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Search Results for " leukotriene d4 "

26

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T38128	Leukotriene D4 Leukotriene D4 MaxSpec® Standard,LTD4
	Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4 . Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of...
T37261	14,15-Leukotriene D4 14,15-Leukotriene D4
	14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both ...
T37493	11-trans Leukotriene D4 11-trans Leukotriene D4
	11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.
T28529	RG 7152 RG7152,RG-7152	Leukotriene Receptor	GPCR/G Protein
	RG 7152 是白三烯 D4 拮抗剂,具有抗哮喘作用，可作用于研究哮喘。
T27979	Masilukast ICI-D-3523,ZD-3523,ICI D-3523,MCC-847,SA-09012,D-3523	Leukotriene Receptor	GPCR/G Protein
	Masilukast(MCC-847) 是一种口服的白三烯D4 (LTD4) 受体拮抗剂，可用于研究与炎症相关的疾病。
T2583	Cilastatin 西司他丁,MK0791	Proteasome; Antibacterial; Antibiotic	Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	Cilastatin (MK0791) 是一种可逆的竞争性的肾脏脱氢肽酶 I 抑制剂，IC50为 0.1 μM。它抑制细菌金属叶内酰胺酶CphA 的IC50为 178 μM，可用作抗菌辅助剂。
T23390	SR 2640 hydrochloride	Leukotriene Receptor	GPCR/G Protein
	SR 2640 hydrochloride 是白三烯 D4 和 E4 的竞争性拮抗剂，可用于研究人类哮喘中的白三烯。
T6736	Zafirlukast Vanticon,ICI 204219,Accolate,扎鲁司特	Leukotriene Receptor	GPCR/G Protein
	Zafirlukast (ICI 204219) 是一种可口服的白三烯 D4受体拮抗剂，具有平喘、抗炎和抗菌作用。
T1639	Amlexanox 氨来呫诺,CHX3673,Amoxanox,氨来诺,AA673	IL Receptor; FGFR; Others; IκB/IKK	Angiogenesis; Immunology/Inflammation; NF-κB; Others; Tyrosine Kinase/Adaptors
	Amlexanox (AA673) 是一种特异性的 IKKε和 TBK1抑制剂，其 IC50=1-2 μM。
T67959	Pirodomast	Thrombin; Serine Protease	Proteases/Proteasome
	Pirodomast 是血栓素 A（TXA2）合成酶抑制剂。Pirodomast 能抑制白三烯（LT）D4、C4、E4 的形成和血栓素 B2（TXB2）的活性，但对组胺、甲氧胆碱、血清素、LTC4 或血小板活化因子诱导的豚鼠支气管痉挛的拮抗作用较弱或无效。Pirodomast 在体外对豚鼠气管只有微弱的松弛活性。Pirodomast 是一种潜在的抗过敏化合物，在体外可抑制胰蛋白酶的蛋白水解活性，在体内可阻止抗原诱发过敏绵羊的即时和晚期哮喘反应，抑制抗原诱导的过敏绵羊对组胺和卡巴胆碱的气道高反应性。
T27893	LY 203647 LY203647,LY-203647
	LY 203647 is a antagonist of leukotriene D4 and E4 receptor.
T24304	L 648051 4-Apsob,L48051,L-648051
	L 648051 is a leukotriene D4 receptor antagonist.
T2583L	Cilastatin sodium Cilastatinum,Cilastatin Monosodium Salt ;Cilastatin Sodium,Cilastatin Monosodium Salt,MK 791,Cilastatine,Cilastatin,Cilastatin Sodium,MK 0791
	Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor.
T71411	U 19052
	U 19052 is a Leukotriene D4 antagonist.
T68195	SC 39070
	SC 39070 is a leukotriene D4 antagonist.
T35112	WAY 126299A WAY126299A,WAY-126299A
	Way 126299a is a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist.
T10873	CP-96486	Others	Others
	CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor (Kis: 20 and 24 nM).
T11764	KP496	Others	Others
	KP496 is a selective, dual antagonist for Thromboxane A2 receptor and Leukotriene D4 receptor.
T10057	LTD4 antagonist 1	Others	Others
	LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM).
T71039	MDL-28753
	MDL-28753 is an antagonist of leukotriene D4 and antagonist of leukotrine C4.
T10872	CP-96021 hydrochloride	Others	Others
	CP-96021 hydrochloride is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor receptor (Kis: 34 nM and 37 nM).
T10054	CI-949	Others	Others
	CI-949 is an allergic mediator release inhibitor, which inhibits leukotriene C4/D4 (LTC4/LTD4), histamine, and thromboxane B2 (TXB2) release (IC50s: 0.5 μM, 11.4 μM and 0.1 μM).
T12771	RS-601	Leukotriene Receptor; Thrombin	GPCR/G Protein; Proteases/Proteasome
	RS-601 是一种有效的 leukotriene D4/thromboxane A2 双重抑制剂，对抗原诱导的气道高反应性（AHR）有抑制作用且在豚鼠哮喘模型中显示出平喘作用。
T19674	Verlukast MK 0679,MK-679,L 668,019,MK 679,L 668019,L-668,019
	Verlukast is an (R)-enantiomer of MK-571 and a potent and selective LTD4 receptor antagonist. Verlukast showed [3H]leukotriene D4 binding in guinea-pig (IC50 = 3.1 +/- 0.5 nM) and human (IC50 = 8.0 +/- 3.0 nM) lung homogenates and dimethyl sulfoxide diffe
TMIH-0609	Zafirlukast-d7
	Zafirlukast-d7 是 Zafirlukast 的氘代化合物。Zafirlukast 的 CAS 号为 107753-78-6。Zafirlukast 是一种可口服的白三烯 D4受体拮抗剂，具有平喘、抗炎和抗菌作用。
T36618	Rupatadine
	Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu...

