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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T80382	EP2
	EP2是一种具有抗菌功能的肽类化合物，展现出明显的抗细菌和抗真菌活性。针对E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena，其最小抑菌浓度（MIC）为11.4 μg/mL。
T67946	EP2 receptor antagonist-2	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP2 receptor antagonist-2 (CID891729)为EP2受体拮抗剂，能够抑制PGE2诱导的EP2受体激活，并阻断由N-甲基-D-天冬氨酸(NMDA)引起的乳酸脱氢酶(LDH)释放。
T62641	EP2 receptor antagonist-1
	EP2 receptor antagonist-1 是一种可逆的、有效的、激动剂依赖性变构的前列腺素 EP2 受体拮抗剂。EP2 receptor antagonist-1 表现出抗炎活性。
T37088L	pep2m aceate	Others	Others
	pep2m aceate 是 GluR2 亚基 C 端与 N-乙基马来酰亚胺敏感融合蛋白相互作用的肽抑制剂。
TP1943L1	pep2-EVKI acetate(1315378-67-6 free base)	GluR	Neuroscience
	pep2-EVKI acetate(1315378-67-6 free base) 是一种细胞渗透性肽。它干扰与 C 激酶 (PICK1) 相互作用的蛋白质和 GluR2 AMPA 受体亚基之间的相互作用。
TP1945L1	Pep2m, myristoylated acetate Pep2m, myristoylated acetate(1423381-07-0 free base)	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Pep2m, myristoylated acetate(1423381-07-0 free base) 是一种细胞可渗透的肉豆蔻酰化形式的 pep2m。 GluA2（AMPA 受体）亚基的 C 末端与 N-乙基马来酰亚胺敏感融合蛋白 (NSF)（一种调节 AMPA 受体功能的蛋白质）之间相互作用的肽抑制剂。降低 CA1 神经元中的突触后电流、培养的海马神经元中 AMPA 介导的电流和 AMPA 受体表面表达。
TP1942L1	pep2-AVKI acetate(1315378-69-8 free base)	Others	Others
	pep2-AVKI acetate(1315378-69-8 free base) 选择性破坏 AMPA 受体亚基 GluA2（在 C 末端 PDZ 位点）与与 C 激酶 (PICK1) 相互作用的蛋白质结合的抑制剂肽。不影响 GluA2 与 GRIP 或 ABP 的结合，也不增加 AMPA 电流幅度或影响长期抑制 (LTD)。
TP1944L1	pep2-SVKI acetate pep2-SVKI acetate(328944-75-8 free base)	GluR	Neuroscience
	Pep2-SVKI acetate(pep2-SVKI acetate (328944-75-8 free base)) 是一种合成肽盐，可防止 AMPA 型谷氨酸受体的内化。
TP1881	Pep2-8 Pep 2-8
	Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
T37088	pep2m pep2m
	pep2m 可用于生命科学领域的相关研究。其产品编号为 T37088，CAS号为 243843-42-7。
TP1942	pep2-AVKI
	pep2-AVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
TP1943	pep2-EVKI
	pep2-EVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
T75937	Pep2m, myristoylated TFA
	Pep2m, myristoylated TFA (Myr-Pep2m TFA)为具备细胞渗透性的肽。该化合物通过破坏PKMζ与其下游靶点NSF/GluR2的相互作用而发挥作用，其中PKMζ为具有自主活性的PKC同工酶。
TP1944	pep2-SVKI
	Inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and
T83922	Pep2 Peptide
	Pep2 peptide是一种针对跨膜糖蛋白CD36的肽配体，CD36也被称为清道夫受体B2。在1 mM浓度使用时，Pep2 peptide在无细胞检测中选择性地与CD36结合，相比于人血清白蛋白(HSA)、IgG和CD44具有更高的亲和力。与不含Pep2 peptide的胶束相比，包裹抗癌剂多柔比星的Pep2 peptide功能化胶束能增加多柔比星在过表达CD36的HepG2肝细胞癌细胞中的细胞内输送，并提升细胞毒性。
TP1945	Pep2m, myristoylated
	Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces pos
T78013	Pep2-8 TFA
	Pep2-8是增强PCSK9拮抗活性的肽，作用于前蛋白转化酶枯草杆菌蛋白酶/可辛9型(PCSK9)。
T37087	pep2-SVKE pep2-SVKE
	pep2-SVKE 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T37087，CAS号为 1315378-76-7。
T82566	DiaPep277
	DiaPep277为源自HSP60第437-460位点的24个氨基酸组成的多肽，能够抑制NOD小鼠β-细胞破坏进展，并在糖尿病动物模型中对T细胞表现出免疫调节功能。
T3306	PF-04418948 PF 04418948,PF04418948	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	PF-04418948 是一种可口服的，选择性的前列腺素EP2受体拮抗剂，IC50为16 nM。
T14148	AH 6809	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	AH 6809 是 EP 和 DP 受体的拮抗剂，对小鼠 EP2受体的 Ki 值为 350 nM，对克隆的人类 EP1，EP2，EP3-III 和 DP 受体的 Ki 值分别为 1217、1150、1597 和 1415 nM。
T2428	TG6-10-1	5-HT Receptor; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	TG6-10-1 是一种 EP2 拮抗剂。
T5482	TG4-155	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TG4-155 是一种脑渗透性 EP2 拮抗剂，对 EP2 和 DP1 具有低纳摩尔的拮抗活性。它作用于 EP2 的 KB 为 2.4 nM，比对 DP1 受体的选择性高 14 倍，比对 EP1、EP3、EP4 和 IP 的选择性比高 550-4750 倍。
T8603	ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE 靶向前列腺素 E2受体 EP2亚型（人）。
T5150	Treprostinil LRX-15,曲前列环素,Orenitram,曲前列尼尔,Remodulin	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil (Orenitram) 是有效的 DP1、IP 和 EP2 激动剂，EC50分别为0.6、1.9 和 6.2 nM。
T28958	TG6-129 TG6 129	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TG6-129 是有效的EP2受体选择性拮抗剂，可降低 butaprost 诱导的 P388D1 巨噬细胞中炎症因子的表达。
T63349	Treprostinil diethanolamine UT-15C	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil diethanolamine (UT-15C) 是EP2、DP1和IP 的有效激动剂，对EP2、DP1、IP、EP1、EP4、EP3 和 FPKi 的值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 能够促使 cAMP 的上调，进而维持血管系统内的稳态，并造成人肺动脉的血管扩张。
