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Search Results for " dna cross-links "

17

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0164	Oxaliplatin L-OHP,奥沙利铂	DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Oxaliplatin (L-OHP) 是一种 DNA 烷化剂，一种 DNA 合成抑制剂。Oxaliplatin 会导致 DNA 交联损伤，阻止 DNA 复制和转录并导致细胞死亡。Oxaliplatin 可以诱导细胞自噬。
T1798	RITA NSC 652287,RITA (NSC 652287)	Mdm2; DNA Alkylator/Crosslinker; p53; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair
	RITA (NSC-652287) 是 p53-HDM-2相互作用抑制剂，可诱导 DNA-DNA 和 DNA-蛋白质的交联，可与 p53dN 结合，Kd 值为 1.5 nM。
T0975	Chlorambucil CB-1348,Chloroambucil,苯丁酸氮芥,WR-139013	DNA Alkylator/Crosslinker; DNA Alkylation	DNA Damage/DNA Repair
	Chlorambucil (CB-1348) 是一种口服活性的氮芥类双功能烷基化剂，具有抗肿瘤活性，可用于研究淋巴细胞白血病、卵巢癌和乳腺癌以及霍奇金病。
T2410	Nedaplatin 奈达铂,NSC 375101D	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Nedaplatin (NSC-375101D) 是顺铂的衍生物，是肿瘤集落形成单位的 DNA 损伤剂，IC50为94 μM。
T22443	Triglycidyl isocyanurate Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI	Apoptosis	Apoptosis
	Triglycidyl isocyanurate (Teroxirone) 是一种三氮烯三环氧化合物，可通过 p53的激活抑制非小细胞肺癌细胞的生长。它诱导细胞凋亡，具有抗血管生成和抗肿瘤活性，用于癌症研究。
T35271	Yoshi-864 Yoshi864,Improsulfan HCl,NSC102627,Improsulfan hydrochloride
	Yoshi-864 alkylates and cross-links DNA, thereby inhibiting DNA replication. It is an alkyl sulfonate DNA cross-linking agent with potential anti-cancer activity.
T39868	Anticancer agent 11
	Anticancer agent 11 an effective broad-spectrum anticancer agent, exerts its therapeutic potential by suppressing angiogenesis and facilitating the formation of DNA cross-links.
T69038	Teroxirone
	Teroxirone, also known as Triglycidyl Isocyanurate and Tris(2,3-epoxypropyl) Isocyanurate, is a triazene triepoxide with antineoplastic activity. Teroxine alkylates and cross-links DNA, thereby inhibiting DNA replication.
T34628	SG3199 SG 3199,SG-3199
	SG3199 is a PBD dimer which binds in the minor groove of DNA, and forms covalent DNA interstrand cross-links in naked linear plasmid DNA. SG3199 is potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines.
T68675	Porfiromycin
	Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells.
T72817	Colibactin 742
	Colibactin 742 是一种稳定的大肠杆菌素衍生物，可诱导DNA 链间交联、激活 Fanconi Anemia DNA 修复途径和 G2/M 期阻滞。
T36302	PR-104
	PR-104 is a highly specific hypoxia-activated agent that cross-links DNA, enabling its application in various tumor xenograft models. Functioning as a pre-prodrug of nitrogen mustard, PR-104 undergoes efficient conversion to the dinitrobenzamide mustards alcohol form, known as PR-104A[1].
T68592	Mafosfamide sodium
	Mafosfamide sodium is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide sodium alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, Mafosfamide sodium, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, Mafosfamide sodium is potentially useful in the intrathecal treatment of neoplastic meningitis.
T68434	Mafosfamide
	Mafosfamide is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis.
T71453	TriN2755
	TriN2755 is a synthetic triazene derivative with antineoplastic activity. Upon metabolic activation via N-demethylation, TriN2755 is converted into highly reactive carbocations that can alkylate DNA and other macromolecules, thereby resulting in DNA cross links, inhibiting DNA replication and repair, and subsequently inducing apoptosis. This agent has high hydrophilicity and photostability and shows a favorable toxicity profile over the other triazenes.
T4047L	Bisantrene HCl CL216942,CL-216942,NSC-337766,CL 216942
	Bisantrene (CL-216942; NSC 337766) is a topoisomerase II poison and DNA intercalator. It can be used as a Rac1 inhibitor or model compound to study P-glycoprotein-mediated multi-drug resistance (MDR1). Bisantrene inserts and disrupts the configuration of
T68942	Caricotamide
	Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over...

化合物

Cat.No: T0164

Synonym: L-OHP,奥沙利铂

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy

Cat.No: T1798

Synonym: NSC 652287,RITA (NSC 652287)

Target: Mdm2, DNA Alkylator/Crosslinker, p53, Autophagy

Cat.No: T0975

Synonym: CB-1348,Chloroambucil,苯丁酸氮芥,WR-139013

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Cat.No: T2410

Synonym: 奈达铂,NSC 375101D

Target: DNA/RNA Synthesis

Triglycidyl isocyanurate

Cat.No: T22443

Synonym: Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI

Target: Apoptosis

Cat.No: T35271

Synonym: Yoshi864,Improsulfan HCl,NSC102627,Improsulfan hydrochloride

Anticancer agent 11

Cat.No: T39868

Cat.No: T69038

Cat.No: T34628

Synonym: SG 3199,SG-3199

Cat.No: T68675

Cat.No: T72817

Cat.No: T36302

Mafosfamide sodium

Cat.No: T68592

Cat.No: T68434

Cat.No: T71453

Cat.No: T4047L

Synonym: CL216942,CL-216942,NSC-337766,CL 216942

Cat.No: T68942

Cat. No.	Product Name	Target	Signaling Pathways
T0974	Novobiocin Sodium Albamycinsodium,新生霉素钠,Cathomycin,Albamycin	Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy	Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology
	Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。
T4558	Trioxsalen 三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen	DNA Alkylator/Crosslinker; DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Trioxsalen (Trioxysalen) 是一种呋喃香豆素和补骨脂素衍生物，与 UV-A 一起用于光疗治疗白癜风和手部湿疹。它是一种光化学 DNA 交联剂，可用于激光激活定位的基因组链间交联可视化。

天然产物

Novobiocin Sodium

Cat.No: T0974

Synonym: Albamycinsodium,新生霉素钠,Cathomycin,Albamycin

Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy

Cat.No: T4558

Synonym: 三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen

Target: DNA Alkylator/Crosslinker, DHFR

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