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54

抑制剂 & 化合物

28

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1389	Dyclonine hydrochloride 盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl	Sodium Channel; Antibacterial; Antifungal	Membrane transporter/Ion channel; Microbiology/Virology
	Dyclonine hydrochloride (Dyclonine HCl) 是润喉片的有效成分，具有显著的杀菌和杀真菌作用。
T25214	CCR-11 CCR11,CCR 11	Antibiotic	Microbiology/Virology
	CCR-11 是一种具有抗菌活性的绕丹宁衍生物。 CCR-11 可以抑制 B. subtilis细胞和 HeLa 细胞增殖。 CCR-11 通过抑制 FtsZ 的组装和 GTPase 活性来抑制细菌增殖和细菌胞质分裂。 CCR-11 具有潜在的抗肿瘤活性，可用于研究乳腺癌和小儿骨髓增生异常。
T22387	NSC 55655 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione	Others	Others
	NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) 具有抗菌和抗氧化活性，抑制 B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi ，A. niger 和 C. albicans 的增殖，可用于糖尿病。
T7449	o-Phenanthroline monohydrate Phenanthroline monohydrate,1, 10-Phenanthroline monohydrate,邻菲罗啉	MMP	Proteases/Proteasome
	o-Phenanthroline monohydrate (1, 10-Phenanthroline monohydrate) 是一种金属螯合剂，能够与 Fe2+形成红色螯合物，λmax为 510 nm，可防止链脲佐菌素诱导染色体畸变。它也是一种 MMP 的抑制剂。
T10337	Antimicrobial Compound 1	Antibacterial	Microbiology/Virology
	Antimicrobial Compound 1 是一种烷基吡啶鎓化合物，尾部为 12C，头部为 4-羧基。 Antimicrobial Compound 1 对枯草芽孢杆菌和大肠杆菌具有抗菌活性。
T21831	UCM05 G28UCM	Fatty Acid Synthase	Metabolism
	UCM05 (G28UCM) (G28UCM) 是一种有效的脂肪酸合酶 (FASN) 抑制剂，对 HER2+ 乳腺癌异种移植物具有作用活性，且在抗 HER2 耐药细胞系中具有活性。UCM05 是一种丝状温度敏感蛋白 Z (FtsZ) 抑制剂，可抑制革兰氏阳性菌B. subtilis 生长，MIC 值为 100 μM，但对革兰氏阴性菌E. coli 缺乏活性。
T24527	Netzahualcoyone
	Netzahualcoyone inhibited the respiration of intact cells of B. subtilis but had no effect on the respiration of E. coli.
T80380	Cyclopetide 2
	Cyclopeptide 2 (Compound 2) 是中等活性抗菌肽，对B. subtilis的最小抑菌浓度（MIC）为50 μg/mL。
T27389	Frequentin
	Frequentin, an antibiotic originally isolated from P. frequentans, is active against bacteria (MICs = 200 and 300 µg/ml for B. subtilis and S. aureus, respectively) and fungi.
T80379	Cyclopetide 1
	Cyclopeptide 1 (Compound 1) 是抗菌肽，对 B. subtilis 表现出中等抑制效果，最小抑菌浓度 (MIC) 为 25 μg/mL。
T80290	PP102
	PP102为一种抗菌肽，针对革兰氏阴性及革兰氏阳性细菌展现出抗菌效能，具体作用于B. subtilis（MIC: 25 uM）、S. aureus（MIC: 13 uM）、S. lutea（MIC: 63 uM）和B. pumilu（MIC: 23 uM）。
T64054	Antibacterial agent 88
	Antibacterial agent 88 是一种有效的抗细菌剂，能够作用于 B. subtilis (MIC: 4 μg/ml)，对 MRSA、MRSE 和 S. aureus 的 MIC 值均为 ≤0.0156 μg/mL。
T80284	LMW peptide
	LMW peptide是具有广泛抗菌活性的化合物，能有效针对多种细菌，包括革兰氏阳性菌如B. subtilis和L. monocytogenes，以及革兰氏阴性菌如E. coli、P. aeruginosa和V. cholera。
T36659	Boromycin
	Boromycin is a boron-containing macrolide antibiotic that has been found in Streptomyces. Boromycin inhibits growth of B. subtilis (MIC = 0.05 μg/ml) and induces efflux of potassium ions from B. subtilis without affecting Na+/K+-ATPase activity. It decreases the synthesis of protein, RNA, and DNA in B. subtilis when used at a concentration of 0.05 μg/ml. It inhibits the growth of B. halodurans (MIC = 10 ng/ml) and inhibits the futalosine pathway of menaquinone synthesis in B. halodurans. Boromyc...
T37254	Rugulotrosin A
	Rugulotrosin A is an antibiotic originally isolated from Penicillium. It is active against the Gram-positive bacteria E. faecalis, B. cereus, B. subtilis, and S. aureus with 99% lethal dose (LD99) values of 1.6, 3.1, 5.5, and 200 μg/ml, respectively. Rugulotrosin A is inactive against Gram-negative bacteria.
