Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YIL 781是一种选择性ghrelin 受体拮抗剂(GHS-R1a) (Ki = 17 nM)),对运动素受体显示出较弱的亲和力(K = 6 μ M)。YIL 781通过阻断胃饥饿素分泌对体内和体外胰岛素分泌改善体内葡萄糖稳态。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 428 | 现货 | ||
5 mg | ¥ 1,080 | 现货 | ||
10 mg | ¥ 1,570 | 现货 | ||
25 mg | ¥ 3,320 | 现货 | ||
50 mg | ¥ 4,750 | 现货 | ||
100 mg | ¥ 6,620 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,230 | 现货 |
产品描述 | YIL 781 is a selective ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM), showing a weak affinity for kinesin receptors (K = 6 μM). YIL 781 improves glucose homeostasis in vivo and in vitro by blocking ghrelin secretion. |
体外活性 | Post-transcriptional suppression by Ghsr siRNA transfection and treatment with GHS-R antagonist, YIL781, both significantly attenuated the effects of ghrelin in RGC-5 cells.[1] |
体内活性 | YIL781 (ghrelin receptor antagonist; from 0.1 to 5 μg; i.t. pretreatment) markedly attenuated the ghrelin-induced hyperglycemic effect. The plasma insulin level was increased by ghrelin. The enhanced plasma insulin level by ghrelin was reduced by i.t. pretreatment with YIL781.[2] With YIL781 pretreatment, the accumulated radioactivity in the pancreas 15-60min after [11C]3 injection was significantly decreased to 78% of control.[3] |
分子量 | 409.5 |
分子式 | C24H28FN3O2 |
CAS No. | 875258-85-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40.1 mg/mL (90.0 mM)
H2O: 40.1 mg/mL (90.0 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 2.442 mL | 12.21 mL | 24.42 mL | 61.0501 mL |
5 mM | 0.4884 mL | 2.442 mL | 4.884 mL | 12.21 mL | |
10 mM | 0.2442 mL | 1.221 mL | 2.442 mL | 6.105 mL | |
20 mM | 0.1221 mL | 0.6105 mL | 1.221 mL | 3.0525 mL | |
50 mM | 0.0488 mL | 0.2442 mL | 0.4884 mL | 1.221 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
YIL 781 875258-85-8 GPCR/G Protein GHSR YIL-781 YIL781 Inhibitor inhibitor inhibit