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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2048L	α-helical CRF 9-41 acetate 肾上腺皮质素释放因子多肽α-helical CRF 9-41乙酸盐,α-helical CRF 9-41 acetate(90880-23-2 Free base)	CRFR	GPCR/G Protein
	α-helical CRF 9-41 acetate 是 CRF2 的竞争性拮抗剂 (KB = 100 nM) 和 CRF1 的部分激动剂 (EC50 = 140 nM)。
TP2047L	CRF (6-33) acetate(120066-38-8 free base)	CRFR	GPCR/G Protein
	CRF (6-33) acetate(120066-38-8 free base) 是促肾上腺皮质激素释放因子结合蛋白 (CRFBP) 抑制肽；从 CRFBP 中替换 CRF。在体内抑制肥胖大鼠的体重增加并增加运动活动。
TP2047	CRF(6-33)(human) CRF (6-33)
	CRF(6-33)(human) is a Corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo.
TP2048	α-Helical CRF(9-41) α-helical CRF 9-41
	Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).
TP1191	CRF, bovine Corticotropin Releasing Factor bovine
	CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.
TP1190	CRF, bovine TFA (92307-52-3 free base) CRF, bovine TFA,Corticotropin Releasing Factor bovine TFA
	CRF, bovine (TFA) is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM[1]. CRF shows pEC50s of 11.16, 8.53 and 8
T75972	CRF, bovine TFA
	CRF, bovine (TFA) 是一种有效的CRF 受体激动剂，能够取代 [125I-Tyr]ovine CRF，Ki 值为 3.52 nM。
TP1144	Corticotropin-releasing factor (human) Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human
	Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions b
T83665	α-Helical CRF (9-41) TFA α-Helical Corticotropin-Releasing Factor (9-41)
	α-Helical CRF (9-41) 是一种合成的皮质酮释放因子（CRF）拮抗剂。它在0.5至5 µM浓度范围内，能抑制CRF诱导的大鼠前叶垂体细胞释放促肾上腺皮质激素（ACTH）。在体内研究中，α-Helical CRF (9-41) (0.02-0.6 µmol/kg) 能够抑制未经麻醉的完整大鼠体内CRF诱导的ACTH释放，并在0.6 µmol/kg剂量下抑制大鼠应激诱导的ACTH释放。此外，α-Helical CRF (9-41) 在尼古丁诱导的条件性焦虑大鼠模型中增加社交互动时间，并减少小鼠的类似暴饮暴食的乙醇消费。
T75891	α-Helical CRF(9-41) TFA
	α-Helical CRF(9-41) TFA 是一种竞争性 CRF2受体拮抗剂，KB 约为 100 nM。α-Helical CRF(9-41) TFA 也是一种 CRF1受体的部分激动剂，EC50为 140 nM。
T75893	CRF(6-33)(human) TFA
	CRF(6-33)(human) TFA 是一种 CRF 结合蛋白配体 (CRF-BP) 抑制剂，与CRF-BP 竞争性结合，但不与突触后 CRF 受体结合。CRF(6-33)(human) TFA 具有抗肥胖作用。
T12276	NVS-CRF38	Others	Others
	NVS-CRF38 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1).
T76602	(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)
	(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) 作为一种CRF拮抗剂，能有效阻断IL-1a诱发的黄体生成素 (LH) 抑制作用。
T79793	CRF1 receptor antagonist-1	CFTR	Membrane transporter/Ion channel
	CRF1 receptor antagonist-1 (Compound 2)为CRF1受体拮抗剂，适用于先天性肾上腺增生症(CAH)的研究领域。
T69870	ICRF-193
	ICRF-193 is a DNA topoisomerase II inhibitor.
T25893	NU/ICRF 500
	NU/ICRF 500 is a novel anthracenyl-amino acid catalytic inhibitor of topoisomerase II.
T69871	ICRF-196
	ICRF-196 is a Topoisomerase II Inhibitor and antineoplastic agent.
T71177	LCRF-0004
	LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority of pancreatic cancers. Preclinical studies show that inhibition of RON function decreases pancreatic cancer cell migration, invasion, and survival and can sensitize pancreatic cancer cells to chemotherapy. RON receptor tyrosine kinase is a potential as a therapeutic target.