T80365	Maximin H39
	Maximin H39为一种抗菌肽，对C. albicans、S. aureus、B. subtilis展示抗菌活性（MIC: 9.4, 9.4, 18.8 μg/mL），且对人类及兔子红细胞具溶血活性。
T36904	Nanangenine B
	Nanangenine B is a drimane sesquiterpene that has been found inAspergillus.1It is active againstB. subtilis(IC50= 62 μg/ml) and cytotoxic to NS-1 mouse myeloma cells (IC50= 38 μg/ml). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)
T38102	Decatromicin B
	Decatromicin B is a bacterial metabolite that has been found in Actinomadura. It is active against Gram-positive bacteria, including several strains of S. aureus (MICs = 0.39-0.78 μg/ml), two strains of methicillin-resistant S. aureus (MRSA; MICs = 0.39 and 0.78 μg/ml), as well as M. luteus, B. subtilis, and C. bovis (MICs = 0.78, 0.78, and 6.25 μg/ml, respectively).
T80396	Im6
	Im6是一种具有针对金黄色葡萄球菌和枯草芽孢杆菌(革兰氏阳性细菌)的抗菌活性的抗菌肽。
T80369	Maximin 68
	Maximin 68为抗菌肽，其对C. albicans、S. aureus、E. coli、B. subtilis显示出抗菌活性（MIC分别为18.8、9.4、37.5、9.4 μg/mL），并对人和兔红细胞表现出溶血活性。
T80301	Aurein 3.1	Antibiotic	Microbiology/Virology
	Aurein 3.1为一种具备针对革兰氏阳性菌的抗菌活性的抗生素抗菌肽，MIC值显示对M. luteus、S. aureus、S. epidermis、S. mutans及B. subtilis的有效浓度分别为80, 50, 50, 50, 50 μM。
T80300	Aurein 2.6	Antibiotic	Microbiology/Virology
	Aurein 2.6为具有针对革兰氏阳性菌抗菌效力的抗生素肽。该化合物在抗菌活性上表现出对M. luteus、S. aureus、S. epidermis、S. mutans、B. subtilis的最小抑菌浓度（MIC）分别为25、25、30、25、30μM。
T80288	PP13
	PP13是一种具有广谱抗菌活性的抗菌肽，有效针对多种革兰氏阴性及革兰氏阳性细菌，包括E.coli (MIC: 16.7 uM)、B. subtilis (MIC: 13.3 uM)、S. aureus (MIC: 23.3 uM)、S. lutea (MIC: 8.0 uM)以及B. pumilu (MIC: 9.0 uM)。
T38290	Leucomycin A4 Leucomycin A4
	Leucomycin A4 is a macrolide antibiotic that has been found in S. kitasatoensis. It is active against a variety of bacteria, including S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, and H. influenzae (MICs = 0.15, 1.25, 0.15, 0.6, and 0.15 μg/ml, respectively).
T80291	PP113
	PP113是一种具有广谱抗菌性的抗菌肽，能有效作用于多种革兰氏阴性及革兰氏阳性细菌。对E.coli (MIC: 73.3 uM)、B. subtilis (MIC: 23.3 uM)、S. aureus (MIC: 13 uM)、S. lutea (MIC: 16.7 uM)及B. pumilus (MIC: 23.3 uM)表现出不同程度的最小抑菌浓度(MIC)。
T38334	Corynecin III
	Corynecin III is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It inhibits the growth of Gram-positive and Gram-negative bacteria, including S. faecalis, S. aureus, B. subtilis, E. coli, P. aeruginosa, P. vulgaris, S. sonnei, S. typhosa, and K. pneumoniae (MICs = 2.6-83 μg/ml).
T80368	Im5
	Im5 是一种具有针对 Escherichia coli、Staphylococcus aureus、Bacillus subtilis 的抗菌活性（MIC:10、2.5-5、0.5-1 μM)的抗菌肽，同时表现出溶血性（EC50: 28 μM）。
T80364	Maximin 45
	Maximin 45为一种具备抗菌特性的肽类化合物，针对S. aureus、E. coli、B. subtilis展现出了抗菌活性（MIC分别为4.7、9.4、75 μg/mL），同时，Maximin 45对人类和兔子红细胞显示出溶血活性。
T13149	Thiocillin I	Antibacterial	Microbiology/Virology
	Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains(MIC of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively).
T38014	Heronapyrrole B
	Heronapyrrole B is a farnesylated 2-nitropyrrole bacterial metabolite that has been found inStreptomycesand has antibacterial activity.1,2It is active against the Gram-positive bacteriaS. aureusandB. subtilis(MICs = 1.8 and 7.5 μM, respectively) but not Gram-negativeP. aeruginosaorE. coli.1 1.Raju, R., Piggott, A.M., Diaz, L.X.B., et al.Heronapyrroles A-C: farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces spOrg. Lett.12(22)5158-5161(2010) 2.Matsuo, T., Hashimoto, S., Ni...
T80367	Maximin 78
