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22

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9631	IRAK-4 protein kinase inhibitor 2	IRAK	Immunology/Inflammation; NF-κB
	IRAK-4 protein kinase inhibitor 2 是有效的白介素 1 受体相关激酶 4 抑制剂，IC50为 4 μM。它在与炎症和免疫相关的疾病领域有研究价值。
T2457	IRAK-1-4 Inhibitor I IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor	IRAK	Immunology/Inflammation; NF-κB
	IRAK-1-4 Inhibitor I 是一种IRAK1/4双重抑制剂，其IC50分别为 0.2 μM 和 0.3 μM。
T11671	IRAK inhibitor 4 trans	SGLT	GPCR/G Protein
	IRAK inhibitor 4 is a compound that functions as an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). It specifically targets and inhibits the activity of IRAK4. The (trans) form of IRAK inhibitor 4 refers to its specific molecular configuration.
T11672	IRAK inhibitor 4	Others	Others
	IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 inhibitor.
T11673	IRAK4-IN-4	IRAK; cGAS	Immunology/Inflammation; NF-κB
	IRAK4-IN-4 （化合物 15）是白介素-1 受体相关激酶抑制剂，IC50为 2.8 nM。它还抑制环 GMP-AM 合酶，IC50为 2.1 nM。
T4140	IRAK4-IN-1	IRAK	Immunology/Inflammation; NF-κB
	IRAK4-IN-1 是白细胞介素-1 受体相关激酶 4 抑制剂(IC50:7 nM)。
T4299	AS-2444697	IRAK	Immunology/Inflammation; NF-κB
	AS2444697 是一种口服有效的IRAK-4抑制剂，IC50为 21 nM。它对人和大鼠 IRAK-4 活性具有抑制作用。它通过抗炎作用表现出肾脏保护作用。
T5354	IRAK4-IN-7 CA-4948	IRAK	Immunology/Inflammation; NF-κB
	IRAK4-IN-7 (CA-4948) 是白介素 1 受体相关激酶 4 (IRAK4) 的选择性抑制剂，口服有活性。它可用于研究癌症以及炎症疾病。
T14367	AZ1495	IRAK; CDK; Haspin Kinase	Cell Cycle/Checkpoint; Immunology/Inflammation; NF-κB
	AZ1495 是一种口服有活性的白介素-1受体相关激酶 4(IRAK4)抑制剂，能够作用于 IRAK4 (IC50:5 nM)和 IRAK1 (IC50:23 nM)。可用于研究突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 。
T24174	IRAK4-IN-16
	IRAK4-IN-16 (compound 4) 是一种强效的白细胞介素 -1 受体相关激酶 4(IRAK4) 抑制剂，IC50为 2.5 nM。IRAK4-IN-16 对 OCI-LY10、TMD8、Ramos 和 HT 细胞表现出细胞毒性活性，其 IC50分别为 0.2、0.2、0.6 和 2.7 μM。
T11674	IRAK4-IN-6	Others	Others
	IRAK4-IN-6 是一种选择性的、口服有效的IRAK 抑制剂，IC50为 4 nM，靶向 MyD88 L265P 突变型弥漫性大 B 细胞淋巴瘤。
T13843	PROTAC IRAK4 ligand-1	Others	Others
	PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.
T39901	PROTAC IRAK4 degrader-4 PROTAC IRAK4 degrader-4
	PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T13842	PROTAC IRAK4 degrader-1	Others	Others
	PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4).
T39902	PROTAC IRAK4 degrader-5 PROTAC IRAK4 degrader-5
	PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.
T39920	PROTAC IRAK4 degrader-3 PROTAC IRAK4 degrader-3
	PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
T39903	PROTAC IRAK4 degrader-6 PROTAC IRAK4 degrader-6
	PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T7368	IRAK inhibitor 2 IRAK-IN-2	IRAK	Immunology/Inflammation; NF-κB
	IRAK inhibitor 2 (IRAK-IN-2) 是一种有效的白细胞介素1受体相关激酶4（IRAK-4）抑制剂,具有潜在的抗癌和抗癌活性，可用于研究炎症相关性疾病。
T5094	IRAK inhibitor 1	IRAK; JNK	Immunology/Inflammation; MAPK; NF-κB
	IRAK inhibitor 1 是IRAK-4抑制剂(IC50:216 nM)，微弱抑制 JNK-1 (IC50:3.801 μM)和 JNK-2(IC50>10 μM)。
T5110	IRAK inhibitor 6	IRAK	Immunology/Inflammation; NF-κB
	IRAK inhibitor 6 是白细胞介素-1受体相关激酶-4的抑制剂(IC50:160 nM)。
T60012	HS-243	IRAK; MAPK; CDK	Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; NF-κB
	HS-243 是 IRAK-4 和 IRAK-1 的抑制剂，IC50 分别为 20 和 24 nM。 HS-243 显示出抗炎和抗癌活性。
T62473	Edecesertib
	Edecesertib (GS-5718) 是一种选择性的、口服具有活力的 IRAK-4 抑制剂，表现出抗炎活性。Edecessertib 能够用于研究类风湿性关节炎 (RA) 和红斑狼疮 (LE)。

化合物

IRAK-4 protein kinase inhibitor 2

Cat.No: T9631

Target: IRAK

IRAK-1-4 Inhibitor I

Cat.No: T2457

Synonym: IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor

Target: IRAK

IRAK inhibitor 4 trans

Cat.No: T11671

Target: SGLT

IRAK inhibitor 4

Cat.No: T11672

Target: Others

Cat.No: T11673

Target: IRAK, cGAS

Cat.No: T4140

Target: IRAK

Cat.No: T4299

Target: IRAK

Cat.No: T5354

Synonym: CA-4948

Target: IRAK

Cat.No: T14367

Target: IRAK, CDK, Haspin Kinase

Cat.No: T24174

Cat.No: T11674

Target: Others

PROTAC IRAK4 ligand-1

Cat.No: T13843

Target: Others

PROTAC IRAK4 degrader-4

Cat.No: T39901

Synonym: PROTAC IRAK4 degrader-4

PROTAC IRAK4 degrader-1

Cat.No: T13842

Target: Others

PROTAC IRAK4 degrader-5

Cat.No: T39902

Synonym: PROTAC IRAK4 degrader-5

PROTAC IRAK4 degrader-3

Cat.No: T39920

Synonym: PROTAC IRAK4 degrader-3

PROTAC IRAK4 degrader-6

Cat.No: T39903

Synonym: PROTAC IRAK4 degrader-6

IRAK inhibitor 2

Cat.No: T7368

Synonym: IRAK-IN-2

Target: IRAK

IRAK inhibitor 1

Cat.No: T5094

Target: IRAK, JNK

IRAK inhibitor 6

Cat.No: T5110

Target: IRAK

Cat.No: T60012

Target: IRAK, MAPK, CDK

Cat.No: T62473

Cat. No.	Product Name	Target	Signaling Pathways
T4700	1,3,5-Trihydroxy-4-prenylxanthone
	1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 valu

天然产物

1,3,5-Trihydroxy-4-prenylxanthone

Cat.No: T4700

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