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Search Results for " l(-)-carnitine "

27

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37735	Stearoyl-L-carnitine chloride C18 Carnitine,Stearoylcarnitine chloride
	Stearoyl-L-carnitine chloride（Acylcarnitine C18:0）是一种存在于小脑中的长链酰基肉碱，抑制 GlyT2 ，是研究脂代谢的重要组成部分。
T26551	Acetyl-L-carnitine RO 447190,L-Acetylcarnitine,LAC,L-O-Acetylcarnitine,ALCAR,Acetyl L carnitine	Endogenous Metabolite	Metabolism
	Acetyl-L-carnitine(RO 447190) 是一种可透过血脑屏障的氨基酸左旋肉碱，常作为膳食补充剂，对神经炎症有益。Acetyl-L-carnitine 具有神经保护作用，可用以研究像阿尔茨海默病类的神经疾病。
T38253	Lauroyl-L-carnitine (chloride) Lauroyl-L-carnitine Hydrochloride
	Lauroyl-L-carnitine (chloride) (Lauroyl-L-carnitine Hydrochloride)是一种酰基肉碱和表面活性剂，已被用于渗透猪肠细胞，以输送极性荧光探针荧光黄。
T37359	Myristoyl-L-carnitine chloride L-Myristoylcarnitine chloride	Endogenous Metabolite	Metabolism
	Myristoyl-L-carnitine chloride (L-Myristoylcarnitine chloride) 是人体的代谢物之一，与遗传代谢疾病有关。Tetradecanoylcarnitine 是研究糖尿病和自身免疫性肝炎的潜在标记物。
T37407	Arachidonoyl-L-carnitine (chloride) C20:4 Carnitine,Arachidonoyl-L-carnitine (chloride)
	Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism. It does so by accepting acyl groups from fatty acids complexed with coenzyme A, which yields esterified carnitine or acylcarnitines that enable the transport of fatty acyl groups into the inner mitochondrial matrix. β-Oxidation of fatty acids in mitochondria is inhibited by uncoupling conditions, thus changes in circulating levels of various acylcarnitines have been used to identify alte...
T38232	Heptanoyl-L-carnitine (chloride)
	Heptanoyl-L-carnitine is a medium-chain acylcarnitine and derivative of L-carnitine .
T36050	Linoleoyl-L-carnitine (chloride)
	Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine. Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of isoniazid in mice.
T37453	Butyryl-L-carnitine (chloride)
	Butyryl-L-carnitine is a butyrate ester of carnitine. It is an inhibitor of intestinal transporters, blocking carnitine uptake by the carnitine transporter and glycine transport by the amino acid transporter in human retinal pigment epithelial (HRPE) cells (IC50s = 1.5 μM and 4.6 mM, respectively).
T36098	Isovaleryl-L-carnitine (chloride)
	Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated wit...
T38267	Valeryl-L-carnitine (chloride) Valeryl-L-carnitine (chloride),L-Valerylcarnitine
	Valeryl-L-carnitine is a short-chain acylcarnitine and a derivative of L-carnitine . Valeryl-L-carnitine levels increase in the serum of rhesus monkeys following exposure to 7 and 10 Gray units (Gy) of ionizing radiation.[1]
T36663	Decanoyl-L-carnitine (chloride)
	Decanoyl-L-carnitine is an ester derivative of L-carnitine . It increases the formation of C24 fatty acid intermediates, as well as docosapentaenoic and docosahexaenoic acid in rat hepatocytes.
T38233	Hexanoyl-L-carnitine (chloride)
	Hexanoyl-L-carnitine is a medium-chain acylcarnitine. It has been used in the synthesis of acylcarnitine benzyl esters.1 1.Gong, X.-w., Li, J.-p., Wu, J.-f., et al.Synthesis of carnitine benzyl esters as prodrugsJ. Chem. Res.2008(6)327-330(2008)
T37640	trans-2-Hexadecenoyl-L-carnitine
	trans-2-Hexadecenoyl-L-carnitine is an endogenous metabolite in urine[1]. [1]. Pengxiang She, et al. Leucine and protein metabolism in obese Zucker rats. PLoS One. 2013;8(3):e59443.
T37641	trans-2-Octenoyl-L-carnitine