	Maximin 78为一种具有广谱抗菌性能的肽类化合物。该化合物展现出针对C. albicans、S. aureus、B. subtilis的显著抗菌活性，最小抑菌浓度（MIC）分别为37.5、4.7、37.5 μg/mL。此外，Maximin 78对人类和兔子红细胞显示出溶血活性。
T37731	TPU-0037A
	TPU-0037A is an antibiotic and a congener of lydicamycin . It inhibits the growth of Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml), but not Gram-negative E. coli, P. mirabilis, P. vulgaris, or P. aeruginosa strains (MICs = >50 μg/ml).
T37286	1-Undecanoyl-rac-glycerol
	1-Undecanoyl-rac-glycerol is a monoacylglycerol that contains undecanoic acid at the sn-1 position. It completely inhibits the growth of the bacteria B. cereus, B. subtilis, M. luteus, E. faecalis, and S. aureus when used at concentrations ranging from 250 to 1,500 mg/L.1 1-Undecanoyl-rac-glycerol (0.1 and 0.3 mg/ml) also has antifungal activity against K. marxianus, S. cerevisiae, and C. maltosa.2
T63252	Antibacterial agent 113
	Antibacterial agent 113 是有效的抗菌剂 (antibacterial)，对P.aeruginosa、S.mutans、B.subtilis、E.coli、E.faecalis、S.typhimuriumand 和S.aureus microorganisms 表现出抗菌作用，MIC 值均为 15625 μM。
T36025	Deoxyviolacein
	Deoxyviolacein is a bacterial metabolite and byproduct in the biosynthesis of the bisindole alkaloid violacein that has anticancer, antibacterial, and antifungal properties. It inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 μM. Deoxyviolacein (125 μg/ml) has antibacterial activity against Gram-positive bacteria, including S. aureus, B. subtilis, and B. megaterium. It also has antifungal activity against R. solani when used at a concentr...
T38289	Leucomycin A13 Leucomycin A13
	Leucomycin A13 is a macrolide antibiotic and a component of the leucomycin complex originally isolated from S. kitasatoensis. It is active against B. subtilis, S. aureus, M. luteus, and E. coli with MIC values of 0.16, 0.16, 0.08 and >10 μg/ml, respectively. It binds to ribosomes with an IC50 value of 1.2 μM in a radioligand binding assay.
T72002	Carbazomycin C
	Carbazomycin C is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus, the fungi T. asteroides and T. mentagrophytes, and P. falciparum. It is also active against a panel of five plant pathogenic fungi. Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells. It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts.
T75172	Antibacterial agent 143
	Antibacterial agent 143 (Compound 5a) 是一种抗菌 (antibacterial) 剂，对 B. subtilisATCC6633、. aureusATCC6538、P. aeruginosaATCC13525 和E. coliATCC35218 的 MIC 值分别为 25、25、50 和 50 μg/mL。
T37598	D-Glucosamine-6-sulfate
	D-Glucosamine-6-sulfate is a naturally occurring glycosaminoglycan. It activates the glmS ribozyme from B. subtilis, a Gram-positive bacterium, when used at a concentration of 200 μM. It has been used to form polyvalent dendrimer conjugates that inhibit angiogenesis and endothelial cell proliferation induced by FGF-2 in vitro and prevent scar tissue formation in a rabbit model of glaucoma surgery.
T38167	BE-24566B
	BE-24566B is a polyketide fungal metabolite originally isolated fromS. violaceusniger.1It is active againstB. subtilis,B. cereus,S. aureus,M. luteus,E. faecalis, andS. thermophilus(MICs = 1.56, 1.56, 1.56, 1.56, 3.13, and 3.13 μg/ml, respectively). BE-24566B is an endothelin (ET) receptor antagonist (IC50s = 11 and 3.9 μM for ETAand ETBreceptors, respectively).2 1.Kojiri, K., Nakajima, S., Fuse, A., et al.BE-24566B, a new antibiotic produced by Streptomyces violaceusnigerJ. Antibiot. (Tokyo)48(1...
