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Search Results for " imidazoline "

28

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21052	Lysidine 2-甲基咪唑啉,2-Methyl-2-iMidazoline	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Lysidine (2-Methyl-2-iMidazoline) 是在 tRNA 之外很少见到的核苷。 Lysidine 具有更好的翻译保真度。
T22051	BU 224 hydrochloride	Imidazoline Receptor	Neuroscience
	BU 224 hydrochloride 是一种选择性的咪唑啉 I(2) 结合位点配体，具有镇痛和抗抑郁样活性。
T22052	BU 226 hydrochloride	Imidazoline Receptor	Neuroscience
	BU 226 hydrochloride 对咪唑啉受体具有亲和力，尤其是对 I2 结合位点，Ki 为 1.4 nM。 BU 226 hydrochloride 对 alpha 2-adrenoceptors 显示出低 (microM) 亲和力。
T6641	Rilmenidine Phosphate	Apoptosis; Adrenergic Receptor; Autophagy; Imidazoline Receptor	Apoptosis; Autophagy; GPCR/G Protein; Neuroscience
	Rilmenidine phosphate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体激动剂。它可调节白血病细胞增殖，刺激促凋亡蛋白 Bax，从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。它可通过减少交感神经过度活跃而发挥中枢作用，并通过抑制 Na+/H+反向转运而在肾脏中发挥作用。
T1028	Moxonidine 莫索尼定,BDF5895,莫索尼啶	Imidazoline Receptor	Neuroscience
	Moxonidine (BDF5895) 是咪唑啉受体亚型 1 的选择性激动剂，用作抗高血压药物。
T0115	Idazoxan hydrochloride RX 781094,盐酸咪唑克生	Adrenergic Receptor; Imidazoline Receptor	GPCR/G Protein; Neuroscience
	Idazoxan hydrochloride (RX 781094) 是一种 α2-肾上腺素受体拮抗剂，改善帕金森氏病、L-DOPA 引起的运动障碍和实验性帕金森病的运动症状。它也是咪唑啉受体拮抗剂，可竞争性拮抗唑啉样药物的中枢性降压作用。
T6703	Tetrahydrozoline hydrochloride Murine Plus,盐酸四氢萘咪唑,Tetryzoline hydrochloride,Tyzine,Tetrahydrozoline HCl,盐酸四氢唑林	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tetrahydrozoline hydrochloride (Murine Plus) 是一种咪唑啉的衍生物，是一种 α-肾上腺素能 (α-adrenergic) 激动剂，能引起血管收缩，常用于研究鼻充血、结膜充血。
T22492	2-BFI hydrochloride	Imidazoline Receptor	Neuroscience
	2-BFI hydrochloride 是一种 I2-咪唑啉受体的高亲和力激动剂。 2-BFI hydrochloride 可用于预防中风和急性炎症性免疫疾病的研究。
T15010	CR4056 6-(1H-imidazol-1-yl)-2-phenylquinazoline	MAO; Imidazoline Receptor	Metabolism; Neuroscience
	CR4056 (6-(1H-imidazol-1-yl)-2-phenylquinazoline) 是一种特异性 MAO-A 抑制剂，IC50 为 202.7 nM，是 I2-咪唑啉受体的配体，IC50 为 596 nM。
T23283	2-Methoxyidazoxan monohydrochloride RX 821002 hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	L-Albizziin (2-Methoxyidazoxan monohydrochloride) 是高效的 alpha 2r 肾上腺素受体选择性拮抗剂，对 imidazoline 拮抗作用很小或没有。它对 (豚鼠) alpha 2D 肾上腺素受体 (pKd9.7) 的亲和力明显高于 (兔子) alpha 2A 肾上腺素受体 (pKd8.2)。
T28631	RX821002 RX-821002,RX 821002
	RX821002 is a potent and selective antagonist of α2-adrenoceptor with low affinity for imidazoline sites. RX821002 displays selectivity for the α2D over the α2A subtypes (pKd values are 9.7 and 8.2 respectively).
T34470	S 9871 RX-801080,RX 801080,S9871,RX801080,S-9871
	S 9871, also known as RX 801080, is an imidazoline derivative reported to antagonize imidazoline-stimulated insulin secretion.
T23662	Aganodine Aganodin
	Aganodine is a guanidine that activates presynaptic imidazoline receptors. Aganodine inhibits the presynaptic release of norepinephrine through its agonism at imidazoline receptors.
