Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19913 |
CKI-7
CKI 7 2HCl,CKI-7 dihydrochloride,N-(2-氨基乙基)-5-氯异喹啉-8-磺酰胺二盐酸盐,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl |
ROCK; SGK; Casein Kinase; CDK; S6 Kinase | Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells |
CKI-7 是一种有效且 ATP 竞争性的酪蛋白激酶 1 抑制剂,IC50为 6 μM,Ki 为 8.5 μM。它选择性抑制 Cdc7激酶,还抑制 SGK,S6K1以及 MSK1。 | |||
T9652 |
SB-747651A Dihydrochloride
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
SB-747651A dihydrochloride是一种与ATP竞争性相互作用的抑制剂,特别针对丝裂原和应激激活激酶1 (MSK1),IC50值为11 nM。此化合物还能抑制PRK2、RSK1、p70S6K和ROCK-II等酶的活性。因其对上述激酶的抑制作用,SB-747651A dihydrochloride在炎症研究中显示出潜力。 | |||
T6643 |
Ro 31-8220 Mesylate
Ro 31-8220 methanesulfonate,Bisindolylmaleimide IX,Bisindolylmaleimide IX mesylate |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) 是PKC 抑制剂,对 PKCα、PKCβI、PKCβII、PKCγ、PKCε 和大鼠大脑 PKC 的IC50值为 5、24、14、27、24 和 23 nM。它还抑制 MAPKAP-K1b、MSK1、S6K1 和 GSK3β,IC50为3、8、15 和 38 nM。 | |||
T28695 |
SB-747651A
SB 747651A |
||
SB-747651A is a potent, ATP-competitive inhibitor of mitogen- and stress-activated kinase 1 (MSK1, IC50 = 11 nM). It targets the N-terminal kinase domain. SB-747651A inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. | |||
T10829 |
CKI-7 free base
CKI-7 |
Casein Kinase | Metabolism; Stem Cells |
CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1. | |||
T73247 | PIM1-IN-4 | Pim | Chromatin/Epigenetic; JAK/STAT signaling |
PIM1-IN-4(Compound 8)为PIM1高效抑制剂,对SGK-1、PKA、CaMK-1、GSK3β及MSK1五种酶亦展现出显著抑制效应,表现出其在癌症疾病研究中的应用潜力。 | |||
T60585 | RSK2-IN-2 | ||
RSK2-IN-2 (Compound 25) 是 RPS6KA3 (RSK2) 激酶的可逆共价抑制剂,它也能抑制MSK1、MSK2和RSK3。 | |||
T6643L |
Ro 31-8220
|
||
Ro 31-8220 是一种有效的PKC 抑制剂,对 PKCα,PKCβI,PKCβII,PKCγ,PKCε 和大鼠大脑 PKC 的IC50值为 5,24,14,27,24 和 23 nM。Ro 31-8220还显著抑制 MAPKAP-K1b,MSK1,S6K1 和 GSK3β,IC50值分别为3,8,15,38 nM,对 MKK3,MKK4,MKK6 和 MKK7 无作用。 | |||
TP2157L |
TAT-DEF-Elk-1 TFA (1220751-16-5 free base)
TDE TFA,TAT-DEF-Elk-1 TFA |
Others | Others |
TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 act | |||
T83942 |
IDR 1002
|
||
IDR 1002是一种先天性防御调节肽。在小鼠的鼻窦炎感染和细菌性急性肺部感染模型中减少细菌负荷和炎症反应。它抑制LPS诱导的NF-κB和COX-2,促进p38、ERK1/2、MSK1和CREB的磷酸化/激活。 | |||
T81038 |
TAT-DEF-Elk-1 TFA
TDE TFA |
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TAT-DEF-Elk-1 TFA (TDE TFA) 是一种Elk-1的细胞穿透性肽抑制剂,通过模仿Elk-1的DEF域并特异性地阻断其功能来抑制Elk-1。该化合物能够抑制Elk-1的磷酸化作用,阻止其核内转位,同时不影响ERK和MSK1的活化。TAT-DEF-Elk-1 TFA作为一种研究工具,对于探究神经元可塑性及Elk-1在该进程中的角色具有重要价值。 | |||
T39519 |
GSK269962A hydrochloride
GSK 269962 hydrochloride |
||
GSK269962A hydrochloride (GSK 269962 hydrochloride) is a highly potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.6 nM and 4 nM, respectively, for recombinant human isoforms. This compound exhibits both anti-inflammatory and vasodilatory properties. |