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Search Results for " bombesin "

37

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1281	Bombesin
	Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina). It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide.
TP2239L	[D-Phe12]-Bombesin acetate [D-Phe12]-Bombesin acetate(108437-87-2 free base)	Bombesin Receptor	GPCR/G Protein
	[D-Phe12]-Bombesin acetate 抑制铃蟾素刺激的分泌。
TP1916L1	[D-Phe12,Leu14]-Bombesin acetate [D-Phe12,Leu14]-Bombesin acetate(108437-88-3 Free base)	Bombesin Receptor	GPCR/G Protein
	[D-Phe12,Leu14]-Bombesin acetate 抑制铃蟾素刺激的分泌。
TP1281L1	Bombesin acetate(31362-50-2 free base)	Bombesin Receptor	GPCR/G Protein
	Bombesin acetate(31362-50-2 free base) 是一种 14 个氨基酸的肽，是从欧洲火腹蟾蜍 (Bombina bombina) 的皮肤中分离出来的。它在哺乳动物中有两个已知的同源物，称为神经调节蛋白 B 和胃泌素释放肽。
TP2239	[D-Phe12]-Bombesin	Others	Others
	Bombesin receptor antagonist
TP1916	[D-Phe12,Leu14]-Bombesin
	Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.
T83490	[Lys3]-Bombesin
	[Lys3]-Bombesin 是具有生物活性的肽类化合物，用于 PET（正电子发射断层扫描）成像检测 GRPR（胃泌素释放肽受体）阳性的前列腺癌。此外，[Lys3]-Bombesin 及其单克隆抗体的免疫缀合物能特异性诱导 CD64 依赖的单核细胞和中性粒细胞介导的小细胞肺癌细胞裂解。
T4540	ML-18	Bombesin Receptor	GPCR/G Protein
	ML-18是一种非肽铃蟾肽受体亚型-3 拮抗剂，能够抑制肺癌生长。
T76601	(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14)
	'(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin(6-14)是一种蛙皮素(bombesin)拮抗剂，主要应用于癌症研究领域。'
T2126	MK-5046	Bombesin Receptor	GPCR/G Protein
	MK5046是一种新型 BRS-3激动剂，同BRS-3结合 (鼠 Ki = 1.6 nM, 人 Ki = 25 nM)的亲和力高。
TP1701	RC-3095 TFA RC-3095 (TFA)	Bombesin Receptor	GPCR/G Protein
	RC-3095 TFA (RC-3095(TFA)) 是蛙皮素/胃泌素释放肽受体选择性拮抗剂。它能降低关节炎小鼠的胃氧化损伤，从而发挥保护作用。
T28740	SDZ-62-434 SDZ 62 434,SDZ62434	Platelet aggregation	Others
	SDZ-62-434 是一种血小板活化因子抑制剂，具有抗肿瘤活性，抑制静止的瑞士 3T3 细胞中 bombesin 和血小板衍生生长因子诱导的 DNA 合成，可用于研究白血病、人异种移植结直肠癌和肺癌。
TP2219L	Alytesin acetate	Others	Others
	Alytesin acetate 是一种两栖类铃蟾肽样肽。
T20603L	Ranatensin acetate	Others	Others
	Ranatensin acetate 是一种从 Rana pipiens 皮肤中分离出来的十一肽，是一种天然存在的铃蟾肽样肽。
TP1913L1	BA 1 acetate(183241-31-8 free base)	Bombesin Receptor	GPCR/G Protein
	BA 1 acetate(183241-31-8 free base) 是一种有效的铃蟾肽受体激动剂（BB1、BB2 和 BB3 的 IC50 值分别为 0.26、1.55 和 2.52 nM）。它增强肥胖和糖尿病原发性肌细胞中的葡萄糖转运，还可在体外刺激 NCI-H1299 肺癌细胞增殖。
TP1442	Neuromedin B 神经介素 B	Endogenous Metabolite	Metabolism
	Neuromedin B 是由10个氨基酸组成的神经肽，属于蛙肽家族，为铃蟾肽相关肽。
TP1931L1	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base)	cholecystokinin	GPCR/G Protein
	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) 是广谱神经肽反向激动剂和拮抗剂。 ghrelin 受体的强效完全反向激动剂(EC50 = 5.2 nM)；减少组成型生长素释放肽受体信号传导。它也是速激肽、缓激肽、CCK 和铃蟾肽受体的拮抗剂。在体外诱导细胞凋亡并抑制癌细胞生长。
T33439	MK-7725 MK7725
	Mk-7725 is an effective selective bombesin receptor subtype 3 agonist for the treatment of obesity.
T70713	BW-10
	BW-10 potently inhibits bombesin evoked release of gastrointestinal hormones in vitro and in vivo.
T20603	Ranatensin
	Ranatensin, a undecapeptide isolated from skin of Rana pipiens, is a naturally occurring bombesin-like peptide.
T28338	PD 165929 PD-165929,PD165929
