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2

抑制剂 & 化合物

15

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T62788	Pexidartinib hydrochloride
	Pexidartinib hydrochloride (PLX-3397 hydrochloride) 是一种有效的、选择性的、口服具有活力的、ATP-竞争性的集落刺激因子 1 (CSF1R 或 M-CSFR) (IC50: 20 nM) 和 c-Kit (IC50: 10 nM) 抑制剂。Pexidartinib hydrochloride 对 c-Kit 和 CSF1R 的选择性是对其他相关激酶的 10-100 倍，作用于 FLT3 (IC50: 160 nM)、KDR (VEGFR2) (IC50: 350 nM)、LCK (IC50: 860 nM)、FLT1 (VEGFR1) (IC50: 880 nM) 和 NTRK3 (TRKC) (IC50: 890 nM)。Pexidartinib hydrochloride 能够诱导细胞凋亡，表现出抗肿瘤作用。
T2115	Pexidartinib PLX-3397	Apoptosis; c-Fms; FLT; CSF-1R; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Pexidartinib (PLX-3397) 是具有口服活性的选择性ATP-竞争性的集落刺激因子 1 和c-Kit 抑制剂，IC50值分别为 20 和 10 nM。它可诱导细胞凋亡，具有抗肿瘤活性。

化合物

Pexidartinib hydrochloride

Cat.No: T62788

Cat.No: T2115

Synonym: PLX-3397

Target: Apoptosis, c-Fms, FLT, CSF-1R, c-Kit

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00656	M-CSFR/CSF1R/CD115 Protein, Cynomolgus, Recombinant (His) M-CSF R,M-CSFR,HDLS,C-FMS,CSF1R,CSFR,CD115...	Cynomolgus	HEK293 Cells
	M-CSFR/CSF1R/CD115 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 56.3 kDa and the accession number is G7P8P1.
TMPK-00415	M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi), Biotinylated CSF-1-R,M-CSF R,C-FMS,FMSFIM2,CSFR,CD115,M-CSFR...	Human	HEK293 Cells
	M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 57.4 kDa and the accession number is P07333-1.
TMPK-00414	M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi) FMSFIM2,FMS,M-CSF R,HDLS,M-CSFR,CSF1R,CSF-1-R,FIM2,...	Human	HEK293 Cells
	M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 57.4 kDa and the accession number is P07333-1.
TMPY-01037	CSF1R Protein (Met1-Glu512), Human, Recombinant (His) CSF-1R,CD115,HDLS,FIM2,M-CSF-R,MCSF Receptor,colony stimulat...	Human	HEK293 Cells
	CSF1R Protein (Met1-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is P07333-1.
TMPY-05436	CSF1R Protein, Mouse, Recombinant (hFc) AI323359,Csfmr,Fim-2,Fms,colony stimulating factor 1 recepto...	Mouse	HEK293 Cells
	CSF1R Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 81.9 kDa and the accession number is P09581.
TMPY-04938	CSF1R Protein, Mouse, Recombinant (His), Biotinylated CD115,M-CSFR,colony stimulating factor 1 receptor,A...	Mouse	HEK293 Cells
	CSF1R Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.8 kDa and the accession number is P09581.
TMPY-01833	CSF1R Protein, Mouse, Recombinant (His) Fim-2,M-CSF-R,CD115,Csfmr,CSF-1R,colony stimulating factor 1...	Mouse	HEK293 Cells
	CSF1R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.8 kDa and the accession number is P09581.
TMPY-00881	CSF1R Protein, Human, Recombinant FIM2,C-FMS,CD115,CSFR,MCSF Receptor,FMS,CSF-1R,colo...	Human	HEK293 Cells
	CSF1R Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 55.1 kDa and the accession number is P07333-1.
TMPY-05429	CSF1R Protein, Human, Recombinant (hFc) FIM2,C-FMS,FMS,MCSF Receptor,CD115,HDLS,CSF-1R,colony stimul...	Human	HEK293 Cells
	CSF1R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 81.2 kDa and the accession number is P07333-1.
TMPY-06384	CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated HDLS,FMS,colony stimulating factor 1 receptor,MCSF Receptor,...	Human	HEK293 Cells
	CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 57.76 kDa and the accession number is P07333-1.
TMPY-05045	CSF1R Protein, Human, Recombinant (Domain I&II&III, His) M-CSF-R,colony stimulating factor 1 receptor,HDLS,C-FMS,FMS,...	Human	HEK293 Cells
	CSF1R Protein, Human, Recombinant (Domain I&II&III, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.1 kDa and the accession number is P07333-1.
TMPY-05264	CSF1R Protein, Human, Recombinant (mFc) CD115,FIM2,FMS,CSF-1R,colony stimulating factor 1 receptor,H...	Human	HEK293 Cells
	CSF1R Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 81.5 kDa and the accession number is P07333-1.
TMPY-05513	CSF1R Protein (Ala299-Glu512), Human, Recombinant (His) M-CSF-R,HDLS,C-FMS,CSFR,CSF-1R,CD115,FMS,colony sti...	Human	HEK293 Cells
	CSF1R Protein (Ala299-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.3 kDa and the accession number is P07333-1.
TMPY-04358	CSF1R Protein, Human, Recombinant (His & GST) MCSF Receptor,FMS,colony stimulating factor 1 receptor,FIM2,...	Human	Baculovirus Insect Cells
	CSF1R Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76 kDa and the accession number is P07333-1.
TMPY-06389	CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated FMS,CD115,FIM2,MCSF Receptor,colony stimulating factor 1 rec...	Human	HEK293 Cells
	CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 83.04 kDa and the accession number is P07333-1.

重组蛋白

M-CSFR/CSF1R/CD115 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00656

Species: Cynomolgus

Expression System: HEK293 Cells

M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00415

Species: Human

Expression System: HEK293 Cells

M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00414

Species: Human

Expression System: HEK293 Cells

CSF1R Protein (Met1-Glu512), Human, Recombinant (His)

Cat.No: TMPY-01037

Species: Human

Expression System: HEK293 Cells

CSF1R Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-05436

Species: Mouse

Expression System: HEK293 Cells

CSF1R Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-04938

Species: Mouse

Expression System: HEK293 Cells

CSF1R Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01833

Species: Mouse

Expression System: HEK293 Cells

CSF1R Protein, Human, Recombinant

Cat.No: TMPY-00881

Species: Human

Expression System: HEK293 Cells

CSF1R Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05429

Species: Human

Expression System: HEK293 Cells

CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06384

Species: Human

Expression System: HEK293 Cells

CSF1R Protein, Human, Recombinant (Domain I&II&III, His)

Cat.No: TMPY-05045

Species: Human

Expression System: HEK293 Cells

CSF1R Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05264

Species: Human

Expression System: HEK293 Cells

CSF1R Protein (Ala299-Glu512), Human, Recombinant (His)

Cat.No: TMPY-05513

Species: Human

Expression System: HEK293 Cells

CSF1R Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04358

Species: Human

Expression System: Baculovirus Insect Cells

CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06389

Species: Human

Expression System: HEK293 Cells

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