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Search Results for " il-25 "

Targets Recommended: BTK

16

抑制剂 & 化合物

1

天然产物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T73463	NX-2127 NX2127,NX 2127	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	NX-2127 (ETX2514 Triethylamine) 是一种口服有效的 BTK 抑制剂，可诱导细胞中突变的 BTKC481S 降解。NX-2127 具有有效的抗增殖活性，可抑制 BTKC481S 突变体 TMD8 细胞的增殖。NX-2127 有效催化 Ikaros (IKZF1) 和 Aiolos (IKZF3) 降解，作用浓度分别为 25 nM 和 54 nM。NX-2127 与免疫系统有关，刺激 T 细胞活化并增加原代人 T 细胞中 IL-2 的产生。
T8867	RO2959 Hydrochloride RO2959 HCl	IL Receptor; Calcium Channel; Interleukin	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	RO2959 Hydrochloride (RO2959 HCl) 是选择性CRAC 通道抑制剂，IC50为 402 nM。它是人IL-2产生的有效抑制剂，有效阻断 T 细胞受体触发的基因表达和 T 细胞功能途径。它是由Orai1/Stim1通道介导的钙存储进入的有效阻滞剂，IC50为 25 nM。
T21644L	AF 12198 Acetate AF 12198 Acetate (185413-30-3 Free base)	IL Receptor	Immunology/Inflammation
	AF 12198 Acetate 是一种新型的低分子量 IL-1 拮抗剂。
T78175	JAK-IN-25	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-25（化合物19）是一种高效的JAK抑制剂，对TYK2、JAK1、JAK2和JAK3的IC50值分别为6 nM、21 nM、8 nM、1051 nM。该化合物还能抑制人全血中IL-12（HEB IL-12），IC50为28 nM，显示其在癌症研究中的潜在应用价值。
T79733	NLRP3-IN-20	NOD-like Receptor (NLR)	Immunology/Inflammation
	NLRP3-IN-20（compound 11）是一款口服活性的NLRP3炎症小体抑制剂，其抑制IL-1β分泌的IC50值为25 nM。该化合物展现出卓越的药代动力学性质，并在非酒精性脂肪性肝炎、致命性感染性休克以及结肠炎模型中证明了其显著疗效。
T83734	PapRIV TFA
	PapRIV是最初从B. cereus分离出的一种群体感应七肽。它被转译为一个48-氨基酸多肽，由NprB蛋白酶在细胞外分泌和加工形成活性七肽。PapRIV（1-25 µM）在BV-2微胶质细胞中诱导IL-6和TNF-α的产生，并促使NF-κB转移。
T36517	Resveratrol-3-O-sulfate sodium
	Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 μM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-α and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 μM, and induces apoptosis at conc...
T35697	Lauric Acid-13C
	Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Lauric acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.2
T37449	SR 12460
	SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 μM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in themdxmouse model of Duchenne muscular dystrophy. 1.Zhao, J., Zhang...
T71933	GNE-3500
	GNE-3500 is a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist. Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nuclear receptor that plays a major role in the production of interleukin (IL)-17. Considerable efforts have been directed toward the discovery of selective RORc inverse agonists as potential treatments of inflammatory diseases such as psoriasis and rheumatoid arthritis. GNE-3500 poss...
T35468	(±)19(20)-EDP Ethanolamide
	(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-...
T75093	STING agonist-25
	STINGagonist-25 (CF505) 是一种非核苷酸小分子 STING 激动剂。STINGagonist-23 激活 STING，增加 STING、TBK1和 IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。
T36486	Benpyrine
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...
T83735	Pap12-6 TFA
	Pap12-6是一种从蝶类P. xuthus幼虫中发现的papiliocin十二个N-端氨基酸衍生的抗菌肽。它对包括E. coli、P. aeruginosa和S. syphimurium在内的八种革兰氏阴性细菌（MIC50s = 4-8 µM）以及革兰氏阳性细菌S. aureus、耐甲氧西林的S. aureus 3126（MRSA-3126）、B. subtilis和S. epidermidis（MIC50s = 4-8 µM）具有活性，但在25 µM浓度下不影响人类红细胞、小鼠RAW 264.7巨噬细胞、人类HaCaT角质形成细胞或人类HEK293肾细胞的活性。Pap12-6在4和8 µM浓度下可引起E. coli的膜去极化。Pap12-6（10 µM）预处理可降低LPS刺激的RAW 264.7巨噬细胞中一氧化氮（NO2-）、Tnf-α和Il-6的分泌水平。在体内，Pap12-6（10 mg/kg）可以提高感染E. coli的小鼠的存活率，并且在剂量为1 mg/kg时减少感染E. coli小鼠的肺、肝和肾中菌落形成单位（CFUs）的数量。Pap12-6（1 mg/kg）在E. co...
T35406	α-MSH TFA
	α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo...

