Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4656 |
RAD51 Inhibitor B02
B02 |
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RAD51 Inhibitor B02 (B02) 是一种人 RAD51的抑制剂,IC50值为27.4 μM。 | |||
T2286 |
BIIB021
BIIB 021,CNF2024,BIIB-021 |
HSP; Autophagy | Autophagy; Cytoskeletal Signaling; Metabolism |
BIIB021 (CNF2024) 是一种可口服的合成 HSP90 抑制剂,Ki 值和EC50值分别为 1.7 nM 和 38 nM。 | |||
T14491 |
B022
|
NF-κB | NF-κB |
B022 是一种具有选择性和高效性的 NF-κB 诱导激酶(NIK)抑制剂(Ki:4.2 nM),是治疗肝脏炎症和损伤的化学探针。B022 可避免肝脏免受氧化应激和毒素引起的炎症和损伤。 | |||
T9821 |
ART-CHEM-BB B025267
2-(4-二乙基氨基苯基)-6-甲基-5-苯并三唑胺 |
Others | Others |
ART-CHEM-BB B025267 是 utrophin 生成的上调剂,EC50 为 1.8 μM,可用于治疗 Duchenne 肌营养不良症的研究。 | |||
T18060 |
KB02-JQ1
|
Others | Others |
KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or BRD3. The mechanism of action involves covalent modification of the E3 ligase DCAF16, thereby promoting BRD4 degradation. Importantly, KB02-JQ1 demonstrates enhanced stability and durability in facilitating protein degradation within biological systems. The compound forms a complex with the ubiquitin E3 ligase ligand KB02 through a link... | |||
T10704 |
CCB02
|
Microtubule Associated | Cytoskeletal Signaling |
CCB02 是选择性的 CPAP-tubulin 相互作用抑制剂。CCB02能够与 tubulin 结合,竞争 β-tubulin 的 CPAP 结合位点,IC50 值为 689 nM,显示出高效的抗肿瘤活性。CCB02 对其他的蛋白没有抑制作用,包括中心体、细胞周期相关蛋白,对 Aurora A,Plk1,Plk2,CDK2 和 CHK1 的磷酸化状态也无作用。 | |||
T63940 | B026 | ||
B026 是选择性的、口服具有活力的 p300/CBP 组蛋白乙酰转移酶 (p300/CBP HAT) 抑制剂,能够作用于 p300 (IC50: 1.8 nM) 和 CBP (IC50: 9.5 nM)。B026 对雄激素受体阳性 (AR+) 前列腺癌细胞表现出抗癌效果。 | |||
T26505 |
AB023b
AB-023b,AB 023b |
||
AB023b is an antibiotic with antifungal properties. | |||
T78296 |
IMAB027
ASP1650 |
||
IMAB027 (ASP1650)是针对CLDN6 (Claudin 6)的特异性单克隆抗体,CLDN6作为一种紧密连接蛋白,其在多种人类癌症中异常高表达,尤其显著于卵巢癌。IMAB027展现出抗肿瘤特性,并能诱导表达CLDN6的卵巢癌和睾丸癌细胞走向凋亡。 | |||
T26504 |
AB023a
AB 023a,AB-023a |
||
AB023a is an antibiotic with antifungal properties. | |||
T18061 | KB02-SLF | Others | Others |
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of protein degradation in biological systems. The compound SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, resulting in the formation of KB02-SLF[1]. | |||
T68383 |
BIIB028
|
||
BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to o... | |||
T39923 |
KB02-COOH
KB02-COOH |
||
KB02-COOH is a synthetic fragment derived from ubiquitin E3 ligase ligand KB02, which possesses potential utility in the synthesis of PROTAC compounds. Notably, KB02-COOH can be employed in the generation of PROTAC constructs like KB02-JQ1 and KB02-SLF. | |||
T69888 |
SB02024
|
||
SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity... | |||
T9271 |
RAD51-IN-1
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RAD51-IN-1 是 B02 的衍生物,是一种RAD51的有效抑制剂,可研究癌症。 |