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Cat. No. | Product Name | Target | Signaling Pathways |
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T62491 |
STAT3-IN-13
|
STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-13 是一种有效的 STAT3 抑制剂。STAT3-IN-13 具有抗增殖和抗癌活性,通过与 STAT3 SH2 结构域结合发挥作用。STAT3-IN-13 抑制 STAT3 Y705 的磷酸化,诱导细胞凋亡 ,抑制肿瘤细胞的生长和转移。STAT3-IN-13 可用于研究乳腺癌和肝癌。 | |||
T13009 |
STAT3-IN-1
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
STAT3-IN-1 是一种选择性的、口服有效的 STAT3的强效抑制剂,可诱导肿瘤细胞凋亡,其在 HT29 和MDA-MB 231 细胞中的IC50值分别为1.82 μM 和2.14 μM。 | |||
T5198 |
Bobcat339
盐酸Bobcat339,Bobcat339 hydrochloride |
DNA Methyltransferase | Chromatin/Epigenetic |
Bobcat339 是一种基于胞嘧啶的选择性TET 酶抑制剂,抑制TET1和TET2的IC50值分别为 33 和 73 μM。它可作为靶向 DNA 甲基化和基因转录新疗法的起点,用于表观遗传学领域研究。 | |||
T28865 |
STAT3-IN-B9
STAT3 IN B9,B9 |
STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-B9 (B9) 是异常 STAT3 激活的抑制剂,可抑制 MDA-MB-468、MDA-MB-231 和 DU145 等肿瘤细胞的增殖。 | |||
T61030 |
STAT3-IN-11
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
STAT3-IN-11 是一种选择性 STAT3 抑制剂,对 STAT3pTyr705位点的磷酸化和Survivin 的磷酸化有抑制作用。STAT3-IN-11 促使癌细胞凋亡,是治疗癌症的候选化合物。 | |||
T62803 | STAT3-IN-12 | ||
STAT3-IN-12 是一种 STAT3 的有效信号抑制剂,对 IL-6 诱导的 JAK/STAT3 信号通路的激活具有抑制作用。STAT3-IN-12 对癌细胞生长、迁移具有抑制作用,可阻滞细胞周期并诱导细胞凋亡。STAT3-IN-12 能够用于癌症的相关研究(如肝细胞癌 (HCC) 、食管癌)。 | |||
T63426 | mGAT3/4-IN-1 | ||
mGAT3/4-IN-1 是 mGAT3/mGAT4 的有效抑制剂,他们的 pIC50 值分别为 5.31 和 5.24。在糖尿病神经病变小鼠中,mGAT3/4-IN-1 能够明显抑制触觉异常性疼痛。 | |||
T62317 | α7 nAchR-JAK2-STAT3 agonist 1 | ||
α7 nAchR-JAK2-STAT3 agonist 1 是一种 α7 nAchR-JAK2-STAT3 通路的有效抑制剂,能够作用于一氧化氮 (NO) (IC50: 0.32 μM)。α7 nAchR-JAK2-STAT3 agonist 1 在小鼠巨噬细胞 RAW264.7 中对 iNOS、IL-1β 和 IL-6 的表达具有有效的抑制作用。α7 nAchR-JAK2-STAT3 agonist 1 对 LPS 诱导的 NO 释放、NF-κB 激活和细胞因子产生具有抑制作用。α7 nAchR-JAK2-STAT3 agonist 1 能够用于研究败血症。 | |||
TP2222 |
APTSTAT3-9R
|
Others | Others |
APTSTAT3-9R-9R is a STAT3 inhibitor (Ki: 231 nmol/L). STAT3 has been reported to promote the proliferation, survival, metastasis, immune escape, as well as drug resistance of cancer cells, making it a promising target for various diseases. However, though | |||
T64573 |
Stat3 (124H6) Mouse mAb #9139M
|
||
Stat3 (124H6) Mouse mAb #9139M 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64573。 | |||
TP2222L |
APTSTAT3-9R acetate
|
STAT | JAK/STAT signaling; Stem Cells |
APTSTAT3-9R acetate 是一种特异性肽结合 STAT3,具有抗增殖和抗肿瘤活性。 APTSTAT3-9R acetate 并通过特异性阻断 STAT3 磷酸化来抑制 STAT3 活化和下游信号传导。 | |||
T78983 |
STAT3 degrader-2
|
STAT | JAK/STAT signaling; Stem Cells |
STAT3degrader-2为基于PROTAC技术的STAT3降解剂,能有效下调总STAT3蛋白水平, 适用于癌症等病理条件的研究。 | |||
T63408 |
mGAT3/4-IN-2
|
||
mGAT3/4-IN-2 是mGAT3/mGAT4的有效抑制剂,他们的pIC50值分别为 5.44 和 5.25。 | |||
T72754 |
JAK2/STAT3-IN-1
|
||
JAK2/STAT3-IN-1 -10a) 是一种有效的 GP130抑制剂,IC50为 3.04 µM。JAK2/STAT3-IN-1 显示出抗肿瘤活性。 | |||
T79609 |
STAT3-IN-18
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
STAT3-IN-18 (compound SPP),一种带紫檀芪衍生轴向配体的铂(IV)络合物,能抑制乳腺癌(BC)细胞的JAK2-STAT3通路,显示出抗增殖活性。它激活caspase-3和裂解聚ADP-核糖聚合酶,诱导apoptosis。此外,STAT3-IN-18可促进树突状细胞成熟与抗原呈递,体现了良好的体内安全性。 | |||