化合物

Cat.No: T73463

Synonym: NX2127,NX 2127

Target: BTK

RO2959 Hydrochloride

Cat.No: T8867

Synonym: RO2959 HCl

Target: IL Receptor, Calcium Channel, Interleukin

AF 12198 Acetate

Cat.No: T21644L

Synonym: AF 12198 Acetate (185413-30-3 Free base)

Target: IL Receptor

Cat.No: T78175

Target: JAK

Cat.No: T79733

Target: NOD-like Receptor (NLR)

Cat.No: T83734

Resveratrol-3-O-sulfate sodium

Cat.No: T36517

Lauric Acid-13C

Cat.No: T35697

Cat.No: T37449

Cat.No: T71933

(±)19(20)-EDP Ethanolamide

Cat.No: T35468

STING agonist-25

Cat.No: T75093

Cat.No: T36486

Cat.No: T36629

Cat.No: T83735

Cat.No: T35406

Cat. No.	Product Name	Target	Signaling Pathways
T83916	Cytogenin
	Cytogenin（一种源自S. eurocidicum的香豆素衍生物）具有多种生物活性。在每日给药25 mg/kg剂量下，能减轻Ehrlich鼠自发性腺癌模型的肿瘤重量。在体内，Cytogenin（每日30和100 mg/kg）可减少链脲佐菌素诱导的体重下降和血浆葡萄糖水平上升，以及小鼠糖尿病模型中巨噬细胞胰腺浸润。同时，在每日100 mg/kg的剂量下，能降低小鼠巨噬细胞中zymosan和LPS诱导的一氧化氮产生，及LPS诱导的Il-6水平增加。