T36330	Terrecyclic Acid
	Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs = 25, 50, and 25 μg/ml, respectively). Terrecyclic acid induces a heat shock response, increases levels of reactive oxygen species (ROS), and inhibits NF-κB activity and cell growth in 3T3-Y9-B12 cells. In vivo, terrecyclic acid (0.1, 1, and 10 mg/ml) reduces the number of ascitic fluid tumor cells in a mouse model of P3...
T37719	Galbinic Acid
	Galbinic acid is a depsidone lichen metabolite that has been found in U. undulata.1,2 It is active against the Gram-positive bacteria B. cereus, B. subtilis, and S. aureus, but not S. epidermidis (MICs = 62.5, 62.5, 250, and >250 μg/ml, respectively), as well as the Gram-negative bacterium E. coli, but not S. sonnei (MICs = 125 and >250 μg/ml, respectively).3 \|1. Salgado, F., Albornoz, L., Cortéz, C., et al. Secondary metabolite profiling of species of the genus Usnea by UHPLC-ESI-OT-MS-MS. Mole...
T36748	Heliquinomycin
	Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.1It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis, and methicillin-sensitive or -resistantS. aureus(MICs = <0.05-0.39 μg/ml). Heliquinomycin inhibits the activity of DNA helicase with a Kivalue of 6.8 μM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 μg/ml, resp...
T36183	Neospiramycin I
	Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain ofS. aureus(MICs = 3.12 and >100 μg/ml, respectively), as well asB. cereus,B. subtilis,M. luteus,E. coli, andK. pneumoniae(MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 μg/ml, respectively). Neospiramycin I binds toE. coliribosomes with an IC50value of 1.2 μM. It protects against mortality in a mouse model ofS. pneumoniaetype III...
T36021	Flumequine-13C3 Flumequine-13C3
	Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl...
T35671	Salazinic Acid
	Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively).2 It increases the wound closure rate in scratch-wounded HaCaT monolay...
T36431	7,10-dihydroxy-8(E)-Octadecenoic Acid
	7,10-dihydroxy-8(E)-Octadecenoic acid is a hydroxy fatty acid and metabolite of oleic acid that is produced byP. aeruginosafrom vegetable oils.1It is active against the food-borne pathogenic bacteriaS. aureus,S. typhimurium,L. monocytogenes,B. subtilis, andE. coli(MIC50s = 31.3, 125, 125, 62.5, and 250 μg/ml, respectively), as well as the plant pathogenic bacteriaErwinia,R. solanacearum,C. glutamicum, andP. syringae(MIC90s = 125, 125, 250, and 500 μg/ml, respectively).2,1 1.Sohn, H.-R., Bae, J.-...
T37468	Siamycin I
	Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities. It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 μM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = ...
T64160	MraY-IN-3
	MraY-IN-3 (12a) 是一种细菌转位酶 MraY 的有效抑制剂 (IC50: 140 μM)。MraY-IN-3 能够作用于 E. coli K12 (MIC: 7 μg/ml)、B. subtilis W23 (MIC: 32 μg/ml)、P. fluorescens Pf-5 (MIC: 46 μg/ml)。
T36096	Thiocoraline
	Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus,B. subtilis, andM. luteus(MICs = 0.05, 0.05, and 0.03 μg/ml, respectively) but not Gram-negativeE. coli,K. pneumoniae, orP. aeruginosa(MICs = >100 μg/ml for all).1Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 μg/ml, respectively), as well as RNA and DNA sy...

