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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T10031	EP1-antagonist-1 EP1-antanoist-1,EP1 antagonist 1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP1-antagonist-1 (EP1 antagonist 1) 是 EP1 的拮抗剂，pKi 和 pIC50 分别为 7.54 和 8.5。
T5841	Travoprost 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Travoprost (Fluprostenol isopropyl ester) 是一种异丙基酯前药，是一种高亲和力的，选择性的 FP 前列腺素全受体激动剂。它能够降低眼压，有潜力应用于青光眼和眼高压。
T78846	EP12	Apoptosis	Apoptosis
	EP12是一种c-Myc抑制剂及c-MycG4稳定剂，能够诱导多发性骨髓瘤细胞的细胞凋亡(apoptosis)及DNA损伤，并通过干扰NF-κB信号通路破坏P65/P50的核转位，从而抑制多发性骨髓瘤的生长。
T74445	ZA3-Ep10
	ZA3-Ep10是一种两性离子的脂质，用于合成脂质纳米颗粒，用于体内 RNA 传递和非病毒 CRISPR/Cas 基因编辑。
TP2197	Pep1-TGL	Others	Others
	Peptide containing the 'TGL' motif that corresponds to the C-terminus of GluR1 subunit
T11210	EP1013 F1013	Caspase	Apoptosis; Proteases/Proteasome
	EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.
T80420	TAT-NEP1-40 acetate	Apoptosis	Apoptosis
	TAT-NEP1-40 acetate 是促进脑卒中后轴突再生和功能恢复的候选分子。该化合物能够抵御PC12细胞的氧和葡萄糖剥夺(OGD)损伤，并促进神经突生长。它通过抑制神经元凋亡(apoptosis)作用，保护大脑免受缺血再灌注伤害，并能有效传递至大鼠的脑内。
T80419	TAT-NEP1-40 TFA	Apoptosis	Apoptosis
	TAT-NEP1-40 TFA 是一种能够穿透血脑屏障的多肽。它能够保护 PC12 细胞抵御缺氧和葡萄糖剥夺 (OGD) 的损害，并促进神经突的生长。此外，TAT-NEP1-40 TFA 可通过减少缺血性脑损伤中的细胞凋亡，以改善神经系统功能。该化合物在中枢神经系统损伤，包括中风后轴突再生及功能恢复的研究中具有潜在应用价值。
T76273	Pep19-2.5
	Pep19-2.5为合成抗毒素肽，能阻断内毒素信号级联。通过抑制跨膜及胞质模式识别受体（PRRs）介导的脂肽（LP）与脂多糖（LPS）的信号通路，Pep19-2.5关键调控与炎症及细胞焦亡（pyroptosis）相关的信号级联。
TP2196	Pep1-AGL	Others	Others
	Analog of Pep1-TGL
T80418	TAT-NEP1-40	Apoptosis	Apoptosis
	TAT-NEP1-40是一种能够穿透血脑屏障的多肽。它能够保护PC12细胞不受缺氧和葡萄糖剥夺(OGD)所致的损伤，同时促进神经突的生长。此外，TAT-NEP1-40通过阻断缺血性脑损伤中的细胞凋亡，对缺血后的神经功能恢复具有积极作用。该化合物适用于中枢神经系统损伤，特别是中风后的轴突再生与功能恢复方面的研究。
T81517	PEP1
	PEP1为具生物活性的肽类化合物。它在低浓度时能够与POPC SLB结合，在高浓度下则会引起POPC SLB的裂解。
T14148	AH 6809	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	AH 6809 是 EP 和 DP 受体的拮抗剂，对小鼠 EP2受体的 Ki 值为 350 nM，对克隆的人类 EP1，EP2，EP3-III 和 DP 受体的 Ki 值分别为 1217、1150、1597 和 1415 nM。
T21976	ONO-8130	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	ONO-8130 是前列腺素 EP1 受体选择性拮抗剂，口服有活力，能够阻断 L6 脊髓中ERK 的磷酸化。它可缓解环磷酰胺致膀胱炎小鼠的膀胱疼痛，可用于研究间质性膀胱炎。
T11211	EP4 receptor antagonist 1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP4 receptor antagonist 1 是一种有效的特异性前列腺素 EP4受体拮抗剂，对人和小鼠 EP4受体的 IC50分别为6.1 nM 和16.2 nM。 EP4 receptor antagonist 1 可用于癌症免疫治疗的研究。
T63667	ONO-8713	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	ONO-8713 是一种选择性的前列腺素E受体亚型EP1拮抗剂，可用于研究圣经系统疾病和代谢相关疾病。
T14975	CJ-42794 CJ-042794	Others	Others
	CJ-42794 (CJ-042794)是前列腺素受体 EP4的选择性拮抗剂, 抑制[3H]-PGE2与 EP4受体结合的平均 pKi 为8.5, 对 EP4选择性比 EP1, EP2和 EP3高200多倍。
T63349	Treprostinil diethanolamine UT-15C	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil diethanolamine (UT-15C) 是EP2、DP1和IP 的有效激动剂，对EP2、DP1、IP、EP1、EP4、EP3 和 FPKi 的值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 能够促使 cAMP 的上调，进而维持血管系统内的稳态，并造成人肺动脉的血管扩张。
T3306	PF-04418948 PF 04418948,PF04418948	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	PF-04418948 是一种可口服的，选择性的前列腺素EP2受体拮抗剂，IC50为16 nM。
T5482	TG4-155	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TG4-155 是一种脑渗透性 EP2 拮抗剂，对 EP2 和 DP1 具有低纳摩尔的拮抗活性。它作用于 EP2 的 KB 为 2.4 nM，比对 DP1 受体的选择性高 14 倍，比对 EP1、EP3、EP4 和 IP 的选择性比高 550-4750 倍。
