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Search Results for " cd80 "

Targets Recommended: Bombesin Receptor

8

抑制剂 & 化合物

1

天然产物

26

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10722	CD80-IN-3	Bombesin Receptor	GPCR/G Protein
	CD80-IN-3 是一种CD80抑制剂，抑制 CD80/CD28 互作的EC50=630 nM，Kd=125 nM。
T80598	Davoceticept CD80 vIgD-Fc,ALPN-202
	Davoceticept (ALPN-202; CD80 vIgD-Fc) 是一种靶向CTLA-4的单克隆抗体。它包含CD80的(1-107)片段，该片段通过肽基连接子与IGHG1 Fc连接。Davoceticept通常在CHO（中国仓鼠卵巢）细胞中表达。
T11126	Durvalumab MEDI 4736	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Durvalumab (MEDI 4736) 是一种人源化的抗 PD-L1 蛋白单克隆抗体，可阻断 PD-L1 与 PD-1 和 CD80 结合的能力，其 IC50 分别为 0.1 和 0.04 nM。Durvalumab 常与铂类化合物联合一起用来治疗非小细胞肺癌和晚期肝癌细胞。
T73642	PD-1/PD-L1-IN 3 TFA
	PD-1/PD-L1-IN 3 TFA，一大环肽类化合物，有效且选择性抑制PD-1/PD-L1与CD80/PD-L1相互作用。该化合物通过结合PD-L1，干扰其与PD-1和CD80的结合，具有分别为5.60 nM和7.04 nM的IC50值。适用于癌症及传染病等疾病研究。
T76809	Galiximab
	Galiximab (IDEC 114)，一种IgG1类免疫球蛋白单克隆抗体，针对CD80抗原。其可变区来源于灵长类动物，而恒定区则来自人类。Galiximab主要用于研究B细胞淋巴瘤。
T74915	ODN D-SL03
	ODN D-SL03是C类CpG寡核苷酸，能诱导PBMCs产生高水平IFN-α，激活人B细胞、NK细胞和单个核细胞，同时上调PBMCs亚群表面CD80、CD86和HLA-DR的表达，还能抑制肿瘤生长。ODN D-SL03序列：5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'。
T36984	Cyclic di-IMP (sodium salt)
	Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p...
T83866	LCC-12 formate
	LCC-12是一种铜(II)螯合剂，为二甲双胍的衍生物。作为单体，它能结合铜(II)并在20 µM的浓度下减少氢过氧化物依赖的NADH向NAD+的氧化。在10 µM的浓度下，LCC-12降低一次性人类细胞因子激活的单核衍生的巨噬细胞(MDMs)中IL-1β、IL-2、IL-6、IL-8和TNF-α的细胞因子水平，以及JAK2、STAT2和IL-1受体相关激酶4(IRAK4)的水平。此外，同样浓度的LCC-12减少了细胞因子激活的MDMs中CD80+和CD86+的数量。每日0.3 mg/kg的剂量可提高LPS或盲肠结扎穿孔模型小鼠的存活率。

化合物

Cat.No: T10722

Target: Bombesin Receptor

Cat.No: T80598

Synonym: CD80 vIgD-Fc,ALPN-202

Cat.No: T11126

Synonym: MEDI 4736

Target: PD-1/PD-L1

PD-1/PD-L1-IN 3 TFA

Cat.No: T73642

Cat.No: T76809

Cat.No: T74915

Cyclic di-IMP (sodium salt)

Cat.No: T36984

Cat.No: T83866

Cat. No.	Product Name	Target	Signaling Pathways
TN5912	Macluraxanthone 3-Hydroxyblancoxanthone	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Macluraxanthone (3-Hydroxyblancoxanthone) 具有许多生物活性，包括抗胆碱酯酶、抗氧化、抗癌、抗疟疾、抗炎和免疫调节作用。Macluraxanthone 通过增加表达CD86的巨噬细胞的百分比，同时减少其CD14、CD11b 和CD80的表达，来促进M1类促炎症巨噬细胞的极化。Macluraxanthone 在促炎症刺激物脂多糖的存在下明显减少了TNF-α和IL-10细胞因子的产生。

