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Search Results for " alk3 "

Targets Recommended: ALK TGF-beta/Smad

14

抑制剂 & 化合物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1944	LDN-214117	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN214117 是一种高效的 ALK2 选择性抑制剂(IC50:22nM)，也是一种 BMP6 抑制剂(IC50:100nM)，对ALK5抑制力弱100倍。
T1935	LDN193189 LDN-193189,DM-3189,LDN 193189	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN193189 (LDN-193189) 是BMPI 型受体的选择性抑制剂，能够抑制 ALK2 (IC50:5 nM)、 ALK3 (IC50:30 nM)。对 ALK4、ALK5 和 ALK7 的作用效果弱 (IC50≥500 nM)。
T10287	ALK2-IN-2	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	ALK2-IN-2是一种强效且具有选择性激活素受体样激酶2（ALK2）的抑制剂（IC50：9 nM），对 ALK2的抑制作用比 ALK3高700倍。
T1943	ML347 LDN 193719	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	ML347 (LDN 193719) 是一种选择性的 ALK1/ALK2 抑制剂，它们的 IC50 分别为 46/32 nM，比对 ALK3 的抑制性高 300 倍。
T1977	Dorsomorphin Compound C,BML-275	AMPK; Autophagy; TGF-beta/Smad	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	Dorsomorphin (BML-275) 是一种 AMPK 抑制剂 (Ki=109 nM)，具有选择性和 ATP 竞争性。Dorsomorphin 可以抑制 BMP I 型受体 ALK2、ALK3 和 ALK6。Dorsomorphin 可诱导自噬，具有抗肿瘤活性。
T35348	LDN-193189 2HCl LDN-193189 2HCl,DM-3189 2HCl	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN-193189 2HCl (DM-3189 2HCl) 是一种选择性 BMP 信号抑制剂，对ALK1,ALK2,ALK3和ALK6有抑制作用，在激酶实验中显示的 IC50 分别为 0.8 nM、0.8 nM、5.3 nM 和 16.7 nM。LDN-193189 2HCl 在C2C12细胞中对BMP I 型受体ALK2和ALK3的转录活性有抑制作用，IC50分别为5 nM 和30 nM，作用于BMP 比作用于TGF-β选择性高200倍。
T1914	K02288 K 02288	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	K 02288是骨形态发生蛋白 (BMP) I 型受体抑制剂，能够抑制 ALK1 (IC50:1.8nM)、ALK2 (IC50:1.1nM)、ALK6 (IC50:6.4nM)。对 ALK3 和 ALK6 的抑制稍弱，IC50在 5-34 nM 之间。
T24897	TP0427736 TP427736,TP-0427736,TP-427736	TGF-beta/Smad	Stem Cells
	TP0427736 是一种有效的选择性 ALK5 抑制剂，IC50 为 2.72 nM，比对 ALK3 的抑制作用高 300 倍。 TP0427736 可降低人外根鞘细胞中 TGF-β 诱导的生长抑制，并延长小鼠毛囊中的生长期。
T1942	DMH-1 DMH1	ALK; Autophagy; TGF-beta/Smad	Angiogenesis; Autophagy; Stem Cells; Tyrosine Kinase/Adaptors
	DMH-1 是一种选择性 BMP 抑制剂，对 ALK1、ALK2、ALK3和 ALK6的 IC50值分别为 27、107.9、<5和 47.6 nM。
T6146	Dorsomorphin dihydrochloride BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride	AMPK; Autophagy; TGF-beta/Smad	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	Dorsomorphin dihydrochloride (BML-275 2HCl) 是一种选择性和 ATP 竞争性的AMPK 抑制剂，Ki 为 109 nM。它诱导自噬，通过靶向抑制 I 型受体ALK2，ALK3和ALK6来抑制 BMP 途径。
T1900	LDN-212854 LDN212854,BMP Inhibitor III	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN-212854 (BMP Inhibitor III) 是一种新型BMP 抑制剂，抑制 ALK2 的IC50=1.3 nM，比对ALK1，ALK3，ALK4和ALK5的抑制性高2，66，1641和7135倍。
T6158	LDN-193189 HCl LDN193189 Hydrochloride	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	LDN-193189 HCl (LDN193189 Hydrochloride) 是一种选择性 BMP I 型受体激酶抑制剂。
T63897	LDN193189 Tetrahydrochloride
	LDN193189 Tetrahydrochloride 是 BMPI 型受体的选择性抑制剂，能够抑制 ALK2 (IC50: 5 nM) 和 ALK3 (IC50: 30 nM)，对 ALK4，ALK5 和 ALK7 的作用效果弱 (IC50≥500 nM)。
T61029	TP0427736 hydrochloride
	TP0427736 hydrochloride 可用于雄激素性脱发 (AGA) 研究。TP0427736 hydrochloride 可抑制由 TGF-β1 诱导的 A549 细胞中 Smad2/3 的磷酸化，IC50值为 8.68 nM。它也是ALK5激酶的有效抑制剂，IC50值为 2.72 nM，比对 ALK3 836 nM 的抑制作用高 300 倍。

