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Search Results for " amiodarone "

14

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21370	Amiodarone Nexterone,胺碘酮,Amiodarona,Cordarone,Aratac,Amiodaronum
	Amiodarone is categorized as a class III antiarrhythmic agent and prolongs phase 3 of the cardiac action potential. It also has numerous other effects, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. Amiodarone chemic
T1496	Amiodarone hydrochloride 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone	Potassium Channel; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
T25301	Deiodoamiodarone Amiodarone hydrochloride impurity A,Dideiodo Amiodarone
	Deiodoamiodarone is an intermediate of amiodarone. Amiodarone is an α/β-adrenergic receptor antagonist and coronary vasodilator.
T20143	L-6424 L 6424,Amiodarone related compound G
	L-6424 is an intermediate of Amiodarone and a non-selective ion channel blocker. It has an antiarrhythmic.
T20141	L-6355 L 6355,Amiodarone related compound E,Demonoiodoamiodarone
	L-6355 is an agent of bioactive chemicals.
T80650	Di-N-desethyl amiodarone hydrochloride	Autophagy	Autophagy
	Di-N-desethyl Amiodarone hydrochloride为Amiodarone的代谢产物，作为一种强效的呼吸链抑制剂。该 Amiodarone作为抗心律失常剂，其机制涉及抑制ATP敏感性钾通道。
T20659	Desethylamiodarone N-Deethylamiodarone,DAMI,LB-33020,LB 33020,N-Monodesethylamiodarone,LB33020
	Diethylamiodarone is the main metabolite of amiodarone in vivo.
T11002	Desethylamiodarone hydrochloride N-desethylamiodarone hydrochloride,LB 33020 hydrochloride	Others	Others
	Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is formed by the CYP3A isozyme. Amiodarone is an antiarrhythmic drug that inhibits ATP-sensitive potassium channels with an IC50 of 19.1 μM. It is the main active metabolite of amiodaro
T1073	Dronedarone hydrochloride Dronedarone HCl,SR33589,决奈达隆盐酸盐,盐酸决奈达隆	Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Dronedarone hydrochloride (SR33589) 是一种胺碘酮类似物，可抑制 Na+,K+andCa2+的电流，有可能治疗心房颤动。
T30374	Benziodarone Coronal-crinos,Carofam,Dilacoron,Dila-Vasal,Corofam
	Benziodarone is a vasodilator that acts as an amiodarone-like action.
T30607	Budiodarone ATI2042,ATI-2042,ATI 2042
	Budiodarone（ATI-2042）is a chemical analog of an antiarrhythmic drug and amiodarone. Budedalone is promising as an antiarrhythmic agent for the prevention of atrial fibrillation.
T74678	Budiodarone tartrate
	Budiodarone (ATI-2042) tartrate 是 Amiodarone 的化学类似物，具有平衡的、多种心脏离子通道 (potassium,sodiumandcalcium channels) 抑制活性。Budiodarone tartrate 是一种抗心律失常剂。
T32030	GYKI-16638 HCl GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638
	GYKI-16638 is a novel antiarrhythmic agent that demonstrates combined class IB and class III antiarrhythmic properties in human ventricular muscles, similar to the electrophysiological findings after chronic amiodarone treatment. In addition, GYKI 16638 h
T35712	Debutyldronedarone hydrochloride SR35021 hydrochloride
	N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h...

化合物

Cat.No: T21370

Synonym: Nexterone,胺碘酮,Amiodarona,Cordarone,Aratac,Amiodaronum

Amiodarone hydrochloride

Cat.No: T1496

Synonym: 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone

Target: Potassium Channel, Adrenergic Receptor, Autophagy

Deiodoamiodarone

Cat.No: T25301

Synonym: Amiodarone hydrochloride impurity A,Dideiodo Amiodarone

Cat.No: T20143

Synonym: L 6424,Amiodarone related compound G

Cat.No: T20141

Synonym: L 6355,Amiodarone related compound E,Demonoiodoamiodarone

Di-N-desethyl amiodarone hydrochloride

Cat.No: T80650

Target: Autophagy

Desethylamiodarone

Cat.No: T20659

Synonym: N-Deethylamiodarone,DAMI,LB-33020,LB 33020,N-Monodesethylamiodarone,LB33020

Desethylamiodarone hydrochloride

Cat.No: T11002

Synonym: N-desethylamiodarone hydrochloride,LB 33020 hydrochloride

Target: Others

Dronedarone hydrochloride

Cat.No: T1073

Synonym: Dronedarone HCl,SR33589,决奈达隆盐酸盐,盐酸决奈达隆

Target: Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, Autophagy

Cat.No: T30374

Synonym: Coronal-crinos,Carofam,Dilacoron,Dila-Vasal,Corofam

Cat.No: T30607

Synonym: ATI2042,ATI-2042,ATI 2042

Budiodarone tartrate

Cat.No: T74678

Cat.No: T32030

Synonym: GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638

Debutyldronedarone hydrochloride

Cat.No: T35712

Synonym: SR35021 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
T7056	Dronedarone 决奈达隆,SR 33589	P450; Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Dronedarone (SR 33589) 是一种胺碘酮类似物，对治疗心房颤动可能有效。它是CYP3A4的底物和中度抑制剂。它是多种离子电流的有效阻滞剂，通过非竞争性结合到肾上腺素能受体显示出抗肾上腺素能的效果。

天然产物

Cat.No: T7056

Synonym: 决奈达隆,SR 33589

Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy

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