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Search Results for " mhc "

51

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2270	MHC class II antigen (45-57) [Homo sapiens]	Others	Others
	MHC class II antigen (45-57) [Homo sapiens] is a peptide with the sequence H2N-Asp-Leu-Asp-Lys-Lys-Glu-Thr-Val-Trp-His-Leu-Glu- Glu-OH, MW= 1868.07. MHC (major histocompatibility complex) class II molecules are found only on antigen-presenting cells and l
T8005	Cardiogenol C hydrochloride 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Cardiogenol C hydrochloride (Cardiogenol C) 是一种细胞渗透性嘧啶诱导剂，能够促使 ESCs 分化为心肌细胞。在有限的可塑性范围内，它可以对已经沿袭的祖细胞类型产生心肌生成效应，是一种心肌生成试剂，在动物模型中可以用作细胞移植研究中提高心脏修复的工具。
T2161	Cardiogenol C	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Cardiogenol C 是一种细胞渗透性嘧啶诱导剂，能够诱导 ESCs 分化为心肌细胞(EC50:100 nM)。在有限的可塑性范围内，它可以对已经沿袭的祖细胞类型产生心肌病，是一种心肌发生剂。
T40898	DMHCA
	DMHCA, a potent, selective LXR agonist, specifically activates the LXR pathway's cholesterol efflux arm, avoiding triglyceride synthesis stimulation. This compound exhibits anti-inflammatory properties and is utilized in researching cholesterol homeostasis and diabetes.
TP1591L	OVA G4 peptide acetate(148274-82-2 free base) SIIGFEKL acetate	Others	Others
	OVA G4 peptide acetate(148274-82-2 free base) (SIIGFEKL acetate) 是激动剂卵清蛋白 (OVA) 肽 (257-264) SIINFEKL 的变体。 OVA 肽是卵清蛋白的 I 类 (Kb) 限制性肽表位，由 I 类 MHC（主要组织相容性复合物）分子 H-2Kb（小鼠 MHC I 类基因）呈递。
TP2502	KYGVSVQDI Acetate	Others	Others
	KYGVSVQDI Acetate 是编码来自Listeria monocytogenes 的 MHC I 类限制性肽 p60(217-225) 的 DNA 序列。
TP1327L	OVA Peptide 257-264 2TFA (138831-86-4 free base) OVA Peptide 257-264 2TFA 1262751-08-5(TFA-2TFA)	Others	Others
	OVA Peptide 257-264 2TFA (138831-86-4 free base) 是 OVA 的 I 类 (Kb) 限制性肽表位，OVA 是卵清蛋白的八聚体肽，由 I 类 MHC 分子 H-2Kb 呈递。
TP1777L	p2Ca acetate(142606-55-1 free base)	Others	Others
	p2Ca acetate(142606-55-1 free base) 是一种天然加工的肽，来源于普遍存在的酶 α-酮戊二酸脱氢酶，并被 CTL 克隆 (2C) 识别为与 I 类 MHC 蛋白 Ld 结合。
T73133	FGF22-IN-1	Others	Others
	FGF22-IN-1 是一种潜在的 CD4 N-末端免疫球蛋白可变区样结构域（CD4 D1）抑制剂。FGF22-IN-1 可抑制CD4 与主要组织相容性复合体（MHC） II 类蛋白之间的相互作用，抑制免疫应答。
TP1543L	G280-9 acetate(156761-76-1 free base)	Others	Others
	G280-9 acetate(156761-76-1 free base) 是一种常见的黑色素瘤 gp100 表位，受 MHC 相关 HLA-A2 限制。 G280-9 序列是独特的，因为它可以在非常低的浓度下被细胞毒性 T 淋巴细胞识别，但是它显示出低的总免疫原性，这可能是由于该肽对 HLA-A2 的亲和力相对较低。
T9901A-001	Relatlimab BMS-986016	Others	Others
	Relatlimab(BMS-986016) 是一种靶向人抗 LAG-3 的单克隆抗体，由携带重组 LAG-3 蛋白的人免疫球蛋白的转基因小鼠免疫生成。Relatlimb 有阻断作用，可阻断 LAG-3/MHC II 的相互作用（IC50 ： 0.67 nM），阻断了 LAG-3/FGL1 的相互作用（ IC50：0.019 nM）。Relatlimab 常与 Nivoluma 一起用来治疗晚期黑色素瘤。
