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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78575 |
KCL-286
|
Retinoid Receptor | Metabolism |
KCL-286是一种可口服且具有有效性的视黄酸受体β激动剂,可用于改善脊髓损伤(SCI)。 | |||
T34413 |
KCL-440
RS57639,RS-57639,RS 57639 |
||
RS 57639 is a bioactive chemical. | |||
T14194 |
β-NETA
α-NETA |
AChE | Neuroscience |
β-NETA(α-NETA) 是胆碱乙酰转移酶(ChA;IC50=76 μM) 和胆碱酯酶 (ChE;IC50=40 µM)的非竞争性抑制剂,对乙酰胆碱酯的作用微弱 (AChE;IC50=1 mM)。 | |||
T68123 |
Oxodipine
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Oxodipine 是一种二氢吡啶型钙拮抗剂 ,抑制了KCl 诱导的兔主动脉收缩,降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中,Oxodipine 降低了L 型Ca 电流(I),IC 为0.24μM,对T 型Ca 电流(I)的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。 | |||
T27806 |
Lecozotan HCl
SRA-333,SRA333,SRA 333,Lecozotan hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Lecozotan HCl (SRA-333) 是一种强效且具有选择性的 5-HT 拮抗剂。Lecozotan HCl能明显增强氯化钾刺激海马齿状回谷氨酸和乙酰胆碱的释放并具有增强认知能力的特性。在表明 5-HT(1A) 受体功能的行为模型中,长期服用Lecozotan HCl不会诱发 5-HT(1A) 受体耐受或脱敏。 | |||
T11528 |
H100
|
Others | Others |
H100 is a Cl- transport inhibitor, no effect against KCl cotransporter. It has partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger. | |||
T68547 | SNJ-1945 | ||
SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin a... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1724 |
Harmalol hydrochloride
Harmidol hydrochloride |
P450; Antioxidant | Metabolism; oxidation-reduction |
Harmalol hydrochloride (Harmidol hydrochloride) 是一种可从Peganum harmala L.的种子中提取出来的β-咔啉生物碱。Harmalol hydrochloride 是Harmaline 的主要代谢产物,在转录和翻译后水平上显著抑制二恶英介导的 CYP1A1 诱导。Harmalol hydrochloride 在去氧肾上腺素或KCl 预先收缩的分离大鼠胸主动脉制剂中显示出血管松弛活性。 Harmalol hydrochloride 具有抗氧化活性. | |||
TN4484 | Macrophylline | Others | Others |
Macrophylline A shows weak inhibitory action on KCl-induced contraction. |