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Cat. No. | Product Name | Target | Signaling Pathways |
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T35327 |
Carrageenan
kappa-Carrageenan |
Antiviral | Immunology/Inflammation |
Carrageenan (kappa-Carrageenan) 是一种从食用红海藻中提取的天然碳水化合物(多糖)。Carrageenan 具有抗凝活性、抗血栓形成活性、抗病毒活性、抗肿瘤活性和免疫调节活性。 | |||
T36534 |
SDZ 224-015
SDZ 224015 |
IL Receptor; Caspase | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
SDZ 224-015 是白细胞介素-1β(IL-1β)转化酶和 Caspase-1 的口服活性抑制剂。SDZ 224-015 具有抗 COVID-19 和抗炎活性,可减少角叉菜胶诱导的大鼠爪子水肿。 | |||
T25658 |
Lemnalol
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Lemnalol is a natural marine compound from the Formosan soft coral Lemnalia cervicorni. It exhibits anti-inflammatory and analgesic effects in carrageenan-injected rats. | |||
T80502 |
P4pal10
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P4pal10为PAR4拮抗剂,能在体内抑制凝血酶介导的小鼠血小板聚集,并显著减少Carrageenan引起的水肿及粒细胞浸润。 | |||
T15167 |
Draflazine
R-75231 |
Others | Others |
Draflazine is an ENT1 inhibitor. It completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia. Draflazine also completely reverses the hypersensitivity of the carrageenan inflammation model of therma | |||
T38544 |
Fasitibant chloride
MEN16132 free base,Fasitibant chloride |
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Fasitibant chloride (MEN16132 free base) is a powerful and specific nonpeptide antagonist of the bradykinin B2 receptor (B2R). This compound effectively reduces joint pain and mitigates joint edema in a rat model of Carrageenan-induced arthritis. | |||
T24950 |
VUF-10214
VUF 10214,VUF10214 |
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VUF-10214 is an H4 receptor-ligand. VUF-10214 has significant anti-inflammatory properties in the carrageenan-induced paw edema model in vivo studies in the rat reveal. | |||
T78967 |
Anti-inflammatory agent 40
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Parasite | Microbiology/Virology |
Anti-inflammatory agent 40 是潜在的口服抗疟疾(anti-malarial)与抗炎(Anti-inflammatory)化合物,能抑制卡拉胶诱导的足跖肿胀。 | |||
T69850 |
SHR0687
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SHR0687 is a Highly Potent KOR Agonist. SHR0687 showed excellent selectivity over other opioid receptors, such as MOR and DOR. In addition, SHR0687 displayed favorable PK profiles across species, as well as robust in vivo efficacy in a rat carrageenan-induced pain model. Notably, SHR0687 exhibited negligible blood−brain barrier penetration, which was meaningful in minimizing CNS-related side effects. | |||
T35579 | PKSI-527 | ||
PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of in... | |||
T23676 |
AHR-10037
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AHR-10037是一种非甾体抗炎药,具有镇痛和解热特性以及高治疗指数,低胃毒性,它在抑制急性(伊文思蓝卡拉胶胸腔积液)和慢性(佐剂诱导的关节炎)炎症方面与吲哚美辛相当。研究表明,它在体内转化为环氧合酶抑制剂的前药。 | |||
T71212 |
Lornoxicam-d4
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Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e... | |||
T80501 |
Myr-TAT-CBD3
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Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Myr-TAT-CBD3是CRMP2-CaV2.2交互作用的抑制剂,有效减弱角叉菜胶诱导的热超敏反应,并能逆转大鼠术后疼痛模型的热超敏反应,适用于炎症和术后疼痛研究。 | |||
T37182 |
AX 048
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The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes. AX 048 is a potent group IVA cPLA2 inhibitor that demonstrates 50% inhibition of the enzyme at a mole fraction (XI(50)) of 0.022. Pretreatment with AX 048 (ED50 = 1.2 mg/kg) dose-dependently reduces thermal hyperalgesia evoked by carrageenan injection of r... | |||
T83143 |
Alloferon 1
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Alloferon 1 是一种具有抗病毒和抗肿瘤功能的肽。它能激活人外周血淋巴细胞的天然细胞毒性,诱导IFN合成,并在小鼠体内增强其抗病毒和抗肿瘤的防御机制。此外,Alloferon 1 在 λ-角叉菜胶诱导的足水肿模型中展现出抗炎作用。它可从双翅目昆虫丽蝇Calliphora vicina的血液中提取。 | |||
T36235 |
5-Chlorouracil
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5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. ... | |||
T83739 |
Myr-Tat-CBD3 TFA
Myr-Tat-Calcium Channel-binding Domain 3,N-myristate-Tat-CBD3 |