	PD 165929 is a selective antagonist of Bombesin BB1.
T35669	Neuromedin C (trifluoroacetate salt)
	Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction and the release of gastrin , somatostatin, and amylase in rats. Neuromedin C is a truncated form of gastrin-releasing peptide corresponding to the GRP amino acids 18-27. It inhibits GRP and bombesin binding to rat pancreatic membranes (IC50s = 0.4 and 2.2 nM, respectively), which can be reduced by sodium chloride and guanylyl imidodiphosphate . Neuromedin C induces scratching and mast cell degranulatio...
T25522	Ici 216140 m216140,Ici216140,m 216140,Ici-216140,m-216140
	ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50: 2 nM in vitro). At 2 mg/kg, it can decrease bombesin-stimulated pancreatic amylase secretion in rats. At 1 mM, it has been proved to attenuate bombesin-stimulated increases in blood pressure in rat
TP2219	Alytesin	Others	Others
	Amphibian bombesin-like peptide
T20413	Spantide I Spantide
	Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.
T83548	(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate
	'(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate)' 是一种对 Substance P 及 Bombesin 担任拮抗作用的化合物，能针对眼部三叉神经反向刺激引起的炎症反应产生效果。
T71596	Bag-2
	Bag-2 is a Novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist.
T71595	Bag-1
	Bag-1 is a novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist.
T75945	BA 1 TFA
	BA 1 TFA是一种bombesin (BB)受体家族的激动剂，与Bombesin受体亚型3 (BRS3)、胃泌素释放肽受体 (GRPR)以及神经调节素B受体 (NMBR)具有高度亲和力，其IC50值分别为6、0.4、2.5 nM。
TP1931	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
	Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. In
T80148	GRP (14-27) (human, porcine, canine)	Bombesin Receptor	GPCR/G Protein
	GRP (14-27) (human, porcine, canine) 表现为铃蟾肽受体配体。其特异性结合受到 GTP 和 GDP 的抑制作用，但 GMP 对此无影响。
TP2153	RC-3095 acetate	Others	Others
	RC-3095 acetate is an antagonist of bombesin/gastrin-releasing peptide receptor (GRPR). It exerts protective effects by reducing gastric oxidative injury in the arthritic mice.
T36925	Neuromedin C (porcine)
	Neuromedin C (porcine) 是一种铃蟾肽样神经肽，可从猪脊髓中获得。Neuromedin C (porcine) 对大鼠子宫具有收缩活性。Neuromedin C (porcine) 有研究神经系统相关疾病的潜力。
T75707	BIM-26226
	BIM-26226 是一种胃泌素释放肽，是一种强效选择性的bombesin receptor 拮抗剂。 BIM-26226 抑制 BN 或 GRP 刺激的淀粉酶释放，IC50值在纳摩尔范围内。BIM-26226 可用于癌症研究。
TP2026	GRP (porcine)
	Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice
TP1913	BA 1
	Potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 lung cancer cell proliferation in vitro.
T37819	Brain-Derived Acidic Fibroblast Growth Factor (102-111) (bovine) (trifluoroacetate salt)
	Brain-derived acidic fibroblast growth factor (102-111) is a peptide fragment of brain-derived acidic fibroblast growth factor (aFGF). aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. It also shares sequence homology with the known neuropeptides neuromedin C , bombesin , neuromedin K , substance K , substance P , physalaemin, and eledoisin. aFGF (102-111) corresponds to amino acid residues 102-111 of the fulllength pept...

