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34

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T74287	MGlc-DAG
	MGlc-DAG 是一种糖脂甘油酯，可用于合成药物递送化合物。
T78669	(1R,4S)-Yimitasvir diphosphate (1R,4S)-DAG-181 diphosphate,(1R,4S)-Emitasvir diphosphate
	Yimitasvir (Emitasvir) diphosphate是一口服活性HCV NS5A抑制剂，适用于研究慢性丙型肝炎病毒感染。
T22465	1,2-Distearoyl-sn-glycerol	Others	Others
	1,2-Distearoyl-sn-glycerol 是一种内标物，可用于分离和鉴定 1,2-diacyl-sn-glycerol (DAG) 的分子种类。
T10954	DAGLβ-IN-1	Others	Others
	DAGLβ-IN-1，一种针对二酰基甘油脂肪酶 β (DAGLβ) 的抑制剂，可用作DAGL特异性活性探针的通用中间体。
T1502	Vildagliptin 维达列汀,NVP-LAF 237,维格列汀,LAF237	Apoptosis; Ferroptosis; Proteasome; DPP-4	Apoptosis; Proteases/Proteasome; Ubiquitination
	Vildagliptin (LAF237) 是一种选择性二肽基肽酶IV (DPP-IV) 抑制剂，在人 Caco-2 细胞中抑制 DPP-IV 的IC50为 3.5 nM。它具有出色的口服生物利用度和降血糖活性。
T27119L	(Rac)-Daglutril SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid	Others	Others
	(Rac)-Daglutril (SLV 306 acetic acid) 是 Daglutril 的消旋体。Daglutril 是一种口服活性的混合中性内肽酶/内皮素转化酶抑制剂，正在开发用于治疗原发性高血压和充血性心力衰竭。
T11015	Midaglizole hydrochloride (±)-DG5128,(±)-DG5128 hydrochloride,DG5128 hydrochloride,DG5128	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Midaglizole hydrochloride ((±)-DG5128) (DG5128) 是有效的 α2-肾上腺素受体拮抗剂。Midaglizole hydrochloride (DG5128) 对 α2-肾上腺素能受体的亲和力 (pKi= 6.28) 比 α1-肾上腺素能受体高 7.4 倍。
T8369	Adagrasib MRTX849	Ras	GPCR/G Protein; MAPK
	Adagrasib (MRTX849) 是一种 KRAS G12C 共价抑制剂，具有口服活性和选择性。Adagrasib 与 KRAS G12C 非活性构象的 GDP 状态结合，抑制 KRAS 及其下游信号的传导。Adagrasib 对 KRAS G12C 突变肿瘤具有抑制活性。
T33939	Dagrocorat hydrochloride PF-0251802,PF 0251802,PF-0251802 HCl,PF0251802
	PF-0251802 HCl is a bio-active chemical.
T15340	Fosdagrocorat PF-04171327	Others	Others
	Fosdagrocorat is an agonist of the dissociated glucocorticoid receptor.
T15048	Dagrocorat PF-00251802	Others	Others
	Dagrocorat is a novel and dissociated agonist of glucocorticoid receptor.
T31191	Dagapamil hydrochloride
	Dagapamil hydrochloride 是一种钙通道阻滞剂。Dagapamil hydrochloride 在动物模型中具有降压、抗心律失常、心脏保护、抗过敏和抑制血小板聚集的作用。
T31133	Cyclo-cadagac Cyclo cadagac
	Cyclo-cadagac is a cyclic heptapeptide.
T80238	NODAGA-LM3 TFA
	NODAGA-LM3 TFA 是一种可用68Ga标记的SSTR2拮抗剂，适用于PET成像，专门针对SSTR阳性副神经节瘤进行成像诊断。
T27239	Edaglitazone Edaglitazone sodium,BM-13.1258,RO-2052349-602,依格列宗,R-483,RO-2052349-000
	Edaglitazone is a PPARγ agonist. Edarglitazone restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse.
T61076	Vildagliptin dihydrate
	Vildagliptin dihydrate (LAF237 dihydrate) is a powerful and stable dipeptidyl peptidase IV (DPP-IV) inhibitor, demonstrating selectivity with an IC50 of 3.5 nM in human Caco-2 cells. This compound exhibits exceptional oral bioavailability and significant antihyperglycemic activity [1].
T68098	Midaglizole (±)-DG5128 free base,DG5128 free base,(±)-DG5128 free base ; DG5128 free base
	Midaglizole ((±)-DG5128 free base, DG5128 free base) 是一种有效的α2-adrenoceptor 拮抗剂。Midaglizole 是一种降血糖药。Midaglizole 在具有升高血压并降低血糖水平的作用。
T80237	NODAGA-LM3
	NODAGA-LM3可通过68Ga标记用于PET成像。具体而言，68Ga-NODAGA-LM3作为一种SSTR2拮抗剂，用于成像SSTR阳性的副神经节瘤。
T27119	Daglutril SLV306,SLV 306,SLV-306