化合物

Cat.No: T1944

Target: ALK, TGF-beta/Smad

Cat.No: T1935

Synonym: LDN-193189,DM-3189,LDN 193189

Target: ALK, TGF-beta/Smad

Cat.No: T10287

Target: ALK, TGF-beta/Smad

Cat.No: T1943

Synonym: LDN 193719

Target: ALK, TGF-beta/Smad

Cat.No: T1977

Synonym: Compound C,BML-275

Target: AMPK, Autophagy, TGF-beta/Smad

LDN-193189 2HCl

Cat.No: T35348

Synonym: LDN-193189 2HCl,DM-3189 2HCl

Target: ALK, TGF-beta/Smad

Cat.No: T1914

Synonym: K 02288

Target: ALK, TGF-beta/Smad

Cat.No: T24897

Synonym: TP427736,TP-0427736,TP-427736

Target: TGF-beta/Smad

Cat.No: T1942

Synonym: DMH1

Target: ALK, Autophagy, TGF-beta/Smad

Dorsomorphin dihydrochloride

Cat.No: T6146

Synonym: BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride

Target: AMPK, Autophagy, TGF-beta/Smad

Cat.No: T1900

Synonym: LDN212854,BMP Inhibitor III

Target: ALK, TGF-beta/Smad

Cat.No: T6158

Synonym: LDN193189 Hydrochloride

Target: ALK

LDN193189 Tetrahydrochloride

Cat.No: T63897

TP0427736 hydrochloride

Cat.No: T61029

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01764	BMPR1A/ALK-3 Protein, Human, Recombinant (His) bone morphogenetic protein receptor, type IA,ALK	Human	HEK293 Cells
	BMPR1A/ALK-3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is P36894.
TMPY-05485	BMPR1A/ALK-3 Protein, Human, Recombinant (hFc) ACVRLK3,SKR5,10q23del,CD292,bone morphogen...	Human	HEK293 Cells
	BMPR1A/ALK-3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.9 kDa and the accession number is P36894.
TMPY-01374	BMPR1A/ALK-3 Protein, Mouse, Recombinant (His) ALK3,BMPR-IA,bone morphogenetic protein re...	Mouse	HEK293 Cells
	BMPR1A/ALK-3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.8 kDa and the accession number is P36895.
TMPJ-00325	BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His) BMP Type-1A Receptor,Bone Morphogenetic Protein Receptor Typ...	Human	HEK293 Cells
	Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A is a single-pass type I membrane protein and highly expressed in skeletal muscle. BMPR1A contains one GS domain and one protein protein kinase domain. BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. BMPR1A can activate SMAD transcriptional regulators, ...
TMPY-00962	BMPR1A/ALK-3 Protein, Mouse, Recombinant (His & hFc) Bmpr,bone morphogenetic protein receptor, type IA,BMPR-IA,AU...	Mouse	HEK293 Cells
	BMPR1A/ALK-3 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 42 kDa and the accession number is P36895.

重组蛋白

BMPR1A/ALK-3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01764

Species: Human

Expression System: HEK293 Cells

BMPR1A/ALK-3 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05485

Species: Human

Expression System: HEK293 Cells

BMPR1A/ALK-3 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01374

Species: Mouse

Expression System: HEK293 Cells

BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00325

Species: Human

Expression System: HEK293 Cells

BMPR1A/ALK-3 Protein, Mouse, Recombinant (His & hFc)

Cat.No: TMPY-00962

Species: Mouse

Expression System: HEK293 Cells

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