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Search Results for " il-27 "

Targets Recommended: IL Receptor TNF Interleukin

10

抑制剂 & 化合物

15

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1813	VGX-1027 VGX1027,VGX 1027,GIT 27	IL Receptor; TNF; Interleukin	Apoptosis; Immunology/Inflammation
	VGX-1027 (GIT 27) 是一种口服有效的异恶唑化合物，靶向巨噬细胞，减少促炎性介质 TNF-α、IL-1β和 IL-10 的产生，具有免疫调节特性。它通过限制细胞因子介导的免疫炎症而具有抗糖尿病作用。
T0097	MRT67307 MRT67307 HCl	IκB/IKK; Autophagy	Autophagy; NF-κB
	MRT67307 是一种IKKε和TBK-1的双抑制剂，IC50分别为 160 和 19 nM。它抑制细胞自噬，也可抑制ULK1和ULK2，IC50分别为 45 和 38 nM。
T80568	Casdozokitug SRF-388
	Casdozokitug (SRF-388) 是一种针对IL27的IgG1κ类型抗体。
T74971	Diamino lipid DAL4
	Diamino lipid DAL4 是一种新型脂质纳米颗粒 (LNPs)，可包裹编码 IL-12、IL-27 和 GM-CSF 等细胞因子的 mRNA。Diamino lipid DAL4 能够传递细胞因子 mRNA 给肿瘤细胞，发挥抗肿瘤效力。
T36998	7β,27-dihydroxy Cholesterol 7β,27-DHC,7β,27-dihydroxy Cholesterol
	7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 &#181M. It increases IL-17A production in Th17-polarized isolated hum...
T79256	DPP-4-IN-8
	DPP-4-IN-8 (compound 27) 是一种高效的选择性DPP4抑制剂，具有 0.96 μM 的 Ki。该化合物能够抑制 Caco-2 和 HepG-2 细胞中的 DPP4 二肽酶活性，并剂量依赖性地降低 TNF-α、IL-6 和 IL-1β 的表达水平[1]。
T62221	NLRP3-IN-8
	NLRP3-IN-8 (compound 27) 是具有口服活性的、与 NLRP3直接结合的 NLRP3炎性体抑制剂，对 IL-1β 的 IC50值为1.23 μM. NLRP3-IN-8 对肝微粒体具有良好的代谢稳定性 (t1/2= 138.63 min)，几乎没有毒性 (against L02: IC50> 100 μM) 。
T81678	NF(N-Me)GA(N-Me)IL Amylin (22-27) [NMeG24, NMeI26], human (IAPP)
	NF(N-Me)GA(N-Me)IL是一种改性的生物活性肽，对应于人胰岛淀粉样蛋白多肽hIAPP中的22至27氨基酸片段（NFGAIL），其G24和I26的酰胺键经N-甲基化处理。引入N-甲基基团使得原本促进淀粉样蛋白形成及具细胞毒性的序列变为不促进淀粉样蛋白形成和无细胞毒性。此肽可高亲和力结合至全长hIAPP，并有效抑制其纤维化过程。
T23028	MRT67307 HCl (1190378-57-4 free base) MRT67307 HCl	Others	Others
	MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...

化合物

Cat.No: T1813

Synonym: VGX1027,VGX 1027,GIT 27

Target: IL Receptor, TNF, Interleukin

Cat.No: T0097

Synonym: MRT67307 HCl

Target: IκB/IKK, Autophagy

Cat.No: T80568

Synonym: SRF-388

Diamino lipid DAL4

Cat.No: T74971

7β,27-dihydroxy Cholesterol

Cat.No: T36998

Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol

Cat.No: T79256

Cat.No: T62221

NF(N-Me)GA(N-Me)IL

Cat.No: T81678

Synonym: Amylin (22-27) [NMeG24, NMeI26], human (IAPP)

MRT67307 HCl (1190378-57-4 free base)

