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Search Results for " k12 "

Targets Recommended: GPR

19

抑制剂 & 化合物

1

天然产物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2701	GSK1292263	GPR	Endocrinology/Hormones; GPCR/G Protein
	GSK1292263 是口服具有活性的 GPR119 激动剂，对人和大鼠 GPR119的pEC50分别为 6.9 和 6.7，它可用于研究 2 型糖尿病 (T2DM) 。
T40290	CDK12-IN-5 CDK12-IN-5
	CDK12-IN-5 is a pyrazolotriazine compound that effectively inhibits CDK12, with an IC50 value of 23.9 nM at a high ATP concentration of 2 mM. However, CDK12-IN-5 does not exhibit inhibitory effects on CDK2/Cyclin E (IC50 = 173 μM) and CDK9/Cyclin T1 (IC50 = 127 μM) at the same high ATP concentration of 2 mM, as stated in WO2021116178A1.
T39752	CDK12-IN-2 CDK12 inhibitor 2,CDK12-IN-2	CDK	Cell Cycle/Checkpoint
	CDK12-IN-2 (CDK12 inhibitor 2) 是一种有效的选择性 CDK12 抑制剂，对 CDK12、CDK2、CDK7 和 CDK9 的 IC50 为 52 nM、>100 μM、>10 μM 和 16 μM。 CDK12-IN-2可用于研究CDK12的功能。
T63059	CRK12-IN-1	Antibiotic	Microbiology/Virology
	CRK12-IN-1 是一种有效的CRK12抑制剂。CRK12-IN-1具有杀虫活性，对布氏锥虫 (T.b. brucei) 和刚果锥虫 (T. congolense) 具有抑制作用EC50分别为1.3和18 nM。CRK12-IN-1能迅速杀死病原细胞。
T24105	GSK121 GSK-121,GSK 121	PAD	Chromatin/Epigenetic
	GSK121 Trifluoroacetate 是PAD4的选择性抑制剂。
T63727	CRK12-IN-2	Parasite	Microbiology/Virology
	CRK12-IN-2 是一种有效的 CRK12 的抑制剂。CRK12-IN-2 对寄生虫具有抑制作，对Trypanosoma congolense 和 Trypanosoma vivax 的 EC50 值分别为 3.2 和 0.08 nM。CRK12-IN-2 可用于预防和治疗动物锥体虫病。
T2079	GSK126 GSK2816126A,EZH2 inhibitor	Histone Methyltransferase	Chromatin/Epigenetic
	GSK126 (GSK2816126A) 是一种选择性的EZH2甲基转移酶抑制剂，IC50为 9.9 nM。
T40289	CDK12-IN-6 CDK12-IN-6
	CDK12-IN-6, a pyrazolotriazine compound, is a powerful inhibitor of CDK12. Its inhibitory activity is significant with an IC50 value of 1.19 μM when tested at high ATP concentration (2 mM). Notably, CDK12-IN-6 does not exhibit any inhibitory effect on CDK2/Cyclin E (IC50 >20 μM) and CDK9/Cyclin T1 (IC50 >20 μM) when tested under the same high ATP conditions (2 mM) (WO2021116178A1).
T36095	Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)
	Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) 可用于生命科学领域的相关研究，其产品编号为 T36095。
T41085	UK122 UK122
	UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). Functioning as a 4-oxazolidinone analogue, UK122 is an anticancer agent that effectively inhibits cancer cell migration and invasion.
T32001	GSK124576A GSK-124576A,GSK 124576A
	GSK124576A is a bioactive chemical.
T14915	CDK12-IN-E9	CDK	Cell Cycle/Checkpoint
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).
T64284	PROTAC CDK12/13 Degrader-1
	PROTAC CDK12/13 Degrader-1 (7f) 是一种高效的、选择性的细胞周期蛋白依赖性激酶 CDK12 (DC50: 2.2 nM) 和 CDK13 (DC50: 2.1 nM) 双重降解剂。PROTAC CDK12/13 Degrader-1 表现出抗增殖效果，能够用于研究乳腺癌。
T40288	CDK12-IN-4 CDK12-IN-4
	CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM). Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or CDK9/Cyclin T1 (IC50 > 20 μM) under the influence of high ATP (2 mM) levels (WO2021116178A1).
T35897	ASK120067
	ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT...
T14990	CDK12-IN-3	CDK	Cell Cycle/Checkpoint
	CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).
T78654	MraY-IN-3 hydrochloride
	MraY-IN-1（compound 12a）是一种针对细菌转位酶MraY的有效抑制剂，具有140 μM的IC50值。其对Escherichia coli K12、Bacillus subtilis W23和Pseudomonas fluorescens Pf-5展现出抗菌活性，相应的MIC50为7 µg/mL、12 µg/mL和46 µg/mL。MraY-IN-1适用于抗菌药物的研究领域。
T64172	MraY-IN-1
	MraY-IN-1 (compound 12a) 是细菌转位酶 MraY 的有效抑制剂 (IC50: 140 μM)。MraY-IN-1 对大肠杆菌 K12 (MIC50: 7 μg/ml)、枯草芽孢杆菌 W23 (MIC50: 12 μg/ml) 和荧光假单胞杆菌 Pf-5 (MIC50: 46 μg/ml) 具有抗菌作用。MraY-IN-1 能够用于抗菌的研究。
T64160	MraY-IN-3
	MraY-IN-3 (12a) 是一种细菌转位酶 MraY 的有效抑制剂 (IC50: 140 μM)。MraY-IN-3 能够作用于 E. coli K12 (MIC: 7 μg/ml)、B. subtilis W23 (MIC: 32 μg/ml)、P. fluorescens Pf-5 (MIC: 46 μg/ml)。