T68931	Tracizoline
	Tracizoline is a potent I2-imidazoline receptor agonist.
T22760	Efaroxan hydrochloride	Others	Others
	α2 adrenoceptor antagonist and imidazoline I1 receptor ligand
T40869	Moxonidine hydrochloride BDF5895hydrochloride,盐酸莫索尼定
	Moxonidine Hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. Target: I1-R Moxonidine Hydrochloride is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and α2-AR (adrenergic) agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Moxonidine reduced stimulated NE overflow (log EC50: -6.15 +/- 0.14). AGN192403, a selective ligand at I1-R, had no influence on the dose-response...
T23263	RS 45041-190 hydrochloride	Others	Others
	Highly selective I2 imidazoline receptor ligand
T60425	Tetrahydrozoline nitrate
	Tetrahydrozoline (Tetryzoline) nitrate 是咪唑啉的衍生物。它是一种引起血管收缩的α-肾上腺素能 (α-adrenergic) 激动剂。Tetrahydrozoline 广泛用于鼻充血和结膜充血的研究。
T17113	Tolonidine	Others	Others
	Tolonidine is orally active and has been shown to possess hypotensive. Tolonidine is a derivative of imidazoline.
T26171	S23757 S-23757,S 23757
	S23757 is an imidazoline 1 receptor (I1R) selective ligand.
T69670	Clonazoline HCl
	Clonazoline HCl is the salt form of Clonazoline, a coronary vasodilator that is an imidazoline sympathomimetic, an alpha-adrenoreceptor agonist. It was used as a nasal decongestant and vasoconstrictor.
T70216	Clonazoline
	Clonazoline is a coronary vasodilator that is an imidazoline sympathomimetic, an alpha-adrenoreceptor agonist. It was used as a nasal decongestant and vasoconstrictor.
T61516	PI3K/mTOR Inhibitor-3
	PI3K/mTOR Inhibitor-3 (compound 12) is an imidazoline compound with potent dual inhibitory effects on PI3K and mTOR. This compound exhibits notable anti-cancer activity [1].
T27155	Dexisometheptene TNX 201,TNX-201,(R)-Isometheptene,TNX201
	Dexisometheptene is an antimigraine drug candidate. Dexisometheptene significantly increases the pain threshold of acute pain response, and potently and selectively binds to receptors in the central nervous system known as imidazoline type-1 (I1) receptor
T73214	RX 801077 2 BFI free base
	RX 801077 (2 BFI free base) 为选择性咪唑啉 I2 受体 (I2R) 激动剂，其Ki值为70.1 nM，展现抗炎及神经保护效果，具备用于创伤性脑损伤 (TBI) 研究的潜力。
T21911	Rilmenidine hemifumarate Rilmenidine (hemifumarate),S-3341 hemifumarate	Apoptosis; Imidazoline Receptor	Apoptosis; Neuroscience
	Rilmenidine hemifumarate (S-3341 hemifumarate) 是一种新型且具有口服活性和选择性的 I1咪唑啉受体 (I1 imidazoline receptor) 和α2肾上腺素受体激动剂，可诱导自噬，调节白血病细胞增殖，刺激促凋亡蛋白 Bax，诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。
T80636	SARS-CoV-2-IN-59	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-59（compound E07）为咪唑啉衍生物，其为一种针对SARS-CoV-2的非肽类小分子抑制剂，主要作用于冠状病毒的Mpro。SARS-CoV-2-IN-59于Mpro残基（Met 165, Gln 166,Met165, His 41, Gln 189）处展现出强烈的相互作用。
T35591	Guanfacine-13C,15N3 Guanfacine-13C,15N3
	Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin...

