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Search Results for " elk "

Targets Recommended: MELK Others

11

抑制剂 & 化合物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP2157	TAT-DEF-Elk-1 TDE	Others	Others
	TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.
TP2157L	TAT-DEF-Elk-1 TFA (1220751-16-5 free base) TDE TFA,TAT-DEF-Elk-1 TFA	Others	Others
	TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 act
T81038	TAT-DEF-Elk-1 TFA TDE TFA
	TAT-DEF-Elk-1 TFA (TDE TFA) 是一种Elk-1的细胞穿透性肽抑制剂，通过模仿Elk-1的DEF域并特异性地阻断其功能来抑制Elk-1。该化合物能够抑制Elk-1的磷酸化作用，阻止其核内转位，同时不影响ERK和MSK1的活化。TAT-DEF-Elk-1 TFA作为一种研究工具，对于探究神经元可塑性及Elk-1在该进程中的角色具有重要价值。
T38362	Guselkumab CNTO 1959	IL Receptor	Immunology/Inflammation
	Guselkumab (CNTO 1959) 是一种针对IL-23p19亚基的重组人IgG1单克隆抗体。Guselkumab 与人和食蟹猴IL-23结合，Kd 值分别为3.3和1.9 pmol/L。Guselkumab 对IL-23信号通路下游细胞因子的产生具有抑制作用，可用于银屑病关节炎的研究。
T11997	MELK-IN-1 Nintedanib Impurity L,MELK inhibitor 17,尼达尼布杂质L	MELK	PI3K/Akt/mTOR signaling
	MELK-IN-1 (MELK inhibitor 17)是一种母体胚胎亮氨酸拉链激酶的有效抑制剂，IC50=3 nM，Ki=0.39 nM。
T11996	MELK-8a hydrochloride	MELK	PI3K/Akt/mTOR signaling
	MELK-8a hydrochloride 是一种有效的母体胚胎亮氨酸拉链激酶抑制剂，IC50 为 2 nM。
T62417	MELK-8a
	MELK-8a (NVS-MELK8a) 是一种高效的、选择性的母体胚胎亮氨酸拉链激酶 (MELK) 抑制剂 (IC50: 2 nM)。MELK-8a 也能够抑制 Flt3 (ITD) (IC50: 0.18 μM)、Haspin (IC50: 0.19 μM)、PDGFRα (IC50: 0.42 μM)。其中 MELK 在调节癌细胞的细胞有丝分裂中具有重要作用。
T35342	MELK-8a Dihydrochloride	MELK	PI3K/Akt/mTOR signaling
	MELK-8a Dihydrochloride 是一种新型的母体胚胎亮氨酸拉链激酶（MELK）抑制剂，其 IC50值为2 nM。
T38347	Zelkovamycin
	Zelkovamycin is a cyclic peptide antibiotic originally isolated from Streptomyces.1 It inhibits growth of X. oryzae, P. oryzae, S. aureus, and A. laidlawii in a concentration-dependent manner when used at concentrations ranging from 0.01 to 300 μg/ml.References1. Zhang, H., Tomoda, H., Tabata, N., et al. Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. I. Production, isolation and biological properties. J. Antibiot. (Tokyo) 52(1), 29-33 (1999). Zelkovamycin is a cycl...
T20759	XRP44X XRP-44-X,XRP 44X,XRP-44X,XRP 44 X	Ras	GPCR/G Protein; MAPK
	XRP44X (XRP 44X) 是Ras 诱导的转录激活的抑制剂，IC50为 10 nM，通过 FGF-2 抑制 Ras-Erk-1/2 通路激活。它抑制Elk3。它还对微管有影响。
T26879	BNC-1 BNC 1
	BNC-1 is a modulator of amyloid pathology. BNC-1 significantly decreases amyloid burden and improves markers of synaptic integrity in well-established mouse models of amyloid deposition by promoting phosphorylation and activation of Elk-1.

