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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1564 |
Cisplatin
cis-Diaminodichloroplatinum,CDDP,顺铂 |
DNA Alkylator/Crosslinker; Ferroptosis; DNA/RNA Synthesis; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Cisplatin (CDDP) 是一种 DNA 交联剂。Cisplatin 具有抗肿瘤活性,能够通过在癌细胞中形成 DNA 加合物来抑制 DNA 合成。Cisplatin 还可激活铁死亡并诱导自噬。 | |||
T78227 |
L-Methioninamide hydrochloride
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
L-Methioninamide hydrochloride 是一种有效的甲硫氨酰-tRNA 合成酶 (Methionyl-tRNA synthetase) 抑制剂,能够降低CDDP毒性。 | |||
T16351 | NSC16168 | Estrogen/progestogen Receptor | Endocrinology/Hormones |
NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM). | |||
T30095 |
APG-1387
SM 1387,SM-1387,SM1387,APG 1387l |
||
APG-1387 (SM-1387) is an IAP inhibitor that promotes the rapid degradation of cIAP1/2 and XIAP and exerts an anti-tumor effect on nasopharyngeal carcinoma stem cells. Studies have shown that APG-1387 combined with NPC's CDDP and 5-FU enhance chemoresensit | |||
T39594 |
AKR1B10-IN-1
AKR1B10-IN-1 |
||
AKR1B10-IN-1, a powerful AKR1B10 (Aldo-Keto Reductase 1B10) inhibitor, demonstrates an IC50 value of 3.5 nM. This compound effectively curtails the proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells. | |||
T74491 | Antitumor agent-61 | ||
Antitumor agent-61 (Compound 9b),Irinotecan (Ir)的衍生物,展现出对多种肿瘤细胞(包括SK-OV-3、SK-OV-3/CDDP、U2OS、MCF-7、A549与MG-63)具有显著的抑制效果,其IC50值分别为0.92、1.39、1.75、2.20、3.05和3.23 μM。该化合物主要通过线粒体途径引发SK-OV-3细胞的凋亡。 | |||
T74844 | Antiproliferative agent-23 | ||
Antiproliferative agent-23,一种微管去稳定剂(MDA),通过扰乱微管蛋白-微管系统来发挥作用。该化合物通过降低Bcl-2蛋白水平、提高Bax和Cyt c蛋白水平以及激活半胱天冬酶级联反应和线粒体依赖途径来诱导细胞凋亡。此外,Antiproliferative agent-23还能在A549/CDDP细胞(顺铂耐药癌细胞系)中通过PERK/ATF4/CHOP信号通路激活ROS介导的内质网应激,展现出抗肿瘤活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3867 |
Alpinetin
山姜素,(-)-alpinetin |
BCL; PPAR | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Alpinetin ((-)-alpinetin) 是从草豆蔻中分离得到的一种黄酮类天然产物,能够活化PPAR-γ,具有抗炎、抗菌活性。它通过抑制增殖、调节 Bcl-2 家族和 XIAP 表达、释放细胞色素 c 和激活 caspase 具有很强的抗肝癌和胰腺癌细胞作用。 |