化合物

Cat.No: T21052

Synonym: 2-甲基咪唑啉,2-Methyl-2-iMidazoline

Target: Nucleoside Antimetabolite/Analog

BU 224 hydrochloride

Cat.No: T22051

Target: Imidazoline Receptor

BU 226 hydrochloride

Cat.No: T22052

Target: Imidazoline Receptor

Rilmenidine Phosphate

Cat.No: T6641

Target: Apoptosis, Adrenergic Receptor, Autophagy, Imidazoline Receptor

Cat.No: T1028

Synonym: 莫索尼定,BDF5895,莫索尼啶

Target: Imidazoline Receptor

Idazoxan hydrochloride

Cat.No: T0115

Synonym: RX 781094,盐酸咪唑克生

Target: Adrenergic Receptor, Imidazoline Receptor

Tetrahydrozoline hydrochloride

Cat.No: T6703

Synonym: Murine Plus,盐酸四氢萘咪唑,Tetryzoline hydrochloride,Tyzine,Tetrahydrozoline HCl,盐酸四氢唑林

Target: Adrenergic Receptor

2-BFI hydrochloride

Cat.No: T22492

Target: Imidazoline Receptor

Cat.No: T15010

Synonym: 6-(1H-imidazol-1-yl)-2-phenylquinazoline

Target: MAO, Imidazoline Receptor

2-Methoxyidazoxan monohydrochloride

Cat.No: T23283

Synonym: RX 821002 hydrochloride

Target: Adrenergic Receptor

Cat.No: T28631

Synonym: RX-821002,RX 821002

Cat.No: T34470

Synonym: RX-801080,RX 801080,S9871,RX801080,S-9871

Cat.No: T23662

Synonym: Aganodin

Cat.No: T68931

Efaroxan hydrochloride

Cat.No: T22760

Target: Others

Moxonidine hydrochloride

Cat.No: T40869

Synonym: BDF5895hydrochloride,盐酸莫索尼定

RS 45041-190 hydrochloride

Cat.No: T23263

Target: Others

Tetrahydrozoline nitrate

Cat.No: T60425

Cat.No: T17113

Target: Others

Cat.No: T26171

Synonym: S-23757,S 23757

Clonazoline HCl

Cat.No: T69670

Cat.No: T70216

PI3K/mTOR Inhibitor-3

Cat.No: T61516

Dexisometheptene

Cat.No: T27155

Synonym: TNX 201,TNX-201,(R)-Isometheptene,TNX201

Cat.No: T73214

Synonym: 2 BFI free base

Rilmenidine hemifumarate

Cat.No: T21911

Synonym: Rilmenidine (hemifumarate),S-3341 hemifumarate

Target: Apoptosis, Imidazoline Receptor

SARS-CoV-2-IN-59

Cat.No: T80636

Target: SARS-CoV

Guanfacine-13C,15N3

Cat.No: T35591

Synonym: Guanfacine-13C,15N3

Cat. No.	Product Name	Target	Signaling Pathways
T0925	Allantoin Glyoxyldiureide,尿囊素,5-Ureidohydantoin	Endogenous Metabolite; Imidazoline Receptor	Metabolism; Neuroscience
	Allantoin (Glyoxyldiureide) 是一种存在于尿液和植物中的尿素乙内酰脲，用于皮肤病制剂。
T3158	Harmane Loturine,Harman,Aribine,哈尔满碱	Adrenergic Receptor; Monoamine Oxidase; Imidazoline Receptor	GPCR/G Protein; Neuroscience
	Harmane (Loturine) 是一种在咖啡和烟草烟雾中发现的 β-咔啉生物碱，是有效的神经毒素，可引起严重的动作震颤和精神病学表现。它还是选择性的单胺氧化酶抑制剂，具有致突变作用，对 MAO A/B 的 IC50值分别为 0.5 和 5 μM。
T4808	Agmatine sulfate Agmatine sulfate salt,硫酸胍基丁胺	Endogenous Metabolite; NO Synthase; Imidazoline Receptor	Immunology/Inflammation; Metabolism; Neuroscience
	Agmatine sulfate (Agmatine sulfate salt) 是咪唑啉受体的内源性激动剂和一氧化氮合酶抑制剂。它靶向神经递质系统，离子通道和一氧化氮合成。

天然产物

Cat.No: T0925

Synonym: Glyoxyldiureide,尿囊素,5-Ureidohydantoin

Target: Endogenous Metabolite, Imidazoline Receptor

Cat.No: T3158

Synonym: Loturine,Harman,Aribine,哈尔满碱

Target: Adrenergic Receptor, Monoamine Oxidase, Imidazoline Receptor

Agmatine sulfate

Cat.No: T4808

Synonym: Agmatine sulfate salt,硫酸胍基丁胺

Target: Endogenous Metabolite, NO Synthase, Imidazoline Receptor

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