化合物

TAT-DEF-Elk-1

Cat.No: TP2157

Synonym: TDE

Target: Others

TAT-DEF-Elk-1 TFA (1220751-16-5 free base)

Cat.No: TP2157L

Synonym: TDE TFA,TAT-DEF-Elk-1 TFA

Target: Others

TAT-DEF-Elk-1 TFA

Cat.No: T81038

Synonym: TDE TFA

Cat.No: T38362

Synonym: CNTO 1959

Target: IL Receptor

Cat.No: T11997

Synonym: Nintedanib Impurity L,MELK inhibitor 17,尼达尼布杂质L

Target: MELK

MELK-8a hydrochloride

Cat.No: T11996

Target: MELK

Cat.No: T62417

MELK-8a Dihydrochloride

Cat.No: T35342

Target: MELK

Cat.No: T38347

Cat.No: T20759

Synonym: XRP-44-X,XRP 44X,XRP-44X,XRP 44 X

Target: Ras

Cat.No: T26879

Synonym: BNC 1

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04416	EphB1 Protein, Human, Recombinant (aa 565-984, His & GST) EPH receptor B1,EPHT2,ELK,Hek6,NET	Human	Baculovirus Insect Cells
	EphB1 Protein, Human, Recombinant (aa 565-984, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.3 kDa and the accession number is AAI11745.1.
TMPY-01997	EphB1 Protein, Human, Recombinant (His) EPHT2,Hek6,ELK,EPH receptor B1,NET	Human	HEK293 Cells
	EphB1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is P54762-1.
TMPY-01171	Ephrin B1/EFNB1 Protein, Human, Recombinant (His) EFL3,CFND,EPLG2,CFNS,EFB1,Elk-L,LERK2,ephrin-B1	Human	HEK293 Cells
	Ephrin B1/EFNB1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.5 kDa and the accession number is P98172.
TMPJ-00230	EFNB1 Protein, Mouse, Recombinant (hFc & His) EFNB1,LERK-2,EPH-related receptor tyrosine kinase ligand 2,<...	Mouse	HEK293 Cells
	Mouse Ephrin-B1 is a single-pass type I membrane protein which belongs to the ephrin family. It contains an ephrin RBD (ephrin receptor-binding) domain, and expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Ephrin-B1 is cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. It binds promiscuously Eph receptors residing on...
TMPY-01286	Ephrin B1/EFNB1 Protein, Human, Recombinant (His & hFc) EFL3,Elk-L,CFNS,LERK2,EFB1,EPLG2,ephrin-B1,CFND	Human	HEK293 Cells
	Ephrin B1/EFNB1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 51.2 kDa and the accession number is P98172.
TMPY-02206	EphB1 Protein, Mouse, Recombinant (His) Cek6,Hek6,C130099E04Rik,AW488255,Elkh,Elk,...	Mouse	HEK293 Cells
	EphB1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.6 kDa and the accession number is Q8CBF3-1.
TMPY-04436	EphB1 Protein, Mouse, Recombinant (His & GST) Net,ENSMUSG00000074119,Cek6,Hek6,EPH receptor B1,9330129L11,...	Mouse	Baculovirus Insect Cells
	EphB1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 72.4 kDa and the accession number is Q8CBF3-1.
TMPJ-00406	EphA8 Protein, Human, Recombinant (His) EPH- and ELK-related tyrosine kinase,EPH receptor A...	Human	HEK293 Cells
	EphA8, also known as Hek3 and Eek, is a 120 kDa glycosylated member of the Eph family of transmembrane receptor tyrosine kinases. The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent c...
TMPY-01753	Ephrin B1/EFNB1 Protein, Mouse, Recombinant (His) ephrin-B1,EFL-3,Eplg2,Epl2,Elk-L,Cek5-L,Stra1,Lerk2...	Mouse	HEK293 Cells
	Ephrin B1/EFNB1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P52795.
TMPY-00598	Ephrin B3/EFNB3 Protein, Mouse, Recombinant (hFc) ephrin-B3,EFL-6,Epl8,ELF-3,NLERK-2,LERK-8,Elk-L3	Mouse	HEK293 Cells
	Ephrin B3/EFNB3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.8 kDa and the accession number is O35393.
TMPY-01752	Ephrin B1/EFNB1 Protein, Mouse, Recombinant (hFc) Cek5-L,ephrin-B1,Eplg2,LERK-2,Lerk2,Epl2,Stra1,EFL-3,Elk...	Mouse	HEK293 Cells
	Ephrin B1/EFNB1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49 kDa and the accession number is P52795.
TMPY-00447	Ephrin B3/EFNB3 Protein, Mouse, Recombinant (His) ephrin-B3,EFL-6,ELF-3,NLERK-2,LERK-8,Elk-L3,Epl8	Mouse	HEK293 Cells
	Ephrin B3/EFNB3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.5 kDa and the accession number is O35393.
TMPJ-00403	EphB1 Protein, Human, Recombinant (hFc) EPHT2,EPH Tyrosine Kinase 2,EK6,Tyrosine-Protein Kinase Rece...	Human	HEK293 Cells
	Ephrin Type-B Receptor 1 (EPHB1) is a single-pass type I membrane protein that belongs to the Ephrin-B family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. EPHB1/EPHT2 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile α motif) domain. EPHB1 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner, which also correlated with its association with Grb7, an adaptor molecule i...
TMPY-02442	ELK1 Protein, Human, Recombinant (His & GST) ELK1, member of ETS oncogene family	Human	Baculovirus Insect Cells
	E twenty-six (ETS)-like transcription factor 1, also known as Elk1 or Member of ETS oncogene family (ELK1), is a member of the ETS oncogene superfamily which is characterized by a common protein domain that regulates DNA binding to target sequences. Elk1 is expressed in the nuclei of non-neuronal cells and function as a transcription activator. It plays important roles in various contexts, including long-term memory formation, drug addiction, Alzheimer's disease, Down syndrome, breast cancer, an...
TMPH-01642	MELK Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. ...
TMPH-01370	SNCG Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. SNCG Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.3 kDa a...
TMPH-02430	SNCG Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. SNCG Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.3 kDa and the accession number is Q2P...
TMPY-02519	BLVRB Protein, Human, Recombinant (His) HEL-S-10,biliverdin reductase B,FLR,BVRB,SDR43U1	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step i...