化合物

Cat.No: T2701

Target: GPR

Cat.No: T40290

Synonym: CDK12-IN-5

Cat.No: T39752

Synonym: CDK12 inhibitor 2,CDK12-IN-2

Target: CDK

Cat.No: T63059

Target: Antibiotic

Cat.No: T24105

Synonym: GSK-121,GSK 121

Target: PAD

Cat.No: T63727

Target: Parasite

Cat.No: T2079

Synonym: GSK2816126A,EZH2 inhibitor

Target: Histone Methyltransferase

Cat.No: T40289

Synonym: CDK12-IN-6

Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)

Cat.No: T36095

Synonym: Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)

Cat.No: T41085

Synonym: UK122

Cat.No: T32001

Synonym: GSK-124576A,GSK 124576A

Cat.No: T14915

Target: CDK

PROTAC CDK12/13 Degrader-1

Cat.No: T64284

Cat.No: T40288

Synonym: CDK12-IN-4

Cat.No: T35897

Cat.No: T14990

Target: CDK

MraY-IN-3 hydrochloride

Cat.No: T78654

Cat.No: T64172

Cat.No: T64160

Cat. No.	Product Name	Target	Signaling Pathways
T13750	L-Fucitol L-岩藻糖醇,1-Deoxy-D-galactitol	Others	Others
	L-Fucitol (1-Deoxy-D-galactitol) 是一种糖醇，从肉豆蔻 (Nutmeg) 中分离得到。