	trans-2-Octenoyl-L-carnitine is a synthetic carnitine.1It has been used as a standard for the detection of carnitines in human urine. 1.Yang, S., Minkler, P., and Hoppel, C.cis-3,4-methylene-heptanoylcarnitine: Characterization and verification of the C8:1 acylcarnitine in human urineJ. Chromatogr. B. Analyt. Technol. Biomed. Life Sci.857(2)251-258(2007)
T20193	L-Carnitine tartrate L-Carnitine L-tartrate,Carnipure tartrate
	L-Carnitine tartrate is a Carnitine/ Constituent of striated muscle and liver. It is used to treatment of hyperlipoproteinemias.
T37516	[(3R)-3-Hydroxydodecanoyl]-L-carnitine
	[(3R)-3-Hydroxydodecanoyl]-L-carnitine is an endogenous metabolite[1]. [1]. Hunter WG, et al. Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure. J Am Heart Assoc. 2016;5(8):e003190. Published 2016 Jul 29.
T83872	Oleoyl-L-carnitine chloride L-Carnitine oleoyl ester,L-Octadecanoylcarnitine,C18:1 Carnitine,CAR 18:1
	Oleoyl-L-carnitine是一种长链酰基肉碱，也是一种糖苷转运体2（GlyT2；IC50 = 340 nM）的抑制剂，对GlyT2比对GlyT1（IC50 = >10,000 nM）具有选择性。慢性肾脏病或接受初始血液透析的终末期肾脏病患者的血浆中Oleoyl-L-carnitine水平增高，这与心血管死亡率相关。
T1182	Levocarnitine propionate hydrochloride Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,丙酰左旋肉碱盐酸盐,ST-261,丙酰肉碱盐酸盐	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Levocarnitine propionate hydrochloride (ST-261) 可用于肾功能恶化，充血性心脏衰竭，间歇性跛行等疾病的研究。
T24042	Erucyllevocarnitine Erucyl-L-carnitine,L-Erucoylcarnitine
	Erucyllevocarnitine is an inhibitor of palmityl-carnitine oxidation.
T73766	Isobutyryl-L-carnitine chloride
	Isobutyryl-L-carnitine chloride 是酰基辅酶 A 脱氢酶的产物。
T1182L	Levocarnitine propionate L-Propionylcarnitine,ST261,ST 261,Propionyl-L-carnitine,ST-261
	Propionylcarnitine is present in high abundance in the urine of patients with Methylmalonyl-CoA mutase (MUT) deficiency.
T29598	Acetylcarnitine arginyl amide ST-857,acetyl-L-carnitine arginine amide
	Acetylcarnitine arginyl amide is able to stimulate neurite outgrowth in a manner similar to that elicited by nerve growth factor (NGF). Neurite induction by this molecule requires de novo mRNA synthesis and is independent of the action of several common t
T37299	L-Palmitoylcarnitine chloride
	Palmitoyl-L-carnitine is a naturally occurring long-chain acylcarnitine and the L-enantiomer of palmitoyl-DL-carnitine . In cells, palmitoyl-L-carnitine is transported into mitochondria via carnitine palmitoyl transferase II to deliver palmitate for fatty acid oxidation and energy production. It also inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma when used at a concentration of 500 μM. In vivo, palmitoyl-L-carnitine increases intestinal absorption of the ant...
T3268	Mildronate Kvaterin,米屈肼,Meldonium,Quaterin	Hydroxylase	Metabolism
	Mildronate (Meldonium) 是心血管保护药，能够竞争性的抑制 BBOX1和 OCTN2。作用于人重组 BBOX 的(IC50:34-62 μM)、人 OCTN2 (EC50:21 μM)。它 n 能够诱导长链脂肪酸代谢从线粒体向过氧化物酶体的重定向。
T13113	Teglicar	Others	Others
	Teglicar is a selective and reversible liver isoform of carnitine palmitoyl-transferase 1 (L-CPT1) inhibitor.
T37245	Palmitoyl-D-carnitine (chloride)
	Palmitoyl-D-carnitine is a long-chain acylcarnitine, an isomer of palmitoyl-L-carnitine , and the D enantiomer of palmitoyl-DL-carnitine . It inhibits carnitine palmitoyltransferase with a Ki value of 2.1 mM for 14C-palmitoylcarnitine synthesis by erythrocyte membranes.
T36842	Isobutyryl Coenzyme A (sodium salt)
	Isobutyryl coenzyme A (isobutyryl-CoA) is a short-chain branched acyl CoA. Isobutyryl-CoA is a substrate for isobutyryl-CoA dehydrogenase (IBDH) in the catabolism of valine and an intermediate in the synthesis of isobutyryl-L-carnitine , which accumulates in IBDH deficiency.

