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Search Results for " gep "

Targets Recommended: CGRP Receptor

22

抑制剂 & 化合物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8682	Vazegepant hydrochloride Vazegepant HCl	CGRP Receptor	GPCR/G Protein; Neuroscience
	Vazegepant hydrochloride (Vazegepant HCl) 是一种用于偏头痛的鼻用 gepant，是一种高度亲和性CGRP 受体拮抗剂 (hCGRPKi=0.023 nM)。它可能有助于有效管理 COVID-19 相关肺部炎症。
T19917	Gepirone	5-HT Receptor	GPCR/G Protein; Neuroscience
	Gepirone 属于丁螺环酮家族的 5-HT1A 受体激动剂。它对 5-HT1A 受体的选择性高于 SSRIs。
T12883	Fezagepras PBI-4050,3-戊基苯乙酸,Setogepram	GPR	Endocrinology/Hormones; GPCR/G Protein
	Fezagepras (Setogepram) 是一种可口服的 GPR40激动剂和GPR84拮抗剂或反向激动剂。它减轻肾、肝和胰腺纤维化，具有抗纤维化、抗炎和抗增殖作用。
T12293L	Olcegepant BIBN-4096,BIBN 4096BS	CGRP Receptor	GPCR/G Protein; Neuroscience
	Olcegepant (BIBN-4096) 是一种选择性的降钙素基因相关肽1 (CGRP1) 受体拮抗剂，IC50=0.03 nM，Ki=14.4 pM。
T4610	Rimegepant BMS 927711,BMS-927711,BMS927711,BHV-3000	CGRP Receptor	GPCR/G Protein; Neuroscience
	Rimegepant (BMS 927711) 是一种有效的降钙素基因相关肽 (CGRP) 受体拮抗剂，其 Ki=0.027 nM，IC50=0.14 nM。
T12375	Fezagepras sodium Setogepram sodium salt,PBI-4050 sodium salt	GPR	Endocrinology/Hormones; GPCR/G Protein
	Fezagepras sodium (Setogepram sodium salt) 是口服有效的 GPR40 激动剂及 GPR84 拮抗剂或反向激动剂。Fezagepras sodium 可以减轻肝，肾和胰腺纤维化。Fezagepras sodium 具有抗炎，抗增殖和抗纤维化作用。
T38734	Vazegepant Zavegepant,BHV-3500
	Vazegepant is an intranasal CGRP receptor antagonist utilized for conducting acute migraine research.
T17194	Ubrogepant MK-1602	CGRP Receptor	GPCR/G Protein; Neuroscience
	Ubrogepant (MK-1602) 是新型的、口服有效的降钙素基因相关肽受体拮抗剂。Ubrogepant 有潜力用于急性偏头痛的相关研究。
T12293	Olcegepant hydrochloride BIBN-4096 hydrochloride,BIBN4096BS hydrochloride	Others	Others
	Olcegepant hydrochloride is a potent and selective non-peptidethe calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (with IC50 of 0.03 nM for human CGRP).
T79049	Tegeprotafib PTPN2/1-IN-1	Phosphatase	Metabolism
	Tegeprotafib (PTPN2/1-IN-1) 是一种可口服活性PTPN1和PTPN2抑制剂，PTPN2的IC50为4.4 nM，PTPN1B的IC50介于1-10 nM之间。
T73703	(3R,5R,6S)-Atogepant
	(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) 是Atogepant 的异构体.Atogepant 是降钙素基因相关肽受体 (CGRP) 拮抗剂。Atogepant 可用于研究偏头痛。
T71490	Gepotidacin hydrochloride
	Gepotidacin hydrochloride, also known as GSK-2140944 hydrochloride, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin hydrochloride is a novel antibacterial drug candidate. Gepotidacin hydrochloride Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin hydrochloride is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, Gepotidacin hydrochloride...
T26682	Atogepant MK 8031,MK8031. Atogepant,MK-8031
	Atogepant is an antagonist of calcitonin gene-related peptide receptor.
T11314	Fosmanogepix APX001,E1211	Others	Others
	Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.
T70837	Rimegepant sulfate hydrate
	Rimegepant, also known as BMS-927711 and BHV-3000, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraines. Rimegepant has shown in vivo efficacy without vasoconstriction effect. BMS-927711 is superior to placebo at several different doses (75 mg, 150 mg, and 300 mg) and has an excellent tolerability profile.
T11391L	Gepotidacin GSK2140944	Others	Others
	Gepotidacin is a novel triazaacenaphthylene inhibitor of bacterial type II topoisomerase.
T11391	Gepotidacin S enantiomer GSK2140944 S enantiomer	Others	Others
	Gepotidacin S enantiomer is an S enantionmer of gepotidacin.
T16093	Telcagepant MK-0974	Others	Others
	Telcagepant is an orally active antagonist of calcitonin gene-related peptide (CGRP) receptor (Kis: 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively).
T31922	Gepefrine, (+/-)-
	Gepefrine, (+/-)- is a bioactive chemical.
T77023	Geptanolimab
	Geptanolimab (CBT-501) 为一种针对程序性死亡-1 (PD-1) 的人源化 IgG4κ 单克隆抗体。通过竞争性抑制 PD-L1/L2 与 PD-1 的结合，Geptanolimab 在癌症研究中发挥作用。
T73216	Gepefrine
	Gepefrine为具口服活性的升压剂及拟交感神经作用剂，能有效改善动脉压早期直立性失调。
T70358	Gepotidacin mesylate dihydrate
	Gepotidacin mesylate dihydrate, also known as GSK-2140944 mesylate dihydrate, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin mesylate dihydrate is a novel antibacterial drug candidate. Gepotidacin mesylate dihydrate Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin mesylate dihydrate is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, ...