T12079	ML604440	Proteasome	Proteases/Proteasome; Ubiquitination
	ML604440 是一种特异性的、有效的、细胞可渗透的蛋白酶体 β1i (LMP2) 亚基抑制剂，能够破坏 MHC I 类细胞表面表达，IL-6 分泌以及 naïve T helper 向 17 T helper 细胞的分化。它可以改善实验性结肠炎和 EAE 疾病。
TP2315	glatiramer Acetate	Others	Others
	Glatiramer acetate 是髓鞘碱性蛋白的合成类似物和免疫调节剂，可用于多发性硬化症的研究。它能够诱导 T 辅助细胞 2 的特异性抑制细胞迁移到大脑并导致原位旁观者抑制。它能够于 MHC 分子强而杂乱的结合，因此与各种髓鞘抗原竞争，使其呈现给 T 细胞。
TP2360	A2-Binding peptide
	A2-Binding peptide has involved in the assembly of MHC Class I molecules.
TP1327	OVA Peptide(257-264) TFA OVA Peptide (257-264) TFA
	OVA Peptide (257-264) TFA, an octameric peptide epitope from ovalbumin, is presented by the class I MHC molecule, H-2Kb, showcasing a class I (Kb)-restricted profile.
TP1591	OVA G4 peptide
	G4 peptide (SIIGFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).
TP1652	OVA G4 peptide TFA (148274-82-2 free base) OVA G4 peptide TFA
	OVA G4 peptide TFA is an TFA salt form of OVA G4 peptide. G4 peptide (SIIGFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).
TP1126	InsB 9-23 Insulin B chain (9-23)
	InsB (9-23) is an insulin B-chain peptide that binds to a class II histocompatibility complex (MHC) allele called I-Ag7.
T36116	Concanamycin B
	Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell su...
T7619	OVA Peptide(257-264) OVA Peptide 257-264,OVA Peptide 257-264 (2TFA)	Others	Others
	OVA Peptide(257-264) 是 OVA 的 I 类 (Kb)-限制性肽表位，其中OVA 是一种来自卵清蛋白的八聚体肽，由 I 类 MHC 分子 H-2Kb 所呈递。
T83861	Bactobolamine
	Bactobolamine是一种免疫抑制剂。在200 µg/ml的浓度下，该化合物能够抑制CTLL细胞的IL-2产生。在体内实验中，Bactobolamine（200 mg/kg）能够延长MHC兼容及MHC不兼容的大鼠心脏移植物存活时间。此外，它还能在大鼠肝脏移植模型和犬类肾脏移植模型中延长存活时间。
T80907	TYVPANASL
	TYVPANASL为由HER2/neu的9个氨基酸组成的MHC I结合CD8 T细胞表位，可用于制备J-LEAPS疫苗。
T39005	OVA (55-62)
	OVA 55-62 is a truncated peptide derived from the ovalbumin (OVA) antigen, specifically designed to bind to the H2-Kb mouse major histocompatibility complex (MHC) class I molecule.
T38794	LLO (91-99) LLO (91-99),Listeriolysin O (91-99)
	LLO (91-99), also known as Listeriolysin O (91-99), is a class I MHC-restricted T-cell epitope derived from listeriolysin (LLO), an exotoxin. It plays a vital role as an antigen in the induction of T-cell mediated immunity in vivo.
T80906	TYVPANASL TFA
	TYVPANASL TFA，一种由HER2/neu的9个氨基酸组成，可结合MHC I并与CD8 T细胞表位相关的化合物。该化合物可用于制备J-LEAPS疫苗。
T76529	HBV Seq2 aa:28-39
	HBVSeq2 aa:28-39 是一种 HBsAg 肽，可与主要组织相容性复合体 (MHC) I 类分子结合。