天然产物

Macluraxanthone

Cat.No: TN5912

Synonym: 3-Hydroxyblancoxanthone

Target: Antioxidant, TNF

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00674	B7-1 Protein, Human, Recombinant CD28LG1,B7,CD80 molecule,LAB7,B7....	Human	HEK293 Cells
	B7-1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.5 kDa and the accession number is A0N0P2.
TMPY-00037	B7-1 Protein, Rat, Recombinant (hFc) CD80 molecule	Rat	HEK293 Cells
	B7-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51 kDa and the accession number is Q62680.
TMPJ-00630	B7-1 Protein, Cynomolgus, Recombinant (hFc) B7,CD80,T-lymphocyte activation antigen	Cynomolgus	HEK293 Cells
	Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the ...
TMPY-06909	B7-1 Protein, Rat, Recombinant (His) CD80 molecule	Rat	HEK293 Cells
	B7-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.38 kDa and the accession number is AAB60503.1.
TMPY-04349	B7-1 Protein, Cynomolgus, Rhesus, Recombinant (His) CD80 molecule	Cynomolgus,Rhesus	HEK293 Cells
	B7-1 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.4 kDa.
TMPY-03741	B7-1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) CD80 molecule	Cynomolgus,Rhesus	HEK293 Cells
	B7-1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.9 kDa and the accession number is O77684.
TMPJ-00958	B7-1 Protein, Rabbit, Recombinant (His) Activation B7-1 antigen,T-lymphocyte activation antigen ...	Rabbit	HEK293 Cells
	Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can ...
TMPK-00178	B7-1 Protein, Human, Recombinant (His & Avi) B71,CD80,BB1,LAB7,B7-1,B7.1,B7,CD...	Human	HEK293 Cells
	Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. B7-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.8 kDa and the accession number is P33681-1.
TMPK-00179	B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated B7.1,CD80,B7,CD80 molecu...	Human	HEK293 Cells
	Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.8 kDa and the accession number is P33681-1.
TMPY-01063	B7-1 Protein, Human, Recombinant (His) BB1,CD28LG1,B7-1,CD28LG,B7,B7.1,LAB7,C...	Human	HEK293 Cells
	B7-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.4 kDa and the accession number is A0N0P2.
TMPY-06298	B7-1 Protein, Human, Recombinant (His & Avi), Biotinylated CD28LG1,B7-1,B7.1,BB1,CD28LG,CD	Human	HEK293 Cells
	B7-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 27.12 kDa and the accession number is A0N0P2.
TMPY-06711	B7-1 Protein, Mouse, Recombinant (His & Avi), Biotinylated MIC17,Ly-53,Cd28l,B71,Ly53,TSA1,CD80	Mouse	HEK293 Cells
	B7-1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 26.94 kDa and the accession number is Q00609-1.
TMPY-02363	B7-1 Protein, Mouse, Recombinant (hFc) Ly-53,CD80 molecule,MIC17,B71,Cd2...	Mouse	HEK293 Cells
	B7-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is Q00609-1.
TMPY-05811	B7-1 Protein, Mouse, Recombinant (His), Biotinylated B71,Cd28l,Ly-53,MIC17,Ly53,CD80 m...	Mouse	HEK293 Cells
	B7-1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.1 kDa and the accession number is Q00609-1.
TMPY-02307	B7-1 Protein, Mouse, Recombinant (His) TSA1,Ly-53,Cd28l,MIC17,Ly53,B71,CD80	Mouse	HEK293 Cells
	B7-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.1 kDa and the accession number is Q00609-1.
TMPY-05379	B7-1 Protein, Human, Recombinant (hFc) B7-1,B7.1,LAB7,CD28LG,CD80 molecu...	Human	HEK293 Cells
	B7-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is A0N0P2.
TMPK-00110	CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi) CD28 molecule,MGC138290,CD28,CD28...	Human,Cynomolgus,Rhesus	HEK293 Cells
	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 18.2 kDa and the acc...
TMPK-01177	CD28 Protein, Canine, Recombinant (mFc) CD28 molecule,CD28 antigen (Tp44),CD	Canine	HEK293 Cells
	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Canine, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 41.6 kDa and the accession number is Q9GKP3.
TMPK-01176	CD28 Protein, Canine, Recombinant (His) CD28 antigen (Tp44),MGC138290,CD28,CD<...	Canine	HEK293 Cells
	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 16.7 kDa and the accession number is Q9GKP3.
TMPK-00111	CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated CD28 antigen (Tp44),CD28 molecule,CD	Human,Cynomolgus,Rhesus	HEK293 Cells
	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 18.2 k...
TMPJ-00099	CD28 Protein, Mouse, Recombinant (hFc & His) T-cell-specific surface glycoprotein CD28,CD	Mouse	HEK293 Cells
	T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals, which are required for their activation. It is the receptor for CD80 and CD86. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. It ...
TMPK-00112	CTLA-4 Protein, Human, Recombinant (His & Avi), Biotinylated IDDM12,ICOS,CD152,GRD4,CTLA4,CELIAC3,GSE,ALPS5	Human	HEK293 Cells
	CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
TMPY-02555	VSTM1 Protein, Human, Recombinant (His) SIRL-1,UNQ3033,MGC119161,V-set and transmembrane domain cont...	Human	HEK293 Cells
	V-set and transmembrane domain containing 1 (VSTM1) is a protein containing the V-set domains. V-set domains are immunoglobulin-like domains resembling the antibody variable region. V-set domains are found in many kinds of protein families, including immunoglobulin light and heavy chains, several T-cells such as CD2, CD4, CD80, and CD86, myelin membrane adhesion molecules, junction adhesion molecules (JAM), tyrosine-protein kinase receptors, and the programmed cell death protein1. VSTM1 Protein,...
TMPY-02563	VSTM1 Protein, Human, Recombinant (hFc) VSTM1,V-set and transmembrane domain containing 1,SIRL1,UNQ3...	Human	HEK293 Cells
	V-set and transmembrane domain containing 1 (VSTM1) is a protein containing the V-set domains. V-set domains are immunoglobulin-like domains resembling the antibody variable region. V-set domains are found in many kinds of protein families, including immunoglobulin light and heavy chains, several T-cells such as CD2, CD4, CD80, and CD86, myelin membrane adhesion molecules, junction adhesion molecules (JAM), tyrosine-protein kinase receptors, and the programmed cell death protein1. VSTM1 Protein,...
TMPJ-00219	BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated BTF3,BTN3A2,Butyrophilin subfamily 3 member A2,BTF4,BT3.2	Human	HEK293 Cells
	Butyrophilin subfamily 3 member A2, also known as BT3.2, BTF3, BTF4 and BTN3A2, is a single-pass type I membrane protein. It is a member of the butyrophilin (BTN) family and the immunoglobulin (IG) superfamily. Mature human BTN3A2 is a 305 amino acid (aa) glycoprotein. It contains a 219 aa extracellular region with one V-type Ig-like domain, and a 65 aa cytoplasmic tail. The cytoplasmic region undergoes phosphorylation on two serines. There are three potential splice forms. BTN3A2 is postulated ...
TMPJ-00420	CTLA-4 Protein, Mouse, Recombinant (Flag) Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-ass...	Mouse	HEK293 Cells
	Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their fu...

