18
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40412L |
BAD (103-127) (human) acetate
BAD (103-127) (human) acetate (331762-68-6 Free base) |
Others | Others |
BAD (103-127) (human) acetate 是一种来自于 BAD 的 BH3结构域的25-mer Bad 多肽,可拮抗 Bcl-xl 的作用。 | |||
T40412 |
BAD (103-127) (human)
|
||
BAD (103-127) (human) is a 25-mer peptide obtained from the BH3 domain of BAD. It effectively counteracts the activity of Bcl-xL. Notably, BAD (103-127) (human) exhibits an approximately 800-fold greater binding affinity for Bcl-xL compared to the 16-mer peptide. | |||
T80223 |
Bad BH3 (mouse)
|
||
Bad BH3 (mouse) 是源自 Bad 蛋白的 BH3 结构域(亦称死亡结构域)的氨基酸残基 140 至 165 的一种生物活性肽,它是 bcl-2 结合肽。 | |||
T1834 |
CX-6258
CX 6258 |
Pim | Chromatin/Epigenetic; JAK/STAT signaling |
CX-6258是一种强效选择性的泛 Pim 激酶抑制剂,对Pim-1、Pim-2 和 Pim-3 作用的IC50值分别为 5、25 和 16 nM。 | |||
T76082 |
BAD (103-127) (human), FAM-labeled
|
||
BAD (103-127) (human), FAM-labeled 是带 FAM 标签的人 BAD (103-127) 。BAD (103-127) (human) 是 25-mer Bad 多肽,来自 BAD 的 BH3 结构域,具有拮抗Bcl-xL 的作用。 | |||
T6148 |
CX-6258 hydrochloride
CX-6258 HCl,Pim-Kinase Inhibitor X |
Pim | Chromatin/Epigenetic; JAK/STAT signaling |
CX-6258 hydrochloride (Pim-Kinase Inhibitor X) 是一种强效选择性的泛 Pim 激酶抑制剂,对Pim-1、Pim-2 和 Pim-3 作用的IC50值分别为 5、25 和 16 nM。 | |||
T8978 |
DD1
3,3'-Diamino-4'-methoxyflavone,HUN85111 |
Proteasome | Proteases/Proteasome; Ubiquitination |
DD1 (HUN85111) 是一种蛋白酶体抑制剂,可诱导人髓系肿瘤选择性凋亡。 | |||
T22596 |
BADGE
|
PPAR | DNA Damage/DNA Repair; Metabolism |
BADGE 是一种标准化的化学过敏原。它的生理作用是通过增加组胺释放和细胞介导的免疫来实现的。 | |||
T0770 |
Carbadox
Getroxel,卡巴多,Mecadox |
Antibacterial; Antibiotic | Microbiology/Virology |
Carbadox (Mecadox) 是一种喹喔啉二氧化氮抗生素,用于育龄期的猪,治疗猪痢疾和肠炎,促进成长。 | |||
T14498 |
Barbadin
|
Arrestin | GPCR/G Protein |
Barbadin 是一种新型且具有特异性的 β-arrestin/β2-adaptin 相互作用抑制剂,对β-arestin1 的 IC50 值为 19.1 μM,对β-arestin2 的 IC50 值为 15.6 μM。Barbadin 增强氯卡色林对 POMC 神经元和减肥的长期影响,可阻断激动剂促进的原型 β2-肾上腺素能、V2-血管加压素和血管紧张素-II-1 型受体的内吞,可用于研究肥胖。 | |||
T35760 |
Carnaubadiol
|
||
Carnaubadiol is a triterpene that has been found in E. corollata and has antiprotozoal activities.1,2 It is active against L. infantum promastigotes and amastigotes, as well as T. cruzi trypomastigotes (IC50s = 46.2, 7.8, and 14.9 μM, respectively).2 |1. Piatak, D.M., and Reimann, K.A. Plant investigations IV. Corollatadiol A new triterpene from euphorbia corollata. Tetrahedron Lett. 13(44), 4525-4528 (1972).|2. de Almeida, B.C., Araújo, B.Q., Carvalho, A.A., et al. Antiprotozoal activity of ext... | |||
T40635 |
Desoxycarbadox
|
||
Desoxycarbadox, derived from Carbadox, is a quinoxaline-di-N-oxide antibiotic compound. | |||
T33404 |
MitoBADY
Mito-BADY,Mito BADY |
||
Mitobady is a sensitive and specific Raman probe, which can be used for living cell imaging of mitochondria. | |||
T78067 |
Stobadine
(-)-Stobadine |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Stobadine是一种抗氧化剂,能抑制自由基导致的内质网膜流动性变化,可作为基于抗氧化和清除自由基机制的心脏和神经保护剂研发的侯选药物[sup][1]。 | |||
T12249 |
NPB
Alpha-NPB |
Others | Others |
NPB (Alpha-NPB) 是一种特异且有效的抑制 BAD Ser99 磷酸化的抑制剂, IC50为 0.41 μM。 | |||
TP2127 |
R18
|
||
Antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. | |||
TP2128 |
R8-T198wt
|
||
Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells | |||
T71230 |
VMY-1-103
|
||
VMY-1-103 is a potent CDK inhibitor, is also a novel dansylated analog of purvalanol B, was shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B. VMY-1-103 , but not purvalanol B, significantly decreased the proportion of cells in S phase and increased the proportion of cells in G(2)/M. VMY-1-103 increased the sub G(1) fraction of apoptotic cells, induced PARP and caspase-3 cleavage and increased the levels of the Death ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15258 |
Euphorbadienol
alpha-Euphorbol |
Others | Others |
Euphorbadienol is a triterpenic compound isolated from the latex of Euphorbia resinifera. It has antileishmanial and antitrypanosomal activity. | |||
T4S0498 |
Glaucocalyxin A
蓝萼甲素,Wangzaozin B,Leukamenin F |
Apoptosis; Akt; Caspase; PI3K | Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。 | |||
T4827 |
Trimethylammonium chloride
三甲胺盐酸盐,Trimethylamine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
Trimethylammonium chloride (Trimethylamine hydrochloride) 是动植物分解的产物。它是造成鱼腥味的主要物质,通常与脏鱼、细菌性阴道感染和口臭有关。它也与服用大剂量胆碱有关。三甲胺尿是一种遗传性疾病,身体无法从食物中代谢三甲胺。食用富含胆碱的食物后,患者的汗液、尿液和呼吸中会出现特有的鱼腥味。三甲胺尿症是一种常染色体隐性遗传病,涉及三甲胺氧化酶缺乏症。三甲氨基尿症在罗德岛红鸡中也有发现,这种鸡产的蛋有腥味。尿液中的 Trimethylammonium chloride 是食用豆类的生物标志物。 | |||
TN6419 | Chamaejasmine | ||
Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and induces Bax expression to desintegrate |