化合物

Dyclonine hydrochloride

Cat.No: T1389

Synonym: 盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl

Target: Sodium Channel, Antibacterial, Antifungal

Cat.No: T25214

Synonym: CCR11,CCR 11

Target: Antibiotic

Cat.No: T22387

Synonym: 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione

Target: Others

o-Phenanthroline monohydrate

Cat.No: T7449

Synonym: Phenanthroline monohydrate,1, 10-Phenanthroline monohydrate,邻菲罗啉

Target: MMP

Antimicrobial Compound 1

Cat.No: T10337

Target: Antibacterial

Cat.No: T21831

Synonym: G28UCM

Target: Fatty Acid Synthase

Netzahualcoyone

Cat.No: T24527

Cat.No: T80380

Cat.No: T27389

Cat.No: T80379

Cat.No: T80290

Antibacterial agent 88

Cat.No: T64054

Cat.No: T80284

Cat.No: T36659

Cat.No: T37254

Cat.No: T80365

Cat.No: T36904

Cat.No: T38102

Cat.No: T80396

Cat.No: T80369

Cat.No: T80301

Target: Antibiotic

Cat.No: T80300

Target: Antibiotic

Cat.No: T80288

Cat.No: T38290

Synonym: Leucomycin A4

Cat.No: T80291

Cat.No: T38334

Cat.No: T80368

Cat.No: T80364

Cat.No: T13149

Target: Antibacterial

Heronapyrrole B

Cat.No: T38014

Cat.No: T80367

Cat.No: T37731

1-Undecanoyl-rac-glycerol

Cat.No: T37286

Antibacterial agent 113

Cat.No: T63252

Cat.No: T36025

Cat.No: T38289

Synonym: Leucomycin A13

Cat.No: T72002

Antibacterial agent 143

Cat.No: T75172

D-Glucosamine-6-sulfate

Cat.No: T37598

Cat.No: T38167

Terrecyclic Acid

Cat.No: T36330

Cat.No: T37719

Cat.No: T36748

Neospiramycin I

Cat.No: T36183

Flumequine-13C3

Cat.No: T36021

Synonym: Flumequine-13C3

Cat.No: T35671

7,10-dihydroxy-8(E)-Octadecenoic Acid

Cat.No: T36431

Cat.No: T37468

Cat.No: T64160

Cat.No: T36096

Cat. No.	Product Name	Target	Signaling Pathways
T2785	4-Methylherniarin 羟甲香豆素甲醚,7-Methoxy-4-methylcoumarin	Others; Antibacterial	Microbiology/Virology; Others
	4-Methylherniarin (7-Methoxy-4-methylcoumarin) 可荧光标记，是香豆素衍生物，具有抗革兰氏阳性和革兰氏阴性细菌染色的活性。它对B. subtilis 和S.sonnei 有活性，IC50值为 11.76 μg/ml 和 13.47 μg/ml。
T24729	Roseoflavin	Antibacterial	Microbiology/Virology
	Roseoflavin 是天然色素，起初分离自Streptomyces davawensis。Roseoflavin 是核黄素和黄素单核苷酸的抗代谢类似物，显示出抗菌活性。
T37267	Pachybasin	Antibacterial	Microbiology/Virology
	Pachybasin 是一种蒽醌真菌代谢物。 Pachybasin 对大肠杆菌、枯草芽孢杆菌、M. luteus、S. cerevisiae、C. albicans、A. niger 和 A. flavus 具有抗菌活性，MIC 值为 64.0 μg/mL，对金黄色葡萄球菌具有抗菌活性和尖孢镰刀菌，MIC 值分别为 32.0 和 16.0 μg/mL。
T36473	trans-Nerolidol
	trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In a disc assay,trans-nerolidol inhibits the growth ofS. aureus,B. subtilis,E. coli, andS. cerevisiaewith zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.2It reduces viability of CaCo-2 adenocarcinoma cells with an IC50value of 28.7 mg/L and reduces production of re...
T40695	Isouvaretin
	Isouvaretin demonstrates potent antibacterial activity against B. subtilis and S. epidermidis.
T40665	Uvaretin
	Uvaretin demonstrates potent antibacterial activity against B. subtilis (EC50: 8.7 μM) and S. epidermidis (IC50: 7.9 μM).
T71909	Kumbicin C
	Kumbicin C inhibits the growth of NS-1 mouse myeloma cells (IC50 = 0.74 μg/ml) and the growth of the Gram-positive bacteria B. subtilis (MIC = 1.6 μg/ml).
TN4028	Euchrestaflavanone B	PARP; Antifection	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of
T83918	Clazamycin A hydrochloride NSC 332188
	Clazamycin A是一种最初从链霉菌中分离出的抗生素和微生物代谢产物。它对多种细菌具有活性，包括S. aureus、B. anthracis、B. subtilis、E. coli和P. aeruginosa（MICs分别为100、6.25、100、50和25 µg/ml）。
T38019	Nybomycin
	Nybomycin is a fungal metabolite originally isolated from Streptomyces sp. A717 and has antibacterial activity. It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae (MICs = 0.025, 2, 0.8, 0.2, and 0.003 μg/ml, respectively). Nybomycin is also active against M. tuberculosis and M. bovis (MICs = 4.5 and 1 μg/ml, respectively).
TN3978	Epitaraxerol	Antifection	Microbiology/Virology
	Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis.
T36044	17-hydroxy Venturicidin A
