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3
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79683 |
HDAC/CD13-IN-1
|
Others | Others |
HDAC/CD13-IN-1 (Compound 12) 作为HDAC/CD13抑制剂, 对hCD13的IC50为0.34 μM, 猪CD13为0.53 μM, 对HDAC1/2/3的IC50分别为0.03、0.06、0.02 μM。此化合物有效抑制MV4-11、K562、Jeko-1 和 HL60细胞增殖, IC50范围为0.25-2.04 μM,并诱导癌细胞凋亡。同时表现出抗转移和抗侵袭的特性。 | |||
T76568 |
Aminopeptidase N Ligand (CD13) NGR peptide
|
||
AminopeptidaseN Ligand (CD13) NGR peptide 是靶向CD13的多肽,常见于癌症研究中,用作细胞内传递的载体介质。 | |||
T78847 | BC-05 | Others | Others |
BC-05为一CD13及20S蛋白酶体的口服有效抑制剂,分别对人CD13和20S蛋白酶体的IC50值为0.13 μM与1.39 μM。该化合物适用于进行多发性骨髓瘤相关研究。 | |||
TP1771 |
NGR peptide Trifluoroacetate
|
||
NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature. | |||
T36943 | Aminopeptidase N Inhibitor | ||
Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3529 |
Bestatin hydrochloride
盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素 |
Integrin; Aminopeptidase; Antibacterial; Antibiotic | Cytoskeletal Signaling; Metabolism; Microbiology/Virology |
Bestatin hydrochloride (Ubenimex hydrochloride) 是CD13(Aminopeptidase N)/APN 和leukotriene A4 hydrolase 抑制剂,可研究癌症。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
T62258 |
Bestatin trifluoroacetate
|
||
Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是一种 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,经常用于研究癌症。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00665 |
Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His)
alanyl (membrane) aminopeptidase,LAP1,APN,CD13<... |
Human | HEK293 Cells |
Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104.2 kDa and the accession number is A0A024RC61. | |||
TMPY-00758 |
Aminopeptidase N/CD13 Protein, Mouse, Recombinant (His)
Cd13,AP-N,Apn,AP-M,P150,alanyl (membrane) ... |
Mouse | HEK293 Cells |
Aminopeptidase N/CD13 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104 kDa and the accession number is P97449. | |||
TMPH-03099 |
Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc)
gp130,pAPN,AP-M,Aminopeptidase M,CD13<... |
Sus scrofa (Pig) | E. coli |
Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.1 kDa and the accession number is P15145. | |||
TMPY-01743 |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His)
4-1BB,tumor necrosis factor receptor superfamily, member 9,<... |
Human | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.8 kDa and the accession number is Q07011. | |||
TMPY-01650 |
CD131 Protein, Human, Recombinant (His)
CDw131,IL5RB,colony stimulating factor 2 r... |
Human | HEK293 Cells |
CD131 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P32927-1. | |||
TMPY-05767 |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (His)
tumor necrosis factor receptor superfamily, member 9,AA40849... |
Mouse | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.00 kDa and the accession number is P20334. | |||
TMPY-02028 |
RON/CD136 Protein, Human, Recombinant (His)
CD136,macrophage stimulating 1 receptor, |
Human | HEK293 Cells |
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in... | |||
TMPY-05594 |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CDw137,CD137,4-1BB,tumor... |
Human | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 45.8 kDa and the accession number is Q07011. | |||
TMPY-05504 |
4-1BB/CD137/TNFRSF9 Protein, Rhesus, Recombinant (His), Biotinylated
tumor necrosis factor receptor superfamily, member 9 |
Rhesus | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Rhesus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.7 kDa and the accession number is XP_005544945.1&NP_001253057.1. | |||
TMPY-05376 |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc)
4-1BB,tumor necrosis factor receptor superfamily, member 9,<... |
Human | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44 kDa and the accession number is Q07011. | |||
TMPY-06528 |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (soluble CD137, His)
tumor necrosis factor receptor superfamily, member 9,4-1BB,<... |
Human | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (soluble CD137, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.70 kDa and the accession number is Q07011. | |||
TMPY-04995 |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (soluble form, rFc)
A930040I11Rik,tumor necrosis factor receptor superfamily, me... |
Mouse | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (soluble form, rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 46.1 kDa. | |||
TMPY-03690 |
CD133/PROM1 Protein, Rat, Recombinant (mFc)
prominin 1 |
Rat | HEK293 Cells |
CD133/PROM1 Protein, Rat, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 60 kDa and the accession number is Q7TSL4. | |||
TMPK-00987 |
IL-2 R gamma/CD132 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
IL-2 R γ/CD132,IL-2 R gamma,IMD4,gammaC,SC... |
Cynomolgus | HEK293 Cells |
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein (Primary Amine Labeling)... | |||
TMPY-04283 |
CD131 Protein, Rat, Recombinant (hFc)
colony stimulating factor 2 receptor, beta, low-affinity (gr... |
Rat | HEK293 Cells |
CD131 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.1 kDa and the accession number is Q78ZF5. | |||
TMPY-06794 |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-187, His & Avi), Biotinylated
tumor necrosis factor receptor superfamily, member 9,AA40849... |
Mouse | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-187, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 20.81 kDa and the accession number is NP_001070977.1. | |||
TMPY-05105 |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His), Biotinylated
CDw137,ILA,4-1BB,CD137,t... |
Human | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.7 kDa and the accession number is Q07011. | |||
TMPJ-00144 |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & His)
CD137,4-1BB ligand receptor,T-cell antigen... |
Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9/4-1BBL, and possibly active during T cell activation. 4-1BB/CD137/TNFRSF9 Pro... | |||