T27466	GSK-269984B
	GSK-269984B is a novel antagonist of EP1 receptor.
T15421	GSK-269984A	Others	Others
	GSK-269984A is an antagonist of Prostaglandin E2 Receptor 1 (EP1) (pIC50: 7.9).
T23330	SC 19220	Others	Others
	EP1 receptor antagonist
T23332	SC 51322	Others	Others
	SC 51322 is an EP1 prostanoid receptor antagonist.
T15689	L-798106 CM9,GW671021	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, >5000 nM, and >5000 nM at EP4, EP1, and EP2, respectively).
T22125	ONO-8711
	ONO-8711 是一种有效且选择性的 EP1 受体竞争性拮抗剂(对人和小鼠 EP1 的 Ki 分别为 0.6 和 1.7 nM)。ONO-8711 在结肠癌、乳腺癌和口腔癌小鼠模型中的有效降低肿瘤发生率和多样性。
T16388	Omidenepag isopropyl	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropy
T23404	Sulprostone	Others	Others
	EP3 and EP1 receptor agonist
T15642	KAG-308	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing,
T37996	17-phenyl trinor Prostaglandin E2 ethyl amide 17-phenyl trinor Prostaglandin E2 ethyl amide
	17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to inc...
T69229	ONO-8539
	ONO-8539 is a prostanoid EP1 receptor antagonist.
T69602	ONO-DI-004
	ONO-DI-004 is a selective EP1 Prostanoid receptor agonist.
T27517	GW848687X GW-848687X,GW 848687X
	GW848687X, a potent and selective prostaglandin EP1 receptor antagonist, is used for the treatment of inflammatory pain.
T72513	SC 51089 free base
	SC 51089 free base 是一种选择性的前列腺素受体EP1拮抗剂，对EP1，TP，EP3和FP 受体的Ki 值分别为 1.3，11.2，17.5 和 61.1 μM。SC 51089 free base 具有神经保护活性。
T36080	Rivenprost ONO-4819
	Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]
T37778	19(R)-hydroxy Prostaglandin E1 19(R)-hydroxy Prostaglandin E1
	19(R)-hydroxy Prostaglandin E1 是 EP1 和 EP3 受体亚型的激动剂，并对平滑肌表现出收缩活性，也是灵长类动物精液中的主要前列腺素。
T36212	16(S)-Iloprost
	Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(S)-Iloprost potently inhibits platelet aggregation with an IC50 value of 3.5 nM.
T26925	Butaprost Butaprostum,TR-4979,(R)-Butaprost
	Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butaprost demonstrates lower activity against murine EP1, EP3, and EP4 receptors. Furthermore, it effectively attenuates fibrosis by inhibiting the TGF-β/Smad2 signaling pathway [1] [2] [3].
T21869	BW A868C
	BW A868C 是一种乙内酰脲化合物，是 BW245C 结构类似物。BW A868C 是一种选择性强的前列腺素 D2 (PGD2) 竞争性拮抗剂。BW A868C 对其他前列腺素受体 (IP、EP1、EP2、TP 和 FP) 没有影响。
T29907	Alprostadil sodium PGE1 sodium salt,Prostaglandin E1 sodium
	Alprostadil sodium 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。
T38171	Ro 1138452 hydrochloride
	Selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable. Clark et al (2004) Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg.Med.Chem.Lett. 14 1053 PMID:15013022 \|Jones et al (2006) Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel ...
T36211	16(R)-Iloprost
	Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(R)-Iloprost inhibits platelet aggregation with an IC50 value of 65 nM.
T23331	SC 51089 SC 51089 free base	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	SC 51089 是一种选择性的前列腺素受体 PGE2 拮抗剂，对前列腺素受体亚型具有选择性，具有抗伤害活性，可改善亨廷顿病 R6/1 小鼠模型中的运动缺陷并挽救记忆力下降。
T16389	Omidenepag	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag displays binding affinities (IC50: 10 nM for h-EP2).

