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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39778	Influenza A virus-IN-1
	Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.
T8555	Neuraminidase-IN-1 Novel NA Inhibitor,Compound Y-1	Others; Influenza Virus	Microbiology/Virology; Others
	Neuraminidase-IN-1 (Compound Y-1) 是一种神经氨酸酶抑制剂，其IC50值为 0.21 μM，具有抗H1N1流感病毒的活性。
T60697	Influenza virus-IN-1
	Influenza virus-IN-1 (compound 14) 具有抗甲型流感病毒活性，它是甲型流感病毒的有效抑制剂，其CC50值 >200 μM，EC50值为 2.46 μM。Influenza virus-IN-1 对 PAN 核酸内切酶显示出浓度依赖性的抑制活性 (EC50 = 312.36 nM)。
T63808	Cap-dependent endonuclease-IN-1	Others	Others
	Cap-dependent endonuclease-IN-1 是一种具有高效性和口服活性的帽依赖内切酶抑制剂，具有抗病毒活性，可用于研究流感病毒感染。
T60951	Molnupiravir EIDD-2801,Lagevrio,MK-4482	SARS-CoV; Influenza Virus	Microbiology/Virology
	Molnupiravir (MK-4482) (EIDD-2801) 是核糖核苷类似物 EIDD-1931 的异丙酯前体药物，具有口服生物利用度。Molnupiravir 可用于 COVID-19 ，季节性和流行性流感的研究，对多种冠状病毒和流感病毒具有广谱的抗病毒活性，例如，SARS-CoV-2，MERS-CoV，SARS-CoV。
T64297	Triton X-100
	Triton X-100 是一种溶解脂膜的非变性洗涤剂。Triton X-100 通常用于实验室，并在生产过程的不同阶段应用于疫苗。Triton X-100 被列为某些疫苗,包括裂解病毒流感疫苗的赋形剂。Triton X-100 是一种非离子表面活性剂。
T37466	CAY10766
	CAY10766 is an antiviral compound.1It inhibits entry of influenza virus-like particles pseudotyped with hemagglutinin A (HA) from H5N1 influenza A virus into A549 cells (EC50= 0.24 μM). CAY10766 (1 μM) reduces H1N1 and H5N1 influenza A viral titers in infected MDCK cells. It also exhibits synergy with oseltamivir carboxylate in MDCK cells infected with the influenza A reporter PR8-NS1-Gluc virus.
T61557	Influenza A virus-IN-4
	Influenza A virus-IN-4 (compound 23b), a derivative of Oseltamivir, is a highly effective neuraminidase inhibitor. It exerts potent inhibitory effects on influenza viruses [1].
T62216	Influenza virus-IN-5
	Influenza virus-IN-5 (Compound 5f) 是一种流感病毒血球凝集素 (hemagglutinin (HA)) 抑制剂，能够作用于 A/H3N2 病毒 (EC50: 1 nM)。
T60810	Influenza virus-IN-2
	Influenza virus-IN-2 (compound 19) 具有抗甲型流感病毒活性，是有效的流感病毒抑制剂，CC50值为 150.85 μM，EC50值为 2.58 μM,。Influenza virus-IN-2 浓度依赖性的抑制 PAN 核酸内切酶，EC50为 489.39 nM。
T61877	Influenza A virus-IN-5
	Influenza A virus-IN-5 (Compound 16e) is a highly potent and orally active agent against the influenza A virus (IAV), exhibiting an IC 50 of 1.29 μM. It effectively inhibits the transcription and replication of viral RNA while maintaining acceptable levels of cytotoxicity [1].
T72450	Influenza virus-IN-6	Influenza Virus	Microbiology/Virology
	Influenza virus-IN-6 (Compound 35) 是一种针对流感病毒聚合酶酸性蛋白亚基内切酶N端结构域(PAN)的高效抑制剂，展现出0.20 μM的IC50值。
T73323	RdRP-IN-5	Influenza Virus	Microbiology/Virology
	RdRP-IN-5 (compound 20) 为一种抑制流感病毒RNA依赖性RNA聚合酶(RdRP)的有效药物，适用于该病毒研究。
T38340	10-Norparvulenone
	10-Norparvulenone is a fungal metabolite originally isolated fromMicrosphaeropsis.1It decreases viral sialidase activity in, and increases survival of, MDCK cells infected with the mouse-adapted influenza virus A/PR/8/34 when used at a concentration of 1 μg/ml. 1.Fukami, A., Nakamura, T., Kim, Y.P., et al.A new anti-influenza virus antibiotic, 10-norparvulenone from Microsphaeropsis sp. FO-5050J. Antibiot. (Tokyo)53(10)1215-1218(2000)
T61217	RSV-IN-3
	RSV-IN-3 (Compound 1) 是呼吸道合胞病毒 (RSV) 和流感病毒 A (IAV) 的双重抑制剂。RSV-IN-3 具有抗 RSV 活性 (EC50=32.70 μM)。
T60910	RSV-IN-4
	RSV-IN-4 (Compound 2) 具有抗 RSV 活性，EC50值为11.76 μM。RSV-IN-4 是呼吸道合胞病毒 (RSV) 和甲流病毒 A (IAV) 的双重抑制剂。
T79444	HA-IN-1	Influenza Virus	Microbiology/Virology
	HA-IN-1（compound 5g）是靶向血凝素（HA）胰蛋白酶切割位点的配体，表现出高亲和力。该化合物能够抑制HA介导的膜融合，并在体内有效降低肺部病毒滴度，展现其作为甲型流感病毒（IAV）抑制剂和抗流感药物的潜力。
T74762	Influenza A virus-IN-8
	Influenza A virus-IN-8 (S5) 为一种大环肽，无细胞毒性，并作为甲型流感病毒 (IAV) 的有效抑制剂，显示出较好的蛋白酶稳定性。其对 H1 和 H5 变体的IC50值分别低至 6.7 nM 和 6.6 nM。此外，Influenza A virus-IN-8 能够与 HA 茎的一个保守区域结合，特别是对 H1 变体展现出 1.0 nM 的高亲和性Kd 值。
