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3

抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T1073 Dronedarone hydrochloride

Dronedarone HCl,SR33589,决奈达隆盐酸盐,盐酸决奈达隆

Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; Autophagy Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
Dronedarone hydrochloride (SR33589) 是一种胺碘酮类似物,可抑制 Na+,K+andCa2+的电流,有可能治疗心房颤动。
T35712 Debutyldronedarone hydrochloride

SR35021 hydrochloride

N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h...
T19273 Debutyldronedarone D7

SR-35021 D7

Others Others
Debutyldronedarone D7 is deuterium-labeled Debutyldronedarone, which is the main circulating active metabolite of dronedarone in the body.

化合物

Dronedarone hydrochloride
Cat.No: T1073
Synonym: Dronedarone HCl,SR33589,决奈达隆盐酸盐,盐酸决奈达隆
Target: Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, Autophagy
Debutyldronedarone hydrochloride
Cat.No: T35712
Synonym: SR35021 hydrochloride
Target:
Debutyldronedarone D7
Cat.No: T19273
Synonym: SR-35021 D7
Target: Others
Cat. No. Product Name Target Signaling Pathways
T7056 Dronedarone

决奈达隆,SR 33589

P450; Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; AChR; Autophagy Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
Dronedarone (SR 33589) 是一种胺碘酮类似物,对治疗心房颤动可能有效。它是CYP3A4的底物和中度抑制剂。它是多种离子电流的有效阻滞剂,通过非竞争性结合到肾上腺素能受体显示出抗肾上腺素能的效果。

天然产物

Dronedarone
Cat.No: T7056
Synonym: 决奈达隆,SR 33589
Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy
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