天然产物

Cat.No: T13750

Synonym: L-岩藻糖醇,1-Deoxy-D-galactitol

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02045	SECTM1 Protein, Human, Recombinant (His) K12,secreted and transmembrane 1	Human	HEK293 Cells
	Secreted and transmembrane 1 (SECTM1), also known as K12, is a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein of SECTM family. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. The human K12 protein has been shown to be primarily expressed in spleen, prostate, testis, small intestine, and in peripheral blood leukocytes. The K12 protein is expressed on the cell surface in such sma...
TMPK-00877	C-MPL Protein, Human, Recombinant (aa 26-491, His) MPL,c-Mpl,CD110,TPO-R,K12,MPLV	Human	HEK293 Cells
	C-MPL Protein, Human, Recombinant (aa 26-491, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.6 kDa and the accession number is P40238-1.
TMPK-00494	C-MPL Protein, Cynomolgus, Recombinant (His) TPO-R,MPLV,K12,CD110,MPL,c-Mpl	Cynomolgus	HEK293 Cells
	C-MPL Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.48 kDa and the accession number is A0A2K5UGC7.
TMPK-00940	C-MPL Protein, Mouse, Recombinant (aa 26-482, His) MPL,c-Mpl,CD110,TPO-R,MPLV,K12	Mouse	HEK293 Cells
	C-MPL Protein, Mouse, Recombinant (aa 26-482, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 52.3 kDa and the accession number is Q08351-1.
TMPK-00596	SECTM1 Protein, Human, Recombinant (hFc) SECTM1,K-12	Human	HEK293 Cells
	SECTM1 is a T/NK cell "co-stimulatory" molecule that is expressed in the peripheral blood by neutrophils and monocytes.Human monocytic cells also displayed a pronounced negative regulation of SECTM1 mRNA expression by LPS, while at the protein level SECTM1 expression was also shown to be regulated by IFN and LPS. This tight regulation of SECTM1 gene expression and rapid upregulation highlights its relevance in the innate immune response.
TMPY-04430	p38 gamma/MAPK12 Protein, Human, Recombinant mitogen-activated protein kinase 12,SAPK-3,P38 γ/MAPK12<...	Human	Baculovirus Insect Cells
	p38 gamma/MAPK12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.1 kDa and the accession number is P53778.
TMPY-04429	p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) ERK3,SAPK3,PRKM12,ERK6,P38γ,P38GAMMA,mitogen-activated prote...	Human	Baculovirus Insect Cells
	p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.8 kDa and the accession number is P53778.
TMPH-01806	OBP2A Protein, Human, Recombinant (C114S & K127N, His & SUMO)	Human	E. coli
	Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids. OBP2A Protein, Human, Recombinant (C114S & K127N, His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.8 kDa and the accession number is Q9NY56.
TMPY-04591	Influenza A H5N8 (A/duck/Jiangsu/k1203/2010) Hemagglutinin/HA1 Protein (His) Harvey rat sarcoma viral oncogene homolog	H5N8	HEK293 Cells
	Influenza A H5N8 (A/duck/Jiangsu/k1203/2010) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.7 kDa and the accession number is M9NJD2.
TMPJ-00039	FGF-2 Protein, Human, Recombinant (K128N) FGF2,bFGF,FGFB,Heparin-binding growth factor 2,HBGF-2,Fibrob...	Human	E. coli
	FGF-2 Protein, Human, Recombinant (K128N) is expressed in E. coli expression system. The predicted molecular weight is 17 KDa and the accession number is P09038-2.
TMPH-03069	CSL3 Protein, Oncorhynchus keta, Recombinant (His) L-rhamnose-binding lectin CSL3	Oncorhynchus keta	E. coli
	L-rhamnose binding lectin. Has hemagglutinating activity towards rabbit erythrocytes, human type A erythrocytes, human type B erythrocytes, human type O erythrocytes and sheep erythrocytes. Hemagglutinating activity is inhibited by smooth-type lipopolysaccharide (LPS) from S.flexneri 1A, A.salmonicida and E.coli K12, but not by rough-type LPS from S.flexneri, E.coli K12 and E.coli EH100. Agglutinates E.coli K12 and B.subtilis.

重组蛋白

SECTM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02045

Species: Human

Expression System: HEK293 Cells

C-MPL Protein, Human, Recombinant (aa 26-491, His)

Cat.No: TMPK-00877

Species: Human

Expression System: HEK293 Cells

C-MPL Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00494

Species: Cynomolgus

Expression System: HEK293 Cells

C-MPL Protein, Mouse, Recombinant (aa 26-482, His)

Cat.No: TMPK-00940

Species: Mouse

Expression System: HEK293 Cells

SECTM1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00596

Species: Human

Expression System: HEK293 Cells

p38 gamma/MAPK12 Protein, Human, Recombinant

Cat.No: TMPY-04430

Species: Human

Expression System: Baculovirus Insect Cells

p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04429

Species: Human

Expression System: Baculovirus Insect Cells

OBP2A Protein, Human, Recombinant (C114S & K127N, His & SUMO)

Cat.No: TMPH-01806

Species: Human

Expression System: E. coli

Influenza A H5N8 (A/duck/Jiangsu/k1203/2010) Hemagglutinin/HA1 Protein (His)

Cat.No: TMPY-04591

Species: H5N8

Expression System: HEK293 Cells

FGF-2 Protein, Human, Recombinant (K128N)

Cat.No: TMPJ-00039

Species: Human

Expression System: E. coli

CSL3 Protein, Oncorhynchus keta, Recombinant (His)

Cat.No: TMPH-03069

Species: Oncorhynchus keta

Expression System: E. coli

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