T78247	Ieramilimab IMP701,LAG525
	Ieramilimab（LAG525；IMP701）是一款针对LAG-3的人源化IgG4单克隆抗体，它通过结合到LAG-3来阻断其与MHC-II 分子的相互作用。
T40115	GAD65 (206-220) GAD65 (206-220)
	GAD65 (206-220) is a synthetic peptide derived from glutamic acid decarboxylase (GAD) 65, specifically corresponding to residues 180-188. It is known that GAD65 interacts with I-Ag7 MHC class II molecules and is a significant pancreatic antigen that self-reactive T cells target in type I diabetes mellitus.
T40590	NY-ESO-1 (87-111)
	NY-ESO-1 (87-111) is a pan-MHC class II-restricted peptide that interacts with various HLA-DR and HLA-DP4 molecules, inducing activation of CD4+ T cells with Th1-type and Th-2/Th0-type responses, when presented in conjunction with HLA-DR and HLA-DP4 molecules.
T81590	OVA peptide
	OVA peptide，主要源于鸡蛋清，作为I类MHC（主要组织相容性复合体）分子H-2Kb（小鼠MHC的I类基因）所呈递的特定卵白蛋白Kb限制性表位。在过敏性研究领域，OVA peptide具有广泛应用。
TP1589	EGFRvIII peptide (PEPvIII) EGFRvIII peptide PEPvIII
	PEPvIII, a peptide sequence from EGFRvIII, was designed to represent a target of glioma and is presented by MHC I/II complexes.
T82743	CFP10 (71–85)
	CFP10 (71–85) 是具生物活性的肽类，能激活表达不同MHC II类与I类分子的人类CD4+和CD8+ T细胞，诱导IFN-γ产生及CTL活性。(CFP10 71–85).
TP1629	LCMV gp33-41 (TFA) (151705-84-9 free base) LCMV gp33-41 (TFA)
	LCMV gp33-41 (TFA), the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes[1].
T38794L	LLO (91-99) acetate LLO (91-99) acetate(137856-41-8 free base)	Others	Others
	LLO (91-99) acetate 是一种外毒素，是李斯特菌溶血素的 I 类 MHC 限制性 T 细胞表位。 LLO (91-99) 醋酸盐对于诱导体内 T 细胞介导的免疫至关重要。
TP1777	p2Ca
	p2Ca, a naturally processed peptide that derives from a ubiquitous enzyme, alpha-ketoglutarate dehydrogenase, and is recognized in association with the class I MHC protein, Ld, by a CTL clone (2C).
T75982	LCMV gp33-41 TFA
	LCMV gp33-41 (TFA)是一种带有羧基延伸的11-aa长肽，作为淋巴细胞脉络丛脑膜炎病毒序列，在MHC I类H-2Db分子的限制下，能够被呈递给细胞毒性T淋巴细胞。
T81790	Miptenalimab BI-754111
	Miptenalimab (BI-754111)为一种高亲和力抗人LAG-3抗体，其对hLAG-3的结合常数(KD)为88.6 nM。该抗体能有效阻断LAG-3与其主要配体MHC-II之间的相互作用。
T80857	VLHDDLLEA
	VLHDDLLEA是从MHC复合体HLA-A0201分子中分离得到的多肽，具有被HLA-A0201-限制性细胞毒T细胞(CTLs)识别的特性。该多肽可应用于移植物抗宿主病(GvHD)的研究。
TP1543	G280-9
	The G280-9 peptide, a common melanoma gp100 epitope restricted by MHC-associated HLA-A2. The G280-9 sequence is unique because it could be recognized by cytotoxic T lymphocytes at very low concentrations, however it shows low total immunogenicity that may
TP1502	MAGE-A3 (195-203) MAGE-A3 195-203
