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Cat. No. | Product Name | Target | Signaling Pathways |
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T25779 |
MDK-4683
MDK 4683,CA IX/XII Inhibitor |
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MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor. | |||
T2017 |
U-104
NSC-213841,MST-104 |
Carbonic Anhydrase | Metabolism |
U-104 (NSC-213841) 是 CA IX 和 CA XII 碳酸酐酶 (CA) 抑制剂,其 Ki 分别为 45.1 nM 和 4.5 nM。小鼠模型中,它能够表现出明显的抑制肿瘤生长的作用。 | |||
T36758 |
CAIX Inhibitor S4
S4 |
Carbonic Anhydrase | Metabolism |
CAIX Inhibitor S4 (S4) 是一种有效的碳酸酐酶 IX/XII 抑制剂,Ki 分别为 7 nM 和 2 nM。 CA II 和 CA I 的 Ki 分别为 546 和 5600 nM。 | |||
T77631 |
Enpp/Carbonic anhydrase-IN-2
|
Apoptosis; PDE; Carbonic Anhydrase | Apoptosis; Metabolism |
Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells. | |||
T61745 |
hCAI/II-IN-6
|
Carbonic Anhydrase | Metabolism |
hCAI/II-IN-6 是一种具有选择性和口服活性的human carbonic anhydrase(CA) 抑制剂。hCAI/II-IN-6对 hCA I,hCA II,hCA VII 和 hCA XII 有抑制作用,Ki 值分别为 220,4.9,6.5 和 >50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性。hCAI/II-IN-6 可以用于研究癫痫。 | |||
T79753 |
hCAIX/XII-IN-8
|
Carbonic Anhydrase | Metabolism |
hCAIX/XII-IN-8(compound 3g)是一种对人类(碳酸酐酶)CA IX和XII高效的抑制剂,Ki值分别为8.5和6.7 nM。该化合物对与肿瘤相关的膜结合异构体hCA IX和XII表现出显著的抑制作用,且相对于胞内异构体hCA I和II具有较高的选择性。 | |||
T72840 |
hCAIX/XII-IN-6
|
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hCAIX/XII-IN-6 是具有口服活性的碳酸酐酶(CA)抑制剂,能够抑制人体 CA 亚型 hCA I、II、IV、IX 及 XII,其 Ki 值分别为 6697 nM、2950 nM、4093 nM、4.1 nM 和 7.7 nM。适用于类风湿关节炎(RA)研究。 | |||
T63276 |
hCAXII-IN-4
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hCAXII-IN-4 是选择性的、有效的 CA XII 抑制剂,对人CA XII 的Ki 值为 6.4 nM。 | |||
T73177 |
hCAII-IN-9
|
Carbonic Anhydrase | Metabolism |
hCAII-IN-9 是一种强效的碳酸酐酶抑制剂,对hCA II、hCA IX 和hCA XII 有抑制作用,IC50 分别为 1.18 μM 和 0.17 μM , and 2.99 μM 。hCAII-IN-9 没有血脑屏障透过性。 | |||
T63005 |
Carbonic anhydrase inhibitor 11
|
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Carbonic anhydrase inhibitor 11 (compound VI) 是一种有效的、选择性碳酸酐酶抑制剂,能够作用于 CA II (Ki: 40 nM)、CA IX (Ki: 39 nM) 和 CA XII (Ki: 900 nM)。 | |||
T83137 |
ALP/Carbonic anhydrase-IN-1
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Carbonic Anhydrase | Metabolism |
ALP/Carbonic anhydrase-IN-1(Compound 1e)为碳酸酐酶(CA)与碱性磷酸酶(ALP)的双效抑制剂。对CA-II、CA-IX、CA-XII和ALP具有显著抑制活性,其IC50值分别为0.44 µM、1.61 µM、0.51 µM和0.107 µM。 | |||
T60602 | hCAIX/XII-IN-5 | ||
hCAIX/XII-IN-5 (Coumarin 9a) 是一种碳酸酐酶 (CA) 抑制剂,具有出色的 hCA IX/XII 选择性,对 hCA I 和 hCA II 的Ki 值分别为 93.9 和 85.7 nM。hCAIX/XII-IN-5 对癌细胞具有抗增殖活性,可延迟细胞周期并诱导细胞凋亡。 | |||