TP2221L	ANP (1-11), rat acetate Atrial natriuretic factor (1-11) acetate,ANP (1-11), rat醋酸盐,Atriopeptide (1-11) acetate	Others	Others
	ANP (1-11), rat acetate (Atrial natriuretic factor (1-11) acetate) 是心房利钠因子之一，是 CRF 刺激的 ACTH 分泌的抑制剂。
TP1448L	Astressin acetate Astressin acetate (170809-51-5 Free base)	CRFR	GPCR/G Protein
	Astressin acetate 是促肾上腺皮质激素释放因子 (CRF) 的拮抗剂，对 CRF 结合蛋白具有低亲和力，对克隆垂体受体具有高亲和力 (Ki = 2 nM)。
T7361	Verucerfont NBI77860,3-(4-甲氧基-2-甲基苯基)-2,5-二甲基-N-[(1S)-1-(3-甲基-1,2,4-恶二唑-5-基)丙基]吡唑并[1,5-A]嘧啶-7-胺,GSK561679	CRFR	GPCR/G Protein
	Verucerfont (NBI77860) 是促肾上腺皮质激素释放因子受体 1 (CRF1) 拮抗剂，作用于 CRF1(IC50:6.1 nM)，CRF2 (IC50>1000 nM)和 CRF-BP (IC50>1000 nM)。
T60126	4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine	Others; CRFR	GPCR/G Protein; Others
	4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine 是SSR-125543的对映异构体. SSR-125543是一种有效的CRF-R1拮抗剂，对人CRF-R1的Ki＝1.0nM。
TP1199L	Urotensin I acetate (83930-33-0 Free base)	CRFR	GPCR/G Protein
	Urotensin I acetate 是一种 CRF 样神经肽，可作为 CRF 受体激动剂，对 CHO 细胞中的人 CRF1、人 CRF2 和大鼠 CRF2α 受体的 pEC50 分别为 11.46、9.36 和 9.85，对 CHO 细胞的 Kis 分别为 0.4、1.8 和 5.7 nM hCRF1、rCRF2α 和 mCRF2β 受体分别为。
T16713	R121919 NBI30775	Others	Others
	R121919 (NBI30775) 是一种高效的促肾上腺皮质激素释放因子受体 1 （CRF1）小分子受体拮抗剂，具有抗抑郁和抗焦虑活性，抑制 CRF1 受体、 CRF2 受体和 CRF 结合蛋白。
T12492	Pivagabine CXB-722,匹伐加宾	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Pivagabine (CXB-722) 是疏水性 4-氨基丁酸的衍生物，具有神经调节活性。它可穿透大鼠的血脑屏障，拮抗足部休克对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
T70433	Antalarmin
	Antalarmin is a CRF-1 antagonist. By blocking CRF-1 activity the release of ACTH is reduced, and chronic stress is decreased in response to chronic stress. Antalarmin could be useful in reducing the adverse health consequences of chronic stress in humans, as well as treating anxiety, depression, and drug addiction.
T76204	a-Helical Corticotropin Releasing Factor (9-41)
	α-Helical Corticotropin Releasing Factor (9-41) 为corticotropin releasing factor (CRF)的拮抗剂，具有降低体内血浆生长激素(GH)水平的功能。
TP1504	Urocortin III, mouse TFA (357952-10-4 free base) Urocortin III, mouse TFA
	Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in th
T27666	JNJ-19567470 JNJ19567470
	JNJ-19567470 is a selective, non-peptide CRF receptor 1 antagonist.
T31052	CP-376395 HCl CP-376395,UNII-5113G7FP34,CP376395
	CP 376395 hydrochloride is a potent and selective CRF-RI receptor antagonist.
T76180	Urocortin III (human)
	Urocortin III (human) 是一种促肾上腺皮质激素释放因子 (CRF) 相关肽。Urocortin III (human) 优先结合并激活CRF-R2，并且具有离散的中枢神经系统和外周分布。Urocortin III (human) 选择性结合 2 型 CRF 受体，mCRF2β、rCRF2α 和 hCRF1 的Ki 值分别为 13.5、21.7 和 >100 nM。Urocortin III (human) 介导Insulin(human) 分泌的生长抑素依赖性负反馈控制。
T25864	NGD9002 NGD-9002,NGD 9002
	NGD9002 is a novel generation, topology 2 selective corticotropin releasing factor-1 (CRF-1) receptor antagonist agent.
