Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3118 |
Dimethylenastron
|
Kinesin | Cytoskeletal Signaling |
Dimethylenastron 是一种驱动蛋白Eg5抑制剂,IC50值为 200 nM。它可阻止具有单极纺锤体的细胞,所有染色体都以单极纺锤体方式附着在该纺锤体上。 | |||
T4048 |
Monastrol
(±)-Monastrol |
Apoptosis; Kinesin | Apoptosis; Cytoskeletal Signaling |
Monastrol ((±)-Monastrol) 是一种具有高效性和细胞渗透性的有丝分裂驱动蛋白Eg5的抑制剂,IC50值为 14 μM。 | |||
T6209 |
CW-069
CW069 |
Kinesin; Microtubule Associated | Cytoskeletal Signaling |
CW-069 是一种微管运动蛋白 HSET 的变构选择性抑制剂,IC50值为 75 μM,对 KSP 具有显着的特异性。 | |||
T36816 |
S-trityl-L-Cysteine
STLC |
Kinesin | Cytoskeletal Signaling |
S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM,抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。 | |||
T2039 |
GSK-923295
|
Apoptosis; Kinesin | Apoptosis; Cytoskeletal Signaling |
GSK923295 是一种特异性的变构着丝粒相关蛋白-E 驱动蛋白 ATPase 活性抑制剂,作用于人类和犬类此酶,Ki 分别为 3.2±0.2 nM 和 1.6±0.1 nM。 | |||
T6393 |
ARQ 621
|
Kinesin | Cytoskeletal Signaling |
ARQ 621 是一种变构和选择性 Eg5 有丝分裂运动蛋白抑制剂,具有抗肿瘤活性。 | |||
T12359 |
Paprotrain
(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile |
Kinesin | Cytoskeletal Signaling |
Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) 是可渗透细胞的 kinesin MKLP-2的抑制剂,抑制 MKLP-2 的 ATPase 活性,IC50值为 1.35 μM,Ki 值为 3.36 μM。它对 DYRK1A 有中等的抑制作用,IC50值为 5.5 μM。 | |||
T3120 |
K858 (Racemic)
K858 Racemic,K858 |
Apoptosis; Kinesin | Apoptosis; Cytoskeletal Signaling |
K858 Racemic (K858) 是一种选择性有丝分裂驱动蛋白 Eg5 抑制剂,以 ATP 非竞争性方式起作用,IC50值为 1.3 μM。 | |||
T2255 |
SB-743921 hydrochloride
SB743921 HCl,SB743921 |
Kinesin; KSP | Cell Cycle/Checkpoint; Cytoskeletal Signaling |
SB-743921 hydrochloride (SB743921 HCl) 是一种有效的驱动蛋白纺锤体蛋白 KSP 抑制剂,Ki 值为 0.1 nM。 | |||
T2103 |
Ispinesib
伊匹尼塞,伊斯平斯,CK0238273,SB-715992 |
Apoptosis; Kinesin; KSP | Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling |
Ispinesib (SB-715992) 是一种选择性可逆的驱动蛋白纺锤体蛋白抑制剂,具有抗肿瘤特性。 | |||
T8342 |
BRD9876
6-叔丁基-2,3-二氰基萘 |
Others; Kinesin; Microtubule Associated | Cytoskeletal Signaling; Others |
BRD9876 是一种 MM1S 生长的选择性抑制剂,可将驱动蛋白 5 锁定在增强微管结合的状态,从而导致 MT 的捆绑和稳定。它特异性靶向微管结合的 Eg5,选择性抑制 CD34 细胞的骨髓瘤,有用于多发性骨髓瘤的研究潜力。 | |||
T9207 |
GW406108X
GW108X |
Kinesin; Autophagy | Autophagy; Cytoskeletal Signaling |
GW406108X (GW108X) 是一种 Kif15 抑制剂,在 ATPase 测定中的 IC50 为 0.82 uM。 它也是一种 ULK1 激酶抑制剂,pIC50 值为 6.37(427 nM),可阻断自噬通量。 | |||
T9207L |
GW406108X(Z/E)
|
Kinesin; Autophagy | Autophagy; Cytoskeletal Signaling |
GW406108X(Z/E) 是不同配置的 GW406108X 的混合物,它是 Kinesin-12 和 ULK1 的抑制剂。 | |||
T39994 |
Sovilnesib
|
Microtubule Associated | Cytoskeletal Signaling |
Sovilnesib 是一种有效kinesin-like protein KIF18A 抑制剂。它可用于癌症的研究。 | |||
T77586 | Eg5-IN-1 | Kinesin | Cytoskeletal Signaling |
Eg5-IN-1 是一种有效的驱动蛋白家族运动蛋白 (Eg5) 抑制剂,对 Eg5 的 IC50 值为 1.97 µM。Eg5-IN-1 可用于研究癌症。 | |||
T23543 |
YIL 781
|
GHSR | GPCR/G Protein |
YIL 781是一种选择性ghrelin 受体拮抗剂(GHS-R1a) (Ki = 17 nM)),对运动素受体显示出较弱的亲和力(K = 6 μ M)。YIL 781通过阻断胃饥饿素分泌对体内和体外胰岛素分泌改善体内葡萄糖稳态。 | |||
TQ0318 |
Filanesib
ARRY-520,ARRY 520 |
KSP | Cell Cycle/Checkpoint |
Filanesib (ARRY 520) 是一种选择性的驱动蛋白纺锤体蛋白(KSP)的抑制剂(IC50 = 6 nM),具有强大的抗增殖活性。 | |||
T9682 |
AZD-4877
AZD4877 |
Apoptosis; Kinesin | Apoptosis; Cytoskeletal Signaling |
