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28

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22136	PRL-3 Inhibitor I PRL-3 Inhibitor,BR-1	Phosphatase; Others	Metabolism; Others
	PRL-3 Inhibitor I (BR-1) 是 PRL-3 抑制剂，IC50=0.9 μM。它在细胞检测中显示降低侵袭性。
TP1549L	NY-BR-1 p904 A2 acetate(347142-73-8 free base)	Others	Others
	NY-BR-1 p904 A2 acetate(347142-73-8 free base) 对这种 NY-BR-1 表位 (p904) 特异的 T 细胞克隆可以识别表达 NY-BR-1 的乳腺肿瘤细胞。
T18161	m-PEG2-Br 1-溴-2-(2-甲氧基乙氧基)乙烷	Others; PROTAC Linker	Others; PROTAC
	m-PEG2-Br 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
TP1549	NY-BR-1 p904 (A2) NY-BR-1 p904 A2
	T-cell clones specific for this NY-BR-1 epitope (p904) can recognize breast tumor cells expressing NY-BR-1.
T9855	BR102910 4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-	Others	Others
	BR102910 (4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-) 是一种选择性的成纤维细胞活化蛋白（FAP）的抑制剂。
T38717	Cyclohexane-PEG1-Br Cyclohexane-PEG1-Br
	Cyclohexane-PEG1-Br is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18552	Pomalidomide-amido-C1-Br	Others	Others
	Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1].
T39160	N-Ethyl-N-methylpropionamide-PEG1-Br N-Ethyl-N-methylpropionamide-PEG1-Br
	N-Ethyl-N-methylpropionamide-PEG1-Br is a PEG-derived PROTAC linker suitable for the synthesis of PROTACs.
T39021	N-Ethylpropionamide-PEG1-Br N-Ethylpropionamide-PEG1-Br
	N-Ethylpropionamide-PEG1-Br is a polyethylene glycol (PEG) derived PROTAC linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs).
T77835	Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Br
	Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Br 为ADC linker，适用于ABBV-154、ABBV-927及ABBV-368或相似化合物的合成。
T75130	Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br
	Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br 作为一种Drug-linker conjugates for ADC，主要用于抗CD40抗体活性分子偶联物 (ADCs) 的合成, 充当反应试剂。
T17654	Boc-NH-C6-Br N-BOC-6-溴代己胺	Others	Others
	Boc-NH-C6-Br 是一种可切割的 ADC 接头，用于合成抗体-药物偶联物。
T40574	Br-C3-methyl ester Br-C3-methyl ester
	Br-C3-methyl ester is an alkyl/ether-based PROTAC linker utilized for the synthesis of PROTAC PD-1/PD-L1 degrader-1.
T14771	Br-PEG4-C2-Boc	Others	Others
	Br-PEG4-C2-Boc is a cleavable 4-unit PEG ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T60359	cis-4-Br-2,5-F2-PCPA
	cis-4-Br-2,5-F2-PCPA (S1024) 抑制 LSD1 和 LSD2，Ki 值分别为 94 nM 和 8.4 μM。癌症干细胞中 LSD1异常表达，cis-4-Br-2,5-F2-PCPA 能够通过增加 CCRF-CEM 细胞中二甲基化组蛋白 H3 的 K4 (H3K4) 水平，抑制 LSD1活性和癌细胞增殖。
T18668	(S,R,S)-AHPC-Me-C10-Br	Others	Others
	(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate that functions as a ligand-linker for E3 ligases. This compound incorporates a VHL E3 ligase linker and MS432, derived from the MEK1/2 inhibitor PD0325901[1].
T16619	Propargyl-PEG4-Br	Others	Others
	Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T15872	m-PEG4-Br	Others	Others
	m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in v
T14772	Br-PEG4-CH2-Boc	Others	Others
	Br-PEG4-CH2-Boc, a PEG- and Alkyl/ether-based PROTAC linker, serves as a valuable component for the synthesis of PROTACs[1].
T83513	(αR)-Cyclopropaneacetamide-Exatecan
	(αR)-Cyclopropaneacetamide-Exatecan (化合物2-A)作为一种Exenotecan衍生物，具有细胞毒性。该化合物在抑制U87MG和SK-BR-3细胞株的增殖方面表现出显著效力，其IC50值分别为8.11 μM和2.31 μM。
T23028	MRT67307 HCl (1190378-57-4 free base) MRT67307 HCl	Others	Others
	MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth...
T82602	DCI-Br-3
	DCI-Br-3是一种检测癫痫脑硫醇的快速、高灵敏度和选择性探针（λex=537 nm，λem=675 nm），能有效穿透血脑屏障（BBB）。
T74751	Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
	Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V)，作为抗体偶联药物(ADC)的药物连接体部分，该化合物通过linker与topoisomeraseI抑制剂相连。
T77906	Briobacept BR 3FC
	Briobacept (BR 3FC)为专门针对BLyS(BAFF)的单克隆抗体，具有诱导B细胞凋亡(apoptosis)的能力。该化合物是一种重组糖蛋白，由两个BLyS受体(BR3)以及人类IgG1 Fc结构域构成。Briobacept主要用于类风湿关节炎(RA)的研究领域。
T37564	C4 Ceramide (d18:1/4:0) C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)
	C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing...
T35683	2-deoxy-D-Glucose-13C6 2-deoxy-D-Glucose-13C6
	2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B oste...
T35840	4-Amino-6-chloro-1,3-benzenedisulfonamide
	4-Amino-6-chloro-1,3-benzenedisulfonamide is a carbonic anhydrase inhibitor.1 Formulations containing this compound are diuretics.2 4-Amino-6-chloro-1,3-benzenedisulfonamide is detected as a hydrolysis product of chlorothiazide in the urine.2 Diuretics, including chlorothiazide, have been abused as performance-enhancing drugs and masking agents in sports doping.3References1. Nishimori, I., Vullo, D., Minakuchi, T., et al. Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies ...
T37297	Ru360
	Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2]. Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial ce...