T76025	Urocortin III, mouse TFA
	Urocortin III, mouse TFA是CRF（促肾上腺皮质激素释放因子）相关的肽。该化合物主要通过结合并激活CRF-R2发挥作用。Urocortin III（Ucn3）是已知参与调节行为压力反应体系的组分之一。它和CRF-R2在大脑杏仁核中共同作用，从而参与调控复杂的社会动力学行为。
T26855	BMS-665053 BMS665053
	BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM). In addi
T76492	(Tyr0)-Urocortin, rat
	(Tyr0)-Urocortin, rat 是针对促肾上腺皮质激素释放因子受体1型(CRF-R1)和2型(CRF-R2)的高亲和力激动剂，其抑制结合常数(Ki)为1-2 nM。
T27057	CP 154,526 CP-154,526,CP154,526
	CP 154,526 is a selective CRF1 receptor antagonist (Ki = 2.7 nM). CP 154,526 blocks CRF-induced activation of adenylate cyclase and the HPA axis.
T37111	Corticotropin-releasing factor (human) (acetate)
	Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
T33607	NBI-34041 NBI34041,SB 723620,SB-723620,SB723620
	NBI-34041 is an effective and high-affinity CRF1 receptor antagonist that effectively reduces endocrine responses to CRF(1) receptor-mediated pharmacological and behavioral challenges.
TP1448	Astressin
	Astressin is an amino-terminal truncated analog of CRF that retains high affinity binding to the extracellular domain of the receptor and is believed to act as a neutral competitive antagonist of receptor activation.
T69374	NGD 98-2
	NGD 98-2 is a new generation, topology 2 selective orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
T35374L	(Ala13)-Apelin-13 acetate	Apelin receptor	GPCR/G Protein
	(Ala13)-Apelin-13 acetate，一种 APJ 拮抗剂，可调节CRF 诱导的增强的结肠运动、内脏敏感性和肠屏障。
T36373	Urocortin II (mouse) (trifluoroacetate salt)
	Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin . It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF...
T75976	Urotensin I TFA
	Urotensin I (Catostomus urotensin I) TFA 是一种类 CRF 样肽，可作为 CRF 受体激动剂，在细胞实验中，对人 CRF1，CRF2和大鼠 CRF2α受体的 pEC50值分别为 11.46，9.36 和 9.85，对 hCRF1，rCRF2α和 mCRF2β受体的 Ki 值分别为 0.4，1.8 和 5.7 nM。
T62444	NBI-27914
	NBI-27914 是一种有效的、选择性的 CRFR1 拮抗剂。其中 CRF 受体 CRFR1 和 CRFR2 是 G 蛋白偶联受体超家族的成员。
TP1020	Urocortin, rat Urocortin (Rattus norvegicus),Rat urocortin
	Endogenous CRF agonist. Ki values are 13, 1.5 and 0.97 nM for hCRF1, rCRF2α and mCRF2β respectively.
T75804	K41498 TFA
	K41498 TFA 是一种强选择性的CRF2 receptor 拮抗剂，其对人 CRF2α、CRF2β和 CRF1受体的Ki 值分别为 0.66 nM、0.62 nM 和425 nM。K41498 TFA 是 antisauvagine-30 (aSvg-30) 的类似物，可抑制 sauvagine 刺激的 cAMP 在 hCRF2α/hCRF2β表达细胞中的积累。K41498 可用于低血压研究。
T75805	Antisauvagine-30 TFA
	Antisauvagine-30 TFA (aSvg-30 TFA) 是有效的、高度选择性的、竞争性的CRF2受体的多肽拮抗剂。Antisauvagine-30 TFA 对 mCRFR2β 和CRFR1的Kd 值分别为1.4 nM 和150 nM。
TP1860	Urocortin II, human
	Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor.
T76510	[Asu1,6-Arg8]Vasopressin
	[Asu1,6-Arg8]Vasopressin 是一种加压素 (vasopressin) 激动剂，可增强培养的大鼠垂体前叶细胞中由促肾上腺皮质激素释放因子 (CRF) 诱导的环AMP 积累和ACTH 释放。
T35814	Urocortin III (human) (trifluoroacetate salt)
	Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III , mouse urocortin II , human urocortin , and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively)....