T5171	Treprostinil Sodium 曲前列尼尔钠,UT-15	VEGFR; c-RET; Prostaglandin Receptor	Angiogenesis; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Treprostinil Sodium (UT-15) 是有效的 DP1、IP 和 EP2 激动剂，EC50分别为0.6、1.9 和 6.2 nM。
T11211	EP4 receptor antagonist 1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP4 receptor antagonist 1 是一种有效的特异性前列腺素 EP4受体拮抗剂，对人和小鼠 EP4受体的 IC50分别为6.1 nM 和16.2 nM。 EP4 receptor antagonist 1 可用于癌症免疫治疗的研究。
T14975	CJ-42794 CJ-042794	Others	Others
	CJ-42794 (CJ-042794)是前列腺素受体 EP4的选择性拮抗剂, 抑制[3H]-PGE2与 EP4受体结合的平均 pKi 为8.5, 对 EP4选择性比 EP1, EP2和 EP3高200多倍。
T15259	Evatanepag CP-533536 free acid,2-[3-[N-(4-叔丁基苄基)-N-(吡啶-3-基磺酰基)氨基甲基]苯氧基]乙酸	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Evatanepag (CP-533536 free acid) 是一种 EP2 受体选择性前列腺素 E2 (PGE2) 激动剂，可诱导局部骨形成，EC50 为 0.3 nM。它在大鼠骨折愈合模型中以单剂量局部给药时表现出愈合骨折的能力。
T16389	Omidenepag	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag displays binding affinities (IC50: 10 nM for h-EP2).
T14146	AGN 210676 Simenepag	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM).
T26578	AH13205 AH-13205,AH 13205
	AH13205 is an agonist of EP2 prostanoid receptor.
T15689	L-798106 CM9,GW671021	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, >5000 nM, and >5000 nM at EP4, EP1, and EP2, respectively).
T14139	Aganepag AGN 210937	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Aganepag, a potent Prostanoid EP2 receptor agonist, exhibits remarkable selectivity with an EC50 of 0.19 nM, demonstrating no activity at the EP4 receptor. Its applications are primarily in the fields of wound healing, scar reduction, scar prevention, and the treatment and prevention of wrinkles.
T16988	Taprenepag isopropyl PF-04217329	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Taprenepag isopropyl is a highly selective agonist of the EP2 receptor.
T26263	TG3-95-1 TG3951,TG 3951,TG-3951
	TG3-95-1 is an EP2 allosteric potentiator agent.
T68514	PGN-9856
	PGN-9856 is a novel potent, selective prostaglandin EP2 receptor agonist
T69256	ONO-AE1-259 lysine
	ONO-AE1-259 is a highly selective agonist of prostaglandin e2 receptor (ep2)
T29707	Aganepag ethanediol AGN-212409,AGN212409
	Aganepag ethanediol 是一种降低眼压的抗青光眼化合物。Aganepag ethanediol 是一种选择性 EP2 受体激动剂。
T16388	Omidenepag isopropyl	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropy
T69608	TG11-77 HCl
	TG11-77 HCl is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 HCl has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 HCl are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
T69609	TG11-77 free base
	TG11-77 free base is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 free base has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 free base are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
T69755	Evatanepag sodium
	Evatanepag, also known as CP-533536, is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. CP-533536 demonstrated the ability to heal fractures when administered locally as a single dose in rat models of fracture healing.
T15642	KAG-308	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing,
T41369	(S)-Butaprost free acid
	(S)-Butaprost (free acid) 是有效的、选择性的EP2受体激动剂。
T10046	16,16-Dimethyl prostaglandin E2 16,16-dimethyl PGE2	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway.
T26925	Butaprost Butaprostum,TR-4979,(R)-Butaprost
	Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butaprost demonstrates lower activity against murine EP1, EP3, and EP4 receptors. Furthermore, it effectively attenuates fibrosis by inhibiting the TGF-β/Smad2 signaling pathway [1] [2] [3].
T39165	Treprostinil palmitil Treprostinil palmitil,INS-1009
	Treprostinil Palmitil (TP), a prodrug of the DP1 and EP2 agonist Treprostinil (UT-15), exhibits EC50 values of 0.6 and 6.2 nM, respectively. It is a pure prodrug without any inherent binding affinity for G-protein coupled receptors, including prostanoid receptors.

