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8

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35418	β-D-Glucosamine Pentaacetate
	β-D-Glucosamine pentaacetate is an N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production.
T37598	D-Glucosamine-6-sulfate
	D-Glucosamine-6-sulfate is a naturally occurring glycosaminoglycan. It activates the glmS ribozyme from B. subtilis, a Gram-positive bacterium, when used at a concentration of 200 μM. It has been used to form polyvalent dendrimer conjugates that inhibit angiogenesis and endothelial cell proliferation induced by FGF-2 in vitro and prevent scar tissue formation in a rabbit model of glaucoma surgery.
T37901	UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)
	UDP-N-acetyl-D-Glucosamine is a natural nucleotide sugar that is used by glycosyltransferases to transfer N-acetyl-D-glucosamine residues to substrates.1It is an important component of antibiotic biosynthesis pathways in fungi and lipopolysaccharide production in bacteria.2,3 1.Roseman, S.Reflections on glycobiologyJ. Biol. Chem.276(45)41527-41542(2001) 2.Kudo, F., and Eguchi, T.Biosynthetic genes for aminoglycoside antibioticsJ. Antibiot. (Tokyo)62(9)471-481(2009) 3.Mulrooney, E.F., Poon, K.K.,...
T20949	NAGKi NAGK-i,NAGK i,3-O-Methyl-N-acetyl-D-glucosamine
	NAGKi is an inhibitor of N-acetylmannosamine kinase (NAMK) and N-acetylglucosamine kinase (NAGK).
T74549	N-Acetyl-α-D-glucosamine 1-phosphate disodium
	N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P) 为异位糖磷酸盐，关键中间体于N-糖蛋白生物合成。该化合物同时作为细菌细胞壁组分磷胆酸和鼠胺的代谢前体。
T10789	Chitosan oligosaccharide COS,壳聚糖低聚乳酸酯	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Chitosan oligosaccharide (COS) 是 β-(1→4)-连接的 D-氨基葡萄糖的寡聚体，Chitosan oligosaccharide可激活 AMPK ，抑制NF-κB 和 MAPK在内的炎症信号通路。
T37276	2,5-Deoxyfructosazine (hydrochloride)
	2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL...
T71525	AB05831
	AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis of terminal, non-reducing N-acetyl-\|3-D-glucosamine (GlcNAc) andN-acetyl-(3-D-galactosamine (GalNAc) residues in glycoproteins, gan-gliosides, and glycosaminoglycans (GAGs). HEX, released by chondrocytes into the extracellular compartment, promotes cartilage matrix degradation. ...

化合物

β-D-Glucosamine Pentaacetate

Cat.No: T35418

D-Glucosamine-6-sulfate

Cat.No: T37598

UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)

Cat.No: T37901

Cat.No: T20949

Synonym: NAGK-i,NAGK i,3-O-Methyl-N-acetyl-D-glucosamine

N-Acetyl-α-D-glucosamine 1-phosphate disodium

Cat.No: T74549

Chitosan oligosaccharide

Cat.No: T10789

Synonym: COS,壳聚糖低聚乳酸酯

Target: AMPK

2,5-Deoxyfructosazine (hydrochloride)