化合物

Leukotriene D4

Cat.No: T38128

Synonym: Leukotriene D4 MaxSpec® Standard,LTD4

14,15-Leukotriene D4

Cat.No: T37261

Synonym: 14,15-Leukotriene D4

11-trans Leukotriene D4

Cat.No: T37493

Synonym: 11-trans Leukotriene D4

Cat.No: T28529

Synonym: RG7152,RG-7152

Target: Leukotriene Receptor

Cat.No: T27979

Synonym: ICI-D-3523,ZD-3523,ICI D-3523,MCC-847,SA-09012,D-3523

Target: Leukotriene Receptor

Cat.No: T2583

Synonym: 西司他丁,MK0791

Target: Proteasome, Antibacterial, Antibiotic

SR 2640 hydrochloride

Cat.No: T23390

Target: Leukotriene Receptor

Cat.No: T6736

Synonym: Vanticon,ICI 204219,Accolate,扎鲁司特

Target: Leukotriene Receptor

Cat.No: T1639

Synonym: 氨来呫诺,CHX3673,Amoxanox,氨来诺,AA673

Target: IL Receptor, FGFR, Others, IκB/IKK

Cat.No: T67959

Target: Thrombin, Serine Protease

Cat.No: T27893

Synonym: LY203647,LY-203647

Cat.No: T24304

Synonym: 4-Apsob,L48051,L-648051

Cilastatin sodium

Cat.No: T2583L

Synonym: Cilastatinum,Cilastatin Monosodium Salt ;Cilastatin Sodium,Cilastatin Monosodium Salt,MK 791,Cilastatine,Cilastatin,Cilastatin Sodium,MK 0791

Cat.No: T71411

Cat.No: T68195

Cat.No: T35112

Synonym: WAY126299A,WAY-126299A

Cat.No: T10873

Target: Others

Cat.No: T11764

Target: Others

LTD4 antagonist 1

Cat.No: T10057

Target: Others

Cat.No: T71039

CP-96021 hydrochloride

Cat.No: T10872

Target: Others

Cat.No: T10054

Target: Others

Cat.No: T12771

Target: Leukotriene Receptor, Thrombin

Cat.No: T19674

Synonym: MK 0679,MK-679,L 668,019,MK 679,L 668019,L-668,019

Cat.No: TMIH-0609

Cat.No: T36618

Cat. No.	Product Name	Target	Signaling Pathways
TN5180	Triptinin B	Others	Others
	Triptinin A and triptinin B are leukotriene D4 antagonist constituents.

天然产物

Cat.No: TN5180

Target: Others

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