T72125	Cap-dependent endonuclease-IN-9	Influenza Virus	Microbiology/Virology
	Cap-dependent endonuclease-IN-9 是高效的 CEN 抑制剂，其对流感病毒具明显抑制作用，同时展现低细胞毒性、良好的体内药剂动力学及药效学特性。此化合物强力抑制 A 病毒 RNA 聚合酶活性。
T38118	Zanamivir-13C,15N2 Zanamivir-13C,15N2
	Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50values ranging from 0.6 to 7.9 nMin vitro. Intra...
T74765	Viral polymerase-IN-1 hydrochloride
	Viral polymerase-IN-1 hydrochloride 是一种 Gemcitabine 衍生物，有效抑制甲型和乙型流感病毒 (influenza) 感染，IC90值为 11.4-15.9 μM。Viral polymerase-IN-1 hydrochloride 对 SARS-CoV-2感染具有活性。Viral polymerase-IN-1 hydrochloride 通过影响细胞中的病毒 RNA 复制/转录来抑制流感病毒感染。
T73336	Ketotifen 酮替芬,HC 20-511
	Ketotifen (HC 20-511)为第二代口服活性非竞争性组胺1(H1)受体阻滞剂兼肥大细胞稳定剂，能体外阻断6-磷酸葡萄糖酸脱氢酶(6-PGD)。其对SARS-CoV-2及流感病毒(Influenza virus)展现出抗病毒活性，适用于自身免疫性脑脊髓炎(EAE)与哮喘发作预防研究。
T80279	Urumin	Influenza Virus	Microbiology/Virology
	Urumin 对人类甲型流感病毒显示出抗病毒活性，通过靶向 H1 血凝素的保守茎部位，能有效中和耐药 H1 流感病毒。它在抑制 PR8 流感病毒的生长中的半抑制浓度（IC50）为 3.8 μM，并能保护幼鼠免遭致命流感病毒感染。
T7911	Arbidol
	Umifenovir 是一种有效的口服活性广谱抗病毒药物，对许多包膜病毒和非包膜病毒具有活性。Umifenovir 既能抑制病毒繁殖又能调节炎性细胞因子的表达，可用作抗流感病毒剂 (anti-influenza virus)，并具有抗炎活性。Umifenovir 有效抑制病毒与宿主细胞的融合。 Umifenovir 是体外有效的 SARS-CoV-2的抑制剂。
TMIH-0105	Baloxavir-d4
	Baloxavir-d4 是 Baloxavir 的氘代化合物。Baloxavir 的 CAS 号为 1985605-59-1。Baloxavir 是衍生自前药 Baloxavir marboxil，是流感病毒聚合酶 PA 亚基的一流帽依赖性核酸内切酶抑制剂。它抑制病毒 RNA 的转录和复制，具有强大的抗病毒活性。
T77158	Diridavumab
	Diridavumab为一种针对HA茎的单克隆抗体。它能稳定HA的融合前结构，阻断细胞膜与病毒膜在核内体内因pH变化引起的融合。此抗体主要用于H2流感病毒研究。
T38008	KBC-007
	KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer). It induces IL-4 and IFN-γ secretion by mouse splenocytes when used at a concentration of 0.5 ng/ml and IL-2 secretion by DN32.D3 NKT hybridoma cells co-cultured with CD1d-transfected RBL cells pre-loaded with KBC-007 at a concentration of 8 ng/ml. KBC-007 (1 μg per animal) increases levels of IL-4, but not IFN-γ, to a similar degree as α-GalCer in mouse serum. KBC-007 (0.5 μg per animal) increases the sur...
T79567	Antiviral agent 35	Influenza Virus	Microbiology/Virology
	Antiviralagent 35 (compound 4d) 作为一种口服抗流感病毒药物，针对流感病毒复制的早期阶段有效。该化合物能够阻断流感病毒引发的ROS积聚、自噬及细胞凋亡，同时在肺部感染的小鼠模型中，抑制RIG-1通路所介导的炎症响应。Antiviralagent 35展现出低细胞毒性（CC50>800 μM，MDCK细胞）且对H1N1（A/Weiss/43）展现出显著的抗病毒活性，EC50为2.28 μM。
T77021	Gedivumab
	Gedivumab (MHAA4549A; RG7745)，一种高特异性人源单克隆抗体，靶向甲型流感病毒 (IAV)，通过与IAV血凝素蛋白的高度保守茎区结合，阻止其成熟并阻断核内体中的血凝素介导的膜融合，适用于IAV感染疾病研究。
T38103	Defensin HNP-3 (human) (trifluoroacetate salt)
	Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd...
T75291	Trimethoprim hydrochloride
	Trimethoprim hydrochloride 是一种口服活性的抑菌抗生素，同时也是二氢叶酸还原酶抑制剂。它对多种革兰氏阳性及革兰氏阴性需氧细菌有效。用于尿路感染、志贺氏菌病和肺孢子菌肺炎的研究。与锌联合使用时，可抑制甲型流感病毒对鸡胚的感染。
T36986	Colletodiol
	Colletodiol is a fungal metabolite that has been found inD. grovesiiand has immunosuppressant and antiviral activities.1,2It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC50s = 12 and 5 μg/ml, respectively).1Colletodiol inhibits influenza A viral replication in HeLa-IAV-Luc cells.2 1.Fujimoto, H., Nagano, J., Yamaguchi, K., et al.Immunosuppressive components from an ascomycete, Diplogelasinospora grovesiChem. Pharm. Bull.46(3)423-429(1998) 2.Lai, W., Wang...
T38297	Ribavirin-13C5 Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...
T37843	Australine (hydrochloride)
	Australine is a pyrrolizidine alkaloid originally isolated fromC. australethat has enzyme inhibitory activities.1,2,3It is an inhibitor of glucoamylase (IC50= 5.8 μM) that also inhibits glucosidase I, sucrase, maltase, andA. nigerα-glucosidase (IC50s = 20, 28, 35, and 28 μM, respectively).2,3Australine is selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 μM, β-glucosidase, with only 5% inhibition at 66 μM, as well as isomaltase and trehal...