	Daglutril, a NEP/ECE inhibitor, is potentially used for the treatment of hypertension, heart failure andpulmonary. Daglutril inhibits systemic conversion of big endothelin-1 in humans.
T31191L	Dagapamil Dagapamilum
	Dagapamil 是一种钙通道阻滞剂。Dagapamil 在动物模型中具有降压、抗心律失常、心脏保护、抗过敏和抑制血小板聚集的作用。
T35815	Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)
	Vildagliptin carboxylic acid metabolite is the major metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor vildagliptin in humans. Vildagliptin carboxylic acid metabolite has an IC50 value of 477 μM for DPP-4 in human Caco-2 cells. It is formed from hydrolysis of the cyano group on vildagliptin.
T28445	PPZ2 PPZ-2,PPZ 2
	PPZ2 is a novel DAG-activated TRPC3/TRPC6/TRPC7 channels activator.
T33814	OptoDArG Opto-DArG,Opto DArG
	OptoDArG is a diacylglycerol (DAG) photoswitch, which enables efficient control of TRPC3 by light.
T28444	PPZ1 PPZ 1,PPZ-1
	PPZ1 is a novel DAG-activated TRPC3/TRPC6/TRPC7 channels activator.
T71755	QNN33358
	QNN33358 is an alkylacylglycerol acts as a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist.
T36907	1-Oleoyl Lysophosphatidic Acid Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid
	1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase.[1] Hydrolysis of the fatty acid at the sn-2 position by phospholipase A2 (PLA2) yields bioactive LPA. LPA binds to one of five differe...
T37030	PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- ...
T40757	1-Stearoyl-2-arachidonoyl-sn-glycerol
	1-Stearoyl-2-arachidonoyl-sn-glycerol, a diacylglycerol (DAG) encompassing polyunsaturated fatty acids, possesses the ability to activate PKC. Moreover, this compound has the potential to enhance nonselective cation channel (NSCC) activity.
T36937	PtdIns-(1,2-dioctanoyl) (sodium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this anal...
T35786	O-7460
	In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM). It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s > 10 μM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis > 10 μM). At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-depe...
T37122	1,2-Dilinoleoyl-sn-glycerol
	1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (18:2) side chains attached at both the sn-1 and sn-2 positions. It has been found as a component of phosphatidic acid in rat liver mitochondria and in spinach chloroplast membranes. 1,2-Dilinoleoyl-sn-glycerol is upregulated in some pregnant women and has been used as a biomarker to predict later preeclampsia in early pregnancy.
T36938	PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt) PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and DAG stereochemistry as the natural compound. PtdIns-(3)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (Ptd...
T82007	JH-131e-153
	JH-131e-153, 作为一种二酰基甘油(DAG)内酯，具有激活 Munc13-1 的功能，靶向其 C1 结构域。JH-131e-153 对 Munc13-1 激活效率表现为 WT>I590≈R592A≈W588A。值得注意的是，Munc13-1 的 C1 结构域与蛋白激酶 C (PKC) 在序列和结构上具有同源性。对于 Munc13-1 和 PKC 的激活效率，JH-131e-153 的效果排序为 PKCα>Munc13-1>PKCε。该化合物通过调节 Munc13-1，对神经元过程产生影响，因此可用于神经退行性疾病的相关研究。
T36939	PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transd...