	This peptide MAGE-3-encoded HLA-A24 epitope is a high MHC binder.The identification of this MAGE-3/HLA-A24 peptide may as a result effectiveially offer the opportunities to design peptide-based immunotherapeutic approaches that might prove to be potent in
T78332	Eftilagimod alfa IMP321,LAG-3Ig
	Eftilagimod alfa为重组LAG-3Ig融合蛋白，具有MHC II 类分子结合能力。该药物通过介导抗原提呈细胞(APC)的激活进而激活CD8 T细胞，可用于研究转移性黑色素瘤及转移性乳腺癌。
T82414	Favezelimab MK-4280
	Favezelimab（MK-4280）为人源化抗LAG-3单克隆抗体，能够抑制LAG-3与其配体MHC II类结合。该抗体联合PD-L1抑制剂Pembrolizumab在结直肠癌（CRC）治疗研究中展现出应用前景。
T82471	Encelimab
	Encelimab是一种抗LAG3抗体，能够阻断 LAG-3 与 MHC II 的交互作用并增强T细胞活性。在单独应用或与抗PD-1抗体结合时，Encelimab能有效减小A20细胞异种移植瘤小鼠模型中的淋巴瘤肿瘤体积。
T39311	Tyrosinase-related Protein 2 (TRP-2) (181-188)
	Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide derived from the tyrosinase-related protein 2 (TRP-2), specifically corresponding to residues 180-188. It is the primary epitope within TRP-2 that is recognized by anti-B16 CTLs. Moreover, It is a peptide that conforms to the binding motif of the MHC class I H2-Kb.
TP1758	LCMV gp33-41
	LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes.This is the H-2Db restricted epitope derived from the lymphocytic
T76985	Tebotelimab
	Tebotelimab (MGD-013) 是一种人源的 IgG4κ 双特异性 PD-1/LAG-3双亲和再靶向 (DART) 抗体。Tebotelimab 结合 NS0 细胞表面表达的 PD-1和 LAG-3，EC50分别为 1.65 nM 和 0.41 nM。Tebotelimab 阻断 PD-1/PD-L1、PD-1/PD-L2 和 LAG-3/HLA (MHC-II) 相互作用和 PD-1信号。Tebotelimab 可恢复耗尽的 T 细胞功能并增强抗肿瘤免疫力。
T81423	Polzastobart JTX 8064
	Polzastobart (JTX-8064) 为一种人源化IgG4单克隆抗体，特异性与LILRB2结合，阻断其与配体及MHC I分子（经典与非经典）的相互作用。此抗体通过抑制LILRB2与HLA-A/B和/或HLA-G（癌细胞免疫耐受的标志）的结合，可增强巨噬细胞产生促炎细胞因子。Polzastobart 作为巨噬细胞免疫检查点抑制剂发挥作用。
TP1855	Moth Cytochrome C (MCC) (88-103) Moth Cytochrome C (MCC) 88-103
	Moth Cytochrome C (MCC) (88-103), derived from the carboxyl terminus of moth cytochrome c, induces positive selection of TCR transgenic thymocytes.This peptide is derived from the carboxyl terminus of moth cytochrome c. Thymic positive and negative select
T36984	Cyclic di-IMP (sodium salt)
	Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p...
T83852	EGFRvIII Peptide TFA PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide
	EGFRvIII peptide是一种合成肽，对应于特异性肿瘤、具有持续激活性的EGFR变体EGFRvIII的融合接头，该变体缺少野生型EGFR的第6至273个氨基酸。在25 µg/ml的浓度下，它能与MHC I类亚型HLA-A*0201阳性的T2细胞结合。在用于分离的人外周血单个核细胞（PBMCs）衍生的树突状细胞中，EGFRvIII peptide可诱导抗原呈递，进而刺激CD8+细胞毒性T淋巴细胞的激活和IFN-γ产生。与toll样受体5（TLR5）激动剂鞭毛蛋白B共同免疫EGFRvIII peptide（15 µg/动物），在正交GL261胶质母细胞瘤小鼠异种移植模型中，增加了CD8+ T细胞数量，减少了调节性T细胞（Tregs）数量，减少了肿瘤体积，并提高了生存率。