	17-hydroxy Venturicidin A is a macrolide fungal metabolite originally isolated from Streptomyces. It has antibiotic activity against M. luteus, B. subtilis, and S. aureus and antifungal activity against V. dahlia, Fusarium, and C. tropicalis in a disc assay.
TN4098	Gancaonin I	GTPase; Antifection	GPCR/G Protein; Microbiology/Virology
	Gancaonin I exhibits anti-BsFtsZ GTPase activities; it also shows significant inhibitory activity against B. subtilis, with a MIC value of 5 uM.
T75441	(8′α,9′β-Dihydroxy)-3-farnesylindole
	(8'α,9'β-Dihydroxy)-3-farnesylindole 对枯草芽孢杆菌具有较强的抑制活性（EC509.8μM）。
T69368	GKK1032B
	GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis.
T83920	4-Trehalosamine
	4-Trehalosamine是一种在Streptomyces中发现的微生物代谢产物，具有抗生素活性。在杯碟法测试中，当浓度为0.5、1和2 mg/ml时，对E. coli、K. pneumoniae和B. subtilis展现出活性。
T38258	Phanerosporic Acid
	Phanerosporic acid is a fungal secondary metabolite originally isolated from P. chrysosporum that has antibacterial activity against B. cereus, B. subtilis, and E. coli and antifungal activity against S. cerevisiae, A. niger, O. ulmi, U. maydis, C. cucmerinum, C. cladosporioides, and B. cinerea.1 It has been used in the synthesis of macrolide derivatives.References1. Arnone, A., Assante, G., Nasini, G., et al. Phanerosporic acid, a β-resorcylate obtained from Phanerochaete chrysosporium. Phytoch...
T37444	Aranorosin
	Aranorosin is a fungal metabolite originally isolated from P. roseus. It has antimicrobial activity against B. subtilis, A. niger, and C. albicans when used at a concentration of 1 mg/ml. Aranorosin also reduces viability in apoptosis-resistant HeLa/Bcl-2 cells.
TN5404	(+)-Conocarpan
	Conocarpan has antinociceptive effects. Conocarpan is quite active against S. aureus and B. subtilis with MIC of 6.25 micrograms/ml, it also shows activity against M. tuberculosis (MIC=15.6 ug/ml). Conocarpan shows considerable activity against epimastigo
T83862	Bactobolin A hydrochloride BN-183B
	Bactobolin A 是一种最初从 Pseudomonas 中分离出的微生物代谢产物，具有抗生素和抗癌活性。它对 S. aureus、S. epidermidis、S. faecalis、B. anthracis、B. subtilis、E. coli、S. typhi 和 S. dysenteriae 活跃(MICs = 0.1-12.5 µg/ml)。在体内，bactobolin A (0.25-4 mg/kg) 提高了 L1210 小鼠白血病模型的存活率。
T38086	Neohydroxyaspergillic Acid
	Neohydroxyaspergillic acid is a fungal metabolite produced by A. sclerotiorum that has antibiotic and antifungal activities. It inhibits the growth of P. aeruginosa, M. smegmatis, S. aureus, E. coli, K. pneumoniae, B. mycoides, and B. subtilis bacteria (MICs = 125-500 μg/ml). Neohydroxyaspergillic acid also inhibits the growth of G. convolute, S. consortiale, P. blakesleeanus, C. globosum, and T. mentagrophytes (MICs = 175-700 μg/ml) but not A. niger, P. notatum, M. verrucaria, or S. cerevisiae ...
T75439	Angustifoline hydrochloride
	Angustifoline hydrochloride是从狭叶狼疮(Lupinus angustifolius L.)的生物碱提取物中分离出的一种生物碱，展现出对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌和苏云金芽孢杆菌的抑制作用，证明了其抗菌活性。
TN4264	Isoapetalic acid 胡桐，海棠木	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis a
T37552	(+)-Macrosphelide A
	(+)-Macrosphelide A is a fungal metabolite originally isolated from Microsphaeropsis. It inhibits adhesion of HL-60 human leukemia cells to human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It also inhibits the growth of SKOV3 ovarian cancer cells in a concentration-dependent manner. (+)-Macrosphelide A inhibits the growth of Gram-positive bacteria, including B. subtilis, M. luteus, B. thuringiensis, and S. aureus (MICs = 143, 143, 57, and 57 μg/ml, respectivel...
TN5014	Shoreic acid	Antifection; HSV	Microbiology/Virology
	Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI
T80343	MCF
	MCF为源自蜂毒的抗菌肽，对E.coli W 160-37、S.aureus 8530及B.subtilis展现出抗菌活性，其最小抑菌浓度(MIC)值分别为E.coli W 160-37为35-45 μg/ml，S.aureus 8530为25-35 μg/ml，及B.subtilis为15-25 μg/ml。
T36329	Terpendole I
	Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 \|1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter...
T35751	Violacein
	Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone , a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.[3] Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 &#181M, respectively). It is also active aga...