AZD-4877 是一种高效的纺锤体驱动蛋白 (Eg5) 抑制剂,对其 IC50 值为 2 nM。 AZD-4877 是 Ispinesib 的另一种构型, 能够抑制细胞有丝分裂,诱导形成单极纺锤体表型,介导细胞凋亡(Apoptosis)。 AZD-4877 具有抗肿瘤活性,对循环外周血单核细胞 (PBMC)有抑制作用。 | |||
TQ0318L |
ARRY 520 hydrochloride
|
KSP | Cell Cycle/Checkpoint |
ARRY 520 hydrochloride 是一种驱动蛋白纺锤体蛋白 (KSP) 抑制剂。它通过凋亡诱导细胞死亡,并具有有效的抗增殖活性。 | |||
T60026 |
KIF18A-IN-2
|
Microtubule Associated | Cytoskeletal Signaling |
KIF18A-IN-2 是有丝分裂驱动蛋白 Kif18A 的抑制剂,IC50 为 28 nM,可用于染色体不稳定性相关漏洞的研究。 | |||
T4649 |
(S)-Monastrol
|
Kinesin | Cytoskeletal Signaling |
(S)-Monastroll is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5. | |||
TQ0314 |
EMD534085
|
Kinesin | Cytoskeletal Signaling |
EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM). | |||
T25409 |
FCPT
|
||
FCPT is an ATP competitive kinesin-5 inhibitor. | |||
T25418 |
Filanesib TFA
Filanesib trifluoroacetic acid,ARRY-520 TFA,ARRY 520 TFA,ARRY520 TFA |
||
Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during | |||
T24150 |
HR22C16
HR-22-C-16,HR 22 C 16 |
||
HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor. | |||
T11759 | Kif15-IN-2 | Others | Others |
Kif15-IN-2 is used for the research of cellular proliferative diseases. Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15. | |||
T28694 |
SB-743921 free base
SB743921,SB-921,SB921,SB-743921,GSK-743921,GSK-921 |
||
SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL). | |||
T11859 |
Litronesib Racemate
LY-2523355 Racemate,KF-89617 Racemate |
Others | Others |
Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib. | |||
T11859L |
Litronesib
KF-89617,LY-2523355 |
Kinesin | Cytoskeletal Signaling |
Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity. | |||
T15661 |
Kif15-IN-1
|
Others | Others |
Kif15-IN-1, a mitotic Kinesin family member 15 (Kif15) inhibitor, is utilized in the study of cellular proliferative diseases. | |||
T10428 |
AZ82
|
Microtubule Associated | Cytoskeletal Signaling |
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1). | |||
T21321 |
MK-0731
|
||
MK-0731, a synthetic small molecule with potential antineoplastic activity, selectively inhibits kinesin spindle protein (KSP), leading to the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase and apoptosis in | |||
T68743 |
AZD4877 HCl
|
||
AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neur... | |||
T24490 |
MMV666693
MMV-666693,MMV 666693 |
||
MMV666693 is a selective allosteric Plasmodium Kinesin-5 inhibitor. | |||
T40232 |
KIF18A-IN-1
KIF18A-IN-1 |
||
KIF18A-IN-1 is a potent inhibitor of the mitotic kinesin KIF18A. This compound demonstrates significant anti-tumor properties. | |||
T63726 | AM-5308 | ||
AM-5308 是驱动蛋白 KIF18A 的有效抑制剂。 | |||
T30573 | BQS-481 | ||
BQS-481 inhibits Kinesin-like protein KIF11. | |||
T30308 | BDPSB | ||
BDPSB is a highly efficient photocontroller of mitotic kinesin Eg5 ATPase activity. | |||
T10373 |
(R)-Filanesib
(R)-ARRY-520 |
Others | Others |
(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM). | |||
T78125 |
PVZB1194
|
Kinesin | Cytoskeletal Signaling |
PVZB1194是一种联苯型激酶Eg5(亦称KIF11)抑制剂,与细胞周期相关,可以通过抑制Eg5的ATP酶活性导致细胞周期阻滞和细胞凋亡,从而显现抗癌潜力。该化合物与α4/α6变抗袋结合,展现ATP竞争性活性。 |