化合物

Cat.No: T80382

EP2 receptor antagonist-2

Cat.No: T67946

Target: Prostaglandin Receptor

EP2 receptor antagonist-1

Cat.No: T62641

Cat.No: T37088L

Target: Others

pep2-EVKI acetate(1315378-67-6 free base)

Cat.No: TP1943L1

Target: GluR

Pep2m, myristoylated acetate

Cat.No: TP1945L1

Synonym: Pep2m, myristoylated acetate(1423381-07-0 free base)

Target: PKC

pep2-AVKI acetate(1315378-69-8 free base)

Cat.No: TP1942L1

Target: Others

pep2-SVKI acetate

Cat.No: TP1944L1

Synonym: pep2-SVKI acetate(328944-75-8 free base)

Target: GluR

Cat.No: TP1881

Synonym: Pep 2-8

Cat.No: T37088

Synonym: pep2m

Cat.No: TP1942

Cat.No: TP1943

Pep2m, myristoylated TFA

Cat.No: T75937

Cat.No: TP1944

Cat.No: T83922

Pep2m, myristoylated

Cat.No: TP1945

Cat.No: T78013

Cat.No: T37087

Synonym: pep2-SVKE

Cat.No: T82566

Cat.No: T3306

Synonym: PF 04418948,PF04418948

Target: Prostaglandin Receptor

Cat.No: T14148

Target: Prostaglandin Receptor

Cat.No: T2428

Target: 5-HT Receptor, Prostaglandin Receptor

Cat.No: T5482

Target: Prostaglandin Receptor

ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE

Cat.No: T8603

Target: Prostaglandin Receptor

Cat.No: T5150

Synonym: LRX-15,曲前列环素,Orenitram,曲前列尼尔,Remodulin

Target: Prostaglandin Receptor

Cat.No: T28958

Synonym: TG6 129

Target: Prostaglandin Receptor

Treprostinil diethanolamine

Cat.No: T63349

Synonym: UT-15C

Target: Prostaglandin Receptor

Treprostinil Sodium

Cat.No: T5171

Synonym: 曲前列尼尔钠,UT-15

Target: VEGFR, c-RET, Prostaglandin Receptor

EP4 receptor antagonist 1

Cat.No: T11211

Target: Prostaglandin Receptor

Cat.No: T14975

Synonym: CJ-042794

Target: Others

Cat.No: T15259

Synonym: CP-533536 free acid,2-[3-[N-(4-叔丁基苄基)-N-(吡啶-3-基磺酰基)氨基甲基]苯氧基]乙酸

Target: Prostaglandin Receptor

Cat.No: T16389

Target: Prostaglandin Receptor

Cat.No: T14146

Synonym: Simenepag

Target: Prostaglandin Receptor

Cat.No: T26578

Synonym: AH-13205,AH 13205

Cat.No: T15689

Synonym: CM9,GW671021

Target: Prostaglandin Receptor

Cat.No: T14139

Synonym: AGN 210937

Target: Prostaglandin Receptor

Taprenepag isopropyl

Cat.No: T16988

Synonym: PF-04217329

Target: Prostaglandin Receptor

Cat.No: T26263

Synonym: TG3951,TG 3951,TG-3951

Cat.No: T68514

ONO-AE1-259 lysine

Cat.No: T69256

Aganepag ethanediol

Cat.No: T29707

Synonym: AGN-212409,AGN212409

Omidenepag isopropyl

Cat.No: T16388

Target: Prostaglandin Receptor

Cat.No: T69608

TG11-77 free base

Cat.No: T69609

Evatanepag sodium

Cat.No: T69755

Cat.No: T15642

Target: Prostaglandin Receptor

(S)-Butaprost free acid

Cat.No: T41369

16,16-Dimethyl prostaglandin E2

Cat.No: T10046

Synonym: 16,16-dimethyl PGE2

Target: Prostaglandin Receptor

Cat.No: T26925

Synonym: Butaprostum,TR-4979,(R)-Butaprost

Treprostinil palmitil

Cat.No: T39165

Synonym: Treprostinil palmitil,INS-1009

Cat. No.	Product Name	Target	Signaling Pathways
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。

天然产物

Prostaglandin E1

Cat.No: T1626

Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil

Target: Endogenous Metabolite, Prostaglandin Receptor

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