化合物

Vazegepant hydrochloride

Cat.No: T8682

Synonym: Vazegepant HCl

Target: CGRP Receptor

Cat.No: T19917

Target: 5-HT Receptor

Cat.No: T12883

Synonym: PBI-4050,3-戊基苯乙酸,Setogepram

Target: GPR

Cat.No: T12293L

Synonym: BIBN-4096,BIBN 4096BS

Target: CGRP Receptor

Cat.No: T4610

Synonym: BMS 927711,BMS-927711,BMS927711,BHV-3000

Target: CGRP Receptor

Fezagepras sodium

Cat.No: T12375

Synonym: Setogepram sodium salt,PBI-4050 sodium salt

Target: GPR

Cat.No: T38734

Synonym: Zavegepant,BHV-3500

Cat.No: T17194

Synonym: MK-1602

Target: CGRP Receptor

Olcegepant hydrochloride

Cat.No: T12293

Synonym: BIBN-4096 hydrochloride,BIBN4096BS hydrochloride

Target: Others

Cat.No: T79049

Synonym: PTPN2/1-IN-1

Target: Phosphatase

(3R,5R,6S)-Atogepant

Cat.No: T73703

Gepotidacin hydrochloride

Cat.No: T71490

Cat.No: T26682

Synonym: MK 8031,MK8031. Atogepant,MK-8031

Cat.No: T11314

Synonym: APX001,E1211

Target: Others

Rimegepant sulfate hydrate

Cat.No: T70837

Cat.No: T11391L

Synonym: GSK2140944

Target: Others

Gepotidacin S enantiomer

Cat.No: T11391

Synonym: GSK2140944 S enantiomer

Target: Others

Cat.No: T16093

Synonym: MK-0974

Target: Others

Gepefrine, (+/-)-

Cat.No: T31922

Cat.No: T77023

Cat.No: T73216

Gepotidacin mesylate dihydrate

Cat.No: T70358

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00978	Progranulin Protein, Human, Recombinant (His) PGRN,PCDGF,CLN11,Granulin,GP88,GEP,Granulin Precurs...	Human	HEK293 Cells
	Progranulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 63.2 kDa and the accession number is P28799-1.

重组蛋白

Progranulin Protein, Human, Recombinant (His)

Cat.No: TMPY-00978

Species: Human

Expression System: HEK293 Cells

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