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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1073 |
Dronedarone hydrochloride
Dronedarone HCl,SR33589,决奈达隆盐酸盐,盐酸决奈达隆 |
Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Dronedarone hydrochloride (SR33589) 是一种胺碘酮类似物,可抑制 Na+,K+andCa2+的电流,有可能治疗心房颤动。 | |||
T35712 |
Debutyldronedarone hydrochloride
SR35021 hydrochloride |
||
N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h... | |||
T19273 |
Debutyldronedarone D7
SR-35021 D7 |
Others | Others |
Debutyldronedarone D7 is deuterium-labeled Debutyldronedarone, which is the main circulating active metabolite of dronedarone in the body. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7056 |
Dronedarone
决奈达隆,SR 33589 |
P450; Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; AChR; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Dronedarone (SR 33589) 是一种胺碘酮类似物,对治疗心房颤动可能有效。它是CYP3A4的底物和中度抑制剂。它是多种离子电流的有效阻滞剂,通过非竞争性结合到肾上腺素能受体显示出抗肾上腺素能的效果。 |