T75099 |
PROTAC STAT3 degrader-2
|
||
PROTACSTAT3 degrader-2 是一种选择性、有效的STAT3蛋白PROTAC 降解剂,在 Molm-16 细胞中的DC50为 3.54 μM。PROTACSTAT3 degrader-2 具有用于癌症研究的潜力。 | |||
T71550 | STAT3-IN-8 | STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-8(即化合物H172)是一种高效的STAT3抑制剂,具备在癌症研究中应用的潜力。 | |||
T79662 | STAT3-IN-20 | STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-20(Compound 40)是一种选择性地靶向STAT3的SH2结构域,展现了在DU145和MDA-MB-231癌细胞中的抗增殖效果(IC50分别为2.97 μM和3.26 μM),并诱导细胞周期停滞与细胞凋亡。该抑制剂有效抑制了STAT3的磷酸化、核内易位及其下游基因的转录活性(IC50: 0.65 μM)。 | |||
T73114 | STAT3-IN-7 | ||
STAT3-IN-7 是一种芳基磺胺氮杂环丁烷化合物,是一种具有口服活性的STAT3抑制剂,具有抗癌活性。 | |||
T60765 |
STAT3-IN-10
|
||
STAT3-IN-10 (A11) 是一种STAT3抑制剂,可直接结合 STAT3 SH2 结构域,抑制肿瘤细胞生长并且诱导肿瘤细胞凋亡 (IC 50 = 5.18 μM)。 | |||
T64629 | Phospho-Stat3 (Tyr705) Antibody #9131R | ||
Phospho-Stat3 (Tyr705) Antibody #9131R 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64629。 | |||
T71351 | STAT3-IN-A69 | ||
STAT3-IN-A69 is an inhibitor targeting the DNA-binding domain of STAT3, suppressing tumor growth, metastasis and STAT3 target gene expression in vivo. | |||
T61012 | Bobcat339 hydrochloride | ||
Bobcat339 hydrochloride 可用于表观遗传学领域,并作为靶向 DNA 甲基化和基因转录的新疗法的起点。它是一种有效的选择性胞嘧啶的 TET 酶的抑制剂,对 TET1和 TET2的 IC50值分别为 33 μM 和 73 μM。 | |||
T74545 |
STAT3 degrader-1
|
||
STAT3degrader-1 (compound 295) 是一种有效的 STAT3降解剂。STAT3degrader-1 可用于抗癌研究。 | |||
T13010 |
STAT3-IN-3
|
STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator. | |||
T73035 |
STAT3-IN-15
|
||
STAT3-IN-15是一款有效、具口服活性的STAT3抑制剂,用于对抗特发性肺纤维化(IPF)。该化合物阻止STAT3磷酸化,同时抑制TGF-β1引起的上皮细胞迁移及变形,并防止上皮间质转化(EMT)。 | |||
T61779 |
STAT3-IN-9
|
||
STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at the G2/M phase [1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T73070 |
STAT3-IN-14
|
||
STAT3-IN-14是一种STAT3抑制剂,具有STAT3磷酸化抑制活性,可直接与 STAT3的铰链区结合。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00916 |
Antithrombin III Protein, Human, Recombinant (His)
AT3D,THPH7,ATIII,AT3... |
Human | HEK293 Cells |
Antithrombin III Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.5 kDa and the accession number is A0A024R944. | |||
TMPY-00569 |
B3GAT3 Protein, Human, Recombinant (His)
beta-1,3-glucuronyltransferase 3,glcUA... |
Human | E. coli |
B3GAT3, encoding beta-1,3-glucuronyltransferase 3, has an important role in proteoglycan biosynthesis. Homozygous B3GAT3 mutations have been associated with short stature, skeletal deformities, and congenital heart defects. There is a novel B3GAT3-related disorder with craniosynostosis and bone fragility, due to a unique homozygous mutation in B3GAT3. | |||
TMPH-02539 |
MGAT3 Protein, Mouse, Recombinant (His & Myc)
|
Mouse | E. coli |
It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition,... | |||
TMPY-06624 |
STAT3 Protein, Human, Recombinant (His)
ADMIO,signal transducer and activator of transcript... |
Human | E. coli |
STAT3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 65.31 kDa and the accession number is P40763-1. |