-PEG3-maleimide

Cat.No: T18767

Target: Others

Alkyne-PEG4-maleimide

Cat.No: T14183

Target: Others

DBCO-NHCO-PEG2-maleimide

Cat.No: T17766

Target: Others

DBCO-NHCO-PEG12-maleimide

Cat.No: T17760

Target: Others

N-(4-Carboxycyclohexylmethyl)maleimide

Cat.No: T16167

Target: Others

Sulfo DBCO-PEG4-Maleimide

Cat.No: T16958

Target: Others

N-(5-Hydroxypentyl)maleimide

Cat.No: T18369

Target: Others

Maleimide, N-(5-(p-aminophenoxy)pentyl)-

Cat.No: T33167

DSPE-PEG-Maleimide (MW 5000)

Cat.No: T17853

Target: Others

Cy5 maleimide

Cat.No: T74120

(+)-JQ1 maleimide

Cat.No: T83929

Biotin-PEG7-Maleimide

Cat.No: T82875

BDP FL maleimide

Cat.No: T82906

Mal-amido-PEG16-acid

Cat.No: T18239

Synonym: Maleimide-NH-PEG16-CH2CH2COOH

Target: Others

Mal-amido-PEG9-acid

Cat.No: T15964

Synonym: Maleimide-NH-PEG9-CH2CH2COOH

Target: Others

DSPE-PEG-Maleimide

Cat.No: T64567

5-FAM maleimide

Cat.No: T83290

TAMRA-PEG2-Maleimide

Cat.No: T81047

N-(9-Acridinyl)maleimide

Cat.No: T78438

Cat.No: T82618

Synonym: N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide

DSPE-PEG-Maleimide (MW 2000)

Cat.No: T74168

N-[4-(2-Benzimidazolyl)phenyl]maleimide

Cat.No: T81718

Bisindolylmaleimide IV

Cat.No: T7659

Target: Others, PKC

p-Tolylmaleimide

Cat.No: T21044

Synonym: p Tolylmaleimide

Target: Aquaporin

Bisindolylmaleimide VIII acetate

Cat.No: T10549

Synonym: Ro 31-7549 acetate,Bis VIII acetate

Target: Apoptosis, PKC

Bisindolylmaleimide I

Cat.No: T6513

Synonym: GF109203X,Go 6850,3-[1-[3-(二甲氨基)丙基]1H-吲哚-3-基]-4-(吲哚-3-基)1H-吡咯-2,5二酮

Target: PDGFR, PKC

Bisindolylmaleimide V

Cat.No: T7790

Synonym: 双吲哚马来酰亚胺 V,双吲哚马来酰亚胺

Target: PKC, S6 Kinase

N-Ethylmaleimide

Cat.No: T3088

Synonym: 1-Ethyl-1H-pyrrole-2,5-dione,n-乙基马来酰亚胺,Ethylmaleimide,NEM

Target: Cysteine Protease, DUB

Bisindolylmaleimide III

Cat.No: T77628

Target: PKC

Bisindolylmaleimide X hydrochloride

Cat.No: T10550

Synonym: BIM-X hydrochloride,Ro31-8425 hydrochloride

Target: CDK, PKC

Cat.No: T19957

Synonym: XU 292A,XU-292A,XU292A

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4820	Maleimide 马来酰亚胺,2,5-Pyrroledione	Others	Others
	Maleimide (2,5-Pyrroledione) 可用于制备荧光探针，主要用于硫醇分析物的特异性检测。它也可用于制备用于癌症研究的抗体-药物偶联物 (ADC)。
TN6106	2-Ethyl-3-methylmaleimide N-β-D-glucopyranoside
	2-Ethyl-3-methylmaleimide N-β-D-glucopyranoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6106，CAS号为 182228-46-2。

天然产物

Cat.No: T4820

Synonym: 马来酰亚胺,2,5-Pyrroledione

Target: Others

2-Ethyl-3-methylmaleimide N-β-D-glucopyranoside

Cat.No: TN6106

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