化合物

α-helical CRF 9-41 acetate

Cat.No: TP2048L

Synonym: 肾上腺皮质素释放因子多肽α-helical CRF 9-41乙酸盐,α-helical CRF 9-41 acetate(90880-23-2 Free base)

Target: CRFR

CRF (6-33) acetate(120066-38-8 free base)

Cat.No: TP2047L

Target: CRFR

CRF(6-33)(human)

Cat.No: TP2047

Synonym: CRF (6-33)

α-Helical CRF(9-41)

Cat.No: TP2048

Synonym: α-helical CRF 9-41

Cat.No: TP1191

Synonym: Corticotropin Releasing Factor bovine

CRF, bovine TFA (92307-52-3 free base)

Cat.No: TP1190

Synonym: CRF, bovine TFA,Corticotropin Releasing Factor bovine TFA

CRF, bovine TFA

Cat.No: T75972

Corticotropin-releasing factor (human)

Cat.No: TP1144

Synonym: Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human

α-Helical CRF (9-41) TFA

Cat.No: T83665

Synonym: α-Helical Corticotropin-Releasing Factor (9-41)

α-Helical CRF(9-41) TFA

Cat.No: T75891

CRF(6-33)(human) TFA

Cat.No: T75893

Cat.No: T12276

Target: Others

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)

Cat.No: T76602

CRF1 receptor antagonist-1

Cat.No: T79793

Target: CFTR

Cat.No: T69870

Cat.No: T25893

Cat.No: T69871

Cat.No: T71177

ANP (1-11), rat acetate

Cat.No: TP2221L

Synonym: Atrial natriuretic factor (1-11) acetate,ANP (1-11), rat醋酸盐,Atriopeptide (1-11) acetate

Target: Others

Astressin acetate

Cat.No: TP1448L

Synonym: Astressin acetate (170809-51-5 Free base)

Target: CRFR

Cat.No: T7361

Synonym: NBI77860,3-(4-甲氧基-2-甲基苯基)-2,5-二甲基-N-[(1S)-1-(3-甲基-1,2,4-恶二唑-5-基)丙基]吡唑并[1,5-A]嘧啶-7-胺,GSK561679

Target: CRFR

4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine

Cat.No: T60126

Target: Others, CRFR

Urotensin I acetate (83930-33-0 Free base)

Cat.No: TP1199L

Target: CRFR

Cat.No: T16713

Synonym: NBI30775

Target: Others

Cat.No: T12492

Synonym: CXB-722,匹伐加宾

Target: GABA Receptor

Cat.No: T70433

a-Helical Corticotropin Releasing Factor (9-41)

Cat.No: T76204

Urocortin III, mouse TFA (357952-10-4 free base)

Cat.No: TP1504

Synonym: Urocortin III, mouse TFA

Cat.No: T27666

Synonym: JNJ19567470

Cat.No: T31052

Synonym: CP-376395,UNII-5113G7FP34,CP376395

Urocortin III (human)

Cat.No: T76180

Cat.No: T25864

Synonym: NGD-9002,NGD 9002

Urocortin III, mouse TFA

Cat.No: T76025

Cat.No: T26855

Synonym: BMS665053

(Tyr0)-Urocortin, rat

Cat.No: T76492

Cat.No: T27057

Synonym: CP-154,526,CP154,526

Corticotropin-releasing factor (human) (acetate)

Cat.No: T37111

Cat.No: T33607

Synonym: NBI34041,SB 723620,SB-723620,SB723620

Cat.No: TP1448

Cat.No: T69374

(Ala13)-Apelin-13 acetate

Cat.No: T35374L

Target: Apelin receptor

Urocortin II (mouse) (trifluoroacetate salt)

Cat.No: T36373

Urotensin I TFA

Cat.No: T75976

Cat.No: T62444

Cat.No: TP1020

Synonym: Urocortin (Rattus norvegicus),Rat urocortin

Cat.No: T75804

Antisauvagine-30 TFA

Cat.No: T75805

Urocortin II, human

Cat.No: TP1860

[Asu1,6-Arg8]Vasopressin

Cat.No: T76510

Urocortin III (human) (trifluoroacetate salt)

Cat.No: T35814

Cat. No.	Product Name	Target	Signaling Pathways
T8150	Nudifloramide 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide,1-甲基-6-氧代吡啶-3-甲酰胺	PARP; Endogenous Metabolite	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) 是烟酰胺-腺嘌呤二核苷酸(NAD) 降解的一种最终产物，可显著抑制PARP-1活性。

天然产物

Cat.No: T8150

Synonym: 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide,1-甲基-6-氧代吡啶-3-甲酰胺

Target: PARP, Endogenous Metabolite

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