化合物

MHC class II antigen (45-57) [Homo sapiens]

Cat.No: TP2270

Target: Others

Cardiogenol C hydrochloride

Cat.No: T8005

Synonym: 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C

Target: Wnt/beta-catenin

Cat.No: T2161

Target: Wnt/beta-catenin

Cat.No: T40898

OVA G4 peptide acetate(148274-82-2 free base)

Cat.No: TP1591L

Synonym: SIIGFEKL acetate

Target: Others

KYGVSVQDI Acetate

Cat.No: TP2502

Target: Others

OVA Peptide 257-264 2TFA (138831-86-4 free base)

Cat.No: TP1327L

Synonym: OVA Peptide 257-264 2TFA 1262751-08-5(TFA-2TFA)

Target: Others

p2Ca acetate(142606-55-1 free base)

Cat.No: TP1777L

Target: Others

Cat.No: T73133

Target: Others

G280-9 acetate(156761-76-1 free base)

Cat.No: TP1543L

Target: Others

Cat.No: T9901A-001

Synonym: BMS-986016

Target: Others

Cat.No: T12079

Target: Proteasome

glatiramer Acetate

Cat.No: TP2315

Target: Others

A2-Binding peptide

Cat.No: TP2360

OVA Peptide(257-264) TFA

Cat.No: TP1327

Synonym: OVA Peptide (257-264) TFA

Cat.No: TP1591

OVA G4 peptide TFA (148274-82-2 free base)

Cat.No: TP1652

Synonym: OVA G4 peptide TFA

Cat.No: TP1126

Synonym: Insulin B chain (9-23)

Cat.No: T36116

OVA Peptide(257-264)

Cat.No: T7619

Synonym: OVA Peptide 257-264,OVA Peptide 257-264 (2TFA)

Target: Others

Cat.No: T83861

Cat.No: T80907

Cat.No: T39005

Cat.No: T38794

Synonym: LLO (91-99),Listeriolysin O (91-99)

Cat.No: T80906

HBV Seq2 aa:28-39

Cat.No: T76529

Cat.No: T78247

Synonym: IMP701,LAG525

GAD65 (206-220)

Cat.No: T40115

Synonym: GAD65 (206-220)

NY-ESO-1 (87-111)

Cat.No: T40590

Cat.No: T81590

EGFRvIII peptide (PEPvIII)

Cat.No: TP1589

Synonym: EGFRvIII peptide PEPvIII

CFP10 (71–85)

Cat.No: T82743

LCMV gp33-41 (TFA) (151705-84-9 free base)

Cat.No: TP1629

Synonym: LCMV gp33-41 (TFA)

LLO (91-99) acetate

Cat.No: T38794L

Synonym: LLO (91-99) acetate(137856-41-8 free base)

Target: Others

Cat.No: TP1777

LCMV gp33-41 TFA

Cat.No: T75982

Cat.No: T81790

Synonym: BI-754111

Cat.No: T80857

Cat.No: TP1543

MAGE-A3 (195-203)

Cat.No: TP1502

Synonym: MAGE-A3 195-203

Eftilagimod alfa

Cat.No: T78332

Synonym: IMP321,LAG-3Ig

Cat.No: T82414

Synonym: MK-4280

Cat.No: T82471

Tyrosinase-related Protein 2 (TRP-2) (181-188)

Cat.No: T39311

Cat.No: TP1758

Cat.No: T76985

Cat.No: T81423

Synonym: JTX 8064

Moth Cytochrome C (MCC) (88-103)

Cat.No: TP1855

Synonym: Moth Cytochrome C (MCC) 88-103

Cyclic di-IMP (sodium salt)

Cat.No: T36984

EGFRvIII Peptide TFA

Cat.No: T83852

Synonym: PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide

Cat. No.	Product Name	Target	Signaling Pathways
T0948L	Corticosterone 皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants)	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Corticosterone (Kendall's compound B) 是一种肾上腺皮质类固醇，有盐皮质激素和糖皮质激素的活性，具有口服活性。Corticosterone 参与体内能量、免疫反应和应激反应的调节。
T5771	Hypocrellin A	Antibacterial; PKC; Parasite	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology
	Hypocrellin A 是一种天然的PKC 抑制剂，具有光诱导的抗肿瘤、抗真菌和抗病毒活性，还对 MHC 限制性抗原呈递发挥免疫调节作用。
TN6925	Pristane 姥鲛烷,2,6,10,14-tetramethylpentadecane	Others	Others
	Pristane (2,6,10,14-tetramethylpentadecane) 是一种天然存在的烃油，是矿物油中最活跃的成分，较少存在于许多植物、各种海洋生物中。它是一种非抗原性佐剂，可诱导大鼠中 MHC II 类限制性关节炎 T 细胞。

天然产物

Cat.No: T0948L

Synonym: 皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants)

Target: Glucocorticoid Receptor, Endogenous Metabolite

Cat.No: T5771

Target: Antibacterial, PKC, Parasite

Cat.No: TN6925

Synonym: 姥鲛烷,2,6,10,14-tetramethylpentadecane

Target: Others

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