化合物

PRL-3 Inhibitor I

Cat.No: T22136

Synonym: PRL-3 Inhibitor,BR-1

Target: Phosphatase, Others

NY-BR-1 p904 A2 acetate(347142-73-8 free base)

Cat.No: TP1549L

Target: Others

Cat.No: T18161

Synonym: 1-溴-2-(2-甲氧基乙氧基)乙烷

Target: Others, PROTAC Linker

NY-BR-1 p904 (A2)

Cat.No: TP1549

Synonym: NY-BR-1 p904 A2

Cat.No: T9855

Synonym: 4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-

Target: Others

Cyclohexane-PEG1-Br

Cat.No: T38717

Synonym: Cyclohexane-PEG1-Br

Pomalidomide-amido-C1-Br

Cat.No: T18552

Target: Others

N-Ethyl-N-methylpropionamide-PEG1-Br

Cat.No: T39160

Synonym: N-Ethyl-N-methylpropionamide-PEG1-Br

N-Ethylpropionamide-PEG1-Br

Cat.No: T39021

Synonym: N-Ethylpropionamide-PEG1-Br

Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Br

Cat.No: T77835

Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br

Cat.No: T75130

Cat.No: T17654

Synonym: N-BOC-6-溴代己胺

Target: Others

Br-C3-methyl ester

Cat.No: T40574

Synonym: Br-C3-methyl ester

Cat.No: T14771

Target: Others

cis-4-Br-2,5-F2-PCPA

Cat.No: T60359

(S,R,S)-AHPC-Me-C10-Br

Cat.No: T18668

Target: Others

Propargyl-PEG4-Br

Cat.No: T16619

Target: Others

Cat.No: T15872

Target: Others

Br-PEG4-CH2-Boc

Cat.No: T14772

Target: Others

(αR)-Cyclopropaneacetamide-Exatecan

Cat.No: T83513

MRT67307 HCl (1190378-57-4 free base)

Cat.No: T23028

Synonym: MRT67307 HCl

Target: Others

Cat.No: T82602

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

Cat.No: T74751

Cat.No: T77906

Synonym: BR 3FC

C4 Ceramide (d18:1/4:0)

Cat.No: T37564

Synonym: C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)

2-deoxy-D-Glucose-13C6

Cat.No: T35683

Synonym: 2-deoxy-D-Glucose-13C6

4-Amino-6-chloro-1,3-benzenedisulfonamide

Cat.No: T35840

Cat.No: T37297

Cat. No.	Product Name	Target	Signaling Pathways
TN5012	Shizukaol C	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxicities against C8166 cells. <br/>
T75558	Bruceine J
	Bruceine J 是一种类黄酮，是一种天然产物，可以从Br. jaVanica 的果实中分离得到。Bruceine J 具有抗巴贝斯活性。
TN4411	Lappaol F	CDK; P-gp; JNK	Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience
	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju
TN2760	2-Hydroxy-1,8-cineole	Antifection	Microbiology/Virology
	1. 2-endo-Hydroxy-1,8-cineole shows antimicrobial and bactericidal activities against against test bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescens) .<BR/>
TN2934	3''-Galloylquercitrin	Others	Others
	1. 3''-Galloylquercitrin possesses the activity for PTK inhibition. <br/>
T82691	Complanatin
	Complanatin，一种从黄芪中分离得到的酰基化黄酮醇苷。
T79932	Eudebeiolide B Plebeiolide D	NF-κB	NF-κB
	Eudebeiolide B，一种自荔枝草分离得的化合物，能通过调控RANKL诱导的NF-κB、c-Fos及钙信号来抑制破骨细胞的生成，适用于研究与破骨细胞相关的疾病。
T37452	Stephacidin B
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: TN5012

Target: HIV Protease, Antifection

Cat.No: T75558

Cat.No: TN4411

Target: CDK, P-gp, JNK

2-Hydroxy-1,8-cineole

Cat.No: TN2760

Target: Antifection

3''-Galloylquercitrin

Cat.No: TN2934

Target: Others

Cat.No: T82691

Cat.No: T79932

Synonym: Plebeiolide D

Target: NF-κB

Cat.No: T37452

Cat.No: T36954

Cat.No: T35779

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