重组蛋白

EphB1 Protein, Human, Recombinant (aa 565-984, His & GST)

Cat.No: TMPY-04416

Species: Human

Expression System: Baculovirus Insect Cells

EphB1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01997

Species: Human

Expression System: HEK293 Cells

Ephrin B1/EFNB1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01171

Species: Human

Expression System: HEK293 Cells

EFNB1 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00230

Species: Mouse

Expression System: HEK293 Cells

Ephrin B1/EFNB1 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-01286

Species: Human

Expression System: HEK293 Cells

EphB1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02206

Species: Mouse

Expression System: HEK293 Cells

EphB1 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04436

Species: Mouse

Expression System: Baculovirus Insect Cells

EphA8 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00406

Species: Human

Expression System: HEK293 Cells

Ephrin B1/EFNB1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01753

Species: Mouse

Expression System: HEK293 Cells

Ephrin B3/EFNB3 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-00598

Species: Mouse

Expression System: HEK293 Cells

Ephrin B1/EFNB1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01752

Species: Mouse

Expression System: HEK293 Cells

Ephrin B3/EFNB3 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00447

Species: Mouse

Expression System: HEK293 Cells

EphB1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00403

Species: Human

Expression System: HEK293 Cells

ELK1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02442

Species: Human

Expression System: Baculovirus Insect Cells

MELK Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01642

Species: Human

Expression System: E. coli

SNCG Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01370

Species: Human

Expression System: E. coli

SNCG Protein, Cynomolgus, Recombinant

Cat.No: TMPH-02430

Species: Cynomolgus

Expression System: E. coli

BLVRB Protein, Human, Recombinant (His)

Cat.No: TMPY-02519

Species: Human

Expression System: E. coli

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