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Search Results for " drp1 "

12

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T62687	Drp1-IN-1
	Drp1-IN-1 (comp A-7) 是一种 Drp1 蛋白抑制剂 (IC50: 0.91 μM)。
T73456	DRP1i27
	DRP1i27是一种有效抑制人源Drp1(动力蛋白相关蛋白1)的化合物。它通过与Drp1的GTPase位点结合，并与Gln34及Asp218形成氢键来发挥作用。DRP1i27主要针对Drp1介导的线粒体裂变细胞系模型，能有效防止模拟缺血再灌注引起的损伤。
TP1947L	P110 TFA	Others	Others
	P110 TFA 是一种 dynamin-related protein 1 (Drp1) 抑制剂，抑制 Drp1 GTPase 活性。
T1907	Mdivi-1 Mitochondrial division inhibitor 1	Apoptosis; Mitophagy; Dynamin; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Mdivi-1 (Mitochondrial division inhibitor 1) 是一种线粒体分裂抑制剂，抑制 DRP1 和 Dynamin I (IC50=1-10 μM)。Mdivi-1 可以抑制线粒体自噬。
T1848	Dynasore Dynamin Inhibitor I	Dynamin; Virus Protease; Autophagy; HSV	Autophagy; Cytoskeletal Signaling; Microbiology/Virology
	Dynasore (Dynamin Inhibitor I) 是一种可渗透细胞的化学物质，可逆且非竞争性地抑制 dynamin 1/2 的 GTPase 活性。它还抑制线粒体动力蛋白 Drp1，对其他小 GTPase 没有影响。
T68788	Ellipticine quinone
	Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.). Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mi...
T27551	Honokiol DCA Honokiol Bis-Dichloroacetate
	Honokiol DCA is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrating activity in Vemurafenib-resistant melanoma in vivo.
T37023	MB 0223
	Dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion. Mallat et al (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1. Biochem.Biophys.Res.Commun. 499 556 PMID:29601815
T83057	Anti-inflammatory agent 49
	Anti-inflammatory agent 49 (化合物 SC9)，一种Drp1-Fis1相互作用的抑制剂，可用于缓解Fis1介导的线粒体功能障碍。该化合物在体外对GTPase的IC50值为270 nM。
T27537	Hexafluoro
	Hexafluoro is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrates activity in Vemurafenib-resistant melanoma in vivo.
TP1947	P110
	Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro.
T36490	AZT triphosphate TEA
	AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in ...

化合物

Cat.No: T62687

Cat.No: T73456

Cat.No: TP1947L

Target: Others

Cat.No: T1907

Synonym: Mitochondrial division inhibitor 1

Target: Apoptosis, Mitophagy, Dynamin, Autophagy

Cat.No: T1848

Synonym: Dynamin Inhibitor I

Target: Dynamin, Virus Protease, Autophagy, HSV

Ellipticine quinone

Cat.No: T68788

Cat.No: T27551

Synonym: Honokiol Bis-Dichloroacetate

Cat.No: T37023

Anti-inflammatory agent 49

Cat.No: T83057

Cat.No: T27537

Cat.No: TP1947

AZT triphosphate TEA

Cat.No: T36490

Cat. No.	Product Name	Target	Signaling Pathways
T3898	Schaftoside 夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside	Dynamin; Antioxidant; TLR; MyD88; Mitochondrial Metabolism; Autophagy	Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; oxidation-reduction
	Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) 是在多种中草药中发现的一种黄酮类天然产物。它抑制 TLR4 和 Myd88 表达，还降低 Drp1 表达和磷酸化，并减少线粒体分裂，具有抗氧化和抗癌活性。

天然产物

Cat.No: T3898

Synonym: 夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside

Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01210	DENR Protein, Human, Recombinant (His & SUMO) DRP,Smooth muscle cell-associated protein 3,DENR,De...	Human	E. coli
	May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited ...
TMPH-01255	DNM1L Protein, Human, Recombinant (His & Myc) Dynamin-like protein IV,Dynamin-related protein 1,D...	Human	E. coli
	Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis...

重组蛋白

DENR Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01210

Species: Human

Expression System: E. coli

DNM1L Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01255

Species: Human

Expression System: E. coli

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