化合物

Cat.No: TP1281

[D-Phe12]-Bombesin acetate

Cat.No: TP2239L

Synonym: [D-Phe12]-Bombesin acetate(108437-87-2 free base)

Target: Bombesin Receptor

[D-Phe12,Leu14]-Bombesin acetate

Cat.No: TP1916L1

Synonym: [D-Phe12,Leu14]-Bombesin acetate(108437-88-3 Free base)

Target: Bombesin Receptor

Bombesin acetate(31362-50-2 free base)

Cat.No: TP1281L1

Target: Bombesin Receptor

[D-Phe12]-Bombesin

Cat.No: TP2239

Target: Others

[D-Phe12,Leu14]-Bombesin

Cat.No: TP1916

[Lys3]-Bombesin

Cat.No: T83490

Cat.No: T4540

Target: Bombesin Receptor

(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14)

Cat.No: T76601

Cat.No: T2126

Target: Bombesin Receptor

Cat.No: TP1701

Synonym: RC-3095 (TFA)

Target: Bombesin Receptor

Cat.No: T28740

Synonym: SDZ 62 434,SDZ62434

Target: Platelet aggregation

Alytesin acetate

Cat.No: TP2219L

Target: Others

Ranatensin acetate

Cat.No: T20603L

Target: Others

BA 1 acetate(183241-31-8 free base)

Cat.No: TP1913L1

Target: Bombesin Receptor

Cat.No: TP1442

Synonym: 神经介素 B

Target: Endogenous Metabolite

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate

Cat.No: TP1931L1

Synonym: [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base)

Target: cholecystokinin

Cat.No: T33439

Synonym: MK7725

Cat.No: T70713

Cat.No: T20603

Cat.No: T28338

Synonym: PD-165929,PD165929

Neuromedin C (trifluoroacetate salt)

Cat.No: T35669

Cat.No: T25522

Synonym: m216140,Ici216140,m 216140,Ici-216140,m-216140

Cat.No: TP2219

Target: Others

Cat.No: T20413

Synonym: Spantide

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate

Cat.No: T83548

Cat.No: T71596

Cat.No: T71595

Cat.No: T75945

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

Cat.No: TP1931

GRP (14-27) (human, porcine, canine)

Cat.No: T80148

Target: Bombesin Receptor

RC-3095 acetate

Cat.No: TP2153

Target: Others

Neuromedin C (porcine)

Cat.No: T36925

Cat.No: T75707

Cat.No: TP2026

Cat.No: TP1913

Brain-Derived Acidic Fibroblast Growth Factor (102-111) (bovine) (trifluoroacetate salt)

Cat.No: T37819

Cat. No.	Product Name	Target	Signaling Pathways
TN1849	Kuwanon H	GPR; Bombesin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Kuwanon H 是分离自桑白皮的黄酮类化合物，具有拮抗非肽类蛙皮素受体的活性。Kuwanon H 特异性抑制细胞内胃泌激素释放肽 CRP 与GRP-preferring 受体的结合，Ki 为 290 nM。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
T20604L	Litorin acetate(55749-97-8 Free base)	Bombesin Receptor	GPCR/G Protein
	Litorin acetate 是一种两栖类铃蟾肽衍生物，是一种铃蟾肽受体激动剂。它刺激平滑肌收缩，刺激胃泌素、胃酸和胰腺分泌，抑制体内营养。
T20604	Litorin
	Litorin, an amphibian bombesin peptide derivative, is found to suppress the nutriment, to stimulate the contraction of smooth muscle, to stimulate gastrin, gastric acid, and pancreatic secretion.

天然产物

Cat.No: TN1849

Target: GPR, Bombesin Receptor

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Litorin acetate(55749-97-8 Free base)

Cat.No: T20604L

Target: Bombesin Receptor

Cat.No: T20604

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