化合物

Influenza A virus-IN-1

Cat.No: T39778

Neuraminidase-IN-1

Cat.No: T8555

Synonym: Novel NA Inhibitor,Compound Y-1

Target: Others, Influenza Virus

Influenza virus-IN-1

Cat.No: T60697

Cap-dependent endonuclease-IN-1

Cat.No: T63808

Target: Others

Cat.No: T60951

Synonym: EIDD-2801,Lagevrio,MK-4482

Target: SARS-CoV, Influenza Virus

Cat.No: T64297

Cat.No: T37466

Influenza A virus-IN-4

Cat.No: T61557

Influenza virus-IN-5

Cat.No: T62216

Influenza virus-IN-2

Cat.No: T60810

Influenza A virus-IN-5

Cat.No: T61877

Influenza virus-IN-6

Cat.No: T72450

Target: Influenza Virus

Cat.No: T73323

Target: Influenza Virus

10-Norparvulenone

Cat.No: T38340

Cat.No: T61217

Cat.No: T60910

Cat.No: T79444

Target: Influenza Virus

Influenza A virus-IN-8

Cat.No: T74762

Cap-dependent endonuclease-IN-9

Cat.No: T72125

Target: Influenza Virus

Zanamivir-13C,15N2

Cat.No: T38118

Synonym: Zanamivir-13C,15N2

Viral polymerase-IN-1 hydrochloride

Cat.No: T74765

Cat.No: T73336

Synonym: 酮替芬,HC 20-511

Cat.No: T80279

Target: Influenza Virus

Cat.No: T7911

Cat.No: TMIH-0105

Cat.No: T77158

Cat.No: T38008

Antiviral agent 35

Cat.No: T79567

Target: Influenza Virus

Cat.No: T77021

Defensin HNP-3 (human) (trifluoroacetate salt)

Cat.No: T38103

Trimethoprim hydrochloride

Cat.No: T75291

Cat.No: T36986

Cat.No: T38297

Synonym: Ribavirin-13C5

Australine (hydrochloride)

Cat.No: T37843

Cat. No.	Product Name	Target	Signaling Pathways
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。

天然产物

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

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