重组蛋白

B7-1 Protein, Human, Recombinant

Cat.No: TMPY-00674

Species: Human

Expression System: HEK293 Cells

B7-1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-00037

Species: Rat

Expression System: HEK293 Cells

B7-1 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPJ-00630

Species: Cynomolgus

Expression System: HEK293 Cells

B7-1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-06909

Species: Rat

Expression System: HEK293 Cells

B7-1 Protein, Cynomolgus, Rhesus, Recombinant (His)

Cat.No: TMPY-04349

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

B7-1 Protein, Cynomolgus, Rhesus, Recombinant (hFc)

Cat.No: TMPY-03741

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

B7-1 Protein, Rabbit, Recombinant (His)

Cat.No: TMPJ-00958

Species: Rabbit

Expression System: HEK293 Cells

B7-1 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00178

Species: Human

Expression System: HEK293 Cells

B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated

Cat.No: TMPK-00179

Species: Human

Expression System: HEK293 Cells

B7-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01063

Species: Human

Expression System: HEK293 Cells

B7-1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06298

Species: Human

Expression System: HEK293 Cells

B7-1 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06711

Species: Mouse

Expression System: HEK293 Cells

B7-1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02363

Species: Mouse

Expression System: HEK293 Cells

B7-1 Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-05811

Species: Mouse

Expression System: HEK293 Cells

B7-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02307

Species: Mouse

Expression System: HEK293 Cells

B7-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05379

Species: Human

Expression System: HEK293 Cells

CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi)

Cat.No: TMPK-00110

Species: Human,Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD28 Protein, Canine, Recombinant (mFc)

Cat.No: TMPK-01177

Species: Canine

Expression System: HEK293 Cells

CD28 Protein, Canine, Recombinant (His)

Cat.No: TMPK-01176

Species: Canine

Expression System: HEK293 Cells

CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00111

Species: Human,Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD28 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00099

Species: Mouse

Expression System: HEK293 Cells

CTLA-4 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00112

Species: Human

Expression System: HEK293 Cells

VSTM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02555

Species: Human

Expression System: HEK293 Cells

VSTM1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02563

Species: Human

Expression System: HEK293 Cells

BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00219

Species: Human

Expression System: HEK293 Cells

CTLA-4 Protein, Mouse, Recombinant (Flag)

Cat.No: TMPJ-00420

Species: Mouse

Expression System: HEK293 Cells

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