11
1
Cat. No. | Product Name | Target | Signaling Pathways |
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T10396 |
ATM Inhibitor-1
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ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM). | |||
T5092 |
AIM-100
AIM100 |
ACK | Tyrosine Kinase/Adaptors |
AIM-100 是选择性的 Ack1 抑制剂 (IC50:21.58 nM)。它还抑制 Tyr267磷酸化,但不抑制其他激酶,包括 PI3K 和 AKT 亚家族成员。它具有抗癌活性。 | |||
T62684 |
ATM Inhibitor-5
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ATM Inhibitor-5 [formula (1)] 是一种丝氨酸/苏氨酸蛋白激酶 ATM 的有效抑制剂。 | |||
T63279 | ATM Inhibitor-2 | ||
ATM Inhibitor -2 是强效的、选择性的 ATM 抑制剂 (IC50<1 nM)。 | |||
T35942 |
AZ 5704
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Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan in tumor bearing, immunocompromised mice. Orally bioavailable. Degorce et al (2016) Discovery of novel 3-quinoline carboxamides as potent, selective and orally bioavailable inhibitors of ataxia telangiecta... | |||
T63714 | ATM-IN-1 | ||
ATM-IN-1 是 ATM 的有效抑制剂。其中 ATM 主要位于细胞核和微粒体中,参与细胞周期进程和细胞周期检查点对 DNA 损伤的反应。ATM-IN-1 对癌症和神经疾病表现出研究潜力。 | |||
T79305 |
ATM Inhibitor-8
|
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
ATMInhibitor-8(Compound 10r)为口服型有效且选择性ATM抑制剂,IC50值为1.15 nM,表现出抗肿瘤活性。 | |||
T63317 | ATM Inhibitor-4 | ||
ATM Inhibitor -4 是选择性的、强效的 ATM 抑制剂 (IC50: 0.32 nM),较强的抑制PI3K 激酶家族的活性,并表现出良好的代谢稳定性。ATM Inhibitor-4 在 1 μM 时能完全抑制mTOR。 | |||
T79306 |
ATM Inhibitor-9
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ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
ATMInhibitor-9 (Compd 7a)是一种针对癌症研究的ATM抑制剂,其针对ATM激酶的IC50为5 nM,显示出高效抑制活性。 | |||
T78711 |
A011
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ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
A011,作为一种选择性的ataxia-telangiectasia mutated (ATM)抑制剂,其IC50为1.0 nM,能够在与CPT-11联合应用时,诱导Apoptosis及G2/M期细胞周期阻滞,显示出显著的抗肿瘤活性。 | |||
T60273 |
Mirin
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Mirin 是一种有效的 Mre11-Rad50-Nbs1 (MRN)复合物抑制剂。Mirin 可在不影响 ATM 蛋白激酶活性的情况下,抑制ATM 的 MRN 依赖性激活(IC50=12 μM),并抑制 Mre11 相关的核酸外切酶活性。与其靶向 MRN 复合物的能力一致,Mirin 可消除哺乳动物细胞中的 G2/M 检查点和同源性依赖性修复。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3824 |
Jaceosidin
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Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 |