TMPK-00148 |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (aa 24-186, hFc & Avi), Biotinylated
TNFRSF9,FLJ43501,4-1BB,4-1BB ligand receptor,ILA,CD... |
Human | HEK293 Cells |
4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (aa 24-186, hFc & Avi), Biotinylated is expressed in HE... | |||
TMPY-02049 |
EPOR & CD131 Heterodimer Protein, Human, Recombinant (hFc)
EPO-R,erythropoietin receptor |
Human | HEK293 Cells |
EPOR & CD131 Heterodimer Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is NP_000112.1&NP_000386.1. | |||
TMPJ-00145 |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)
Tumor necrosis factor receptor superfamily member 9,Tnfrsf9,... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells... | |||
TMPH-02842 |
CD133/PROM1 Protein, Mouse, Recombinant (His & SUMO)
CD133,Prom1,Prominin-like protein 1,Prom,P... |
Mouse | E. coli |
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. | |||
TMPY-06329 |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-211, His&AVI), Biotinylated
CDw137,AI325004,Cd137,Ly... |
Mouse | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-211, His&AVI), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.32 kDa and the accession number is NP_001070976.1. | |||
TMPY-04720 |
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Rhesus, Recombinant (His)
tumor necrosis factor receptor superfamily, member 9 |
Cynomolgus,Rhesus | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.7 kDa and the accession number is XP_005544945.1&NP_001253057.1. | |||
TMPK-00239 |
IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi), Biotinylated
SCIDX,IMD4,IL-2 R gamma,CD132,SCIDX1,IL-2 ... |
Human | HEK293 Cells |
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein, Human, Recombinant (His... | |||
TMPY-00230 |
4-1BB/CD137/TNFRSF9 Protein, Canine, Recombinant (hFc)
tumor necrosis factor receptor superfamily, member 9 |
Canine | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.9 kDa and the accession number is XP_850336.1. | |||
TMPY-02330 |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (soluble form, hFc)
Cd137,A930040I11Rik,tumor necrosis factor ... |
Mouse | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (soluble form, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47 kDa and the accession number is Q8R037. | |||
TMPJ-00140 |
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
CD137,CDw137,4-1BB ligan... |
Cynomolgus | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9/4-1BBL, and possibly active during T cell activation. 4-1BB/CD137/TNFRSF9 Pro... | |||
TMPK-00238 |
IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi)
CD132,gammaC,γC,IMD4,IL2RG,SCIDX1,CIDX,IL-... |
Human | HEK293 Cells |
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein, Human, Recombinant (His... | |||
TMPK-00147 |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & Avi)
T cell antigen ILA,ILA,4-1BB ligand receptor,FLJ43501,TNFRSF... |
Human | HEK293 Cells |
4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with... | |||
TMPY-03691 |
CD133/PROM1 Protein, Rat, Recombinant (His)
prominin 1 |
Rat | HEK293 Cells |
CD133/PROM1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.10 kDa and the accession number is Q7TSL4. | |||
TMPH-00001 |
CD133/PROM1 Protein-VLP, Human, Recombinant (His)
Proml1,Prom1,CD133,Prominin-like protein 1... |
Human | HEK293 Cells |
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. CD133/PROM1 Protein... | |||
TMPY-05031 |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (soluble form, His)
CDw137,4-1BB,AI325004,A930040I11Rik,Cd... |
Mouse | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (soluble form, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.5 kDa and the accession number is Q8R037. | |||
TMPJ-00142 |
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (His)
CDw137,ILA,4-1BB ligand receptor,T-cell an... |
Cynomolgus | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 26-35 KDa and the accession number is A9YYE7. | |||
THMH-00001 |
CD133/PROM1 Recombinant,Human(Yeast expression,His)
|
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TMPY-06382 |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His & Avi), Biotinylated
tumor necrosis factor receptor superfamily, member 9,4-1BB,I... |
Human | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 20.54 kDa and the accession number is NP_001552.2. | |||
TMPK-00986 |
IL-2 R gamma/CD132 Protein, Cynomolgus, Recombinant (His)
SCIDX1,IL2RG,gammaC,γC,CIDX,IL-2 R γ/CD132... |
Cynomolgus | HEK293 Cells |
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein, Cynomolgus, Recombinant... | |||
TMPJ-00141 |
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (hFc)
4-1BB ligand receptor,CD137,CDw |
Cynomolgus | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60 KDa and the accession number is A9YYE7. | |||
TMPY-03773 |
4-1BB/CD137/TNFRSF9 Protein, Canine, Recombinant (His)
tumor necrosis factor receptor superfamily, member 9 |
Canine | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.4 kDa and the accession number is XP_850336.1. | |||
TMPY-04719 |
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Rhesus, Recombinant (hFc)
tumor necrosis factor receptor superfamily, member 9 |
Cynomolgus,Rhesus | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44 kDa and the accession number is XP_005544945.1&NP_001253057.1. | |||
TMPY-06279 |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (His), Biotinylated
Cd137,tumor necrosis factor receptor super... |
Mouse | HEK293 Cells |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.00 kDa and the accession number is P20334. | |||
TMPJ-00143 |
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (aa 24-186, His & Avi), Biotinylated
ILA,4-1BB ligand receptor,T-cell antigen 4-1BB homolog,C... |
Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9/4-1BBL, and possibly active during T cell activation. 4-1BB/CD137/TNFRSF9 Pro... |