Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4343 |
A-196
A 196 |
Histone Methyltransferase | Chromatin/Epigenetic |
A-196 是一种选择性有效的 SUV420H1和 SUV420H2抑制剂,IC50值分别为 0.025 和 0.144 μM。它是一种 SUV4-20的化学探针,以底物竞争性方式抑制 SUV4-20,用于研究组蛋白甲基转移酶在基因组完整性中的作用。 | |||
T5600 |
Darovasertib
LXS196 |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Darovasertib (LXS196) 是一种有效的、选择性的和具有口服活性的蛋白激酶C(PKC) 抑制剂,有用于葡萄膜黑素瘤的研究潜力,对 PKCα、PKCθ 和 GSK3β 的 IC50值分别为 1.9、0.4 和 3.1 μM。 | |||
T83847 |
SP-A (196-215) (human) TFA
Surfactant Protein A,SPA4 |
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表面活性蛋白A(SP-A)(196-215)是一种合成肽,与人类SP-A的C末端碳水化合物识别域的196至215氨基酸序列相对应。当浓度为1和10 µM时,它能抑制JAWSII鼠树突细胞中由LPS诱导的TNF-α释放。SP-A(196-215)(75 µM)促使JAWSII细胞吞噬P. aeruginosa。通过气管内给药,SP-A(196-215)(50 µg/动物)降低了小鼠P. aeruginosa感染模型的疾病严重程度和肺部形成菌落数。 | |||
T80754 | YJ196 | ||
YJ196(Compound 59)作为一种新德里金属-β-内酰胺酶-1(NDM-1)抑制剂,拥有潜在的应用价值。 | |||
T69871 |
ICRF-196
|
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ICRF-196 is a Topoisomerase II Inhibitor and antineoplastic agent. | |||
T4490 |
PF-01247324
|
Sodium Channel | Membrane transporter/Ion channel |
PF01247324是一种选择性的、口服有效的Nav1.8通道阻断物,对人类重组Nav1.8 的IC50为196 nM。 | |||
T3626 |
Acalabrutinib
ACP-196,阿可替尼 |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Acalabrutinib (ACP-196) 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK 抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。 | |||
T36692 |
Fanotaprim
|
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Fanotaprim 是二氢叶酸还原酶的有效抑制剂,抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形虫病方面具有价值。 | |||
T82695 |
Colestilan
MCI-196,Colestimide |
||
Colestilan (MCI-196),一种口服活性的非吸收、非钙基磷酸盐粘合剂,同时为非金属阴离子交换树脂,主要应用于高胆固醇血症的研究。 | |||
T76904 | Amubarvimab | ||
Amubarvimab (BRII-196) 是一种人IgG1mAb,可结合刺突蛋白受体结合域 (RBD) 上的非竞争表位,KD 为 5.88 nM。Amubarvimab 可有效中和 SARS-CoV-2 变异体。 | |||
T79806 |
5-HT2A&5-HT2C agonist-1
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT2A&5-HT2C agonist-1 (Example 2) 是一种选择性的5-HT2A和5-HT2C受体激动剂,其IC50值分别为196 nM和0.9 nM。本化合物主要应用于研究抑郁症、酒精依赖、烟草和可卡因成瘾、炎症、丛集性头痛、PTSD、癫痫等中枢神经系统相关疾病。 | |||
T36974 |
D-threo-PPMP hydrochloride
|
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D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 μM and significantly inhibits DNA synthesis at 3 μM.3[Matreya, LLC. Catalog No. 1865] 1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(201... | |||
T37963 |
Methylchloroisothiazolinone/Methylisothiazolinone Mixture
|
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Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.1,2It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) forS. aureus,P. aeruginosa,A. niger, andC. albicans, respectively.2MCIT/MIT can elicit contact sensitization.3Formulations containing MCIT/MIT have been used for controlling microbial growth in industrial and household products. 1.Frenzel, E., Schmidt... | |||
T36779 |
NG 25 (hydrochloride hydrate)
|
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NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectiv... |