Cat.No: T37276

Cat.No: T71525

Cat. No.	Product Name	Target	Signaling Pathways
T4514	N-Acetyl-D-Glucosamine N-乙酰-D-氨基葡萄糖,NAG,N-Acetyl-2-amino-2-deoxyglucose,Marine Sweet,N-Acetyl-2-amino-2-deoxy-D-glucose,N-乙酰氨基葡萄糖,GlcNAc	Endogenous Metabolite	Metabolism
	N-Acetyl-D-Glucosamine (NAG) 是葡萄糖的单糖衍生物。
T2792	Glucosamine sulfate 硫酸葡萄糖胺,硫酸氨基葡萄糖,D-Glucosamine sulphate,D-Glucosaminesulfate	MMP; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Autophagy	Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Glucosamine sulfate (D-Glucosaminesulfate) 是软骨基质和滑液中糖胺聚糖的天然成分，常用作骨关节炎的治疗方法。它也是一种氨基糖，是糖基化蛋白和脂质生化合成的突出前体，用作膳食补充剂。
T78485	D-Glucosamine 6-phosphate Glucosamine-6-phosphate	Endogenous Metabolite	Metabolism
	D-Glucosamine 6-phosphate为内源性代谢分子，谷氨酰胺果糖-6-磷酸氨基转移酶(GFAT)介导合成。该化合物常用于糖尿病研究领域。
T0429	Glucosamine Chitosamine,D-Glucosamine,氨基葡萄糖,葡糖胺	MMP; Others; TNF; NF-κB; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; CFTR; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Others; Proteases/Proteasome
	Glucosamine (Chitosamine) 是软骨基质和滑液中糖胺聚糖的天然成分，常用作骨关节炎的治疗方法。它也是一种氨基糖，是糖基化蛋白和脂质生化合成的突出前体，用作膳食补充剂。
T1715	Chitosan (MW 150000) 壳聚糖,Chitosan,Poly(D-glucosamine),Deacetylated chitin	Antibacterial; Antifungal	Microbiology/Virology
	Chitosan (MW 150000) (Deacetylated chitin) 是衍生自几丁质的聚阳离子线性多糖。它无毒，具有低致敏性，生物相容性和可生物降解性。它还具有抗肿瘤，抗细菌，抗真菌和抗氧化活性。
T3244	2-Deoxy-2-sulfoamino-D-glucose sodium 氨基葡萄糖硫酸钠盐,N-Sulfo-D-glucosamine sodium salt,N-Sulfo-glucosamine sodium salt,GlcN-2S,2-Deoxy-2-sulfamino-D-glucopyranose	Others; Endogenous Metabolite	Metabolism; Others
	2-Deoxy-2-sulfoamino-D-glucose sodium (GlcN-2S) 是内源性代谢产物的一种。
T2941	Glucosamine hydrochloride Chitosamine hydrochloride,盐酸氨基葡萄糖,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride	Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Autophagy	Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB
	Glucosamine hydrochloride (Chitosamine hydrochloride) 是软骨基质和滑液中糖胺聚糖的天然成分，常用作骨关节炎的治疗方法。它也是一种氨基糖，是糖基化蛋白和脂质生化合成的突出前体，用作膳食补充剂。
T3762	Hyaluronic acid 透明质酸,Hyaluronate,玻尿酸,hyaluronan	Others; Endogenous Metabolite	Metabolism; Others
	Hyaluronic acid (hyaluronan) 由玉米发酵得到，是由二糖的重复单元组成的生物聚合物，应用领域广泛。
T40436	N,N'-Diacetylchitobiose
	N,N'-Diacetylchitobiose, a dimer of β(1,4) linked N-acetyl-D glucosamine, is derived from the hydrolysis of chitin. This compound serves as an alternative carbon source for E. coli.

天然产物

N-Acetyl-D-Glucosamine

Cat.No: T4514

Synonym: N-乙酰-D-氨基葡萄糖,NAG,N-Acetyl-2-amino-2-deoxyglucose,Marine Sweet,N-Acetyl-2-amino-2-deoxy-D-glucose,N-乙酰氨基葡萄糖,GlcNAc

Target: Endogenous Metabolite

Glucosamine sulfate

Cat.No: T2792

Synonym: 硫酸葡萄糖胺,硫酸氨基葡萄糖,D-Glucosamine sulphate,D-Glucosaminesulfate

Target: MMP, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy

D-Glucosamine 6-phosphate

Cat.No: T78485

Synonym: Glucosamine-6-phosphate

Target: Endogenous Metabolite

Cat.No: T0429

Synonym: Chitosamine,D-Glucosamine,氨基葡萄糖,葡糖胺

Target: MMP, Others, TNF, NF-κB, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, CFTR, Autophagy

Chitosan (MW 150000)

Cat.No: T1715

Synonym: 壳聚糖,Chitosan,Poly(D-glucosamine),Deacetylated chitin

Target: Antibacterial, Antifungal

2-Deoxy-2-sulfoamino-D-glucose sodium

Cat.No: T3244

Synonym: 氨基葡萄糖硫酸钠盐,N-Sulfo-D-glucosamine sodium salt,N-Sulfo-glucosamine sodium salt,GlcN-2S,2-Deoxy-2-sulfamino-D-glucopyranose

Target: Others, Endogenous Metabolite

Glucosamine hydrochloride

Cat.No: T2941

Synonym: Chitosamine hydrochloride,盐酸氨基葡萄糖,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride

Target: Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy

Hyaluronic acid

Cat.No: T3762

Synonym: 透明质酸,Hyaluronate,玻尿酸,hyaluronan

Target: Others, Endogenous Metabolite

N,N'-Diacetylchitobiose

Cat.No: T40436

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