化合物

EP1-antagonist-1

Cat.No: T10031

Synonym: EP1-antanoist-1,EP1 antagonist 1

Target: Prostaglandin Receptor

Cat.No: T5841

Synonym: 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221

Target: Prostaglandin Receptor

Cat.No: T78846

Target: Apoptosis

Cat.No: T74445

Cat.No: TP2197

Target: Others

Cat.No: T11210

Synonym: F1013

Target: Caspase

TAT-NEP1-40 acetate

Cat.No: T80420

Target: Apoptosis

TAT-NEP1-40 TFA

Cat.No: T80419

Target: Apoptosis

Cat.No: T76273

Cat.No: TP2196

Target: Others

Cat.No: T80418

Target: Apoptosis

Cat.No: T81517

Cat.No: T14148

Target: Prostaglandin Receptor

Cat.No: T21976

Target: Prostaglandin Receptor

EP4 receptor antagonist 1

Cat.No: T11211

Target: Prostaglandin Receptor

Cat.No: T63667

Target: Prostaglandin Receptor

Cat.No: T14975

Synonym: CJ-042794

Target: Others

Treprostinil diethanolamine

Cat.No: T63349

Synonym: UT-15C

Target: Prostaglandin Receptor

Cat.No: T3306

Synonym: PF 04418948,PF04418948

Target: Prostaglandin Receptor

Cat.No: T5482

Target: Prostaglandin Receptor

Cat.No: T27466

Cat.No: T15421

Target: Others

Cat.No: T23330

Target: Others

Cat.No: T23332

Target: Others

Cat.No: T15689

Synonym: CM9,GW671021

Target: Prostaglandin Receptor

Cat.No: T22125

Omidenepag isopropyl

Cat.No: T16388

Target: Prostaglandin Receptor

Cat.No: T23404

Target: Others

Cat.No: T15642

Target: Prostaglandin Receptor

17-phenyl trinor Prostaglandin E2 ethyl amide

Cat.No: T37996

Synonym: 17-phenyl trinor Prostaglandin E2 ethyl amide

Cat.No: T69229

Cat.No: T69602

Cat.No: T27517

Synonym: GW-848687X,GW 848687X

SC 51089 free base

Cat.No: T72513

Cat.No: T36080

Synonym: ONO-4819

19(R)-hydroxy Prostaglandin E1

Cat.No: T37778

Synonym: 19(R)-hydroxy Prostaglandin E1

Cat.No: T36212

Cat.No: T26925

Synonym: Butaprostum,TR-4979,(R)-Butaprost

Cat.No: T21869

Alprostadil sodium

Cat.No: T29907

Synonym: PGE1 sodium salt,Prostaglandin E1 sodium

Ro 1138452 hydrochloride

Cat.No: T38171

Cat.No: T36211

Cat.No: T23331

Synonym: SC 51089 free base

Target: Prostaglandin Receptor

Cat.No: T16389

Target: Prostaglandin Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。

天然产物

Prostaglandin E1

Cat.No: T1626

Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil

Target: Endogenous Metabolite, Prostaglandin Receptor

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