Cat.No: T23028

Synonym: MRT67307 HCl

Target: Others

Cat.No: T36629

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03153	IL-27 Protein, Mouse, Recombinant (His) p28,Il30,IL-27,白介素,interleukin	Mouse	HEK293 Cells
	IL-27 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.5 kDa and the accession number is O35228&Q8K3I6.
TMPY-03142	IL-27 Protein, Human, Recombinant (His) IL27p28,IL-27,白介素,IL...	Human	CHO Cells
	IL-27 Protein, Human, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is NP_005746.2&NP_663634.2.
TMPY-00856	TCCR Protein, Human, Recombinant (hFc) WSX1,interleukin 27 receptor, α,IL27	Human	HEK293 Cells
	TCCR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79 kDa and the accession number is Q6UWB1.
TMPJ-01210	IL-33 Protein, Mouse, Recombinant Interleukin-1 family member 11,白细胞介素,NF-HEV and	Mouse	E. coli
	Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produ...
TMPK-00356	IL-27RA/TCCR Protein, Human, Recombinant (His) WSX1,IL-27 RA,IL27R α,CR...	Human	HEK293 Cells
	IL-27Ra (also known as TCCR and WSX1) as a gene whose expression can induce the transformation of hematopoietic cells. IL-27Ra (IL-27R) is a type I cytokine receptor that functions as the ligand binding component of the receptor for IL-27 and functions with the glycoprotein 130 (gp130) coreceptor to induce signal transduction in response to IL-27.
TMPY-06792	TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated Tccr,CRL1,IL-27R,interleukin 27 r...	Mouse	HEK293 Cells
	TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 56.37 kDa and the accession number is AAC40121.1.
TMPY-05543	TCCR Protein, Mouse, Recombinant (His) Tccr,Wsx1,CRL1,WSX-1,interleukin 27 receptor, alpha...	Mouse	HEK293 Cells
	TCCR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.6 kDa and the accession number is AAC40121.1.
TMPK-00163	IL-33 Protein, Cynomolgus, Recombinant (His) IL1F11,C9orf26 Z,C9ORF26,DV27,RP11-575C20....	Cynomolgus	HEK293 Cells
	Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions.
TMPJ-01409	CCL27 Protein, Human, Recombinant ILC,Small-Inducible Cytokine A27,IL	Human	E. coli
	Human Chemokine (C-C Motif) Ligand 27 (CCL27) is a small cytokine that is a member of the CC chemokine family; it is expressed in numerous tissues, including gonads, thymus, placenta and skin. CCL27 elicits its chemotactic effects by binding to the chemokine receptor CCR10. Predominantly expressed in the skin, CCL27 is associated with T cell-mediated inflammation of the skin. Human and Mouse CCL27 share 84% sequence identity in the mature form.
TMPJ-00850	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) Protein T1,suppression of tumorigenicity 2,Ly84,DER4,Fit-1,L...	Mouse	HEK293 Cells
	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2.
TMPY-00034	SF20 Protein, Human, Recombinant (His) myeloid-derived growth factor,R33729_1,IL25,IL<...	Human	HEK293 Cells
	SF20 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.3 kDa and the accession number is Q969H8.
TMPY-04264	SF20 Protein, Human, Recombinant (mFc) IL27,EUROIMAGE1875335,myeloid-derived grow...	Human	HEK293 Cells
	SF20 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.2 kDa and the accession number is Q969H8.
TMPK-00334	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi) CDw210a,IL-10 R alpha,IBD28,IL-10 R α,...	Human	HEK293 Cells
	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession number is Q13651.
TMPK-00335	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi), Biotinylated IBD28,IL-10 R α,IL-10RA,HIL-10R,<...	Human	HEK293 Cells
	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession number is Q13651.
TMPJ-01237	IL-17D Protein, Human, Recombinant IL17D,Interleukin-17D,IL-17D	Human	E. coli
	The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence ho...

重组蛋白

IL-27 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03153

Species: Mouse

Expression System: HEK293 Cells

IL-27 Protein, Human, Recombinant (His)

Cat.No: TMPY-03142

Species: Human

Expression System: CHO Cells

TCCR Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00856

Species: Human

Expression System: HEK293 Cells

IL-33 Protein, Mouse, Recombinant

Cat.No: TMPJ-01210

Species: Mouse

Expression System: E. coli

IL-27RA/TCCR Protein, Human, Recombinant (His)

Cat.No: TMPK-00356

Species: Human

Expression System: HEK293 Cells

TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06792

Species: Mouse

Expression System: HEK293 Cells

TCCR Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05543

Species: Mouse

Expression System: HEK293 Cells

IL-33 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00163

Species: Cynomolgus

Expression System: HEK293 Cells

CCL27 Protein, Human, Recombinant

Cat.No: TMPJ-01409

Species: Human

Expression System: E. coli

ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)

Cat.No: TMPJ-00850

Species: Mouse

Expression System: HEK293 Cells

SF20 Protein, Human, Recombinant (His)

Cat.No: TMPY-00034

Species: Human

Expression System: HEK293 Cells

SF20 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04264

Species: Human

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00334

Species: Human

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00335

Species: Human

Expression System: HEK293 Cells

IL-17D Protein, Human, Recombinant

Cat.No: TMPJ-01237

Species: Human

Expression System: E. coli

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