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Cat. No. | Product Name | Target | Signaling Pathways |
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T14336 |
Allitinib
AST-1306,ALS 1306 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Allitinib (AST-1306) 是可口服的 EGFR 和 ErbB2不可逆抑制剂,IC50分别为 0.5 和 3 nM。它具有抗癌活性,抑制 ErbB4,IC50为 0.8 nM。 | |||
T29909 |
ALS-I
ALS1,Acid-Liable Surfactant-1,ALS 1,ALS-1 |
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ALS-1 is an acid-Liable surfactant. | |||
T60120 |
SOD1-Derlin-1 inhibitor 56-59
|
Others | Others |
SOD1-Derlin-1 inhibitor 56-59是SOD1-Dderin-1相互作用的抑制剂。SOD1-Derlin-1 inhibitor 56-59在肌萎缩侧索硬化症(ALS)研究中具有潜力。 | |||
T39924 |
NF-κΒ activator 2
|
NF-κB | NF-κB |
NF-κΒ activator 2 是口服有效的 NF-ҡB 激活剂,EC50为 1.58 μM。它通过增加 NF-κB 的表达和激活来诱导 SOD2。它具有用于研究肌萎缩性侧索硬化症的价值。 | |||
T35689 |
MTP 131 acetate
|
Others | Others |
MTP 131 acetate 是一种小的线粒体靶向四肽。 | |||
T81580 |
Ozanezumab
GSK1223249 |
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Ozanezumab (GSK1223249) 是一种anti-Nogo-A 单克隆抗体,用于肌萎缩侧索硬化症 (ALS) 及多发性硬化症研究。 | |||
T78221 |
TRAF6 peptide TFA
|
E1/E2/E3 Enzyme | Ubiquitination |
TRAF6 peptide TFA是一种抑制TRAF6-p62相互作用的特异性分子,可抑制NGF依赖的TrkA泛素化,展现在阿尔茨海默症(AD)、帕金森病、ALS、创伤性脑损伤、癫痫和中风等神经系统疾病研究中的应用潜力。 | |||
T72959 |
NUCC-0000323
|
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NUCC-0000323 是一种针对超氧化物歧化酶 1 (SOD1) 的有效抑制剂,能够抑制 SOD1 的表达。该化合物在肌萎缩侧索硬化症 (ALS) 研究中有潜在应用。 | |||
T39498 |
Tofersen
BIIB067,ISIS-SOD1Rx |
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Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compound holds potential for amyotrophic lateral sclerosis (ALS) research. | |||
T70941 |
CLR01 sodium
|
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CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. CLR01 inhibits Ebola and Zika virus infection. CLR01 Stabilizes a Disordered Protein-Protein Interface. CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. | |||
T80642 |
Foramsulfuron
|
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Foramsulfuron作为磺酰脲类除草剂,专用于玉米(Zea mays L.)中选择性地防控禾本科以及部分阔叶杂草。该化合物通过抑制关键酶乙酰乳酸合酶(acetolactate synthase, ALS)的活性,从而表现出对杂草的抑制功能,ALS主导支链氨基酸的生物合成途径。 | |||
T76372 |
TRAF6 peptide
|
||
TRAF6 peptide 是一种特异性的TRAF6-p62相互作用抑制剂。TRAF6 peptide 能消除 NGF 依赖性TrkA 泛素化。TRAF6 peptide 在诸如阿尔茨海默症 (AD)、帕金森、ALS、头部外伤、癫痫和中风等神经系统性疾病中具有较好的研究潜力。 | |||
T78603 |
Sotuletinib dihydrochloride
BLZ945 dihydrochloride |
c-Fms | Tyrosine Kinase/Adaptors |
Sotuletinib (BLZ945) dihydrochloride 是一种CSF1-R特异性抑制剂,具有口服活性和血脑屏障透过性 (IC50=1 nM)。它能诱导肿瘤细胞凋亡,并在小鼠模型中有效抑制肿瘤生长,适用于癌症和肌萎缩侧索硬化症 (ALS) 研究。 | |||
T61546 |
c-ABL-IN-3
|
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c-ABL-IN-3, a highly effective c-Abl inhibitor, exhibits promising potential for studying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), as well as cancer [1]. The activation of c-Abl has been strongly implicated in a range of diseases, notably cancer [1]. It offers valuable opportunities for research in these fields [1]. | |||
T61128 |
c-ABL-IN-2
|
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C-ABL-IN-2 is a highly effective inhibitor of the c-Abl protein, which plays a significant role in the development of several diseases, including cancer. This compound exhibits promise for investigating neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), as well as cancer. (Source: WO2020260871A1, compound 25) [1]. | |||
T76243 |
Proteasome-activating peptide 1 TFA
|
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Proteasome-activating peptide 1 TFA 是一种肽类蛋白酶体激活剂,能显著增强胰凝乳蛋白酶样蛋白酶体的催化活性,进而提升体外及培养环境中的蛋白质水解效率。此外,Proteasome-activating peptide 1 TFA 还能有效阻止肌萎缩侧索硬化症细胞模型内的蛋白质聚集现象。 | |||
T38218 |
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
|
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1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 是一种在生物膜中的磷脂,在 sn-1 和 sn-2 位置分别含有硬脂酸和二十二碳六烯酸。它已被用于研究脂膜的组织和动力学。在超氧化物歧化酶 1 突变体转基因小鼠肌萎缩性脊髓侧索硬化症(ALS)模型中1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 的水平在疾病晚期会在 L5 前角下降。1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 可用于研究生物膜。 | |||
T60953 | BSc5367 | ||
BSc5367 是Nek1激酶结构域的有效抑制剂,IC50值为 11.5 nM。Nek1 是一种NIMA 相关的蛋白激酶,在细胞周期调节、DNA 修复和微管调节中起着关键作用。Nek1 功能障碍在肌萎缩侧索硬化症 (ALS)、多囊肾病 (PKD) 和几种类型的放疗耐药性癌症中发挥关键作用。BSc5367 为更好的理解上述疾病提供了有用工具。 | |||
T81372 |
Proteasome-activating peptide 1
|
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Proteasome-activating peptide 1 是一种肽,其作用是提升胰凝乳蛋白酶样蛋白酶体(proteasome)的催化活性,有效增强体外及细胞培养环境下的蛋白质降解效率。此外,该肽能阻止肌萎缩侧索硬化症(Amyotrophic Lateral Sclerosis, ALS)细胞模型中蛋白质的过度聚集。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T75527 |
Chrexanthomycin C
|
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Chrexanthomycin C 是一种具有显著生物活性的海洋天然产物,具有口服活性。Chrexanthomycin C 对 DNA (G4C2)4 G4 具有结合亲和力,Kd 值为 2.8 mM。Chrexanthomycin C 可用于肌萎缩侧索硬化症 (ALS) 等神经退行性疾病的研究。 | |||
T82822 |
Brassicanate A sulfoxide
|
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Brassicanate A sulfoxide 表现出除草效果,它能抑制植物中必需氨基酸的生物合成路径。该化合物通过结合并抑制多种酶的活性来发挥其作用,包括二羟酸脱水酶 (DHAD)、羟甲基丙酮酸双加氧酶 (HPPD)、乙酰乳酸合酶 (ALS)、PYL家族蛋白及转运抑制剂响应 1 (TIR1)。Brassicanate A sulfoxide 可以从甘蓝 (Brassica oleracea) 中提取获得。 |