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Myr-Tat-CBD3是一种抑制N型电压门控钙通道Cav2.2与collapsin response mediator protein 2 (CRMP2)之间的蛋白-蛋白相互作用的抑制剂。在10 µM的浓度下,该化合物能够约81%地抑制Cav2.2-CRMP2相互作用,并在大鼠初级背根神经节(DRG)神经元中抑制钾诱导的钙流入(IC50约为2.8 µM)。在20 µM的浓度下,Myr-Tat-CBD3能抑制钙电流,但不影响钠电流,在初级DRG神经元中表现出这种特性。经过脊髓内给药,myr-Tat-CBD3(20 µg/5 µl)能够防止大鼠脚掌撤回潜伏期因carrageenan注射而减少。此外,Myr-Tat-CBD3减少大鼠因线索引起的寻求可卡因行为的复发。 | |||
T83728 |
Tat-AKAP79 (326-336) TFA
Tat-A-kinase Anchor Protein 79 (326-336) |
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Tat-AKAP79 (326-336) 是一种肽,由HIV-1 Tat蛋白质转导域与对应于A-kinase anchor protein 79 (AKAP79) 326至336残基的11个氨基酸肽链相连组成。在200 µM浓度下,能抑制蛋白激酶A (PKA) 或PKC激活诱导的瞬时受体电位钒通道1 (TRPV1) 在分离的大鼠背根神经节 (DRG) 神经元中的敏感化。在体内,Tat-AKAP79 (326-336) 抑制小鼠由甲醛或phorbol 12-myristate 13-acetate (PMA014) 引发的伤害性行为。它还延长了小鼠对辐射热刺激爪子撤回的潜伏期,并在卡拉胶诱导的炎症性疼痛小鼠模型中增加了爪子撤回的机械阈力。 | |||
T83731 |
Tat-CBD3 TFA
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Tat-CBD3是一种抑制N型电压门控钙通道Cav2.2与collapsin response mediator protein 2 (CRMP2)之间的蛋白质-蛋白质相互作用的抑制剂。它还能抑制CRMP2与NMDA受体NR2B亚单位之间的蛋白质-蛋白质相互作用。在无细胞实验中,Tat-CBD3 (10 µM)能将Cav2.2-CRMP2相互作用抑制43%,并在免疫共沉淀实验中抑制NMDA受体NR2B亚单位-CRMP2相互作用。它能在初级大鼠背根神经节 (DRG) 神经元中减少约60%的电压诱导钙电流,并在初级大鼠海马神经元中减少谷氨酸诱导的胞内钙水平增加。Tat-CBD3 (20 mg/kg)在大鼠中脑动脉闭塞 (MCAO) 引发的脑缺血模型中减少梗死体积。鞘内给药Tat-CBD3 (20 µg/5 µl)可防止大鼠卡拉胶诱导的热敏感性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T38499 | κ-Carrageenan | ||
κ-Carrageenan, a natural polymer found predominantly in red seaweeds, can serve as an effective drug carrier for delivering curcumin to cancer cells and inducing apoptosis. Additionally, κ-Carrageenan holds promise as a potential inflammatory agent, amplifying existing intestinal inflammation. | |||
T78497 | λ-Carrageenan | ||
λ-Carrageenan是广泛应用于基础研究的海藻多糖,常用作促炎剂,并具有有效的抗肿瘤活性。 | |||
T5781 |
taraxasteryl acetate
蒲公英甾醇醋酸酯,醋酸蒲公英酯 |
Antibacterial | Microbiology/Virology |
Taraxasteryl acetate 是分离自矢状疟原虫中,具有广谱的抗炎活性。它能够改善右旋糖酐、酵母聚糖及花生四烯酸诱导的大鼠后爪水肿。它可用于研究局部炎症。 | |||
TN5151 | Tomentin | ||
Tomentin has anti-inflammatory effects, it can inhibit the formation of λ-carrageenan footpad edema at 58%. | |||
TN4493 |
Mannioside A
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Mannioside A has anti-inflammatory activity, inhibits carrageenan-induced paw edema in the rat. | |||
TN4185 |
Hautriwaic acid
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Hautriwaic acid shows anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models, it diminishes the joint edema induced by this mixture of polysaccharides (carrageenan), possibly by acting as immunomodulator of the infl | |||
TN1364 |
Ajugasterone C
筋骨草甾酮 C,筋骨草甾酮C |
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Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to carrageenan-induced inflammation in Sprague Dawley rats. | |||
TN5477 |
GB-2a
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GB 2a shows antioxidant and anti-inflammatory effects, it can prevent the carrageenan-induced paw oedema. GB 2a biflavonoid can promote inhibition on tyrosinase activity and reduced melanin biosynthesis in B16F10 cells, which suggests great potential for | |||
T4484 | 1,7-Dihydroxy-2,3-methylenedioxyxanthone | Prostaglandin Receptor; Antifection | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology |
1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalgesia. | |||
TN3447 |
Arjunglucoside I
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Arjunglucoside I has anti-inflammatory activity, it exhibits significant activity against carrageenan-induced paw edema in rat. It also shows antiproliferative activity against the A2780 human ovarian cancer cell line with an IC(50) value of 1.2 microM. | |||
TN1080 |
Kaji-ichigoside F1
蔷薇苷 |
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Kaji-ichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Kaji-ichigoside F1 exhibits in vivo hepatoprotective effects, it inhibite | |||
TN5466 |
Boeravinone B
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Boeravinone B, a novel efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. aureus, boeravinone B may be used in combination with mupirocin for further development. Boeravinone B exh | |||
T73066 |
Thielavin B
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Thielavin B为Thielavin terricola产生的前列腺素生物合成抑制剂。该化合物能有效抑制内过氧物酶介导的前列腺素E2合成,并在静脉注射后显著降低大鼠因角叉菜胶引发的水肿。 |