化合物

Cat.No: T74287

(1R,4S)-Yimitasvir diphosphate

Cat.No: T78669

Synonym: (1R,4S)-DAG-181 diphosphate,(1R,4S)-Emitasvir diphosphate

1,2-Distearoyl-sn-glycerol

Cat.No: T22465

Target: Others

Cat.No: T10954

Target: Others

Cat.No: T1502

Synonym: 维达列汀,NVP-LAF 237,维格列汀,LAF237

Target: Apoptosis, Ferroptosis, Proteasome, DPP-4

(Rac)-Daglutril

Cat.No: T27119L

Synonym: SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid

Target: Others

Midaglizole hydrochloride

Cat.No: T11015

Synonym: (±)-DG5128,(±)-DG5128 hydrochloride,DG5128 hydrochloride,DG5128

Target: Adrenergic Receptor

Cat.No: T8369

Synonym: MRTX849

Target: Ras

Dagrocorat hydrochloride

Cat.No: T33939

Synonym: PF-0251802,PF 0251802,PF-0251802 HCl,PF0251802

Cat.No: T15340

Synonym: PF-04171327

Target: Others

Cat.No: T15048

Synonym: PF-00251802

Target: Others

Dagapamil hydrochloride

Cat.No: T31191

Cat.No: T31133

Synonym: Cyclo cadagac

Cat.No: T80238

Cat.No: T27239

Synonym: Edaglitazone sodium,BM-13.1258,RO-2052349-602,依格列宗,R-483,RO-2052349-000

Vildagliptin dihydrate

Cat.No: T61076

Cat.No: T68098

Synonym: (±)-DG5128 free base,DG5128 free base,(±)-DG5128 free base ; DG5128 free base

Cat.No: T80237

Cat.No: T27119

Synonym: SLV306,SLV 306,SLV-306

Cat.No: T31191L

Synonym: Dagapamilum

Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)

Cat.No: T35815

Cat.No: T28445

Synonym: PPZ-2,PPZ 2

Cat.No: T33814

Synonym: Opto-DArG,Opto DArG

Cat.No: T28444

Synonym: PPZ 1,PPZ-1

Cat.No: T71755

1-Oleoyl Lysophosphatidic Acid

Cat.No: T36907

Synonym: Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid

PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

Cat.No: T37030

Synonym: PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

1-Stearoyl-2-arachidonoyl-sn-glycerol

Cat.No: T40757

PtdIns-(1,2-dioctanoyl) (sodium salt)

Cat.No: T36937

Cat.No: T35786

1,2-Dilinoleoyl-sn-glycerol

Cat.No: T37122

PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)

Cat.No: T36938

Synonym: PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)

Cat.No: T82007

PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

Cat.No: T36939

Synonym: PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

Cat. No.	Product Name	Target	Signaling Pathways
T75576	Solidagonic acid
	Solidagonic acid 通过促进异常单极纺锤体向双极纺锤体的转变来抑制 HSET 运动活动。Solidagonic acid 抑制裂殖酵母细胞死亡，并使有丝分裂纺锤体从单极形态逆转为双极形态。Solidagonic acid 对 Lactuca sativaL. 和 Lolium multiflorumLam 的幼苗具有生长抑制活性。
T81131	Solidagolactone II
	Solidagolactone II is a clerodane diterpene isolated from the plant Solidago virgaurea L.
T81130	Solidagolactone III
	Solidagolactone III，一种从Solidago属植物中分离得到的活性化合物。
T4950	1,2-Dipalmitoyl-sn-glycerol 1,2-双棕榈酸甘油酯,(S)-1,2-Dipalmitin	Endogenous Metabolite; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	1,2-Dipalmitoyl-sn-glycerol ((S)-1,2-Dipalmitin) 是内源性代谢产物的一种。

天然产物

Solidagonic acid

Cat.No: T75576

Solidagolactone II

Cat.No: T81131

Solidagolactone III

Cat.No: T81130

1,2-Dipalmitoyl-sn-glycerol

Cat.No: T4950

Synonym: 1,2-双棕榈酸甘油酯,(S)-1,2-Dipalmitin

Target: Endogenous Metabolite, PKC

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