天然产物

Cat.No: T83916

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00855	IL-25/IL17E Protein, Mouse, Recombinant (His) interleukin 25,IL-17e,Il17e	Mouse	HEK293 Cells
	IL-25/IL17E Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q8VHH8.
TMPK-00055	IL-25/IL-17E Protein, Human, Recombinant (His & Avi), Biotinylated 白介素,IL-17E,IL-25,IL17E,I...	Human	HEK293 Cells
	IL-25, also known as IL-17E, is a member of the IL-17 cytokine family mostly produced by epithelial cells and innate immune cells. After binding to the IL-17RB/IL-17RA complex, IL-25 induces downstream signaling responses in epithelial cells and type 2 lymphocytes, which initiates, propagates, and sustains type 2 immunity. The function of IL-25 in allergic diseases such as asthma has been well established, and now also is extended to diseases such as inflammatory bowel disease and cancer.
TMPJ-00060	IL-25/IL17E Protein, Human, Recombinant (His) 白细胞介素,IL17E,白介素,IL-17E,IL-25<...	Human	HEK293 Cells
	Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammator...
TMPY-01103	CD25/IL2R alpha Protein, Human, Recombinant (His) interleukin 2 receptor, α,IL-2RA,IDDM10,IL...	Human	HEK293 Cells
	CD25/IL2R alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01589.
TMPY-05584	CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated CD25,p55,interleukin 2 receptor, alpha,TCGFR,IL...	Human	HEK293 Cells
	CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25 kDa and the accession number is P01589.
TMPY-00843	IL-25/IL17E Protein, Human, Recombinant (hFc) interleukin 25,IL17E	Human	HEK293 Cells
	IL-25/IL17E Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9H293-1.
TMPK-00165	IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated IL2RA,CD25,IL-2 R alpha,TCGFR,	Human	HEK293 Cells
	Human IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C...
TMPK-00164	IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi) IL-2 R alpha,IL-2 R α,IL2RA,I...	Human	HEK293 Cells
	Human IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. ...
TMPY-00034	SF20 Protein, Human, Recombinant (His) myeloid-derived growth factor,R33729_1,IL25	Human	HEK293 Cells
	SF20 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.3 kDa and the accession number is Q969H8.
TMPY-04264	SF20 Protein, Human, Recombinant (mFc) IL27,EUROIMAGE1875335,myeloid-derived growth factor...	Human	HEK293 Cells
	SF20 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.2 kDa and the accession number is Q969H8.
TMPY-00858	CD25/IL2R alpha Protein, Human, Recombinant (hFc) CD25,interleukin 2 receptor, alpha,IL2R,ID...	Human	HEK293 Cells
	CD25/IL2R alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.5 kDa and the accession number is P01589.
TMPY-03204	IL-25/IL17E Protein, Rat, Recombinant (hFc) 白介素,白细胞介素,interleukin 25	Rat	HEK293 Cells
	IL-25/IL17E Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.1 kDa and the accession number is D3ZLB1.
TMPY-05563	IL-25/IL17E Protein, Canine, Recombinant (hFc) interleukin 25,白细胞介素,白介素	Canine	HEK293 Cells
	IL-25/IL17E Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is A0A8I3MRV2.
TMPJ-00239	IL-2RG Protein, Mouse, Recombinant (aa 25-263, hFc) Il2rg,Interleukin 2 receptor, gamma chain, isoform ...	Mouse	HEK293 Cells
	The Interleukin-2 receptor gamma chain (IL-2 Rγ, CD132) of the high affinity functional mouse IL-2 receptor complex is a member the hematopoietin receptor family. It is expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. Common IL2 receptor-γ Chain is required for IL-2 receptor signaling. Besides IL-2, the Common IL2 receptor-γ chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15....
TMPJ-00059	IL-7 Protein, Human, Recombinant (His) Interleukin-7,IL7,白细胞介素,IL-7,白介素	Human	HEK293 Cells
	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe...
TMPY-01236	IL-10R beta/IL-10RB Protein, Human, Recombinant (His) CRF2-4,D21S66,CDW210B,interleukin 10 receptor, beta,interleu...	Human	HEK293 Cells
	IL-10R beta/IL-10RB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q08334.
TMPY-02325	IL-10R beta/IL-10RB Protein, Mouse, Recombinant (His) AI528744,interleukin 10 receptor, beta,D21S58h,CRF2-4,Crfb4,...	Mouse	HEK293 Cells
	IL-10R beta/IL-10RB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q8VHM7.
TMPJ-00326	CD122/IL2RB Protein, Human, Recombinant (aa 27-239, His & Avi), Biotinylated IL-2R subunit beta,High affinity IL-2 rece...	Human	HEK293 Cells
	Human IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit c...

重组蛋白

IL-25/IL17E Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00855

Species: Mouse

Expression System: HEK293 Cells

IL-25/IL-17E Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00055

Species: Human

Expression System: HEK293 Cells

IL-25/IL17E Protein, Human, Recombinant (His)

Cat.No: TMPJ-00060

Species: Human

Expression System: HEK293 Cells

CD25/IL2R alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-01103

Species: Human

Expression System: HEK293 Cells

CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05584

Species: Human

Expression System: HEK293 Cells

IL-25/IL17E Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00843

Species: Human

Expression System: HEK293 Cells

IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00165

Species: Human

Expression System: HEK293 Cells

IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00164

Species: Human

Expression System: HEK293 Cells

SF20 Protein, Human, Recombinant (His)

Cat.No: TMPY-00034

Species: Human

Expression System: HEK293 Cells

SF20 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04264

Species: Human

Expression System: HEK293 Cells

CD25/IL2R alpha Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00858

Species: Human

Expression System: HEK293 Cells

IL-25/IL17E Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03204

Species: Rat

Expression System: HEK293 Cells

IL-25/IL17E Protein, Canine, Recombinant (hFc)

Cat.No: TMPY-05563

Species: Canine

Expression System: HEK293 Cells

IL-2RG Protein, Mouse, Recombinant (aa 25-263, hFc)

Cat.No: TMPJ-00239

Species: Mouse

Expression System: HEK293 Cells

IL-7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00059

Species: Human

Expression System: HEK293 Cells

IL-10R beta/IL-10RB Protein, Human, Recombinant (His)

Cat.No: TMPY-01236

Species: Human

Expression System: HEK293 Cells

IL-10R beta/IL-10RB Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02325

Species: Mouse

Expression System: HEK293 Cells

CD122/IL2RB Protein, Human, Recombinant (aa 27-239, His & Avi), Biotinylated

Cat.No: TMPJ-00326

Species: Human

Expression System: HEK293 Cells

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