T60930 | CAXII-IN-1 | ||
CAXII-IN-1 (Compound 17) 具有抗肿瘤活性,它是 CA XII 的选择性抑制剂。CAXII-IN-1 对 hCA XII 和 hCA IX 的 Ki 值分别为 3.8 nM 和 56.0 nM。 | |||
T79540 |
hCA/VEGFR-2-IN-1
|
Carbonic Anhydrase | Metabolism |
hCA/VEGFR-2-IN-1 是一种高效的双靶点抑制剂,对 hCA IX 和 hCA XII 两种碳酸酐酶(CA)具有极低的Ki值,分别为8.3 nM和4.7 nM。同时,hCA/VEGFR-2-IN-1 也是一种有效的 VEGFR-2 抑制剂,其 IC50 值仅为26.3 nM,并且显示出抗癌活性。 | |||
T72164 | Enpp/Carbonic anhydrase-IN-2 | ||
Enpp/Carbonic anhydrase-IN-2 是一种有效的 Enpp 和 carbonic anhydrase 抑制剂,对 NPP1、NPP2、NPP3、CA-IX, CA-XII 的 IC50值分别 1.13、 1.07、 0.74、 0.33、 0.68。Enpp/Carbonic anhydrase-IN-2 对癌细胞具有抗增殖活性,对正常细胞具有低细胞毒性。Enpp/Carbonic anhydrase-IN-2 诱导细胞凋亡 (Apoptosis)。 | |||
T61842 |
Carbonic anhydrase inhibitor 14
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Carbonic anhydrase inhibitor 14 (Compound 8b) is a potent CA inhibitor, exhibiting K i values of 1203, 99.7, 9.4, and 27.7 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. Additionally, it effectively inhibits CDK2 with an IC 50 of 20.3 μM. Furthermore, Carbonic anhydrase inhibitor 14 demonstrates significant antitumor activity [1]. | |||
T35876 |
Chlorthalidone Impurity G
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Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) an... | |||
T79748 |
hCAIX/XII-IN-7
|
Carbonic Anhydrase | Metabolism |
hCAIX/XII-IN-7(compound 3e)为高效的hCA IX与XII抑制剂,对hCA I、II、IX与XII的Ki值分别为3.2 nM、9.2 nM、503.7 nM及59 nM,显示其在缺氧肿瘤研究中的应用潜力。 | |||
T78705 |
COX-2-IN-30
|
COX | Immunology/Inflammation; Neuroscience |
COX-2-IN-30 是苯磺酰胺衍生的口服活性 COX/5-LOX 双重抑制剂,其 IC50 值为 COX 同源物为 49 nM、5-LOX 同源物为 10.4 μM。此化合物还能纳摩尔级别 Ki 值抑制 hCA IX 与 hCA XII 亚型。COX-2-IN-30 具备镇痛、抗炎、致溃疡作用,不引发急性胃部反应。 |
Cat. No. | Product Name | Species | Expression System |
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TMPY-00694 |
Carbonic Anhydrase 12 Protein, Human, Recombinant (His)
HsT18816,FLJ20151,carbonic anhydrase XII,<... |
Human | HEK293 Cells |
Carbonic Anhydrase 12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is O43570-1. | |||
TMPK-00478 |
Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His)
CA12,CAXII,Carbonic anhy... |
Cynomolgus | HEK293 Cells |
Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Carbonic anhydrase XII (CA XII) is a key mediator of several signaling pathways that are involved in cancer development. | |||
TMPY-06944 |
Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated
HsT18816,carbonic anhydrase XII,CA |
Human | HEK293 Cells |
Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 33.45 kDa and the accession number is NP_001209.1. |