化合物

Stearoyl-L-carnitine chloride

Cat.No: T37735

Synonym: C18 Carnitine,Stearoylcarnitine chloride

Acetyl-L-carnitine

Cat.No: T26551

Synonym: RO 447190,L-Acetylcarnitine,LAC,L-O-Acetylcarnitine,ALCAR,Acetyl L carnitine

Target: Endogenous Metabolite

Lauroyl-L-carnitine (chloride)

Cat.No: T38253

Synonym: Lauroyl-L-carnitine Hydrochloride

Myristoyl-L-carnitine chloride

Cat.No: T37359

Synonym: L-Myristoylcarnitine chloride

Target: Endogenous Metabolite

Arachidonoyl-L-carnitine (chloride)

Cat.No: T37407

Synonym: C20:4 Carnitine,Arachidonoyl-L-carnitine (chloride)

Heptanoyl-L-carnitine (chloride)

Cat.No: T38232

Linoleoyl-L-carnitine (chloride)

Cat.No: T36050

Butyryl-L-carnitine (chloride)

Cat.No: T37453

Isovaleryl-L-carnitine (chloride)

Cat.No: T36098

Valeryl-L-carnitine (chloride)

Cat.No: T38267

Synonym: Valeryl-L-carnitine (chloride),L-Valerylcarnitine

Decanoyl-L-carnitine (chloride)

Cat.No: T36663

Hexanoyl-L-carnitine (chloride)

Cat.No: T38233

trans-2-Hexadecenoyl-L-carnitine

Cat.No: T37640

trans-2-Octenoyl-L-carnitine

Cat.No: T37641

L-Carnitine tartrate

Cat.No: T20193

Synonym: L-Carnitine L-tartrate,Carnipure tartrate

[(3R)-3-Hydroxydodecanoyl]-L-carnitine

Cat.No: T37516

Oleoyl-L-carnitine chloride

Cat.No: T83872

Synonym: L-Carnitine oleoyl ester,L-Octadecanoylcarnitine,C18:1 Carnitine,CAR 18:1

Levocarnitine propionate hydrochloride

Cat.No: T1182

Synonym: Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,丙酰左旋肉碱盐酸盐,ST-261,丙酰肉碱盐酸盐

Target: Histamine Receptor

Erucyllevocarnitine

Cat.No: T24042

Synonym: Erucyl-L-carnitine,L-Erucoylcarnitine

Isobutyryl-L-carnitine chloride

Cat.No: T73766

Levocarnitine propionate

Cat.No: T1182L

Synonym: L-Propionylcarnitine,ST261,ST 261,Propionyl-L-carnitine,ST-261

Acetylcarnitine arginyl amide

Cat.No: T29598

Synonym: ST-857,acetyl-L-carnitine arginine amide

L-Palmitoylcarnitine chloride

Cat.No: T37299

Cat.No: T3268

Synonym: Kvaterin,米屈肼,Meldonium,Quaterin

Target: Hydroxylase

Cat.No: T13113

Target: Others

Palmitoyl-D-carnitine (chloride)

Cat.No: T37245

Isobutyryl Coenzyme A (sodium salt)