天然产物

4-Methylherniarin

Cat.No: T2785

Synonym: 羟甲香豆素甲醚,7-Methoxy-4-methylcoumarin

Target: Others, Antibacterial

Cat.No: T24729

Target: Antibacterial

Cat.No: T37267

Target: Antibacterial

trans-Nerolidol

Cat.No: T36473

Cat.No: T40695

Cat.No: T40665

Cat.No: T71909

Euchrestaflavanone B

Cat.No: TN4028

Target: PARP, Antifection

Clazamycin A hydrochloride

Cat.No: T83918

Synonym: NSC 332188

Cat.No: T38019

Cat.No: TN3978

Target: Antifection

17-hydroxy Venturicidin A

Cat.No: T36044

Cat.No: TN4098

Target: GTPase, Antifection

(8′α,9′β-Dihydroxy)-3-farnesylindole

Cat.No: T75441

Cat.No: T69368

4-Trehalosamine

Cat.No: T83920

Phanerosporic Acid

Cat.No: T38258

Cat.No: T37444

Cat.No: TN5404

Bactobolin A hydrochloride

Cat.No: T83862

Synonym: BN-183B

Neohydroxyaspergillic Acid

Cat.No: T38086

Angustifoline hydrochloride

Cat.No: T75439

Isoapetalic acid

Cat.No: TN4264

Synonym: 胡桐，海棠木

Target: HIV Protease, Antifection

(+)-Macrosphelide A

Cat.No: T37552

Cat.No: TN5014

Target: Antifection, HSV

Cat.No: T80343

Cat.No: T36329

Cat.No: T35751

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