Cat.No: T36842

Cat. No.	Product Name	Target	Signaling Pathways
T0846	L-Carnitine L(-)-Carnitine,Levocarnitine,左旋肉碱	Endogenous Metabolite; Fatty Acid Synthase	Metabolism
	L-Carnitine (L(-)-Carnitine) 是一种人内源性分子，在人体内以蛋氨酸和赖氨酸为底物进行生物合成，并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A 转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。
T2563	Acetyl-L-carnitine hydrochloride Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂，具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外，乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应，并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。
T2203	D-Carnitine hydrochloride (S)-Carnitine Hydrochloride,L-Carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) 已被用于研究麦角硫因素转运蛋白 SLC22A4 和肉毒碱转运蛋白 SLC22A5，也被用于使棕榈酸进入线粒体。
T17048	Tetradecanoylcarnitine L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine	Endogenous Metabolite	Metabolism
	Tetradecanoylcarnitine (L-Myristoylcarnitine) 是一种酰基肉碱，参与长链脂肪酸的β-氧化,是极长链酰辅酶A脱氢酶缺乏症的一种潜在标记物。
T19381	Isobutyryl-L-carnitine	5-HT Receptor	GPCR/G Protein; Neuroscience
	Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
T20123	L-Carnitine hydrochloride L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80
	Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. Carnitine is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It has also been used to allow the en
T19564	Stearoylcarnitine Stearoyl-L-carnitine	Endogenous Metabolite	Metabolism
	Stearoylcarnitine (Stearoyl-L-carnitine) 是一种脂肪酯脂质分子，是一种人内源代谢产物，可作为早发型子痫前期和晚发性子痫前期的生物标志物。
T13280	Valerylcarnitine VALERYL-L-CARNITINE	Endogenous Metabolite	Metabolism
	Valerylcarnitine (VALERYL-L-CARNITINE) 是一种短链脂肪酸，可用于研究 2 型糖尿病。
T12295	Oleoylcarnitine Oleoyl-L-carnitine	Endogenous Metabolite	Metabolism
	Oleoylcarnitine (Oleoyl-L-carnitine) 抑制腺嘌呤核苷酸转位酶（AdNT）活性，ic50为14 μM。Oleoylcarnitine 是检测神经分裂的重要指标。
T19340	Glutarylcarnitine O-glutaroyl-L-carnitine	Endogenous Metabolite	Metabolism
	Glutarylcarnitine (O-glutaroyl-L-carnitine) 是大多数串联质谱新生儿筛查计划中监测的丙二酸尿症和谷草酸尿症 I 型的诊断代谢物。
T6475	(±)-Carnitine chloride Monocamin,DL-Carnitine HCl,Bicarnesine,混旋肉碱盐酸盐,DL-Carnitine chloride	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	(±)-Carnitine chloride (Monocamin) 有D 和L 两种异构体。其中 L-carnitine 在脂肪酸的 β-氧化中起重要作用，也具有抗氧化作用和抗炎活性。
T4785	Oxfenicine 4-羟基-L-苯甘氨酸,4-Hydroxy-L-phenylglycine	Others	Others
	Oxfenicine (4-Hydroxy-L-phenylglycine) 是具有口服活性的肉碱棕榈酰转移酶-1 抑制剂。它在缺血期间保护心脏免受坏死组织的损害。它可抑制心脏中脂肪酸的氧化。
T5066	Nε,Nε,Nε-Trimethyllysine chloride Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) 是肠道菌群依赖性形成 N,N,N-trimethyl-5-aminovaleric acid (TMAVA) 的前体。

天然产物

Cat.No: T0846

Synonym: L(-)-Carnitine,Levocarnitine,左旋肉碱

Target: Endogenous Metabolite, Fatty Acid Synthase

Acetyl-L-carnitine hydrochloride

Cat.No: T2563

Synonym: Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride

Target: Others, Endogenous Metabolite

D-Carnitine hydrochloride

Cat.No: T2203

Synonym: (S)-Carnitine Hydrochloride,L-Carnitine hydrochloride

Target: Others, Endogenous Metabolite

Tetradecanoylcarnitine

Cat.No: T17048

Synonym: L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine

Target: Endogenous Metabolite

Isobutyryl-L-carnitine

Cat.No: T19381

Target: 5-HT Receptor

L-Carnitine hydrochloride

Cat.No: T20123

Synonym: L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80

Stearoylcarnitine

Cat.No: T19564

Synonym: Stearoyl-L-carnitine

Target: Endogenous Metabolite

Valerylcarnitine

Cat.No: T13280

Synonym: VALERYL-L-CARNITINE

Target: Endogenous Metabolite

Oleoylcarnitine

Cat.No: T12295

Synonym: Oleoyl-L-carnitine

Target: Endogenous Metabolite

Glutarylcarnitine

Cat.No: T19340

Synonym: O-glutaroyl-L-carnitine

Target: Endogenous Metabolite

(±)-Carnitine chloride

Cat.No: T6475

Synonym: Monocamin,DL-Carnitine HCl,Bicarnesine,混旋肉碱盐酸盐,DL-Carnitine chloride

Target: Reactive Oxygen Species

Cat.No: T4785

Synonym: 4-羟基-L-苯甘氨酸,4-Hydroxy-L-phenylglycine

Target: Others

Nε,Nε,Nε-Trimethyllysine chloride

Cat.No: T5066

Synonym: Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride

Target: Others, Endogenous Metabolite

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